Synthesis of peptidyl ene diones: Selective inactivators of the cysteine proteinases

Chemical Biology and Drug Design

Volumn 69, Issue 3, 2007, Pages 170-179

  Darkins, Paul ^a   Gilmore, Brendan F ^a   Hawthorne, Susan J ^a   Healy, Adrienne ^a   Moncrieff, Hazel ^a   McCarthy, Noreen ^a   Anthony McKervey, M ^a   Brömme, Dieter ^b   Pagano, Maurice ^c   Walker, Brian ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c SORBONNE UNIVERSITÉ   (France)

Author keywords

Cysteine proteinase inactivators; Ene diones

Indexed keywords

2 1 (BENZYL 4 ETHOXYCARBONYL 2 OXO BUT 3 ENYLCARBAMOYL)PYRROLIDINE 1 CARBOXYLIC ACID BENZYLESTER; 5 5 (N BENZYLOXYCARBONYLAMINO) 4 OXO 6 PHENYLETHYLHEX 2 ENOATE; 5 5 (N BENZYLOXYCARBONYLAMINO) 6 METHYL 4 OXO 2 ETHYLHEPTENOATE; 5 METHYL 5 [2' 2' (BENZYLOXYCARBONYLAMINO) 3' PHENYLPROPANOYLAMINO] 4 OXO HEX 2 ENAL; CATHEPSIN B; CATHEPSIN L; CATHEPSIN S; CHYMOTRYPSIN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; ESTER; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL BOND; COMPETITIVE INHIBITION; DRUG EFFICACY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; PRIORITY JOURNAL; PROTEIN FAMILY;

BUTYRIC ACIDS; CATALYSIS; CATHEPSINS; CYSTEINE; CYSTEINE PROTEINASE INHIBITORS; ENZYME ACTIVATION; ESTERS; KINETICS; METHYLATION; MOLECULAR STRUCTURE; NITRO COMPOUNDS; PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34247269043     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2007.00490.x     Document Type: Article

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