Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 10, 2006, Pages 2753-2757

  Vicik, Radim ^a   Hoerr, Verena ^a,b   Glaser, Melanie ^b   Schultheis, Martina ^a   Hansell, Elizabeth ^c   McKerrow, James H ^c   Holzgrabe, Ulrike ^a   Caffrey, Conor R ^c   Ponte Sucre, Alicia ^a,d   Moll, Heidrun ^a   Stich, August ^b   Schirmeister, Tanja ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b Medical Mission Institute   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

Author keywords

Aziridine; Cysteine protease inhibitor; Rhodesain; Sleeping sickness; Trypanosoma brucei

Indexed keywords

ANTITRYPANOSOMAL AGENT; AZIRIDINE DERIVATIVE; CYSTEINE PROTEINASE INHIBITOR; DICARBOXYLIC ACID DERIVATIVE; EFLORNITHINE; LEUCINE; MELARSOPROL; NIFURTIMOX; PAPAIN; PENTAMIDINE ISETHIONATE; PROLINE; PROTEIN; RHODESAIN; SURAMIN; TRIPEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN CONTENT; TRYPANOSOMA BRUCEI;

ANIMALS; ANTIPROTOZOAL AGENTS; CARBOXYLIC ACIDS; CYSTEINE PROTEINASE INHIBITORS; TRYPANOSOMA BRUCEI BRUCEI;

ANIMALIA; PROTOZOA; TRYPANOSOMA BRUCEI;

EID: 33645864646     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.02.026     Document Type: Article

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