Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 314, Issue 3, 2005, Pages 1290-1299

  Kuo, Po Lin ^a   Hsu, Ya Ling ^b   Chang, Cheng Hsiung ^a   Chang, Jiunn Kae ^a  

^a CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; NOGGIN; OSTEOCALCIN; OSTEOPONTIN; OSTHOLE; SMALL INTERFERING RNA; SYNAPTOPHYSIN;

ARTICLE; CELL DIFFERENTIATION; CELL LINE; CELL MATURATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REGULATION; HUMAN; HUMAN CELL; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; UPREGULATION;

BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; COUMARINS; DNA-BINDING PROTEINS; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; OSTEOBLASTS; OSTEOPOROSIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RNA, SMALL INTERFERING; SMAD PROTEINS; SMAD1 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 23944463238     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.105.085092     Document Type: Article

References (34)

1. Berg C, Neumeyer K, and Kirkpatrick P (2003) Teriparatide. Nat Rev Drug Discov 2:257-258.
2. Chae HJ, Jeong BJ, Ha MS, Lee JK, Byun JO, Jung WY, Yun YG, Lee DG, Oh SH, Chae SW, et al. (2002) ERK MAP Kinase is required in 1,25(OH)2D3-induced differentiation in human osteoblasts. Immunopharmacol Immunotoxicol 24:31-41.
3. Chang L and Karin M (2001) Mammalian MAP kinase signalling cascades. Nature (Lond) 410:37-40.
4. Cortizo AM, Lettieri MG, Barrio DA, Mercer N, Etcheverry SB, and McCarthy AD (2003) Advanced glycation end-products (AGEs) induce concerted changes in the osteoblastic expression of their receptor RAGE and in the activation of extracellular signal-regulated kinases (ERK). Mol Cell Biochem 250:1-10.
5. Ducy P, Schinke T, and Karsenty G (2000) The osteoblast: a sophisticated fibroblast under central surveillance. Science (Wash DC) 289:1501-1504.
6. Franceschi RT and Iyer BS (1992) Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3-E1 cells. J Bone Miner Res 7:235-246.
7. Gallea S, Lallemand F, Atfi A, Rawadi G, Ramez V, Spinella-Jaegle S, Kawai S, Faucheu C, Huet L, Baron R, et al. (2001) Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells. Bone 28:491-498.
8. Goswami M, Uzgare AR, and Sater AK (2001) Regulation of MAP kinase by the BMP-4/TAK1 pathway in Xenopus ectoderm. Dev Biol 236:259-270.
9. Guicheux J, Lemonnier J, Ghayor C, Suzuki A, Palmer G, and Caverzasio J (2003) Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation. J Bone Miner Res 18:2060-2068.
10. Hallahan AR, Pritchard JI, Chandraratna RA, Ellenbogen RG, Geyer JR, Overland RP, Strand AD, Tapscott SJ, and Olson JM (2003) BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. Nat Med 9:1033-1038.
11. Hu Y, Chan E, Wang SX, and Li B (2003) Activation of p38 mitogen-activated protein kinase is required for osteoblast differentiation. Endocrinology 144:2068-2074.
12. Huang RL, Chen CC, Huang YL, Hsieh DJ, Hu CP, Chen CF, and Chang C (1996) Osthole increases glycosylation of hepatitis B surface antigen and suppresses the secretion of hepatitis B virus in vitro. Hepatology 24:508-515.
13. Jadlowiec J, Koch H, Zhang X, Campbell PG, Seyedain M, and Sfeir C (2004) Phosphophoryn regulates the gene expression and differentiation of NIH3T3, MC3T3-E1 and human mesenchymal stem cells via the integrin/MAPK signaling pathway. J Biol Chem 279:53323-53330.
14. Jaiswal RK, Jaiswal N, Bruder SP, Mbalaviele G, Marshak DR, and Pittenger MF (2000) Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase. J Biol Chem 275:9645-9652.
15. Jia TL, Wang HZ, Xie LP, Wang XY, and Zhang RQ (2003) Daidzein enhances osteoblast growth that may be mediated by increased bone morphogenetic protein (BMP) production. Biochem Pharmacol 65:709-715.
16. Ko FN, Wu TS, Liou MJ, Huang TF, and Teng CM (1992) Vasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescens. Eur J Pharmacol 219:29-34.
17. Lai CF and Cheng SL (2002) Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cells. J Biol Chem 277:15514-15522.
18. Lane NE and Kelman A (2003) A review of anabolic therapies for osteoporosis. Arthritis Res Ther 5:214-222.
19. Li XX, Hara I, and Matsumiya T (2002) Effects of osthole on postmenopausal osteoporosis using ovariectomized rats; comparison to the effects of estradiol. Biol Pharm Bull 25:738-742.
20. Liu JH, Zschocke S, Reininger E, and Bauer R (1998) Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase. Planta Med 64:525-529.
21. Manolagas SC and Jilka RL (1995) Bone marrow, cytokines and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 332:305-311.
22. Matsuda H, Tomohiro N, Ido Y, and Kubo M (2002) Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol. Biol Pharm Bull 25:809-812.
23. Meng F, Xiong Z, Sun Y, and Li F (2004) Coumarins from Cnidium monnieri (L.) and their proliferation stimulating activity on osteoblast-like UMR106 cells. Pharmazie 59:643-645.
24. Morais S, Sousa JP, Fernandes MH, and Carvalho GS (1998) In vitro biomineralization by osteoblast-like cells. I. Retardation of tissue mineralization by metal salts. Biomaterials 19:13-21.
25. Nohe A, Keating E, Knaus P, and Petersen NO (2004) Signal transduction of bone morphogenetic protein receptors. Cell Signal 16:291-299.
26. Noth U, Tuli R, Seghatoleslami R, Howard M, Shah A, Hall DJ, Hickok NJ, and Tuan RS (2003) Activation of p38 and Smads mediates BMP-2 effects on human trabecular bone-derived osteoblasts. Exp Cell Res 291:201-211.
27. Rodan GA and Martin TJ (2000) Therapeutic approaches to bone diseases. Science (Wash DC) 289:1508-1514.
28. Rodriguez JP, Rios S, Fernandez M, and Santibanez JF (2004) Differential activation of ERK1,2 MAP kinase signaling pathway in mesenchymal stem cell from control and osteoporotic postmenopausal women. J Cell Biochem 92:745-754.
29. Suzuki A, Palmer G, Bonjour JP, and Caverzasio J (1999) Regulation of alkaline phosphatase activity by p38 MAP kinase in response to activation of Gi protein-coupled receptors by epinephrine in osteoblast-like cells. Endocrinology 140:3177-3182.
30. Sykaras N and Opperman LA (2003) Bone morphogenetic proteins (BMPs): how do they function and what can they offer the clinician? J Oral Sci 45:57-73.
31. Teitelbaum SL (2000) Bone resorption by osteoclasts. Science (Wash DC) 289:1504-1508.
32. Teng CM, Lin CH, Ko FN, Wu TS, and Huang TF (1994) The relaxant action of osthole isolated from Angelica pubescens in guinea-pig trachea. Naunyn-Schmiedelberg's Arch Pharmacol 349:202-208.
33. Xiao Y, Haase H, Young WG, and Bartold PM (2004) Development and transplantation of a mineralized matrix formed by osteoblasts in vitro for bone regeneration. Cell Transplant 13:15-25.
34. Yang LL, Wang MC, Chen LG, and Wang CC (2003) Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines. Planta Med 69:1091-1095.