Inhibition of cruzipain visualized in a fluorescence quenched solid-phase inhibitor library assay. D-Amino acid inhibitors for cruzipain, cathepsin B and cathepsin L

Journal of Peptide Science

Volumn 4, Issue 2, 1998, Pages 83-91

  Meldal, Morten ^a   Svendsen, Ib ^a   Juliano, Luiz ^b   Juliano, Maria A ^b   Del Nery, Elaine ^b   Scharfstein, Julio ^c  

^a CARLSBERG LABORATORY   (Denmark)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Cathepsin B and L inhibitors; Fluorescence quenched assay; Inhibitor library; Parasitic protease inhibition; Trypanosoma cruzi

Indexed keywords

TRYPANOSOMA; TRYPANOSOMA CRUZI;

AMINO ACID; CATHEPSIN; CATHEPSIN B; CATHEPSIN L; CRUZIPAIN; CYSTEINE PROTEINASE; ENZYME INHIBITOR; FLUORESCENT DYE; KALLIKREIN; PEPTIDE; PEPTIDE LIBRARY; PROTEINASE; PROTOZOAL PROTEIN;

ANIMAL; ARTICLE; BINDING COMPETITION; BINDING SITE; CHEMICAL STRUCTURE; ENZYME SPECIFICITY; ENZYMOLOGY; HUMAN; KINETICS; MAMMAL; METABOLISM; PHYSIOLOGY; PROTEIN CONFORMATION; SYNTHESIS; TRYPANOSOMA CRUZI;

AMINO ACIDS; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CATHEPSIN B; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; ENZYME INHIBITORS; FLUORESCENT DYES; HUMANS; KALLIKREINS; KINETICS; MAMMALS; MODELS, MOLECULAR; PEPTIDE LIBRARY; PEPTIDES; PROTEIN CONFORMATION; PROTOZOAN PROTEINS; SUBSTRATE SPECIFICITY; TRYPANOSOMA CRUZI;

EID: 0032037456     PISSN: 10752617     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1387(199804)4:2<83::AID-PSC124>3.0.CO;2-Z     Document Type: Article

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