Enhancement of bone morphogenetic protein-2 expression and bone formation by coumarin derivatives via p38 and ERK-dependent pathway in osteoblasts

European Journal of Pharmacology

Volumn 579, Issue 1-3, 2008, Pages 40-49

  Tang, Chih Hsin ^a,b   Yang, Rong Sen ^a   Chien, Mei Yin ^c   Chen, Chien Chich ^d   Fu, Wen Mei ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c KO DA PHARMACEUTICAL CO LTD   (Taiwan)

^d NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

Bone morphogenetic protein; Coumarin; ERK; Osteoblasts; p38

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALKALINE PHOSPHATASE; BERGAPTEN; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; COUMARIN DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PENTOSALEN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL MATURATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; FETUS; IMMUNOHISTOCHEMISTRY; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIBIA;

ALKALINE PHOSPHATASE; ANIMALS; BONE MORPHOGENETIC PROTEINS; CELLS, CULTURED; COLLAGEN TYPE I; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MALE; METHOXSALEN; OSTEOBLASTS; OSTEOGENESIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PSORALENS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SMAD PROTEINS, RECEPTOR-REGULATED; TIBIA; TRANSFORMING GROWTH FACTOR BETA;

EID: 37549069399     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.10.013     Document Type: Article

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