Fluorescence-quenched solid phase combinatorial libraries in the characterization of cysteine protease substrate specificity

Journal of Combinatorial Chemistry

Volumn 1, Issue 6, 1999, Pages 509-523

  St Hilaire, Phaedria M ^a   Willert, Marianne ^a   Juliano, Maria Aparecida ^b   Juliano, Luiz ^b   Meldal, Morten ^a  

^a CARLSBERG LABORATORY   (Denmark)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; OLIGOPEPTIDE; PAPAIN; PEPTIDE; PEPTIDE LIBRARY;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; ENZYME SPECIFICITY; KINETICS; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; PROTEIN CONFORMATION; SYNTHESIS;

AMINO ACID SEQUENCE; BINDING SITES; COMBINATORIAL CHEMISTRY TECHNIQUES; CYSTEINE ENDOPEPTIDASES; KINETICS; MODELS, MOLECULAR; OLIGOPEPTIDES; PAPAIN; PEPTIDE LIBRARY; PEPTIDES; PROTEIN CONFORMATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY;

EID: 0033223445     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc990031u     Document Type: Article

References (5)

1. Furka, A.; Sebestyen, F.; Asgedom, M.; Dibo, G. General method for rapid synthesis of multicomponent peptide mixtures. Int. J. Pept. Protein Res. 1991, 37, 487-493.
2. Lam, K. S.; Salmon, S. E.; Hersh, E. M.; Hruby, V. J.; Kazmierski, W. M.; Knapp, R. J. A new type of synthetic peptide library for identifying ligand-binding activity. Nature 1991, 354, 82-84.
3. Rapp, W.; Zhang, L.; Häbish, R.; Bayer, E. Polystyrene-Polyoxyethylene graftcopolymers for high-speed peptide synthesis. In Peptides 1988, Proc. Eur. Pept. Symp., l ed.; Jung, G., Bayer, E., Eds.; Walter de Gruyter: Berlin, 1989; pp 199-201.
4. Meldal, M. PEGA: A flow stable polyethylene glycol) dimethyl acrylamide copolymer for solid phase synthesis. Tetrahedron Lett. 1992, 33, 3077-3080.
5. Blankemeyer-Menge, B.; Nimtz, M.; Frank, R. An Efficient method for anchoring Fmoc-amino acids to hydroxyl-functionalised solid supports. Tetrahedron Lett. 1990, 31, 1701-1704.