-
2
-
-
28444453715
-
Genetic instability and DNA repair
-
I.F.H.R. Tannock L. Harrington R.G. Bristow 4th ed. McGraw-Hill Ltd New York
-
R.G. Bristow, L. Harrington Genetic instability and DNA repair I.F.H.R. Tannock L. Harrington R.G. Bristow The Basic Science of Oncology 4th ed. 2005 McGraw-Hill Ltd New York 77 99
-
(2005)
The Basic Science of Oncology
, pp. 77-99
-
-
Bristow, R.G.1
Harrington, L.2
-
3
-
-
18244410170
-
Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts
-
C.P. Diggle, J. Bentley, M.A. Knowles Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts Nucleic Acids Res 33 2005 2531 2539
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 2531-2539
-
-
Diggle, C.P.1
Bentley, J.2
Knowles, M.A.3
-
5
-
-
3242890575
-
Mammalian cell cycle checkpoints: Signalling pathways and their organization in space and time
-
J. Lukas, C. Lukas, J. Bartek Mammalian cell cycle checkpoints signalling pathways and their organization in space and time DNA Repair (Amst) 3 2004 997 1007
-
(2004)
DNA Repair (Amst)
, vol.3
, pp. 997-1007
-
-
Lukas, J.1
Lukas, C.2
Bartek, J.3
-
6
-
-
13944263628
-
Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage
-
P.S. Bradshaw, D.J. Stavropoulos, M.S. Meyn Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage Nat Genet 37 2005 193 197
-
(2005)
Nat Genet
, vol.37
, pp. 193-197
-
-
Bradshaw, P.S.1
Stavropoulos, D.J.2
Meyn, M.S.3
-
7
-
-
3042771639
-
The p53 protein family and radiation sensitivity: Yes or no?
-
A.R. Cuddihy, R.G. Bristow The p53 protein family and radiation sensitivity Yes or no? Cancer Metastasis Rev 23 2004 237 257
-
(2004)
Cancer Metastasis Rev
, vol.23
, pp. 237-257
-
-
Cuddihy, A.R.1
Bristow, R.G.2
-
8
-
-
3042814563
-
Radiation and the cell cycle, revisited
-
G.D. Wilson Radiation and the cell cycle, revisited Cancer Metastasis Rev 23 2004 209 225
-
(2004)
Cancer Metastasis Rev
, vol.23
, pp. 209-225
-
-
Wilson, G.D.1
-
9
-
-
2442689078
-
Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo
-
A. Sullivan, N. Syed, M. Gasco Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo Oncogene 23 2004 3328 3337
-
(2004)
Oncogene
, vol.23
, pp. 3328-3337
-
-
Sullivan, A.1
Syed, N.2
Gasco, M.3
-
10
-
-
5144223978
-
Cell cycle checkpoints and their impact on anticancer therapeutic strategies
-
A. Eastman Cell cycle checkpoints and their impact on anticancer therapeutic strategies J Cell Biochem 91 2004 223 231
-
(2004)
J Cell Biochem
, vol.91
, pp. 223-231
-
-
Eastman, A.1
-
11
-
-
0037382008
-
Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors
-
S.J. Collis, M.J. Swartz, W.G. Nelson Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors Cancer Res 63 2003 1550 1554
-
(2003)
Cancer Res
, vol.63
, pp. 1550-1554
-
-
Collis, S.J.1
Swartz, M.J.2
Nelson, W.G.3
-
12
-
-
9744271049
-
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
-
I. Hickson, Y. Zhao, C.J. Richardson Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM Cancer Res 64 2004 9152 9159
-
(2004)
Cancer Res
, vol.64
, pp. 9152-9159
-
-
Hickson, I.1
Zhao, Y.2
Richardson, C.J.3
-
13
-
-
12244298187
-
Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy
-
S.G. Swisher, J.A. Roth, R. Komaki Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy Clin Cancer Res 9 2003 93 101
-
(2003)
Clin Cancer Res
, vol.9
, pp. 93-101
-
-
Swisher, S.G.1
Roth, J.A.2
Komaki, R.3
-
14
-
-
15444377848
-
Clinical trials: The sensitizing side of Onyx-015
-
O. Wildner Clinical trials The sensitizing side of Onyx-015 Gene Ther 12 2005 386 387
-
(2005)
Gene Ther
, vol.12
, pp. 386-387
-
-
Wildner, O.1
-
15
-
-
0033543728
-
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
-
P.G. Komarov, E.A. Komarova, R.V. Kondratov A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy Science 285 1999 1733 1737
-
(1999)
Science
, vol.285
, pp. 1733-1737
-
-
Komarov, P.G.1
Komarova, E.A.2
Kondratov, R.V.3
-
16
-
-
4444344407
-
G2 checkpoint abrogators as anticancer drugs
-
T. Kawabe G2 checkpoint abrogators as anticancer drugs Mol Cancer Ther 3 2004 513 519
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 513-519
-
-
Kawabe, T.1
-
17
-
-
1642323740
-
Protein kinase inhibitors: Insights into drug design from structure
-
M.E. Noble, J.A. Endicott, L.N. Johnson Protein kinase inhibitors Insights into drug design from structure Science 303 2004 1800 1805
-
(2004)
Science
, vol.303
, pp. 1800-1805
-
-
Noble, M.E.1
Endicott, J.A.2
Johnson, L.N.3
-
18
-
-
0036300312
-
7-Hydroxystaurosporine (UCN-01) preferentially sensitizes cells with a disrupted TP53 to gamma radiation in lung cancer cell lines
-
H.H. Xiao, Y. Makeyev, J. Butler 7-Hydroxystaurosporine (UCN-01) preferentially sensitizes cells with a disrupted TP53 to gamma radiation in lung cancer cell lines Radiat Res 158 2002 84 93
-
(2002)
Radiat Res
, vol.158
, pp. 84-93
-
-
Xiao, H.H.1
Makeyev, Y.2
Butler, J.3
-
19
-
-
20244388673
-
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
-
R.G. Syljuasen, C.S. Sorensen, L.T. Hansen Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage Mol Cell Biol 25 2005 3553 3562
-
(2005)
Mol Cell Biol
, vol.25
, pp. 3553-3562
-
-
Syljuasen, R.G.1
Sorensen, C.S.2
Hansen, L.T.3
-
20
-
-
16844384054
-
RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells
-
U.K. Mukhopadhyay, A.M. Senderowicz, G. Ferbeyre RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells Cancer Res 65 2005 2872 2881
-
(2005)
Cancer Res
, vol.65
, pp. 2872-2881
-
-
Mukhopadhyay, U.K.1
Senderowicz, A.M.2
Ferbeyre, G.3
-
21
-
-
0030679652
-
The effect of UCN-01 (7-hydroxystaurosporine), a potent inhibitor of protein kinase C, on fractionated radiotherapy or daily chemotherapy of a murine fibrosarcoma
-
E. Tsuchida, M. Urano The effect of UCN-01 (7-hydroxystaurosporine), a potent inhibitor of protein kinase C, on fractionated radiotherapy or daily chemotherapy of a murine fibrosarcoma Int J Radiat Oncol Biol Phys 39 1997 1153 1161
-
(1997)
Int J Radiat Oncol Biol Phys
, vol.39
, pp. 1153-1161
-
-
Tsuchida, E.1
Urano, M.2
-
22
-
-
0034897107
-
DNA damage-related RNA expression to assess individual sensitivity to ionizing radiation
-
K. Bishay, K. Ory, M.F. Olivier DNA damage-related RNA expression to assess individual sensitivity to ionizing radiation Carcinogenesis 22 2001 1179 1183
-
(2001)
Carcinogenesis
, vol.22
, pp. 1179-1183
-
-
Bishay, K.1
Ory, K.2
Olivier, M.F.3
-
23
-
-
3042699832
-
Normal expression of DNA repair proteins, hMre11, Rad50 and Rad51 but protracted formation of Rad50 containing foci in X-irradiated skin fibroblasts from radiosensitive cancer patients
-
C. Djuzenova, B. Muhl, R. Schakowski Normal expression of DNA repair proteins, hMre11, Rad50 and Rad51 but protracted formation of Rad50 containing foci in X-irradiated skin fibroblasts from radiosensitive cancer patients Br J Cancer 90 2004 2356 2363
-
(2004)
Br J Cancer
, vol.90
, pp. 2356-2363
-
-
Djuzenova, C.1
Muhl, B.2
Schakowski, R.3
-
24
-
-
9244234509
-
Defective DNA strand break repair after DNA damage in prostate cancer cells: Implications for genetic instability and prostate cancer progression
-
R. Fan, T.S. Kumaravel, F. Jalali Defective DNA strand break repair after DNA damage in prostate cancer cells implications for genetic instability and prostate cancer progression Cancer Res 64 2004 8526 8533
-
(2004)
Cancer Res
, vol.64
, pp. 8526-8533
-
-
Fan, R.1
Kumaravel, T.S.2
Jalali, F.3
-
25
-
-
0346457085
-
Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy
-
N. Taneja, M. Davis, J.S. Choy Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy J Biol Chem 279 2004 2273 2280
-
(2004)
J Biol Chem
, vol.279
, pp. 2273-2280
-
-
Taneja, N.1
Davis, M.2
Choy, J.S.3
-
26
-
-
3242886313
-
Homologous recombination-mediated double-strand break repair
-
C. Wyman, D. Ristic, R. Kanaar Homologous recombination-mediated double-strand break repair DNA Repair (Amst) 3 2004 827 833
-
(2004)
DNA Repair (Amst)
, vol.3
, pp. 827-833
-
-
Wyman, C.1
Ristic, D.2
Kanaar, R.3
-
27
-
-
0036141394
-
Elevated levels of Rad51 recombination protein in tumor cells
-
E. Raderschall, K. Stout, S. Freier Elevated levels of Rad51 recombination protein in tumor cells Cancer Res 62 2002 219 225
-
(2002)
Cancer Res
, vol.62
, pp. 219-225
-
-
Raderschall, E.1
Stout, K.2
Freier, S.3
-
28
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
H. Farmer, N. McCabe, C.J. Lord Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy Nature 434 2005 917 921
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
McCabe, N.2
Lord, C.J.3
-
29
-
-
0035312501
-
Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells
-
S.J. Collis, A. Tighe, S.D. Scott Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells Nucleic Acids Res 29 2001 1534 1538
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 1534-1538
-
-
Collis, S.J.1
Tighe, A.2
Scott, S.D.3
-
30
-
-
0242610826
-
Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity
-
J.S. Russell, K. Brady, W.E. Burgan Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity Cancer Res 63 2003 7377 7383
-
(2003)
Cancer Res
, vol.63
, pp. 7377-7383
-
-
Russell, J.S.1
Brady, K.2
Burgan, W.E.3
-
31
-
-
0034760095
-
BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance
-
A. Slupianek, C. Schmutte, G. Tombline BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance Mol Cell 8 2001 795 806
-
(2001)
Mol Cell
, vol.8
, pp. 795-806
-
-
Slupianek, A.1
Schmutte, C.2
Tombline, G.3
-
32
-
-
2342444226
-
DNA-binding properties of poly(ADP-ribose) polymerase: A target for anticancer therapy
-
V.A. Soldatenkov, V.N. Potaman DNA-binding properties of poly(ADP-ribose) polymerase a target for anticancer therapy Curr Drug Targets 5 2004 357 365
-
(2004)
Curr Drug Targets
, vol.5
, pp. 357-365
-
-
Soldatenkov, V.A.1
Potaman, V.N.2
-
33
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
H.E. Bryant, N. Schultz, H.D. Thomas Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase Nature 434 2005 913 917
-
(2005)
Nature
, vol.434
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
-
34
-
-
4544362838
-
The mechanism of non-homologous end-joining: A synopsis of synapsis
-
E. Weterings, D.C. van Gent The mechanism of non-homologous end-joining A synopsis of synapsis DNA Repair 3 2004 1425 1435
-
(2004)
DNA Repair
, vol.3
, pp. 1425-1435
-
-
Weterings, E.1
Van Gent, D.C.2
-
35
-
-
9744220428
-
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci
-
E. Riballo, M. Kuhne, N. Rief A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci Mol Cell 16 2004 715 724
-
(2004)
Mol Cell
, vol.16
, pp. 715-724
-
-
Riballo, E.1
Kuhne, M.2
Rief, N.3
-
36
-
-
16444384872
-
Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM
-
Y. Peng, R.G. Woods, H. Beamish Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM Cancer Res 65 2005 1670 1677
-
(2005)
Cancer Res
, vol.65
, pp. 1670-1677
-
-
Peng, Y.1
Woods, R.G.2
Beamish, H.3
-
37
-
-
0141974936
-
Vanillins - A novel family of DNA-PK inhibitors
-
S. Durant, P. Karran Vanillins - A novel family of DNA-PK inhibitors Nucleic Acids Res 31 2003 5501 5512
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 5501-5512
-
-
Durant, S.1
Karran, P.2
-
38
-
-
2942591949
-
A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia
-
E. Willmore, S. de Caux, N.J. Sunter A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia Blood 103 2004 4659-4565
-
(2004)
Blood
, vol.103
-
-
Willmore, E.1
De Caux, S.2
Sunter, N.J.3
-
39
-
-
0141619287
-
Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1
-
S.J. Veuger, N.J. Curtin, C.J. Richardson Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1 Cancer Res 63 2003 6008 6115
-
(2003)
Cancer Res
, vol.63
, pp. 6008-6115
-
-
Veuger, S.J.1
Curtin, N.J.2
Richardson, C.J.3
-
40
-
-
4944234150
-
Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines
-
J.P. Banath, S.H. Macphail, P.L. Olive Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines Cancer Res 64 2004 7144 7149
-
(2004)
Cancer Res
, vol.64
, pp. 7144-7149
-
-
Banath, J.P.1
MacPhail, S.H.2
Olive, P.L.3
-
41
-
-
0141645624
-
The role of the ubiquitin/proteasome system in cellular responses to radiation
-
W.H. McBride, K.S. Iwamoto, R. Syljuasen The role of the ubiquitin/proteasome system in cellular responses to radiation Oncogene 22 2003 5755 5773
-
(2003)
Oncogene
, vol.22
, pp. 5755-5773
-
-
McBride, W.H.1
Iwamoto, K.S.2
Syljuasen, R.3
-
42
-
-
19944388882
-
Proteasome involvement in the repair of DNA double-strand breaks
-
N.J. Krogan, M.H. Lam, J. Fillingham Proteasome involvement in the repair of DNA double-strand breaks Mol Cell 16 2004 1027 1034
-
(2004)
Mol Cell
, vol.16
, pp. 1027-1034
-
-
Krogan, N.J.1
Lam, M.H.2
Fillingham, J.3
-
43
-
-
0035924178
-
Protease inhibitors restore radiation-induced apoptosis to Bcl-2-expressing lymphoma cells
-
J.F. Kurland, R.E. Meyn Protease inhibitors restore radiation-induced apoptosis to Bcl-2-expressing lymphoma cells Int J Cancer 96 2001 327 333
-
(2001)
Int J Cancer
, vol.96
, pp. 327-333
-
-
Kurland, J.F.1
Meyn, R.E.2
-
44
-
-
0032885416
-
The proteasome inhibitor PS-341 in cancer therapy
-
B.A. Teicher, G. Ara, R. Herbst The proteasome inhibitor PS-341 in cancer therapy Clin Cancer Res 5 1999 2638 2645
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2638-2645
-
-
Teicher, B.A.1
Ara, G.2
Herbst, R.3
-
45
-
-
0037105651
-
The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells
-
F. Pajonk, J. Himmelsbach, K. Riess The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells Cancer Res 62 2002 5230 5235
-
(2002)
Cancer Res
, vol.62
, pp. 5230-5235
-
-
Pajonk, F.1
Himmelsbach, J.2
Riess, K.3
-
46
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
-
J. Bartkova, Z. Horejsi, K. Koed DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis Nature 434 2005 864 870
-
(2005)
Nature
, vol.434
, pp. 864-870
-
-
Bartkova, J.1
Horejsi, Z.2
Koed, K.3
-
48
-
-
0042631357
-
Combined-modality treatment of solid tumors using radiotherapy and molecular targeted agents
-
B.B. Ma, R.G. Bristow, J. Kim Combined-modality treatment of solid tumors using radiotherapy and molecular targeted agents J Clin Oncol 21 2003 2760 2776
-
(2003)
J Clin Oncol
, vol.21
, pp. 2760-2776
-
-
Ma, B.B.1
Bristow, R.G.2
Kim, J.3
|