Selection of cysteine protease inhibitor-resistant malaria parasites is accompanied by amplification of falcipain genes and alteration in inhibitor transport

Journal of Biological Chemistry

Volumn 279, Issue 34, 2004, Pages 35236-35241

  Singh, Ajay ^a   Rosenthal, Philip J ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; ENZYME INHIBITION; GENES; MICROORGANISMS; SULFUR COMPOUNDS;

MALARIA; PARASITES;

PROTEINS;

ANTIMALARIAL AGENT; ARTEMISININ; CHLOROQUINE; CYSTEINE PROTEINASE INHIBITOR; FALCIPAIN; GENE PRODUCT; ISONIPECOTIC LEUCINE TYROSINE PHENYLVINYL SULFONE; LEUPEPTIN; MORPHOLINE UREA LEUCINE HOMOPHENYLALANINE PHENYLVINYL SULFONE; MORPHOLINE UREA PHENYLALANINE HOMOPHENYLALANINE FLUOROMETHYL KETONE; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; N METHYLPIPERAZINEUREA LEUCINE HOMOPHENYLVINYL SULFONE; QUININE; UNCLASSIFIED DRUG; VERAPAMIL; VINYL SULFONE CYSTEINE PROTEINASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG EXPOSURE; DRUG RESISTANCE; DRUG SENSITIVITY; ENZYME ACTIVITY; FALCIPAIN 1 GENE; FALCIPAIN 2 GENE; FALCIPAIN 3 GENE; FALCIPAIN GENE; GENE; GENE AMPLIFICATION; GENE NUMBER; GENE SEQUENCE; GENETIC SELECTION; GENETIC TRANSCRIPTION; IC 50; MALARIA; NONHUMAN; PARASITE DEVELOPMENT; PLASMODIUM FALCIPARUM; PLASMODIUM FALCIPARUM W2; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVERTANT; SEQUENCE HOMOLOGY; TROPHOZOITE;

ANIMALS; ANTIMALARIALS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DRUG RESISTANCE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION; MALARIA; PLASMODIUM FALCIPARUM; PROTEIN TRANSPORT; SULFONES;

CINCHONA PUBESCENS; PLASMODIUM FALCIPARUM;

EID: 4143139772     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M404235200     Document Type: Article

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