Estrogen action and cytoplasmic signaling pathways. Part II: The role of growth factors and phosphorylation in estrogen signaling

Trends in Endocrinology and Metabolism

Volumn 13, Issue 10, 2002, Pages 422-427

  Driggers, Paul H ^a   Segars, James H ^b  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; CELL RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOPLASM PROTEIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; GROWTH FACTOR RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C INHIBITOR; PROGESTERONE RECEPTOR; PROTEIN KINASE B; SOMATOMEDIN C RECEPTOR; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; CYTOPLASM; DNA SYNTHESIS; ENZYME ACTIVATION; ESTROGEN ACTIVITY; ESTROGEN RESPONSIVE ELEMENT; FEEDBACK SYSTEM; GENETIC TRANSCRIPTION; HORMONE ACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REVIEW; SIGNAL TRANSDUCTION;

EID: 0038407651     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(02)00634-3     Document Type: Review

References (72)

1. Smith, C.L. (1998) Cross-talk between peptide growth factor and estrogen receptor signaling pathways. Biol. Reprod. 58, 627-632
2. Tsai, M. et al. (1994) Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu. Rev. Biochem. 63, 451-486
3. McKenna, N. et al. (2002) Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 108, 465-474
4. Nelson, K.G. et al. (1991) Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentiation. Proc. Natl. Acad. Sci. U. S. A. 88, 21-25
5. Ignar-Trowbridge, D.M. et al. (1992) Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptor. Proc. Natl. Acad. Sci. U. S. A. 89, 4658-4662
6. Kato, S. et al. (1995) Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270, 1491-1494
7. Bunone, G. et al. (1996) Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J. 15, 2174-2183
8. Curtis, S.W. et al. (1996) Physiological coupling of growth factor and steroid receptor signaling pathways: estrogen receptor-knockout mice lack estrogen-like response to epidermal growth factor. Proc. Natl. Acad. Sci. U. S. A. 93, 12626-12630
9. Tremblay, A. et al. (1999) Ligand-independent recruitment of SRC-1 to estrogen receptor β through phosphorylation of activation function AF-1. Mol. Cell 3, 513-519
10. Webb, P. et al. (1998) Estrogen receptor activation function 1 works by binding p160 coactivator proteins. Mol. Endocrinol. 12, 1605-1618
11. Joel, P.B. et al. (1998) Estradiol-induced phosphorylation of serine 118 in the estrogen receptor is independent of p42/p44 mitogen-activated protein kinase. J. Biol. Chem. 273, 13317-13323
12. Chen, D. et al. (2000) Activation of estrogen receptor α by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7. Mol. Cell 6, 127-137
13. Lobenhofer, E.K. et al. (2000) Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis. Cell Growth Differ. 11, 99-110
14. Castoria, G. et al. (1999) Non-transcriptional action of oestradiol and progestin triggers DNA synthesis. EMBO J. 18, 2500-2510
15. Singh, M. et al. (2000) Estrogen-induced activation of the mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-α-knockout mice. J. Neurosci. 20, 1694-1700
16. Improta-Brears, T. et al. (1999) Estrogen-induced activation of mitrogen-activated protein kinase requires mobilization of intracellular calcium. Proc. Natl. Acad. Sci. U. S. A. 96, 4686-4691
17. Lu, D. and Giguere, V. (2001) Requirement of Ras-dependent pathways for activation of the transforming growth factor β3 promoter by estradiol. Endocrinology 142, 751-759
18. Rowan, B. et al. (2000) Phosphorylation of steroid receptor coactivator-1. J. Biol. Chem. 275, 4475-4483
19. Font de Mora, J. et al. (2000) AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor. Mol. Cell. Biol. 20, 5041-5047
20. Janknecht, R. et al. (1996) MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP. Biochem. Biophys. Res. Commun. 228, 831-837
21. Liu, Y. et al. (1998) Nerve growth factor upregulates the transcriptional activity of CBP through activation of the p42/p44 MAPK cascade. J. Biol. Chem. 273, 32400-32407
22. Gusterson, R. et al. (2002) The transcriptional coactivators CBP and p300 are activated via phenylephrine through the p42/p44 MAPK cascade. J. Biol. Chem. 277, 2517-2524
23. Ait-Si-Ali, S. et al. (1999) Phosphorylation by p44 MAP kinase-ERK1 stimulates CBP histone acetyl transferase activity in vitro. Biochem. Biophys. Res. Commun. 262, 157-162
24. Migliaccio, A. et al. (1998) Activation of the Src-p21ras-Erk pathway by progesterone receptor via cross-talk with estrogen receptor. EMBO J. 17, 2008-2018
25. Boonyaratanakornkit, V. et al. (2001) Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-src family tyrosine kinases. Mol. Cell 8, 269-280
26. Migliaccio, A. et al. (2000) Steroid-induced androgen receptor-oestradiol receptor β-Src complex triggers prostate cancer cell proliferation. EMBO J. 19, 5406-5417
27. Kousteni, S. et al. (2001) Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 104, 719-730
28. Lee, H. et al. (2000) MEKK1 activation of human estrogen receptor α and stimulation of the agonistic activity of 4-hydroxytamoxifen in endometrial and ovarian cancer cells. Mol. Endocrinol. 14, 1882-1896
29. Driggers, P.H. et al. (2001) The proto-oncoprotein Brx activates estrogen receptor β by a p38 mitogen-activated protein kinase pathway. J. Biol. Chem. 276, 46792-46797
30. Rubino, D. et al. (1998) Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action. Oncogene 16, 2513-2516
31. 12-selective Rho-mediated stress fiber formation. J. Biol. Chem. 276, 44247-44257
32. Zhang, C.C. et al. (2000) Activation of the p38 mitogen-activated protein kinase pathway by estrogen or by 4-hydroxytamoxifen is coupled to estrogen receptor-induced apoptosis. J. Biol. Chem. 275, 479-486
33. Feng, W. et al. (2001) Potentiation of estrogen receptor activation function 1 (AF-1) by Src-JNK through a serine 118-independent pathway. Mol. Endocrinol. 15, 32-45
34. Aronica, S.M. et al. (1994) Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription. Proc. Natl. Acad. Sci. U. S. A. 91, 8517-8521
35. Cho, H. et al. (1993) Synergistic activation of estrogen receptor-mediated transcription by estradiol and protein kinase activators. Mol. Endocrinol, 7, 441-452
36. Aronica, S.M. et al. (1993) Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I. Mol. Endocrinol. 7, 743-752
37. Fujimoto, N. et al. (1994) Alteration in the agonist/antagonist balance of antiestrogens by activation of protein kinase A signaling pathways in breast cancer cells: antiestrogen selectivity and promoter dependence. Mol. Endocrinol. 8, 296-304
38. Le Goff, P. et al. (1994) Phosphorylation of the human estrogen receptor. J. Biol. Chem. 269, 4458-4466
39. Schreihofer, D.A. et al. (2001) Ligand-independent activation of pituitary ER: dependence on PKA-stimulated pathways. Endocrinology 142, 3361-3368
40. Lamb, J. et al. (2000) Regulation of the functional interaction between cyclin D1 and the estrogen receptor. Mol. Cell. Biol. 20, 8667-8675
41. Neuman, E. et al. (1997) Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4. Mol. Cell. Biol. 17, 5338-5347
42. Ince, B.A. et al. (1994) Activation of transcriptionally inactive human estrogen receptors by cyclic adenosine 3′,5′-monophosphate and ligands including antiestrogens. Mol. Endocrinol. 8, 1397-1406
43. El-Tanani, M.K.K. et al. (1996) Interaction between estradiol and cAMP in the regulation of specific gene expression. Mol. Cell. Endocrinol. 124, 71-77
44. Chen, D. et al. (1999) Phosphorylation of human estrogen receptor α by protein kinase A regulates dimerization. Mol. Cell. Biol. 19, 1002-1015
45. Rowan, B. et al. (2000) 8-Bromo-cyclic AMP induces phosphorylation of two sites in SRC-1 that facilitate ligand-independent activation of the chicken progesterone receptor and are critical for functional cooperation between SRC-1 and CREB binding protein. Mol. Cell. Biol. 20, 8720-8730
46. Lan, X. et al. (1998) Signal-specific co-activator domain requirements for Pit-1 activation. Nature 395, 301-306
47. Zanger, K. et al. (1999)A novel mechanism for cyclic adenosine 3′,5′-monophosphate regulation of gene expression by CREB-binding protein. Mol. Endocrinol. 13, 268-275
48. Chawla, S. et al. (1998) CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV. Science 281, 1505-1509
49. Lazennec, G. et al. (2001) Involvement of cyclic AMP-response element-binding protein (CREB) and estrogen receptor phosphorylation in the synergistic activation of the estrogen receptor by estradiol and protein kinase activators. J. Steroid Biochem. Mol. Biol. 77, 193-203
50. Carlstrom, L. et al. (2001) Estrogen modulation of the cyclic AMP-response element-binding protein pathway. Neuroendocrinology 74, 227-243
51. Gu, Q. et al. (1996) 17β-Estradiol potentiates kainate-induced currents via activation of the cAMP cascade. J. Neurosci. 16, 3620-3629
52. Zhou, Y. et al. (1996) Estrogen rapidly induces the phosphorylation of the cAMP-response element-binding protein in rat brain. Endocrinology 137, 2163-2166
53. Beyer, C. et al. (2000) Estrogenic stimulation of neurite growth in midbrain dopaminergic neurons depends on cAMP-protein kinase A signaling. J. Neurosci. Res. 59, 107-116
54. Joel, P.B. et al. (1995) Estradiol and phorbol ester cause phosphorylation of serine 118 in the human estrogen receptor. Mol. Endocrinol. 9, 1041-1052
55. Ignar-Trowbridge, D.M. et al. (1996) Peptide growth factor cross-talk with the estrogen receptor requires the A/B domain and occurs independently of protein kinase C or estradiol. Endocrinology 137, 1735-1744
56. Lahooti, H. et al. (1998) Modulation of mouse estrogen receptor transcription activity by protein kinase C δ. J. Mol. Endocrinol. 20, 245-259
57. 3 mediates the estrogen receptor activity expressed in human cells. Mol. Cell. Endocrinol. 182, 19-26
58. Demay, F. et al. (2001) Steroid-independent activation of ER by GnRH in gonadotrope pituitary cells. Endocrinology 142, 3340-3347
59. Sylvia, V.L. et al. (2001) 17β-Estradiol-BSA conjugates and 17β-estradiol regulate growth plate chondrocytes by common membrane associated mechanisms involving PKC dependent and independent signal transduction. J. Cell. Biochem. 81, 413-429
60. Sylvia, V.L. et al. (2000) The membrane effects of 17β-estradiol on chondrocyte phenotypic expression are mediated by activation of protein kinase C through phospholipase C and G-proteins. J. Steroid Biochem. Mol. Biol. 73, 211-224
61. Migliaccio, S. et al. (1993) Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels. Mol. Endocrinol. 7, 1133-1143
62. Migliaccio, S. et al. (1998) Modulation of estrogen receptor levels in mouse uterus by protein kinase C isoenzymes. Endocrinology 139, 4598-4606
63. Fournier, D.B. et al. (2001) Protein kinase C α expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer. Gynecol. Oncol. 81, 366-372
64. Tonetti, D.A. et al. (2000) Stable transfection of protein kinase C α cDNA in hormone-dependent breast cancer cell lines. Br. J. Cancer 83, 782-791
65. Maizels, E.T. et al. (1996) Hormonal regulation of PKC-δ protein and mRNA levels in the rabbit corpus luteum. Mol. Cell. Endocrinol. 122, 213-221
66. Shanmugam, M. et al. (1999) Regulation of kinase C δ by estrogen in the MCF-7 human breast cancer cell line. Mol. Cell. Endocrinol. 148, 109-118
67. WAFI/CIP1 induction. Cancer Lett. 172, 43-53
68. Reddy, K.B. et al. (1992) Inhibition of breast cancer cell growth in vitro by a tyrosine kinase inhibitor. Cancer Res. 52, 3636-3641
69. Kahlert, S. et al. (2000) Estrogen receptor α rapidly activates the IGF-I receptor pathway. J. Biol. Chem. 275, 18447-18453
70. Dupont, J. et al. (2000) The potentiation of estrogen on insulin-like growth factor I action in MCF-7 human breast cancer cells includes cell cycle components. J. Biol. Chem. 275, 35893-35901
71. Segars, J.H. and Driggers, P.H. (2002) Estrogen action and cytoplasmic signaling cascades. Part I. Membrane-associated signaling complexes. Trends Endocrinol. Metabol. 13, 349-354
72. Cardona-Gomez, G.P. et al. (2000) Insulin-like growth factor I receptors and estrogen receptors colocalize in female rat brain. Neuroscience 99, 751-760