메뉴 건너뛰기




Volumn 22, Issue 1, 2009, Pages 68-81

When nutrition interacts with osteoblast function: Molecular mechanisms of polyphenols

Author keywords

Bone metabolism; Osteoblasts; Polyphenols; Signalling

Indexed keywords

BONE MORPHOGENETIC PROTEIN; ESTROGEN RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; POLYPHENOL; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; FLAVONOID; PHENOL DERIVATIVE; POLYPHENOLS; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR;

EID: 69249209977     PISSN: 09544224     EISSN: 14752700     Source Type: Journal    
DOI: 10.1017/S095442240926402X     Document Type: Review
Times cited : (69)

References (122)
  • 1
    • 35548953717 scopus 로고    scopus 로고
    • The skeletal system
    • MJ Gibney, IA Macdonald and HM Roche, editors. Oxford: Blackwell Publishing
    • Pettifor JM, Prentice A & Cleaton-Jones P (2003) The skeletal system. In Nutrition and Metabolism, pp. 247-283 [MJ Gibney, IA Macdonald and HM Roche, editors]. Oxford: Blackwell Publishing.
    • (2003) Nutrition and Metabolism , pp. 247-283
    • Pettifor, J.M.1    Prentice, A.2    Cleaton-Jones, P.3
  • 2
    • 0034773680 scopus 로고    scopus 로고
    • Biology of bone and how it orchestrates the form and function of the skeleton
    • Sommerfeldt DW & Rubin CT (2001) Biology of bone and how it orchestrates the form and function of the skeleton. Eur Spine J 10, Suppl. 2, S86-S95.
    • (2001) Eur Spine J , vol.10 , Issue.SUPPL. 2
    • Sommerfeldt, D.W.1    Rubin, C.T.2
  • 3
    • 19344364440 scopus 로고    scopus 로고
    • Osteoporosis
    • viii
    • Simon LS (2005) Osteoporosis. Clin Geriatr Med 21, 603-629, viii.
    • (2005) Clin Geriatr Med , vol.21 , pp. 603-629
    • Simon, L.S.1
  • 4
    • 42349096158 scopus 로고    scopus 로고
    • Pharmacological topics of bone metabolism: Recent advances in pharmacological management of osteoporosis
    • DOI 10.1254/jphs.FM0070218
    • Suzuki A, Sekiguchi S, Asano S, et al. (2008) Pharmacological topics of bone metabolism: recent advances in pharmacological management of osteoporosis. J Pharmacol Sci 106, 530-535. (Pubitemid 351556228)
    • (2008) Journal of Pharmacological Sciences , vol.106 , Issue.4 , pp. 530-535
    • Suzuki, A.1    Sekiguchi, S.2    Asano, S.3    Itoh, M.4
  • 5
    • 33644863971 scopus 로고    scopus 로고
    • Nutritional modulators of bone remodeling during aging
    • Mundy GR (2006) Nutritional modulators of bone remodeling during aging. Am J Clin Nutr 83, S427-S430.
    • (2006) Am J Clin Nutr , vol.83
    • Mundy, G.R.1
  • 6
    • 0032711645 scopus 로고    scopus 로고
    • Bone health: The role of micronutrients
    • New SA (1999) Bone health: the role of micronutrients. Br Med Bull 55, 619-633.
    • (1999) Br Med Bull , vol.55 , pp. 619-633
    • New, S.A.1
  • 7
    • 0034510590 scopus 로고    scopus 로고
    • Nutrition in bone health revisited: A story beyond calcium
    • Ilich JZ & Kerstetter JE (2000) Nutrition in bone health revisited: a story beyond calcium. J Am Coll Nutr 19, 715-737.
    • (2000) J Am Coll Nutr , vol.19 , pp. 715-737
    • Ilich, J.Z.1    Kerstetter, J.E.2
  • 9
    • 43049181555 scopus 로고    scopus 로고
    • Phenolic phytochemicals and bone
    • Habauzit V & Horcajada MN (2008) Phenolic phytochemicals and bone. Phytochem Rev 7, 313-344.
    • (2008) Phytochem Rev , vol.7 , pp. 313-344
    • Habauzit, V.1    Horcajada, M.N.2
  • 10
    • 42749092987 scopus 로고    scopus 로고
    • Transcription factors controlling osteoblastogenesis
    • Marie PJ (2008) Transcription factors controlling osteoblastogenesis. Arch Biochem Biophys 473, 98-105.
    • (2008) Arch Biochem Biophys , vol.473 , pp. 98-105
    • Marie, P.J.1
  • 11
    • 30644461820 scopus 로고    scopus 로고
    • Bone and mineral metabolism in health and disease
    • DL Kasper, E Braunwald and AS Fauci, editors. New York: McGraw-Hill
    • Bringhurst FR, Demay MB, Krane SM, et al. (2005) Bone and mineral metabolism in health and disease. In Harrison's Principles of Internal Medicine, pp. 2238-2249 [DL Kasper, E Braunwald and AS Fauci, editors]. New York: McGraw-Hill.
    • (2005) Harrison's Principles of Internal Medicine , pp. 2238-2249
    • Bringhurst, F.R.1    Demay, M.B.2    Krane, S.M.3
  • 12
    • 0036090228 scopus 로고    scopus 로고
    • Regulatory mechanisms of osteoblast and osteoclast differentiation
    • DOI 10.1034/j.1601-0825.2002.01829.x
    • Katagiri T & Takahashi N (2002) Regulatory mechanisms of osteoblast and osteoclast differentiation. Oral Dis 8, 147-159. (Pubitemid 34535063)
    • (2002) Oral Diseases , vol.8 , Issue.3 , pp. 147-159
    • Katagiri, T.1    Takahashi, N.2
  • 13
    • 0035138564 scopus 로고    scopus 로고
    • Local and systemic control of the osteoblast
    • Strewler GJ (2001) Local and systemic control of the osteoblast. J Clin Invest 107, 271-272.
    • (2001) J Clin Invest , vol.107 , pp. 271-272
    • Strewler, G.J.1
  • 16
    • 0034455051 scopus 로고    scopus 로고
    • Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1
    • DOI 10.1210/er.21.4.393
    • Yamaguchi A, Komori T & Suda T (2000) Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocr Rev 21, 393-411. (Pubitemid 32275586)
    • (2000) Endocrine Reviews , vol.21 , Issue.4 , pp. 393-411
    • Yamaguchi, A.1    Komori, T.2    Suda, T.3
  • 17
    • 5044228112 scopus 로고    scopus 로고
    • Wnt signaling in osteoblasts and bone diseases
    • DOI 10.1016/j.gene.2004.06.044, PII S0378111904003853
    • Westendorf JJ, Kahler RA & Schroeder TM (2004) Wnt signaling in osteoblasts and bone diseases. Gene 341, 19-39. (Pubitemid 39335880)
    • (2004) Gene , vol.341 , Issue.1-2 , pp. 19-39
    • Westendorf, J.J.1    Kahler, R.A.2    Schroeder, T.M.3
  • 18
    • 27144464518 scopus 로고    scopus 로고
    • The insulin-like growth factor-I gene and osteoporosis: A critical appraisal
    • DOI 10.1016/j.gene.2005.07.016, PII S0378111905004129
    • Niu TH & Rosen CJ (2005) The insulin-like growth factor-I gene and osteoporosis: a critical appraisal. Gene 361, 38-56. (Pubitemid 41506932)
    • (2005) Gene , vol.361 , Issue.1-2 , pp. 38-56
    • Niu, T.1    Rosen, C.J.2
  • 19
    • 34347257781 scopus 로고    scopus 로고
    • Signaling and transcriptional regulation in osteoblast commitment and differentiation
    • Huang W, Yang S, Shao J, et al. (2007) Signaling and transcriptional regulation in osteoblast commitment and differentiation. Front Biosci 12, 3068-3092.
    • (2007) Front Biosci , vol.12 , pp. 3068-3092
    • Huang, W.1    Yang, S.2    Shao, J.3
  • 20
    • 0027321842 scopus 로고
    • Molecular mechanisms mediating proliferation differentiation interrelationships during progressive development of the osteoblast phenotype
    • Stein GS & Lian JB (1993) Molecular mechanisms mediating proliferation differentiation interrelationships during progressive development of the osteoblast phenotype. Endocr Rev 14, 424-442.
    • (1993) Endocr Rev , vol.14 , pp. 424-442
    • Stein, G.S.1    Lian, J.B.2
  • 21
    • 0036712047 scopus 로고    scopus 로고
    • Mechanical strain and bone cell function: A review
    • Ehrlich PJ & Lanyon LE (2002) Mechanical strain and bone cell function: a review. Osteoporos Int 13, 688-700.
    • (2002) Osteoporos Int , vol.13 , pp. 688-700
    • Ehrlich, P.J.1    Lanyon, L.E.2
  • 22
    • 0141565397 scopus 로고    scopus 로고
    • Strain-derived canalicular fluid flow regulates osteoclast activity in a remodelling osteon - A proposal
    • DOI 10.1016/S0021-9290(03)00126-X
    • Burger EH, Klein-Nulend J & Smit TH (2003) Strain-derived canalicular fluid flow regulates osteoclast activity in a remodelling osteon - a proposal. J Biomech 36, 1453-1459. (Pubitemid 37117352)
    • (2003) Journal of Biomechanics , vol.36 , Issue.10 , pp. 1453-1459
    • Burger, E.H.1    Klein-Nulend, J.2    Smit, T.H.3
  • 23
    • 0018848939 scopus 로고
    • Osteoclasts derived from haematopoietic stem cells
    • Ash P, Loutit JF & Townsend KM (1980) Osteoclasts derived from haematopoietic stem cells. Nature 283, 669-670. (Pubitemid 10099996)
    • (1980) Nature , vol.283 , Issue.5748 , pp. 669-670
    • Ash, P.1    Loutit, J.F.2    Townsend, K.M.S.3
  • 24
    • 0025107432 scopus 로고
    • Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse
    • Felix R, Cecchini MG & Fleisch H (1990) Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse. Endocrinology 127, 2592-2594. (Pubitemid 20381799)
    • (1990) Endocrinology , vol.127 , Issue.5 , pp. 2592-2594
    • Felix, R.1    Cecchini, M.G.2    Fleisch, H.3
  • 25
    • 0025977548 scopus 로고
    • Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor
    • Kodama H, Yamasaki A, Nose M, et al. (1991) Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor. J Exp Med 173, 269-272.
    • (1991) J Exp Med , vol.173 , pp. 269-272
    • Kodama, H.1    Yamasaki, A.2    Nose, M.3
  • 26
    • 0025903876 scopus 로고
    • Essential role of macrophage colony-stimulating factor in the osteoclast differentiation supported by stromal cells
    • Kodama H, Nose M, Niida S, et al. (1991) Essential role of macrophage colony-stimulating factor in the osteoclast differentiation supported by stromal cells. J Exp Med 173, 1291-1294.
    • (1991) J Exp Med , vol.173 , pp. 1291-1294
    • Kodama, H.1    Nose, M.2    Niida, S.3
  • 27
    • 33744992495 scopus 로고    scopus 로고
    • Osteoporosis
    • Sambrook P & Cooper C (2006) Osteoporosis. Lancet 367, 2010-2018.
    • (2006) Lancet , vol.367 , pp. 2010-2018
    • Sambrook, P.1    Cooper, C.2
  • 28
    • 14744302388 scopus 로고    scopus 로고
    • Dietary polyphenols and the prevention of diseases
    • Scalbert A, Manach C, Morand C, et al. (2005) Dietary polyphenols and the prevention of diseases. Crit Rev Food Sci Nutr 45, 287-306.
    • (2005) Crit Rev Food Sci Nutr , vol.45 , pp. 287-306
    • Scalbert, A.1    Manach, C.2    Morand, C.3
  • 29
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • Manach C, Williamson G, Morand C, et al. (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81, 230S-242S.
    • (2005) Am J Clin Nutr , vol.81
    • Manach, C.1    Williamson, G.2    Morand, C.3
  • 30
    • 3042696744 scopus 로고    scopus 로고
    • How should we assess the effects of exposure to dietary polyphenols in vitro?
    • Kroon PA, Clifford MN, Crozier A, et al. (2004) How should we assess the effects of exposure to dietary polyphenols in vitro? Am J Clin Nutr 80, 15-21.
    • (2004) Am J Clin Nutr , vol.80 , pp. 15-21
    • Kroon, P.A.1    Clifford, M.N.2    Crozier, A.3
  • 31
    • 2442430353 scopus 로고    scopus 로고
    • Polyphenols: Food sources and bioavailability
    • Manach C, Scalbert A, Morand C, et al. (2004) Polyphenols: food sources and bioavailability. Am J Clin Nutr 79, 727-747.
    • (2004) Am J Clin Nutr , vol.79 , pp. 727-747
    • Manach, C.1    Scalbert, A.2    Morand, C.3
  • 32
    • 19044388959 scopus 로고    scopus 로고
    • In vitro biological properties of flavonoid conjugates found in vivo
    • Williamson G, Barron D, Shimoi K, et al. (2005) In vitro biological properties of flavonoid conjugates found in vivo. Free Radic Res 39, 457-469.
    • (2005) Free Radic Res , vol.39 , pp. 457-469
    • Williamson, G.1    Barron, D.2    Shimoi, K.3
  • 33
    • 41849125317 scopus 로고    scopus 로고
    • Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones
    • Serra H, Mendes T, Bronze MR, et al. (2008) Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones. Bioorg Med Chem 16, 4009-4018.
    • (2008) Bioorg Med Chem , vol.16 , pp. 4009-4018
    • Serra, H.1    Mendes, T.2    Bronze, M.R.3
  • 34
    • 0035839129 scopus 로고    scopus 로고
    • Flavonoid glucuronides are substrates for human liver β-glucuronidase
    • O'Leary KA, Day AJ, Needs PW, et al. (2001) Flavonoid glucuronides are substrates for human liver β-glucuronidase. FEBS Lett 503, 103-106.
    • (2001) FEBS Lett , vol.503 , pp. 103-106
    • O'Leary, K.A.1    Day, A.J.2    Needs, P.W.3
  • 35
    • 33847774008 scopus 로고    scopus 로고
    • Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems
    • Khlebnikov AI, Schepetkin IA, Domina NG, et al. (2007) Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems. Bioorg Med Chem 15, 1749-1770.
    • (2007) Bioorg Med Chem , vol.15 , pp. 1749-1770
    • Khlebnikov, A.I.1    Schepetkin, I.A.2    Domina, N.G.3
  • 36
    • 45549093293 scopus 로고    scopus 로고
    • Quercetin and its in vivo metabolites inhibit neutrophil-mediated low-density lipoprotein oxidation
    • Loke WM, Proudfoot JM, McKinley AJ, et al. (2008) Quercetin and its in vivo metabolites inhibit neutrophil-mediated low-density lipoprotein oxidation. J Agric Food Chem 56, 3609-3615.
    • (2008) J Agric Food Chem , vol.56 , pp. 3609-3615
    • Loke, W.M.1    Proudfoot, J.M.2    McKinley, A.J.3
  • 37
    • 39449137141 scopus 로고    scopus 로고
    • Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells
    • DOI 10.1016/j.atherosclerosis.2007.07.040, PII S0021915007004832
    • Tribolo S, Lodib F, Connor C, et al. (2008) Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells. Atherosclerosis 197, 50-56. (Pubitemid 351273272)
    • (2008) Atherosclerosis , vol.197 , Issue.1 , pp. 50-56
    • Tribolo, S.1    Lodi, F.2    Connor, C.3    Suri, S.4    Wilson, V.G.5    Taylor, M.A.6    Needs, P.W.7    Kroon, P.A.8    Hughes, D.A.9
  • 38
    • 49149102015 scopus 로고    scopus 로고
    • A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro
    • Suri S, Taylor MA, Verity A, et al. (2008) A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro. Biochem Pharmacol 76, 645-653.
    • (2008) Biochem Pharmacol , vol.76 , pp. 645-653
    • Suri, S.1    Taylor, M.A.2    Verity, A.3
  • 41
    • 0028244459 scopus 로고
    • The natural tyrosine kinase inhibitor genistein produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells
    • DOI 10.1016/0145-2126(94)90079-5
    • Spinozzi F, Pagliacci MC, Migliorati G, et al. (1994) The natural tyrosine kinase inhibitor genistein produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. Leuk Res 18, 431-439. (Pubitemid 24169825)
    • (1994) Leukemia Research , vol.18 , Issue.6 , pp. 431-439
    • Spinozzi, F.1    Pagliacci, M.C.2    Migliorati, G.3    Moraca, R.4    Grignani, F.5    Riccardi, C.6    Nicoletti, I.7
  • 42
    • 0001223839 scopus 로고    scopus 로고
    • Isoflavone and bone metabolism: Its cellular mechanism and preventive role in bone loss
    • Yamaguchi M (2002) Isoflavone and bone metabolism: its cellular mechanism and preventive role in bone loss. J Health Sci 48, 209-222.
    • (2002) J Health Sci , vol.48 , pp. 209-222
    • Yamaguchi, M.1
  • 43
    • 0033966168 scopus 로고    scopus 로고
    • Stimulatory effect of daidzein in osteoblastic MC3T3-E1 cells
    • DOI 10.1016/S0006-2952(99)00351-2, PII S0006295299003512
    • Sugimoto E & Yamaguchi M (2000) Stimulatory effect of daidzein in osteoblastic MC3T3-E1 cells. Biochem Pharmacol 59, 471-475. (Pubitemid 30045585)
    • (2000) Biochemical Pharmacology , vol.59 , Issue.5 , pp. 471-475
    • Sugimoto, E.1    Yamaguchi, M.2
  • 45
    • 0034756194 scopus 로고    scopus 로고
    • Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol ( - )-epigallocatechin-3-gallate
    • DOI 10.1006/taap.2001.9276
    • Katiyar SK, Afaq F, Azizuddin K, et al. (2001) Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol (2)-epigallocatechin-3-gallate. Toxicol Appl Pharmacol 176, 110-117. (Pubitemid 33015861)
    • (2001) Toxicology and Applied Pharmacology , vol.176 , Issue.2 , pp. 110-117
    • Katiyar, S.K.1    Afaq, F.2    Azizuddin, K.3    Mukhtar, H.4
  • 46
    • 0037127310 scopus 로고    scopus 로고
    • Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes
    • DOI 10.1074/jbc.M110376200
    • Balasubramanian S, Efimova T & Eckert RL (2002) Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes. J Biol Chem 277, 1828-1836. (Pubitemid 34968756)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.3 , pp. 1828-1836
    • Balasubramanian, S.1    Efimova, T.2    Eckert, R.L.3
  • 47
  • 48
    • 0346074656 scopus 로고    scopus 로고
    • Cancer chemoprevention by resveratrol: In vitro and in vivo studies and the underlying mechanisms
    • review
    • Aziz MH, Kumar R & Ahmad N (2003) Cancer chemoprevention by resveratrol: in vitro and in vivo studies and the underlying mechanisms (review). Int J Oncol 23, 17-28.
    • (2003) Int J Oncol , vol.23 , pp. 17-28
    • Aziz, M.H.1    Kumar, R.2    Ahmad, N.3
  • 50
    • 33646768213 scopus 로고    scopus 로고
    • Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- And stress-activated protein kinase 1/cAMP response element-binding protein signaling
    • DOI 10.1124/jpet.105.095133
    • Das S, Tosaki A, Bagchi D, et al. (2006) Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen-and stress-activated protein kinase 1/cAMP response element-binding protein signaling. J Pharmacol Exp Ther 317, 980-988. (Pubitemid 43764100)
    • (2006) Journal of Pharmacology and Experimental Therapeutics , vol.317 , Issue.3 , pp. 980-988
    • Das, S.1    Tosaki, A.2    Bagchi, D.3    Maulik, N.4    Das, D.K.5
  • 51
    • 0032970253 scopus 로고    scopus 로고
    • Role of canonical glucocorticoid responsive elements in modulating expression of genes regulated by the arylhydrocarbon receptor
    • DOI 10.1081/DMR-100101917
    • Linder MW, Falkner KC, Srinivasan G, et al. (1999) Role of canonical glucocorticoid responsive elements in modulating expression of genes regulated by the arylhydrocarbon receptor. Drug Metab Rev 31, 247-271. (Pubitemid 29106661)
    • (1999) Drug Metabolism Reviews , vol.31 , Issue.1 , pp. 247-271
    • Under, M.W.1    Falkner, K.C.2    Srinivasan, G.3    Hines, R.N.4    Prough, R.A.5
  • 52
    • 0035878743 scopus 로고    scopus 로고
    • Estrogen receptor interaction with estrogen response elements
    • Klinge CM (2001) Estrogen receptor interaction with estrogen response elements. Nucleic Acids Res 29, 2905-2919. (Pubitemid 32685217)
    • (2001) Nucleic Acids Research , vol.29 , Issue.14 , pp. 2905-2919
    • Klinge, C.M.1
  • 55
    • 0037007643 scopus 로고    scopus 로고
    • Developmental biology - Modular feedback
    • Niehrs C & Meinhardt H (2002) Developmental biology - modular feedback. Nature 417, 35-36.
    • (2002) Nature , vol.417 , pp. 35-36
    • Niehrs, C.1    Meinhardt, H.2
  • 57
    • 0036779405 scopus 로고    scopus 로고
    • Flavanones structure-related inhibition on TPA-induced tumor promotion through suppression of extracellular signal-regulated protein kinases: Involvement of prostaglandin E-2 in anti-promotive process
    • Ko CH, Shen SC, Lin HY, et al. (2002) Flavanones structure-related inhibition on TPA-induced tumor promotion through suppression of extracellular signal-regulated protein kinases: involvement of prostaglandin E-2 in anti-promotive process. J Cell Physiol 193, 93-102.
    • (2002) J Cell Physiol , vol.193 , pp. 93-102
    • Ko, C.H.1    Shen, S.C.2    Lin, H.Y.3
  • 58
    • 33744976109 scopus 로고    scopus 로고
    • Molecular targets for the cancer preventive activity of tea polyphenols
    • DOI 10.1002/mc.20228
    • Yang CS, Lambert JD, Hou Z, et al. (2006) Molecular targets for the cancer preventive activity of tea polyphenols. Mol Carcinog 45, 431-435. (Pubitemid 43865851)
    • (2006) Molecular Carcinogenesis , vol.45 , Issue.6 , pp. 431-435
    • Yang, C.S.1    Lambert, J.D.2    Hou, Z.3    Ju, J.4    Lu, G.5    Hao, X.6
  • 59
    • 0242576442 scopus 로고    scopus 로고
    • Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells
    • DOI 10.1016/j.bcp.2003.07.007
    • O'Prey J, Brown J, Fleming J, et al. (2003) Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells. Biochem Pharmacol 66, 2075-2088. (Pubitemid 37377853)
    • (2003) Biochemical Pharmacology , vol.66 , Issue.11 , pp. 2075-2088
    • O'Prey, J.1    Brown, J.2    Fleming, J.3    Harrison, P.R.4
  • 60
    • 4644313472 scopus 로고    scopus 로고
    • Gene expression changes induced by green tea polyphenol (-)-epigallocatechin-3-gallate in human bronchial epithelial 21BES cells analyzed by DNA microarray
    • Vittal R, Selvanayagam ZE, Sun Y, et al. (2004) Gene expression changes induced by green tea polyphenol (2)- epigallocatechin-3-gallate in human bronchial epithelial 21BES cells analyzed by DNA microarray. Mol Cancer Ther 3, 1091-1099. (Pubitemid 39295006)
    • (2004) Molecular Cancer Therapeutics , vol.3 , Issue.9 , pp. 1091-1099
    • Vittal, R.1    Selvanayagam, Z.E.2    Sun, Y.3    Hong, J.4    Liu, F.5    Chin, K.-V.6    Yang, C.S.7
  • 61
    • 0037380812 scopus 로고    scopus 로고
    • Nutrigenomics: Goals and strategies
    • Muller M & Kersten S (2003) Nutrigenomics: goals and strategies. Nat Rev Genet 4, 315-322.
    • (2003) Nat Rev Genet , vol.4 , pp. 315-322
    • Muller, M.1    Kersten, S.2
  • 62
    • 22644447278 scopus 로고    scopus 로고
    • Regulation of skeletal development by the Runx family of transcription factors
    • DOI 10.1002/jcb.20420
    • Komori T (2005) Regulation of skeletal development by the Runx family of transcription factors. J Cell Biochem 95, 445-453. (Pubitemid 41420175)
    • (2005) Journal of Cellular Biochemistry , vol.95 , Issue.3 , pp. 445-453
    • Komori, T.1
  • 63
    • 23844506742 scopus 로고    scopus 로고
    • Osx transcriptional regulation is mediated by additional pathways to BMP2/Smad signaling
    • Celil AB, Hollinger JO & Campbell PG (2005) Osx transcriptional regulation is mediated by additional pathways to BMP2/Smad signaling. J Cell Biochem 95, 518-528.
    • (2005) J Cell Biochem , vol.95 , pp. 518-528
    • Celil, A.B.1    Hollinger, J.O.2    Campbell, P.G.3
  • 64
    • 0033662188 scopus 로고    scopus 로고
    • Cbfa1: A molecular switch in osteoblast biology
    • Ducy P (2000) Cbfa1: a molecular switch in osteoblast biology. Dev Dyn 219, 461-471.
    • (2000) Dev Dyn , vol.219 , pp. 461-471
    • Ducy, P.1
  • 65
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor Osterix is required for osteoblast differentiation and bone formation
    • DOI 10.1016/S0092-8674(01)00622-5
    • Nakashima K, Zhou X, Kunkel G, et al. (2002) The novel zinc finger-containing transcription factor Osterix is required for osteoblast differentiation and bone formation. Cell 108, 17-29. (Pubitemid 34137009)
    • (2002) Cell , vol.108 , Issue.1 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6    De Crombrugghe, B.7
  • 66
    • 0041328856 scopus 로고    scopus 로고
    • BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2
    • Lee MH, Kwon TG, Park HS, et al. (2003) BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2. Biochem Biophys Res Commun 309, 689-694.
    • (2003) Biochem Biophys Res Commun , vol.309 , pp. 689-694
    • Lee, M.H.1    Kwon, T.G.2    Park, H.S.3
  • 67
    • 29044431644 scopus 로고    scopus 로고
    • Green tea catechin enhances osteogenesis in a bone marrow mesenchymal stem cell line
    • Chen CH, Ho ML, Chang JK, et al. (2005) Green tea catechin enhances osteogenesis in a bone marrow mesenchymal stem cell line. Osteoporos Int 16, 2039-2045.
    • (2005) Osteoporos Int , vol.16 , pp. 2039-2045
    • Chen, C.H.1    Ho, M.L.2    Chang, J.K.3
  • 68
    • 34247182669 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate increases the formation of mineralized bone nodules by human osteoblast-like cells
    • DOI 10.1016/j.jnutbio.2006.06.005, PII S095528630600163X
    • Vali B, Rao LG & El-Sohemy A (2007) Epigallocatechin-3- gallate increases the formation of mineralized bone nodules by human osteoblast-like cells. J Nutr Biochem 18, 341-347. (Pubitemid 46613954)
    • (2007) Journal of Nutritional Biochemistry , vol.18 , Issue.5 , pp. 341-347
    • Vali, B.1    Rao, L.G.2    El-Sohemy, A.3
  • 69
    • 3042712878 scopus 로고    scopus 로고
    • A low dose of daidzein acts as an ERn-selective agonist in trabecular osteoblasts of young female piglets
    • DOI 10.1002/jcp.20008
    • De Wilde A, Lieberherr M, Colin C, et al. (2004) A low dose of daidzein acts as an ERb-selective agonist in trabecular osteoblasts of young female piglets. J Cell Physiol 200, 253-262. (Pubitemid 38885706)
    • (2004) Journal of Cellular Physiology , vol.200 , Issue.2 , pp. 253-262
    • De Wilde, A.1    Lieberherr, M.2    Colin, C.3    Pointillart, A.4
  • 70
    • 0032583546 scopus 로고    scopus 로고
    • Resveratrol stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells
    • DOI 10.1006/bbrc.1998.9870
    • Mizutani K, Ikeda K, Kawai Y, et al. (1998) Resveratrol stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells. Biochem Biophys Res Commun 253, 859-863. (Pubitemid 29039235)
    • (1998) Biochemical and Biophysical Research Communications , vol.253 , Issue.3 , pp. 859-863
    • Mizutani, K.1    Ikeda, K.2    Kawai, Y.3    Yamori, Y.4
  • 71
    • 35548970288 scopus 로고    scopus 로고
    • Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation
    • DOI 10.1016/j.phymed.2007.04.003, PII S094471130700061X
    • Dai Z, Li Y, Quarles LD, et al. (2007) Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation. Phytomedicine 14, 806-814. (Pubitemid 350017876)
    • (2007) Phytomedicine , vol.14 , Issue.12 , pp. 806-814
    • Dai, Z.1    Li, Y.2    Quarles, L.D.3    Song, T.4    Pan, W.5    Zhou, H.6    Xiao, Z.7
  • 72
    • 36348932979 scopus 로고    scopus 로고
    • Simultaneous determination of icariin, icariside II and osthole in rat plasma after oral administration of the extract of Gushudan (a Chinese compound formulation) by LC-MS/MS
    • DOI 10.1016/j.jchromb.2007.10.019, PII S1570023207007283
    • Liu M, Liu HP, Lu XM, et al. (2007) Simultaneous determination of icariin, icariside II and osthole in rat plasma after oral administration of the extract of Gushudan (a Chinese compound formulation) by LC-MS/MS. J Chromatogr B 860, 113-120. (Pubitemid 350161468)
    • (2007) Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences , vol.860 , Issue.1 , pp. 113-120
    • Liu, M.1    Liu, H.2    Lu, X.3    Li, C.4    Xiong, Z.5    Li, F.6
  • 73
    • 40849100000 scopus 로고    scopus 로고
    • Icariin induces osteogenic differentiation in vitro in a BMP- And Runx2- dependent manner
    • Zhao J, Ohba S, Shinkai M, et al. (2008) Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2- dependent manner. Biochem Biophys Res Commun 369, 444-448.
    • (2008) Biochem Biophys Res Commun , vol.369 , pp. 444-448
    • Zhao, J.1    Ohba, S.2    Shinkai, M.3
  • 74
    • 0029990552 scopus 로고    scopus 로고
    • Role of oxidants and antioxidants in the induction of AP-1, NF-κB, and glutathione S-transferase gene expression
    • DOI 10.1074/jbc.271.23.13422
    • Pinkus R, Weiner LM & Daniel V (1996) Role of oxidants and antioxidants in the induction of AP-1, NF-κ B, and glutathione S-transferase gene expression. J Biol Chem 271, 13422-13429. (Pubitemid 26185383)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.23 , pp. 13422-13429
    • Pinkus, R.1    Weiner, L.M.2    Daniel, V.3
  • 76
    • 0036838919 scopus 로고    scopus 로고
    • Functions of AP1 (Fos/Jun) in bone development
    • Wagner EF (2002) Functions of AP1 (Fos/Jun) in bone development. Ann Rheum Dis 61, Suppl. 2, ii40-ii42.
    • (2002) Ann Rheum Dis , vol.61 , Issue.SUPPL. 2
    • Wagner, E.F.1
  • 77
    • 0029034446 scopus 로고
    • Selective expression of fos- And jun-related genes during osteoblast proliferation and differentiation
    • McCabe LR, Kockx M, Lian J, et al. (1995) Selective expression of fos- and jun-related genes during osteoblast proliferation and differentiation. Exp Cell Res 218, 255-262.
    • (1995) Exp Cell Res , vol.218 , pp. 255-262
    • McCabe, L.R.1    Kockx, M.2    Lian, J.3
  • 78
    • 0036307152 scopus 로고    scopus 로고
    • Flavonoid phytochemicals regulate activator protein-1 signal transduction pathways in endometrial and kidney stable cell lines
    • Frigo DE, Duong BN, Melnik LI, et al. (2002) Flavonoid phytochemicals regulate activator protein-1 signal transduction pathways in endometrial and kidney stable cell lines. J Nutr 132, 1848-1853.
    • (2002) J Nutr , vol.132 , pp. 1848-1853
    • Frigo, D.E.1    Duong, B.N.2    Melnik, L.I.3
  • 79
    • 32144442544 scopus 로고    scopus 로고
    • Differential activity of kaempferol and quercetin in attenuating tumor necrosis factor receptor family signaling in bone cells
    • DOI 10.1016/j.bcp.2005.12.023, PII S0006295205008506
    • Pang JL, Ricupero DA, Huang S, et al. (2006) Differential activity of kaempferol and quercetin in attenuating tumor necrosis factor receptor family signaling in bone cells. Biochem Pharmacol 71, 818-826. (Pubitemid 43208838)
    • (2006) Biochemical Pharmacology , vol.71 , Issue.6 , pp. 818-826
    • Pang, J.L.1    Ricupero, D.A.2    Huang, S.3    Fatma, N.4    Singh, D.P.5    Romero, J.R.6    Chattopadhyay, N.7
  • 80
    • 37649023276 scopus 로고    scopus 로고
    • Quercetin accelerates TNF-α-induced apoptosis of MC3T3-E1 osteoblastic cells through caspase-dependent and JNK-mediated pathways
    • Son YO, Kook SH, Choi KC, et al. (2008) Quercetin accelerates TNF-α-induced apoptosis of MC3T3-E1 osteoblastic cells through caspase-dependent and JNK-mediated pathways. Eur J Pharmacol 579, 26-33.
    • (2008) Eur J Pharmacol , vol.579 , pp. 26-33
    • Son, Y.O.1    Kook, S.H.2    Choi, K.C.3
  • 81
    • 41149150641 scopus 로고    scopus 로고
    • Emodin accelerates osteoblast differentiation through phosphatidylinositol 3-kinase activation and bone morphogenetic protein-2 gene expression
    • Lee SU, Shin HK, Min YK, et al. (2008) Emodin accelerates osteoblast differentiation through phosphatidylinositol 3-kinase activation and bone morphogenetic protein-2 gene expression. Int Immunopharmacol 8, 741-747.
    • (2008) Int Immunopharmacol , vol.8 , pp. 741-747
    • Lee, S.U.1    Shin, H.K.2    Min, Y.K.3
  • 83
    • 0242668869 scopus 로고    scopus 로고
    • Bone morphogenetic proteins, their antagonists, and the skeleton
    • DOI 10.1210/er.2002-0023
    • Canalis E, Economides AN & Gazzerro E (2003) Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev 24, 218-235. (Pubitemid 36515285)
    • (2003) Endocrine Reviews , vol.24 , Issue.2 , pp. 218-235
    • Canalis, E.1    Economides, A.N.2    Gazzerro, E.3
  • 84
    • 0029955512 scopus 로고    scopus 로고
    • Subcloning of three osteoblastic cell lines with distinct differentiation phenotypes from the mouse osteoblastic cell line KS-4
    • PII S8756328296002554
    • Yamashita T, Ishii H, Shimoda K, et al. (1996) Subcloning of three osteoblastic cell lines with distinct differentiation phenotypes from the mouse osteoblastic cell line KS-4. Bone 19, 429-436. (Pubitemid 126745120)
    • (1996) Bone , vol.19 , Issue.5 SUPPL. , pp. 429-436
    • Yamashita, T.1    Ishii, H.2    Shimoda, K.3    Sampath, T.K.4    Katagiri, T.5    Wada, M.6    Osawa, T.7    Suda, T.8
  • 85
    • 21344455768 scopus 로고    scopus 로고
    • BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling cross-talk
    • DOI 10.1016/j.cytogfr.2005.01.009, PII S1359610105000390
    • Miyazono K, Maeda S & Imamura T (2005) BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev 16, 251-263. (Pubitemid 40910315)
    • (2005) Cytokine and Growth Factor Reviews , vol.16 , Issue.3 SPEC. ISS , pp. 251-263
    • Miyazono, K.1    Maeda, S.2    Imamura, T.3
  • 86
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • DOI 10.1016/S0092-8674(03)00432-X
    • Shi Y & Massague J (2003) Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113, 685-700. (Pubitemid 36724933)
    • (2003) Cell , vol.113 , Issue.6 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 87
    • 0036894554 scopus 로고    scopus 로고
    • Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: A prospective, randomized clinical pilot trial 2002 volvo award in clinical studies
    • DOI 10.1097/00007632-200212010-00005
    • Boden SD, Kang J, Sandhu H, et al. (2002) Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies. Spine 27, 2662-2673. (Pubitemid 35425320)
    • (2002) Spine , vol.27 , Issue.23 , pp. 2662-2673
    • Boden, S.D.1    Kang, J.2    Sandhu, H.3    Heller, J.G.4
  • 88
    • 0030598829 scopus 로고    scopus 로고
    • The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
    • Zimmerman LB, De Jesús-Escobar JM & Harland RM (1996) The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86, 599-606.
    • (1996) Cell , vol.86 , pp. 599-606
    • Zimmerman, L.B.1    De Jesús-Escobar, J.M.2    Harland, R.M.3
  • 90
    • 0032535785 scopus 로고    scopus 로고
    • Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts
    • Gazzerro E, Gangji V & Canalis E (1998) Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts. J Clin Invest 102, 2106-2114. (Pubitemid 29018817)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.12 , pp. 2106-2114
    • Gazzerro, E.1    Gangji, V.2    Canalis, E.3
  • 91
    • 23944463238 scopus 로고    scopus 로고
    • Ostholemediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells
    • Kuo P-L, Hsu Y-L, Chang C-H, et al. (2005) Ostholemediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells. J Pharmacol Exp Ther 314, 1290-1299.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 1290-1299
    • Kuo, P.-L.1    Hsu, Y.-L.2    Chang, C.-H.3
  • 92
    • 37549069399 scopus 로고    scopus 로고
    • Enhancement of bone morphogenetic protein-2 expression and bone formation by coumarin derivatives via p38 and ERK-dependent pathway in osteoblasts
    • Tang CH, Yang RS, Chien MY, et al. (2008) Enhancement of bone morphogenetic protein-2 expression and bone formation by coumarin derivatives via p38 and ERK-dependent pathway in osteoblasts. Eur J Pharmacol 579, 40-49.
    • (2008) Eur J Pharmacol , vol.579 , pp. 40-49
    • Tang, C.H.1    Yang, R.S.2    Chien, M.Y.3
  • 93
    • 33750479895 scopus 로고    scopus 로고
    • Piceatannol stimulates osteoblast differentiation that may be mediated by increased bone morphogenetic protein-2 production
    • Chang JK, Hsu YL, Teng IC, et al. (2006) Piceatannol stimulates osteoblast differentiation that may be mediated by increased bone morphogenetic protein-2 production. Eur J Pharmacol 551, 1-9.
    • (2006) Eur J Pharmacol , vol.551 , pp. 1-9
    • Chang, J.K.1    Hsu, Y.L.2    Teng, I.C.3
  • 94
    • 34547107359 scopus 로고    scopus 로고
    • Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol
    • DOI 10.1074/jbc.M702452200
    • Su JL, Yang CY, Zhao M, et al. (2007) Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. J Biol Chem 282, 19385-19398. (Pubitemid 47100112)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.27 , pp. 19385-19398
    • Su, J.-L.1    Yang, C.-Y.2    Zhao, M.3    Kuo, M.-L.4    Yen, M.-L.5
  • 95
    • 33845924373 scopus 로고    scopus 로고
    • Myricetin induces human osteoblast differentiation through bone morphogenetic protein-2/p38 mitogen-activated protein kinase pathway
    • Hsu YL, Chang JK, Tsai CH, et al. (2007) Myricetin induces human osteoblast differentiation through bone morphogenetic protein-2/p38 mitogen-activated protein kinase pathway. Biochem Pharmacol 73, 504-514.
    • (2007) Biochem Pharmacol , vol.73 , pp. 504-514
    • Hsu, Y.L.1    Chang, J.K.2    Tsai, C.H.3
  • 96
    • 0036173620 scopus 로고    scopus 로고
    • Piceatannol, a natural analog of resveratrol, inhibits progression through the s phase of the cell cycle in colorectal cancer cell lines
    • Wolter F, Clausnitzer A, Akoglu B, et al. (2002) Piceatannol, a natural analog of resveratrol, inhibits progression through the S phase of the cell cycle in colorectal cancer cell lines. J Nutr 132, 298-302. (Pubitemid 34135611)
    • (2002) Journal of Nutrition , vol.132 , Issue.2 , pp. 298-302
    • Wolter, F.1    Clausnitzer, A.2    Akoglu, B.3    Stein, J.4
  • 97
    • 8444228130 scopus 로고    scopus 로고
    • Cytotoxicity and antiproliferative activities of several phenolic compounds against three melanocytes cell lines: Relationship between structure and activity
    • Yanez J, Vicente V, Alcaraz M, et al. (2004) Cytotoxicity and antiproliferative activities of several phenolic compounds against three melanocytes cell lines: relationship between structure and activity. Nutr Cancer 49, 191-199. (Pubitemid 39487879)
    • (2004) Nutrition and Cancer , vol.49 , Issue.2 , pp. 191-199
    • Yanez, J.1    Vicente, V.2    Alcaraz, M.3    Castillo, J.4    Benavente-Garcia, O.5    Canteras, M.6    Lozano Teruel, J.A.7
  • 101
    • 33747466839 scopus 로고    scopus 로고
    • Structure-function relationship of estrogen receptor a and b: Impact on human health
    • DOI 10.1016/j.mam.2006.07.001, PII S009829970600015X
    • Ascenzi P, Bocedi A & Maria M (2006) Structure-function relationship of estrogen receptor a and b: impact on human health. Mol Aspect Med 27, 299-402. (Pubitemid 44255847)
    • (2006) Molecular Aspects of Medicine , vol.27 , Issue.4 , pp. 299-402
    • Ascenzi, P.1    Bocedi, A.2    Marino, M.3
  • 102
    • 0034783960 scopus 로고    scopus 로고
    • Mechanisms of estrogen action
    • Nilsson S, Makela S, Treuter E, et al. (2001) Mechanisms of estrogen action. Physiol Rev 81, 1535-1565.
    • (2001) Physiol Rev , vol.81 , pp. 1535-1565
    • Nilsson, S.1    Makela, S.2    Treuter, E.3
  • 104
    • 18144406916 scopus 로고    scopus 로고
    • Signaling from the membrane via membrane estrogen receptor-α: Estrogens, xenoestrogens, and phytoestrogens
    • DOI 10.1016/j.steroids.2005.03.002
    • Watson CS, Bulayeva NN, Wozniak AL, et al. (2005) Signaling from the membrane via membrane estrogen receptor-α estrogens, xenoestrogens, and phytoestrogens. Steroids 70, 364-371. (Pubitemid 40616034)
    • (2005) Steroids , vol.70 , Issue.5-7 SPEC. ISS , pp. 364-371
    • Watson, C.S.1    Bulayeva, N.N.2    Wozniak, A.L.3    Finnerty, C.C.4
  • 105
    • 1542345740 scopus 로고    scopus 로고
    • Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway
    • DOI 10.1016/j.bcp.2003.11.009, PII S0006295203009006
    • Prouillet C, Maziere JC, Maziere C, et al. (2004) Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway. Biochem Pharmacol 67, 1307-1313. (Pubitemid 38315096)
    • (2004) Biochemical Pharmacology , vol.67 , Issue.7 , pp. 1307-1313
    • Prouillet, C.1    Maziere, J.-C.2    Maziere, C.3    Wattel, A.4    Brazier, M.5    Kamel, S.6
  • 107
    • 35548970288 scopus 로고    scopus 로고
    • Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation
    • DOI 10.1016/j.phymed.2007.04.003, PII S094471130700061X
    • Dai Z, Li Y, Quarles LD, et al. (2007) Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation. Phytomedicine 14, 806-814. (Pubitemid 350017876)
    • (2007) Phytomedicine , vol.14 , Issue.12 , pp. 806-814
    • Dai, Z.1    Li, Y.2    Quarles, L.D.3    Song, T.4    Pan, W.5    Zhou, H.6    Xiao, Z.7
  • 108
    • 33646396235 scopus 로고    scopus 로고
    • Estrogen deficiency and bone loss: An inflammatory tale
    • Weitzmann MN & Pacifici R (2006) Estrogen deficiency and bone loss: an inflammatory tale. J Clin Invest 116, 1186-1194.
    • (2006) J Clin Invest , vol.116 , pp. 1186-1194
    • Weitzmann, M.N.1    Pacifici, R.2
  • 110
    • 0038407651 scopus 로고    scopus 로고
    • Estrogen action and cytoplasmic signaling pathways. Part II: The role of growth factors and phosphorylation in estrogen signaling
    • Driggers PH & Segars JH (2002) Estrogen action and cytoplasmic signaling pathways. Part II: the role of growth factors and phosphorylation in estrogen signaling. Trends Endocrinol Metab 13, 422-427.
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 422-427
    • Driggers, P.H.1    Segars, J.H.2
  • 111
    • 9744284211 scopus 로고    scopus 로고
    • Mechanisms of naringenin-induced apoptotic cascade in cancer cells: Involvement of estrogen receptor a and b signalling
    • DOI 10.1080/15216540400010792
    • Totta P, Acconcia F, Leone S, et al. (2004) Mechanisms of naringenin-induced apoptotic cascade in cancer cells: involvement of estrogen receptor a and b signalling. IUBMB Life 56, 491-499. (Pubitemid 39582784)
    • (2004) IUBMB Life , vol.56 , Issue.8 , pp. 491-499
    • Totta, P.1    Acconcia, F.2    Leone, S.3    Cardillo, I.4    Marino, M.5
  • 112
    • 33646808062 scopus 로고    scopus 로고
    • Phytochemicals
    • MJ Gibney, IA Macdonald and HM Roche, editors. Oxford: Blackwell Publishing
    • Cassidy A & Dalais FS (2003) Phytochemicals. In Nutrition and Metabolism, pp. 307-317 [MJ Gibney, IA Macdonald and HM Roche, editors]. Oxford: Blackwell Publishing.
    • (2003) Nutrition and Metabolism , pp. 307-317
    • Cassidy, A.1    Dalais, F.S.2
  • 113
    • 0036064771 scopus 로고    scopus 로고
    • Isoflavones regulate interleukin-6 and osteoprotegerin synthesis during osteoblast cell differentiation via an estrogen-receptor-dependent pathway
    • Chen XW, Garner SC & Anderson JJ (2002) Isoflavones regulate interleukin-6 and osteoprotegerin synthesis during osteoblast cell differentiation via an estrogen-receptor-dependent pathway. Biochem Biophys Res Commun 295, 417-422.
    • (2002) Biochem Biophys Res Commun , vol.295 , pp. 417-422
    • Chen, X.W.1    Garner, S.C.2    Anderson, J.J.3
  • 114
    • 0034657277 scopus 로고    scopus 로고
    • Ellagitannins - Nature, occurrence and dietary burden
    • DOI 10.1002/(SICI)1097-0010(20000515)80:7<1118::AID-JSFA570>3.0. CO;2-9
    • Clifford MN & Scalbert A (2000) Ellagitannins - nature, occurrence and dietary burden. J Sci Food Agric 80, 1118-1125. (Pubitemid 30319403)
    • (2000) Journal of the Science of Food and Agriculture , vol.80 , Issue.7 , pp. 1118-1125
    • Clifford, M.N.1    Scalbert, A.2
  • 116
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
    • Simonet WS, Lacey DL, Dunstan CR, et al. (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89, 309-319.
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1    Lacey, D.L.2    Dunstan, C.R.3
  • 117
    • 0019847761 scopus 로고
    • Role of osteoblasts in hormonal control of bone resorption - A hypothesis
    • Rodan GA & Martin TJ (1981) Role of osteoblasts in hormonal control of bone resorption - a hypothesis. Calcif Tissue Int 33, 349-351.
    • (1981) Calcif Tissue Int , vol.33 , pp. 349-351
    • Rodan, G.A.1    Martin, T.J.2
  • 121
    • 57049151379 scopus 로고    scopus 로고
    • Dried plum polyphenols attenuate the detrimental effects of TNF-α on osteoblast function coincident with up-regulation of Runx2, Osterix and IGF-I
    • Bu SY, Hunt TS & Smith BJ (2009) Dried plum polyphenols attenuate the detrimental effects of TNF-α on osteoblast function coincident with up-regulation of Runx2, Osterix and IGF-I. J Nutr Biochem 20, 35-44.
    • (2009) J Nutr Biochem , vol.20 , pp. 35-44
    • Bu, S.Y.1    Hunt, T.S.2    Smith, B.J.3
  • 122
    • 69349100744 scopus 로고    scopus 로고
    • University of Michigan
    • University of Michigan (2005) Bone remodeling. http://www.umich.edu/news/ Releases/2005/Feb05/bone.html
    • (2005) Bone Remodeling


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.