Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B

Journal of Medicinal Chemistry

Volumn 45, Issue 10, 2002, Pages 1971-1982

  St Hilaire, Phaedria M ^a   Alves, Lira C ^b   Herrera, Fatima ^c   Renil, Manat ^a   Sanderson, Sanya J ^d   Mottram, Jeremy C ^d   Coombs, Graham H ^d   Juliano, Maria A ^b   Juliano, Luiz ^b   Arevalo, Jorge ^c   Meldal, Morten ^a  

^a CARLSBERG LABORATORY   (Denmark)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSIDAD PERUANA CAYETANO HEREDIA   (Peru)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPROTOZOAL AGENT; CYSTEINE PROTEASE B; CYSTEINE PROTEINASE; ISOLEUCINE; LEUCINE; LEUCYLLEUCYLHISTIDYLPHENYLANINAMYLLEUCYLLEUCYLVALYLLYSINE; PROTEINASE INHIBITOR; PROTOZOAL PROTEIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA LIBRARY; DRUG EFFICACY; ENZYME SPECIFICITY; IC 50; LEISHMANIA MEXICANA; NONHUMAN; PROTEIN BINDING; SOLID; SYNTHESIS;

AMINATION; ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; CYSTEINE PROTEINASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; LEISHMANIA MEXICANA; MACROPHAGES; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; OLIGOPEPTIDES; OXIDATION-REDUCTION; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037046576     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0110901     Document Type: Article

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