Blocking effect of a biotinylated protease inhibitor on the egress of Plasmodium falciparum merozoites from infected red blood cells

Biological Chemistry

Volumn 386, Issue 5, 2005, Pages 499-502

  Gelhaus, Christoph ^a   Vicik, Radim ^b   Schirmeister, Tanja ^b   Leippe, Matthias ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Affinity label; Aziridine; Cysteine protease inhibitor; Malaria; Plasmodium

Indexed keywords

CYSTEINE PROTEINASE INHIBITOR; DIBENZYL AZIRIDINE 2,3 DICARBOXYLATE; UNCLASSIFIED DRUG;

ARTICLE; CELL LABELING; CELL MATURATION; CELL MEMBRANE; CELL VACUOLE; CYTOSOL; ERYTHROCYTE; FLUORESCENCE MICROSCOPY; HOST CELL; HOST PARASITE INTERACTION; HUMAN; HUMAN CELL; IMMUNOELECTRON MICROSCOPY; INHIBITION KINETICS; MALARIA; MEMBRANE RUPTURE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN TARGETING; PROTEIN TRANSPORT;

AFFINITY LABELS; ANIMALS; AZIRIDINES; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ERYTHROCYTE MEMBRANE; ERYTHROCYTES; HUMANS; MICROSCOPY, FLUORESCENCE; MICROSCOPY, IMMUNOELECTRON; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM;

EID: 26844485133     PISSN: 14316730     EISSN: 14316730     Source Type: Journal    
DOI: 10.1515/BC.2005.059     Document Type: Article

References (17)

1. Bannister, L.H. (2001). Looking for the exit: how do malaria parasites escape from red blood cells? Proc. Natl. Acad. Sci. USA 98, 383-384.
2. Craig, A. and Scherf, A. (2001). Molecules on the surface of the Plasmodium falciparum infected erythrocyte and their role in malaria pathogenesis and immune evasion. Mol. Biochem. Parasitol. 115, 129-143.
3. Debrabant, A. and Delplace, P. (1989). Leupeptin alters the proteolytic processing of P126, the major parasitophorous vacuole antigen of Plasmodium falciparum. Mol. Biochem. Parasitol. 33, 151-158.
4. Dhawan, S., Dua, M., Chishti, A.H., and Hanspal, M. (2003). Ankyrin peptide blocks falcipain-2-mediated malaria parasite release from red blood cells. J. Biol. Chem. 278, 30180-30186.
5. Dua, M., Raphael, P., Sijwali, P.S., Rosenthal, P.J., and Hanspal, M. (2001). Recombinant falcipain-2 cleaves erythrocyte membrane ankyrin and protein 4.1. Mol. Biochem. Parasitol. 116, 95-99.
6. Gelhaus, C., Vicik, R., Hilgenfeld, R., Schmidt, C.L., Leippe, M., and Schirmeister, T. (2004). Synthesis and antiplasmodial activity of a cysteine-protease inhibiting biotinylated aziridine-2,3-dicarboxylate. Biol. Chem. 385, 435-438.
7. Greenbaum, D.C., Baruch, A., Grainger, M., Bozdech, Z., Medzuhradszky, K.F., Engel, J., DeRisi, J., Holder, A.A., and Bogyo, M. (2002). A role for the protease falcipain 1 in host cell invasion by the human malaria parasite. Science 298, 2002-2006.
8. Hanspal, M., Dua, M., Takakuwa, Y., Chishti, A.H., and Mizuno, A. (2002). Plasmodium falciparum cysteine protease falcipain-2 cleaves erythrocyte membrane skeletal proteins at late stages of parasite development. Blood 100, 1048-1054.
9. Johnson, D., Günther, K., Ansorge, I., Benting, J., Kent, A., Bannister, L., Ridley, R., and Lingelbach, K. (1994). Characterization of membrane proteins exported from Plasmodium falciparum into the host erythrocyte. Parasitology 109, 1-9.
10. Lew, V.L. (2001). Packaged merozoite release without immediate host cell lysis. Trends Parasitol. 17, 401-403.
11. Lingelbach, K. and Joiner, K.A. (1998). The parasitophorous vacuole membrane surrounding Plasmodium and Toxoplasma: an unusual compartment in infected cells. J. Cell Sci. 111, 1467-1475.
12. Lyon, J.A. and Haynes, J.D. (1986). Plasmodium falciparum antigens synthesized by schizonts and stabilized at the merozoite surface when schizonts mature in the presence of protease inhibitors. J. Immunol. 136, 2245-2251.
13. Rosenthal, P.J. (2004). Cysteine proteases of malaria parasites. Int. J. Parasitol. 34, 1489-1499.
14. Salmon, B.L., Oksman, A., and Goldberg, D.E. (2001). Malaria parasite exit from the host erythrocyte: a two-step process requiring extraerythrocytic proteolysis. Proc. Natl. Acad. Sci. USA 98, 271-276.
15. Schirmeister, T. (1999). New peptidic cysteine protease inhibitors derived from the electrophilic α-amino acid aziridine-2,3-dicarboxylic acid. J. Med. Chem. 42, 560-572.
16. Wickham, M.E., Culvenor, J.G., and Cowman, A.F. (2003). Selective inhibition of a two-step egress of malaria parasites from the host erythrocyte. J. Biol. Chem. 278, 37658-37663.
17. Winograd, E., Clavijo, C.A., Bustamante, L.Y., and Jaramillo, M. (1999). Release of merozoites from Plasmodium falciparum-infected erythrocytes could be mediated by a non-explosive event. Parasitol. Res. 85, 621-624.