Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 20, 1999, Pages 11000-11007

  Matthews, D A ^a   Dragovich, P S ^a   Webber, S E ^a   Fuhrman, S A ^a   Patick, A K ^a   Zalman, L S ^a   Hendrickson, T F ^a   Love, R A ^a   Prins, T J ^a   Marakovits, J T ^a   Zhou, R ^a   Tikhe, J ^a   Ford, C E ^a   Meador, J W ^a   Ferre, R A ^a   Brown, E L ^a   Binford, S L ^a   Brothers, M A ^a   DeLisle, D M ^a   Worland, S T ^a  

^a AGOURON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL DERIVATIVE; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; RUPINTRIVIR; UNCLASSIFIED DRUG; VIRUS ENZYME; VIRUS PROTEIN; VIRUS RNA;

ANTIVIRAL ACTIVITY; CLINICAL TRIAL; CONFERENCE PAPER; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME STRUCTURE; HELA CELL; HUMAN; HUMAN RHINOVIRUS; NONHUMAN; PICORNAVIRUS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; SEROTYPE;

HUMAN RHINOVIRUS 3; HUMAN RHINOVIRUS SP.; PICORNAVIRIDAE; RHINOVIRUS; RNA VIRUSES;

EID: 13044300859     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.20.11000     Document Type: Article

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