On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences

Journal of Medicinal Chemistry

Volumn 52, Issue 18, 2009, Pages 5662-5672

  Machon, Uwe ^a,b   Buchold, Christian ^b   Stempka, Martin ^b   Schirmeister, Tanja ^b   Gelhaus, Christoph ^c   Leippe, Matthias ^c   Gut, Jiri ^d   Rosenthal, Philip J ^d   Kisker, Caroline ^e   Leyh, Matthias ^e   Schmuck, Carsten ^a,b  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF KIEL   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CATHEPSIN B; CATHEPSIN L; CHLOROQUINE; CYSTEINE PROTEINASE INHIBITOR; EFLORNITHINE; FALCIPAIN 2; FUMARIC ACID DERIVATIVE; FUMARIC ACID GLYCYLGLYCYLPHENYLALANYLASPARAGINYLCYCLOHEXYLGLYCYLVALYLVALINAMIDE; FUMARIC ACID GLYCYLGLYCYLPHENYLALANYLGLUTAMINYLCYCLOHEXYLGLYCYLVALYLVALINAMIDE; FUMARIC ACID GLYCYLGLYCYLPHENYLALANYLPHENYLALANYLLEUCYLLEUCYLVALINAMIDE; MELARSOPROL; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; NIFURTIMOX; PENTAMIDINE; PEPTIDE LIBRARY; PROTOZOAL PROTEIN; RHODESAIN; SURAMIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIMALARIAL ACTIVITY; ARTICLE; COMBINATORIAL LIBRARY; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INACTIVATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN TISSUE; MALARIA FALCIPARUM; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA RHODESIENSE;

AMINO ACID SEQUENCE; ANIMALS; ANTIPROTOZOAL AGENTS; CATHEPSIN L; CATHEPSINS; CATTLE; COMBINATORIAL CHEMISTRY TECHNIQUES; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DIAMIDE; DRUG EVALUATION, PRECLINICAL; FUMARATES; HUMANS; PEPTIDE LIBRARY; PLASMODIUM FALCIPARUM;

EID: 70349210244     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900629w     Document Type: Article

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