메뉴 건너뛰기




Volumn 66, Issue 15, 2009, Pages 2503-2524

A comparative analysis of the cell biology of senescence and aging

Author keywords

Aging; Fibroblast; Lysosomes; Mitochondria; Postmitotic cell; Replicative senescence; Senescence associated heterochromatin foci (SAHF); Telomere dysfunction induced focus (TIF)

Indexed keywords

AGING; CELL ADHESION; CELL AGING; CELL STRUCTURE; CYTOSKELETON; HETEROCHROMATIN; HUMAN; LYSOSOME; MITOCHONDRION; NONHUMAN; REVIEW; SENESCENCE; TELOMERE;

EID: 67650828068     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-009-0034-2     Document Type: Review
Times cited : (145)

References (203)
  • 1
    • 0034774859 scopus 로고    scopus 로고
    • Cellular senescence, cancer and aging: The telomere connection
    • DOI 10.1016/S0531-5565(01)00160-7, PII S0531556501001607
    • J Campisi SH Kim CS Lim M Rubio 2001 Cellular senescence, cancer and aging: the telomere connection Exp Gerontol 36 1619 1637 (Pubitemid 32982869)
    • (2001) Experimental Gerontology , vol.36 , Issue.10 , pp. 1619-1637
    • Campisi, J.1    Kim, S.-H.2    Lim, C.-S.3    Rubio, M.4
  • 2
    • 55349095456 scopus 로고    scopus 로고
    • Cellular senescence: Molecular mechanisms, in vivo significance, and redox considerations
    • M Muller 2009 Cellular senescence: molecular mechanisms, in vivo significance, and redox considerations Antioxid Redox Signal 11 59 98
    • (2009) Antioxid Redox Signal , vol.11 , pp. 59-98
    • Muller, M.1
  • 3
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • M Serrano AW Lin ME McCurrach D Beach SW Lowe 1997 Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a Cell 88 593 602
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 4
    • 0032192153 scopus 로고    scopus 로고
    • Senescence of human fibroblasts induced by oncogenic Raf
    • J Zhu D Woods M McMahon JM Bishop 1998 Senescence of human fibroblasts induced by oncogenic Raf Genes Dev 12 2997 3007
    • (1998) Genes Dev , vol.12 , pp. 2997-3007
    • Zhu, J.1    Woods, D.2    McMahon, M.3    Bishop, J.M.4
  • 5
    • 0033732110 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes
    • O Toussaint EE Medrano T von Zglinicki 2000 Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes Exp Gerontol 35 927 945
    • (2000) Exp Gerontol , vol.35 , pp. 927-945
    • Toussaint, O.1    Medrano, E.E.2    Von Zglinicki, T.3
  • 6
    • 33748422079 scopus 로고    scopus 로고
    • Oncogene-induced cell senescence-halting on the road to cancer
    • WJ Mooi DS Peeper 2006 Oncogene-induced cell senescence-halting on the road to cancer N Engl J Med 355 1037 1046
    • (2006) N Engl J Med , vol.355 , pp. 1037-1046
    • Mooi, W.J.1    Peeper, D.S.2
  • 7
    • 0035834121 scopus 로고    scopus 로고
    • Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
    • A Krtolica S Parrinello S Lockett PY Desprez J Campisi 2001 Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging Proc Natl Acad Sci USA 98 12072 12077
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12072-12077
    • Krtolica, A.1    Parrinello, S.2    Lockett, S.3    Desprez, P.Y.4    Campisi, J.5
  • 8
    • 0034713329 scopus 로고    scopus 로고
    • Is beta-galactosidase staining a marker of senescence in vitro and in vivo?
    • J Severino RG Allen S Balin A Balin VJ Cristofalo 2000 Is beta-galactosidase staining a marker of senescence in vitro and in vivo? Exp Cell Res 257 162 171
    • (2000) Exp Cell Res , vol.257 , pp. 162-171
    • Severino, J.1    Allen, R.G.2    Balin, S.3    Balin, A.4    Cristofalo, V.J.5
  • 10
    • 0037007075 scopus 로고    scopus 로고
    • Endothelial cell senescence in human atherosclerosis: Role of telomere in endothelial dysfunction
    • T Minamino H Miyauchi T Yoshida Y Ishida H Yoshida I Komuro 2002 Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction Circulation 105 1541 1544
    • (2002) Circulation , vol.105 , pp. 1541-1544
    • Minamino, T.1    Miyauchi, H.2    Yoshida, T.3    Ishida, Y.4    Yoshida, H.5    Komuro, I.6
  • 12
    • 0020592264 scopus 로고
    • Growth factor responsiveness of cultured human fibroblasts declines with age
    • A Plisko BA Gilchrest 1983 Growth factor responsiveness of cultured human fibroblasts declines with age J Gerontol 38 513 518
    • (1983) J Gerontol , vol.38 , pp. 513-518
    • Plisko, A.1    Gilchrest, B.A.2
  • 13
    • 0036259159 scopus 로고    scopus 로고
    • Relationship between in vivo age and in vitro aging: Assessment of 669 cell cultures derived from members of the Baltimore Longitudinal Study of Aging
    • JR Smith S Venable TW Roberts EJ Metter R Monticone EL Schneider 2002 Relationship between in vivo age and in vitro aging: assessment of 669 cell cultures derived from members of the Baltimore Longitudinal Study of Aging J Gerontol A Biol Sci Med Sci 57 B239 B246
    • (2002) J Gerontol A Biol Sci Med Sci , vol.57
    • Smith, J.R.1    Venable, S.2    Roberts, T.W.3    Metter, E.J.4    Monticone, R.5    Schneider, E.L.6
  • 14
    • 0032168373 scopus 로고    scopus 로고
    • Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation
    • VJ Cristofalo RG Allen RJ Pignolo BG Martin JC Beck 1998 Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation Proc Natl Acad Sci USA 95 10614 10619
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 10614-10619
    • Cristofalo, V.J.1    Allen, R.G.2    Pignolo, R.J.3    Martin, B.G.4    Beck, J.C.5
  • 17
    • 0021179316 scopus 로고
    • Increased organization of cytoskeleton accompanying the aging of human fibroblasts in vitro
    • E Wang D Gundersen 1984 Increased organization of cytoskeleton accompanying the aging of human fibroblasts in vitro Exp Cell Res 154 191 202
    • (1984) Exp Cell Res , vol.154 , pp. 191-202
    • Wang, E.1    Gundersen, D.2
  • 18
    • 84941325677 scopus 로고
    • Cell size and nucleic acid content in the diploid human cell line WI-38 during aging
    • VJ Cristofalo D Kritchevsky 1969 Cell size and nucleic acid content in the diploid human cell line WI-38 during aging Med Exp Int J Exp Med 19 313 320
    • (1969) Med Exp Int J Exp Med , vol.19 , pp. 313-320
    • Cristofalo, V.J.1    Kritchevsky, D.2
  • 21
    • 0034472888 scopus 로고    scopus 로고
    • Involvement of Rb family proteins, focal adhesion proteins and protein synthesis in senescent morphogenesis induced by hydrogen peroxide
    • QM Chen VC Tu J Catania M Burton O Toussaint T Dilley 2000 Involvement of Rb family proteins, focal adhesion proteins and protein synthesis in senescent morphogenesis induced by hydrogen peroxide J Cell Sci 113 4087 4097
    • (2000) J Cell Sci , vol.113 , pp. 4087-4097
    • Chen, Q.M.1    Tu, V.C.2    Catania, J.3    Burton, M.4    Toussaint, O.5    Dilley, T.6
  • 22
    • 3042781117 scopus 로고    scopus 로고
    • Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts
    • E Hutter K Renner G Pfister P Stockl P Jansen-Durr E Gnaiger 2004 Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts Biochem J 380 919 928
    • (2004) Biochem J , vol.380 , pp. 919-928
    • Hutter, E.1    Renner, K.2    Pfister, G.3    Stockl, P.4    Jansen-Durr, P.5    Gnaiger, E.6
  • 24
    • 0037335554 scopus 로고    scopus 로고
    • Telomere-driven replicative senescence is a stress response
    • Tv Zglinicki J Petrie TBL Kirkwood 2003 Telomere-driven replicative senescence is a stress response Nat Biotech 21 229 230
    • (2003) Nat Biotech , vol.21 , pp. 229-230
    • Tv, Z.1    Petrie, J.2    Kirkwood, T.B.L.3
  • 25
    • 33750499504 scopus 로고    scopus 로고
    • Cell senescence: Hypertrophic arrest beyond the restriction point
    • MV Blagosklonny 2006 Cell senescence: hypertrophic arrest beyond the restriction point J Cell Physiol 209 592 597
    • (2006) J Cell Physiol , vol.209 , pp. 592-597
    • Blagosklonny, M.V.1
  • 27
    • 0037097863 scopus 로고    scopus 로고
    • Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
    • DC Fingar S Salama C Tsou E Harlow J Blenis 2002 Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E Genes Dev 16 1472 1487
    • (2002) Genes Dev , vol.16 , pp. 1472-1487
    • Fingar, D.C.1    Salama, S.2    Tsou, C.3    Harlow, E.4    Blenis, J.5
  • 28
    • 0036176049 scopus 로고    scopus 로고
    • Signals of oxidant-induced cardiomyocyte hypertrophy: Key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase
    • VC Tu JJ Bahl QM Chen 2002 Signals of oxidant-induced cardiomyocyte hypertrophy: key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase J Pharmacol Exp Ther 300 1101 1110
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 1101-1110
    • Tu, V.C.1    Bahl, J.J.2    Chen, Q.M.3
  • 29
    • 3042778581 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts
    • Y Wang A Meng D Zhou 2004 Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts Exp Cell Res 298 188 196
    • (2004) Exp Cell Res , vol.298 , pp. 188-196
    • Wang, Y.1    Meng, A.2    Zhou, D.3
  • 30
    • 0019203659 scopus 로고
    • Recent advances in the cell biology of aging
    • L Hayflick 1980 Recent advances in the cell biology of aging Mech Ageing Dev 14 59 79
    • (1980) Mech Ageing Dev , vol.14 , pp. 59-79
    • Hayflick, L.1
  • 31
    • 0017713288 scopus 로고
    • Comparison by autoradiography of macromolecular biosynthesis in "young" and "old" human diploid fibroblast cultures. A brief note
    • S Razin EA Pfendt T Matsumura L Hayflick 1977 Comparison by autoradiography of macromolecular biosynthesis in "young" and "old" human diploid fibroblast cultures. A brief note Mech Ageing Dev 6 379 384
    • (1977) Mech Ageing Dev , vol.6 , pp. 379-384
    • Razin, S.1    Pfendt, E.A.2    Matsumura, T.3    Hayflick, L.4
  • 32
    • 0035406728 scopus 로고    scopus 로고
    • Down-regulation of amphiphysin-1 is responsible for reduced receptor-mediated endocytosis in the senescent cells
    • JS Park WY Park KA Cho DI Kim BH Jhun SR Kim SC Park 2001 Down-regulation of amphiphysin-1 is responsible for reduced receptor-mediated endocytosis in the senescent cells FASEB J 15 1625 1627
    • (2001) FASEB J , vol.15 , pp. 1625-1627
    • Park, J.S.1    Park, W.Y.2    Cho, K.A.3    Kim, D.I.4    Jhun, B.H.5    Kim, S.R.6    Park, S.C.7
  • 33
    • 0021983008 scopus 로고
    • Are cross-bridging structures involved in the bundle formation of intermediate filaments and the decrease in locomotion that accompany cell aging?
    • E Wang 1985 Are cross-bridging structures involved in the bundle formation of intermediate filaments and the decrease in locomotion that accompany cell aging? J Cell Biol 100 1466 1473
    • (1985) J Cell Biol , vol.100 , pp. 1466-1473
    • Wang, E.1
  • 35
    • 0027096061 scopus 로고
    • Protein synthesis, posttranslational modifications, and aging
    • SI Rattan A Derventzi BF Clark 1992 Protein synthesis, posttranslational modifications, and aging Ann N Y Acad Sci 663 48 62
    • (1992) Ann N y Acad Sci , vol.663 , pp. 48-62
    • Rattan, S.I.1    Derventzi, A.2    Clark, B.F.3
  • 37
    • 0025749689 scopus 로고
    • Effect of age on liver protein synthesis and degradation
    • W Ward A Richardson 1991 Effect of age on liver protein synthesis and degradation Hepatology 14 935 948
    • (1991) Hepatology , vol.14 , pp. 935-948
    • Ward, W.1    Richardson, A.2
  • 38
    • 0034788516 scopus 로고    scopus 로고
    • Senescence and cytoskeleton: Overproduction of vimentin induces senescent-like morphology in human fibroblasts
    • K Nishio A Inoue S Qiao H Kondo A Mimura 2001 Senescence and cytoskeleton: overproduction of vimentin induces senescent-like morphology in human fibroblasts Histochem Cell Biol 116 321 327
    • (2001) Histochem Cell Biol , vol.116 , pp. 321-327
    • Nishio, K.1    Inoue, A.2    Qiao, S.3    Kondo, H.4    Mimura, A.5
  • 39
    • 0025999817 scopus 로고
    • Suppression of the chemically transformed phenotype of BHK cells by a human cDNA
    • MV Eiden L MacArthur H Okayama 1991 Suppression of the chemically transformed phenotype of BHK cells by a human cDNA Mol Cell Biol 11 5321 5329
    • (1991) Mol Cell Biol , vol.11 , pp. 5321-5329
    • Eiden, M.V.M.L.1    Okayama, H.2
  • 40
    • 0034767776 scopus 로고    scopus 로고
    • Role of the intermediate filament protein vimentin in delaying senescence and in the spontaneous immortalization of mouse embryo fibroblasts
    • GV Tolstonog RL Shoeman U Traub P Traub 2001 Role of the intermediate filament protein vimentin in delaying senescence and in the spontaneous immortalization of mouse embryo fibroblasts DNA Cell Biol 20 509 529
    • (2001) DNA Cell Biol , vol.20 , pp. 509-529
    • Tolstonog, G.V.1    Shoeman, R.L.2    Traub, U.3    Traub, P.4
  • 42
    • 0027505566 scopus 로고
    • Activation of the human vimentin gene by the Tax human T-cell leukemia virus. I. Mechanisms of regulation by the NF-kappa B transcription factor
    • A Lilienbaum D Paulin 1993 Activation of the human vimentin gene by the Tax human T-cell leukemia virus. I. Mechanisms of regulation by the NF-kappa B transcription factor J Biol Chem 268 2180 2188
    • (1993) J Biol Chem , vol.268 , pp. 2180-2188
    • Lilienbaum, A.1    Paulin, D.2
  • 43
    • 0348047392 scopus 로고    scopus 로고
    • Involvement of Rel/NF-kappa B transcription factors in senescence
    • K Gosselin C Abbadie 2003 Involvement of Rel/NF-kappa B transcription factors in senescence Exp Gerontol 38 1271 1283
    • (2003) Exp Gerontol , vol.38 , pp. 1271-1283
    • Gosselin, K.1    Abbadie, C.2
  • 45
    • 0029161762 scopus 로고
    • Age-induced hypertrophy of astrocytes in rat supraoptic nucleus: A cytological, morphometric, and immunocytochemical study
    • MT Berciano MA Andres E Calle M Lafarga 1995 Age-induced hypertrophy of astrocytes in rat supraoptic nucleus: a cytological, morphometric, and immunocytochemical study Anat Rec 243 129 144
    • (1995) Anat Rec , vol.243 , pp. 129-144
    • Berciano, M.T.1    Andres, M.A.2    Calle, E.3    Lafarga, M.4
  • 46
    • 0032128308 scopus 로고    scopus 로고
    • Development of vimentin filaments in the cells of the articular disc of the rat squamosomandibular joint with age
    • YC Bae KP Park MJ Park HJ Ihn 1998 Development of vimentin filaments in the cells of the articular disc of the rat squamosomandibular joint with age Arch Oral Biol 43 579 583
    • (1998) Arch Oral Biol , vol.43 , pp. 579-583
    • Bae, Y.C.1    Park, K.P.2    Park, M.J.3    Ihn, H.J.4
  • 48
    • 0024470306 scopus 로고
    • Overexpression of the vimentin gene in transgenic mice inhibits normal lens cell differentiation
    • Y Capetanaki S Smith JP Heath 1989 Overexpression of the vimentin gene in transgenic mice inhibits normal lens cell differentiation J Cell Biol 109 1653 1664
    • (1989) J Cell Biol , vol.109 , pp. 1653-1664
    • Capetanaki, Y.1    Smith, S.2    Heath, J.P.3
  • 49
    • 18744397853 scopus 로고    scopus 로고
    • Senescence-associated alterations of cytoskeleton: Extraordinary production of vimentin that anchors cytoplasmic p53 in senescent human fibroblasts
    • K Nishio A Inoue 2005 Senescence-associated alterations of cytoskeleton: extraordinary production of vimentin that anchors cytoplasmic p53 in senescent human fibroblasts Histochem Cell Biol 123 263 273
    • (2005) Histochem Cell Biol , vol.123 , pp. 263-273
    • Nishio, K.1    Inoue, A.2
  • 51
    • 33746918755 scopus 로고    scopus 로고
    • Age-related changes in focal adhesions lead to altered cell behavior in tendon fibroblasts
    • SM Arnesen MA Lawson 2006 Age-related changes in focal adhesions lead to altered cell behavior in tendon fibroblasts Mech Ageing Dev 127 726 732
    • (2006) Mech Ageing Dev , vol.127 , pp. 726-732
    • Arnesen, S.M.1    Lawson, M.A.2
  • 52
    • 1342279255 scopus 로고    scopus 로고
    • Protein profiling of the human epidermis from the elderly reveals up-regulation of a signature of interferon-γ-induced polypeptides that includes manganese-superoxide dismutase and the p85β Subunit of phosphatidylinositol 3-kinase
    • P Gromov GL Skovgaard H Palsdottir I Gromova M Ostergaard JE Celis 2003 Protein profiling of the human epidermis from the elderly reveals up-regulation of a signature of interferon-γ-induced polypeptides that includes manganese-superoxide dismutase and the p85β Subunit of phosphatidylinositol 3-kinase Mol Cell Proteomics 2 70 84
    • (2003) Mol Cell Proteomics , vol.2 , pp. 70-84
    • Gromov, P.1    Skovgaard, G.L.2    Palsdottir, H.3    Gromova, I.4    Ostergaard, M.5    Celis, J.E.6
  • 54
    • 44449142302 scopus 로고    scopus 로고
    • Nuclear actin dynamics-from form to function
    • MK Vartiainen 2008 Nuclear actin dynamics-from form to function FEBS Lett 582 2033 2040
    • (2008) FEBS Lett , vol.582 , pp. 2033-2040
    • Vartiainen, M.K.1
  • 55
    • 0028109996 scopus 로고
    • Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence
    • ME Venable GC Blobe LM Obeid 1994 Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence J Biol Chem 269 26040 26044
    • (1994) J Biol Chem , vol.269 , pp. 26040-26044
    • Venable, M.E.1    Blobe, G.C.2    Obeid, L.M.3
  • 57
    • 0027326435 scopus 로고
    • Suppression of vinculin expression by antisense transfection confers changes in cell morphology, motility, and anchorage-dependent growth of 3T3 cells
    • JL Rodriguez Fernandez B Geiger D Salomon A Ben-Ze'ev 1993 Suppression of vinculin expression by antisense transfection confers changes in cell morphology, motility, and anchorage-dependent growth of 3T3 cells J Cell Biol 122 1285 1294
    • (1993) J Cell Biol , vol.122 , pp. 1285-1294
    • Rodriguez Fernandez, J.L.1    Geiger, B.2    Salomon, D.3    Ben-Ze'Ev, A.4
  • 58
    • 0030772959 scopus 로고    scopus 로고
    • Role of focal adhesion kinase in integrin signaling
    • J-L Guan 1997 Role of focal adhesion kinase in integrin signaling Int J Biochem Cell Biol 29 1085 1096
    • (1997) Int J Biochem Cell Biol , vol.29 , pp. 1085-1096
    • Guan, J.-L.1
  • 60
    • 0035969233 scopus 로고    scopus 로고
    • Integrin-linked kinase (ILK) and its interactors: A new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes
    • C Wu S Dedhar 2001 Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes J Cell Biol 155 505 510
    • (2001) J Cell Biol , vol.155 , pp. 505-510
    • Wu, C.1    Dedhar, S.2
  • 61
    • 34248191840 scopus 로고    scopus 로고
    • Load-induced focal adhesion mechanotransduction is altered with aging in the Fischer 344/NNiaHSd x Brown Norway/BiNia rat aorta
    • KM Rice DH Desai RS Kinnard R Harris GL Wright ER Blough 2007 Load-induced focal adhesion mechanotransduction is altered with aging in the Fischer 344/NNiaHSd x Brown Norway/BiNia rat aorta Biogerontology 8 257 267
    • (2007) Biogerontology , vol.8 , pp. 257-267
    • Rice, K.M.1    Desai, D.H.2    Kinnard, R.S.3    Harris, R.4    Wright, G.L.5    Blough, E.R.6
  • 62
    • 0030941483 scopus 로고    scopus 로고
    • Expression of endothelin, fibronectin, and mortalin as aging and mortality markers
    • T Kumazaki R Wadhwa SC Kaul Y Mitsui 1997 Expression of endothelin, fibronectin, and mortalin as aging and mortality markers Exp Gerontol 32 95 103
    • (1997) Exp Gerontol , vol.32 , pp. 95-103
    • Kumazaki, T.1    Wadhwa, R.2    Kaul, S.C.3    Mitsui, Y.4
  • 63
    • 0028245337 scopus 로고
    • Altered regulation of fibronectin gene expression in Werner syndrome fibroblasts
    • P Rasoamanantena R Thweatt J Labat-Robert S Goldstein 1994 Altered regulation of fibronectin gene expression in Werner syndrome fibroblasts Exp Cell Res 213 121 127
    • (1994) Exp Cell Res , vol.213 , pp. 121-127
    • Rasoamanantena, P.1    Thweatt, R.2    Labat-Robert, J.3    Goldstein, S.4
  • 65
    • 0014831743 scopus 로고
    • Electron microscopy of human fibroblasts in tissue culture during logarithmic and confluent stages of growth
    • DE Comings TA Okada 1970 Electron microscopy of human fibroblasts in tissue culture during logarithmic and confluent stages of growth Exp Cell Res 61 295 301
    • (1970) Exp Cell Res , vol.61 , pp. 295-301
    • Comings, D.E.1    Okada, T.A.2
  • 66
    • 0015322815 scopus 로고
    • Ultrastructural changes accompanying the aging of human diploid cells in culture
    • J Lipetz VJ Cristofalo 1972 Ultrastructural changes accompanying the aging of human diploid cells in culture J Ultrastruct Res 39 43 56
    • (1972) J Ultrastruct Res , vol.39 , pp. 43-56
    • Lipetz, J.1    Cristofalo, V.J.2
  • 67
    • 38549123398 scopus 로고    scopus 로고
    • Heterogeneous upregulation of lysosomal genes in human fibroblasts and cancer cells undergoing senescence
    • JH Park HW Yi D DiMaio ES Hwang 2007 Heterogeneous upregulation of lysosomal genes in human fibroblasts and cancer cells undergoing senescence Korean J Genet 29 521 527
    • (2007) Korean J Genet , vol.29 , pp. 521-527
    • Park, J.H.1    Yi, H.W.2    Dimaio, D.3    Hwang, E.S.4
  • 68
    • 0021189636 scopus 로고
    • Lysosomal activity in the aging rat liver: II. Morphometry of acid phosphatase positive dense bodies
    • W De Priester R Van Manen DL Knook 1984 Lysosomal activity in the aging rat liver: II. Morphometry of acid phosphatase positive dense bodies Mech Ageing Dev 26 205 216
    • (1984) Mech Ageing Dev , vol.26 , pp. 205-216
    • De Priester, W.1    Van Manen, R.2    Knook, D.L.3
  • 69
    • 0020030177 scopus 로고
    • Effects of the type of dietary fat at two levels of vitamin e in Wistar male rats during development and aging. IV. Biochemical and morphometric parameters of the heart
    • EA Porta HM Sablan NS Joun G Chee 1982 Effects of the type of dietary fat at two levels of vitamin E in Wistar male rats during development and aging. IV. Biochemical and morphometric parameters of the heart Mech Ageing Dev 18 159 199
    • (1982) Mech Ageing Dev , vol.18 , pp. 159-199
    • Porta, E.A.1    Sablan, H.M.2    Joun, N.S.3    Chee, G.4
  • 70
    • 0036123267 scopus 로고    scopus 로고
    • Quantifying dense bodies and lipofuscin during aging: A morphologist's perspective
    • DL Schmucker H Sachs 2002 Quantifying dense bodies and lipofuscin during aging: a morphologist's perspective Arch Gerontol Geriatr 34 249 261
    • (2002) Arch Gerontol Geriatr , vol.34 , pp. 249-261
    • Schmucker, D.L.1    Sachs, H.2
  • 71
    • 0014800006 scopus 로고
    • Morphologic changes accompanying senescence of cultured human diploid cells
    • E Robbins EM Levine H Eagle 1970 Morphologic changes accompanying senescence of cultured human diploid cells J Exp Med 131 1211 1222
    • (1970) J Exp Med , vol.131 , pp. 1211-1222
    • Robbins, E.1    Levine, E.M.2    Eagle, H.3
  • 72
    • 0042707790 scopus 로고    scopus 로고
    • Mitochondrial recycling and aging of cardiac myocytes: The role of autophagocytosis
    • A Terman H Dalen JW Eaton J Neuzil UT Brunk 2003 Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis Exp Gerontol 38 863 876
    • (2003) Exp Gerontol , vol.38 , pp. 863-876
    • Terman, A.1    Dalen, H.2    Eaton, J.W.3    Neuzil, J.4    Brunk, U.T.5
  • 74
    • 54449091329 scopus 로고    scopus 로고
    • Early mitochondrial dysfunction in long-lived Mclk1 +/- mice
    • J Lapointe S Hekimi 2008 Early mitochondrial dysfunction in long-lived Mclk1 +/- mice J Biol Chem 283 26217 26227
    • (2008) J Biol Chem , vol.283 , pp. 26217-26227
    • Lapointe, J.1    Hekimi, S.2
  • 75
    • 0017188298 scopus 로고
    • Characterization of residual bodies formed in phase II cultivated human glia cells
    • VP Collins UT Brunk 1976 Characterization of residual bodies formed in phase II cultivated human glia cells Mech Ageing Dev 5 193 207
    • (1976) Mech Ageing Dev , vol.5 , pp. 193-207
    • Collins, V.P.1    Brunk, U.T.2
  • 76
    • 0017149860 scopus 로고
    • Lysosomal enzyme activities in parenchymal and nonparenchymal liver cells isolated from young, adult and old rats
    • DL Knook EC Sleyster 1976 Lysosomal enzyme activities in parenchymal and nonparenchymal liver cells isolated from young, adult and old rats Mech Ageing Dev 5 389 398
    • (1976) Mech Ageing Dev , vol.5 , pp. 389-398
    • Knook, D.L.1    Sleyster, E.C.2
  • 78
    • 0013239134 scopus 로고    scopus 로고
    • Evaluation of the activities of eight lysosomal hydrolases in sera of humans, rats and pigs of different ages
    • MM Sanchez-Martin JA Cabezas 1997 Evaluation of the activities of eight lysosomal hydrolases in sera of humans, rats and pigs of different ages Mech Ageing Dev 99 95 107
    • (1997) Mech Ageing Dev , vol.99 , pp. 95-107
    • Sanchez-Martin, M.M.1    Cabezas, J.A.2
  • 79
    • 33847184227 scopus 로고    scopus 로고
    • Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence
    • K Johung EC Goodwin D DiMaio 2007 Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence J Virol 81 2102 2116
    • (2007) J Virol , vol.81 , pp. 2102-2116
    • Johung, K.1    Goodwin, E.C.2    Dimaio, D.3
  • 82
    • 18844425714 scopus 로고    scopus 로고
    • Role of compartmentalized redox-active iron in hydrogen peroxide-induced DNA damage and apoptosis
    • M Tenopoulou P-T Doulias A Barbouti U Brunk D Galaris 2005 Role of compartmentalized redox-active iron in hydrogen peroxide-induced DNA damage and apoptosis Biochem J 387 703 710
    • (2005) Biochem J , vol.387 , pp. 703-710
    • Tenopoulou, M.1    Doulias, P.-T.2    Barbouti, A.3    Brunk, U.4    Galaris, D.5
  • 83
    • 0037448105 scopus 로고    scopus 로고
    • Intralysosomal iron: A major determinant of oxidant-induced cell death
    • DOI 10.1016/S0891-5849(03)00109-6
    • Z Yu HL Persson JW Eaton UT Brunk 2003 Intralysosomal iron: a major determinant of oxidant-induced cell death Free Radic Biol Med 34 1243 1252 (Pubitemid 36513967)
    • (2003) Free Radical Biology and Medicine , vol.34 , Issue.10 , pp. 1243-1252
    • Yu, Z.1    Persson, H.L.2    Eaton, J.W.3    Brunk, U.T.4
  • 88
    • 3242714885 scopus 로고    scopus 로고
    • Functional aging and gradual senescence in zebrafish
    • S Kishi 2004 Functional aging and gradual senescence in zebrafish Ann N Y Acad Sci 1019 521 526
    • (2004) Ann N y Acad Sci , vol.1019 , pp. 521-526
    • Kishi, S.1
  • 89
    • 0036203197 scopus 로고    scopus 로고
    • Markers of senescence?
    • PJ Coates 2002 Markers of senescence? J Pathol 196 371 373
    • (2002) J Pathol , vol.196 , pp. 371-373
    • Coates, P.J.1
  • 90
    • 0033971444 scopus 로고    scopus 로고
    • Ceramide induces expression of the senescence histochemical marker, β-galactosidase, in human fibroblasts
    • RE Mouton ME Venable 2000 Ceramide induces expression of the senescence histochemical marker, β-galactosidase, in human fibroblasts Mech Ageing Dev 113 169 181
    • (2000) Mech Ageing Dev , vol.113 , pp. 169-181
    • Mouton, R.E.1    Venable, M.E.2
  • 91
    • 26244436644 scopus 로고    scopus 로고
    • SA β-Gal staining: Biomarker or delusion
    • VJ Cristofalo 2005 SA β-Gal staining: biomarker or delusion Exp Gerontol 40 836 838
    • (2005) Exp Gerontol , vol.40 , pp. 836-838
    • Cristofalo, V.J.1
  • 92
    • 0032764992 scopus 로고    scopus 로고
    • Does pH 6 β-galactosidase activity indicate cell senescence?
    • DR Krishna B Sperker P Fritz U Klotz 1999 Does pH 6 β-galactosidase activity indicate cell senescence? Mech Ageing Dev 109 113 123
    • (1999) Mech Ageing Dev , vol.109 , pp. 113-123
    • Krishna, D.R.1    Sperker, B.2    Fritz, P.3    Klotz, U.4
  • 93
    • 0142217356 scopus 로고    scopus 로고
    • TGF-β cytokines increase senescence-associated beta-galactosidase activity in human prostate basal cells by supporting differentiation processes, but not cellular senescence
    • G Untergasser R Gander H Rumpold E Heinrich E Plas P Berger 2003 TGF-β cytokines increase senescence-associated beta-galactosidase activity in human prostate basal cells by supporting differentiation processes, but not cellular senescence Exp Gerontol 38 1179 1188
    • (2003) Exp Gerontol , vol.38 , pp. 1179-1188
    • Untergasser, G.1    Gander, R.2    Rumpold, H.3    Heinrich, E.4    Plas, E.5    Berger, P.6
  • 94
    • 26244445013 scopus 로고    scopus 로고
    • The limitations and validities of senescence associated-[beta]- galactosidase activity as an aging marker for human foreskin fibroblast Hs68 cells
    • N-C Yang M-L Hu 2005 The limitations and validities of senescence associated-[beta]-galactosidase activity as an aging marker for human foreskin fibroblast Hs68 cells Exp Gerontol 40 813 819
    • (2005) Exp Gerontol , vol.40 , pp. 813-819
    • Yang, N.-C.1    Hu, M.-L.2
  • 96
    • 23044466031 scopus 로고    scopus 로고
    • Quantitative assay of senescence-associated β-galactosidase activity in mammalian cell extracts
    • RK Gary SM Kindell 2005 Quantitative assay of senescence-associated β-galactosidase activity in mammalian cell extracts Anal Biochem 343 329 334
    • (2005) Anal Biochem , vol.343 , pp. 329-334
    • Gary, R.K.1    Kindell, S.M.2
  • 97
    • 0042206639 scopus 로고    scopus 로고
    • Association of increased autophagic inclusions labeled for β-galactosidase with fibroblastic aging
    • L-M Gerland S Peyrol C Lallemand R Branche J-P Magaud M Ffrench 2003 Association of increased autophagic inclusions labeled for β-galactosidase with fibroblastic aging Exp Gerontol 38 887 895
    • (2003) Exp Gerontol , vol.38 , pp. 887-895
    • Gerland, L.-M.1    Peyrol, S.2    Lallemand, C.3    Branche, R.4    Magaud, J.-P.5    Ffrench, M.6
  • 98
    • 0033730616 scopus 로고    scopus 로고
    • Senescence-associated β-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells
    • DJ Kurz S Decary Y Hong JD Erusalimsky 2000 Senescence-associated β-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells J Cell Sci 113 3613 3622
    • (2000) J Cell Sci , vol.113 , pp. 3613-3622
    • Kurz, D.J.1    Decary, S.2    Hong, Y.3    Erusalimsky, J.D.4
  • 101
    • 0019409516 scopus 로고
    • Glycogen accumulation in tibial nerves of experimentally diabetic and aging control rats
    • SA Moore RG Peterson DL Felten BL O'Connor 1981 Glycogen accumulation in tibial nerves of experimentally diabetic and aging control rats J Neurol Sci 52 289 303
    • (1981) J Neurol Sci , vol.52 , pp. 289-303
    • Moore, S.A.1    Peterson, R.G.2    Felten, D.L.3    O'Connor, B.L.4
  • 103
    • 0034665645 scopus 로고    scopus 로고
    • GSK-3: New thoughts on an old enzyme
    • DM Ferkey D Kimelman 2000 GSK-3: new thoughts on an old enzyme Dev Biol 225 471 479
    • (2000) Dev Biol , vol.225 , pp. 471-479
    • Ferkey, D.M.1    Kimelman, D.2
  • 104
    • 42549164807 scopus 로고    scopus 로고
    • Wnt signalling and its impact on development and cancer
    • A Klaus W Birchmeier 2008 Wnt signalling and its impact on development and cancer Nat Rev Cancer 8 387 398
    • (2008) Nat Rev Cancer , vol.8 , pp. 387-398
    • Klaus, A.1    Birchmeier, W.2
  • 105
    • 0035801388 scopus 로고    scopus 로고
    • Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation
    • A Damalas S Kahan M Shtutman A Ben-Ze'ev M Oren 2001 Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation EMBO J 20 4912 4922
    • (2001) EMBO J , vol.20 , pp. 4912-4922
    • Damalas, A.1    Kahan, S.2    Shtutman, M.3    Ben-Ze'Ev, A.4    Oren, M.5
  • 106
    • 0035854803 scopus 로고    scopus 로고
    • Lithium inhibits cell cycle progression and induces stabilization of p53 in bovine aortic endothelial cells
    • CD Mao P Hoang PE DiCorleto 2001 Lithium inhibits cell cycle progression and induces stabilization of p53 in bovine aortic endothelial cells J Biol Chem 276 26180 26188
    • (2001) J Biol Chem , vol.276 , pp. 26180-26188
    • Mao, C.D.1    Hoang, P.2    Dicorleto, P.E.3
  • 108
    • 0021705121 scopus 로고
    • Effects of age on glycogen synthase and phosphorylase activities in rat liver
    • RL Khandelwal TL Enno N Narayanan 1984 Effects of age on glycogen synthase and phosphorylase activities in rat liver Mech Ageing Dev 28 13 22
    • (1984) Mech Ageing Dev , vol.28 , pp. 13-22
    • Khandelwal, R.L.1    Enno, T.L.2    Narayanan, N.3
  • 109
    • 0023125449 scopus 로고
    • Age-related changes in rat muscle glycogen synthase activity
    • E Dall'Aglio H Chang GM Reaven S Azhar 1987 Age-related changes in rat muscle glycogen synthase activity J Gerontol 42 168 172
    • (1987) J Gerontol , vol.42 , pp. 168-172
    • Dall'Aglio, E.1    Chang, H.2    Reaven, G.M.3    Azhar, S.4
  • 110
    • 0026605715 scopus 로고
    • Effect of aging on glycogen synthesis in liver of starved-refed rats
    • A Mysliwski Z Kmiec 1992 Effect of aging on glycogen synthesis in liver of starved-refed rats Arch Gerontol Geriatr 14 85 92
    • (1992) Arch Gerontol Geriatr , vol.14 , pp. 85-92
    • Mysliwski, A.1    Kmiec, Z.2
  • 111
    • 13844280866 scopus 로고    scopus 로고
    • Nuclear accumulation of glycogen synthase kinase-3 during replicative senescence of human fibroblasts
    • JW Zmijewski RS Jope 2004 Nuclear accumulation of glycogen synthase kinase-3 during replicative senescence of human fibroblasts Aging Cell 3 309 317
    • (2004) Aging Cell , vol.3 , pp. 309-317
    • Zmijewski, J.W.1    Jope, R.S.2
  • 112
    • 34447343780 scopus 로고    scopus 로고
    • Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells
    • X Ye B Zerlanko A Kennedy G Banumathy R Zhang P Adams 2007 Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells Mol Cell 27 183 196
    • (2007) Mol Cell , vol.27 , pp. 183-196
    • Ye, X.1    Zerlanko, B.2    Kennedy, A.3    Banumathy, G.4    Zhang, R.5    Adams, P.6
  • 113
    • 34848814178 scopus 로고    scopus 로고
    • Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription
    • M Almeida L Han M Martin-Millan CA O'Brien SC Manolagas 2007 Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription J Biol Chem 282 27298 27305
    • (2007) J Biol Chem , vol.282 , pp. 27298-27305
    • Almeida, M.1    Han, L.2    Martin-Millan, M.3    O'Brien, C.A.4    Manolagas, S.C.5
  • 115
    • 0037205007 scopus 로고    scopus 로고
    • The promise and perils of Wnt signaling through beta-catenin
    • RT Moon B Bowerman M Boutros N Perrimon 2002 The promise and perils of Wnt signaling through beta-catenin Science 296 1644 1646
    • (2002) Science , vol.296 , pp. 1644-1646
    • Moon, R.T.1    Bowerman, B.2    Boutros, M.3    Perrimon, N.4
  • 121
    • 0028109380 scopus 로고
    • Correlation between mitochondrial DNA 4977-bp deletion and respiratory chain enzyme activities in aging human skeletal muscles
    • AMS Lezza D Boffoli S Scacco P Cantatore MN Gadaleta 1994 Correlation between mitochondrial DNA 4977-bp deletion and respiratory chain enzyme activities in aging human skeletal muscles Biochem Biophys Res Commun 205 772 779
    • (1994) Biochem Biophys Res Commun , vol.205 , pp. 772-779
    • Lezza, A.M.S.1    Boffoli, D.2    Scacco, S.3    Cantatore, P.4    Gadaleta, M.N.5
  • 123
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • T Finkel NJ Holbrook 2000 Oxidants, oxidative stress and the biology of ageing Nature 408 239 247
    • (2000) Nature , vol.408 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 124
    • 0038331337 scopus 로고    scopus 로고
    • Mitochondrial dysfunction leads to telomere attrition and genomic instability
    • L Liu JR Trimarchi PJ Smith DL Keefe 2002 Mitochondrial dysfunction leads to telomere attrition and genomic instability Aging Cell 1 40 46
    • (2002) Aging Cell , vol.1 , pp. 40-46
    • Liu, L.1    Trimarchi, J.R.2    Smith, P.J.3    Keefe, D.L.4
  • 125
    • 0041419866 scopus 로고    scopus 로고
    • MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress
    • G Saretzki MP Murphy T von Zglinicki 2003 MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress Aging Cell 2 141 143
    • (2003) Aging Cell , vol.2 , pp. 141-143
    • Saretzki, G.1    Murphy, M.P.2    Von Zglinicki, T.3
  • 126
    • 0021213782 scopus 로고
    • High-voltage electron microscopy of human diploid fibroblasts during ageing in vitro: Morphometric analysis of mitochondria
    • S Goldstein EJ Moerman K Porter 1984 High-voltage electron microscopy of human diploid fibroblasts during ageing in vitro: morphometric analysis of mitochondria Exp Cell Res 154 101 111
    • (1984) Exp Cell Res , vol.154 , pp. 101-111
    • Goldstein, S.1    Moerman, E.J.2    Porter, K.3
  • 127
    • 0036420161 scopus 로고    scopus 로고
    • Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence
    • HC Lee PH Yin CW Chi YH Wei 2002 Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence J Biomed Sci 9 517 526
    • (2002) J Biomed Sci , vol.9 , pp. 517-526
    • Lee, H.C.1    Yin, P.H.2    Chi, C.W.3    Wei, Y.H.4
  • 129
    • 0032429396 scopus 로고    scopus 로고
    • Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lung
    • HC Lee CY Lu HJ Fahn YH Wei 1998 Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lung FEBS Lett 441 292 296
    • (1998) FEBS Lett , vol.441 , pp. 292-296
    • Lee, H.C.1    Lu, C.Y.2    Fahn, H.J.3    Wei, Y.H.4
  • 130
    • 0035028669 scopus 로고    scopus 로고
    • Increases of mitochondrial mass and mitochondrial genome in association with enhanced oxidative stress in human cells harboring 4, 977 BP-deleted mitochondrial DNA
    • YH Wei CF Lee HC Lee YS Ma CW Wang CY Lu CY Pang 2001 Increases of mitochondrial mass and mitochondrial genome in association with enhanced oxidative stress in human cells harboring 4, 977 BP-deleted mitochondrial DNA Ann N Y Acad Sci 928 97 112
    • (2001) Ann N y Acad Sci , vol.928 , pp. 97-112
    • Wei, Y.H.1    Lee, C.F.2    Lee, H.C.3    Ma, Y.S.4    Wang, C.W.5    Lu, C.Y.6    Pang, C.Y.7
  • 131
    • 0032547237 scopus 로고    scopus 로고
    • Increase in intracellular hydrogen peroxide and upregulation of a nuclear respiratory gene evoked by impairment of mitochondrial electron transfer in human cells
    • H Suzuki T Kumagai A Goto T Sugiura 1998 Increase in intracellular hydrogen peroxide and upregulation of a nuclear respiratory gene evoked by impairment of mitochondrial electron transfer in human cells Biochem Biophys Res Commun 249 542 545
    • (1998) Biochem Biophys Res Commun , vol.249 , pp. 542-545
    • Suzuki, H.1    Kumagai, T.2    Goto, A.3    Sugiura, T.4
  • 132
    • 0033614441 scopus 로고    scopus 로고
    • Oxidative stress and upregulation of mitochondrial biogenesis genes in mitochondrial DNA-depleted HeLa cells
    • S Miranda R Foncea J Guerrero F Leighton 1999 Oxidative stress and upregulation of mitochondrial biogenesis genes in mitochondrial DNA-depleted HeLa cells Biochem Biophys Res Commun 258 44 49
    • (1999) Biochem Biophys Res Commun , vol.258 , pp. 44-49
    • Miranda, S.1    Foncea, R.2    Guerrero, J.3    Leighton, F.4
  • 133
    • 0034214103 scopus 로고    scopus 로고
    • Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells
    • HC Lee PH Yin CY Lu CW Chi YH Wei 2000 Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells Biochem J 348 425 432
    • (2000) Biochem J , vol.348 , pp. 425-432
    • Lee, H.C.1    Yin, P.H.2    Lu, C.Y.3    Chi, C.W.4    Wei, Y.H.5
  • 134
    • 44349184864 scopus 로고    scopus 로고
    • Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation
    • X Fu S Wan YL Lyu LF Liu H Qi 2008 Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation PLoS ONE 3 e2009
    • (2008) PLoS ONE , vol.3 , pp. 2009
    • Fu, X.1    Wan, S.2    Lyu, Y.L.3    Liu, L.F.4    Qi, H.5
  • 135
    • 0035854649 scopus 로고    scopus 로고
    • Increased expression of mitochondrial transcription factor A and nuclear respiratory factor-1 in skeletal muscle from aged human subjects
    • AMS Lezza V Pesce A Cormio F Fracasso J Vecchiet G Felzani P Cantatore MN Gadaleta 2001 Increased expression of mitochondrial transcription factor A and nuclear respiratory factor-1 in skeletal muscle from aged human subjects FEBS Lett 501 74 78
    • (2001) FEBS Lett , vol.501 , pp. 74-78
    • Lezza, A.M.S.1    Pesce, V.2    Cormio, A.3    Fracasso, F.4    Vecchiet, J.5    Felzani, G.6    Cantatore, P.7    Gadaleta, M.N.8
  • 136
    • 0003097634 scopus 로고    scopus 로고
    • Protein degradation in mitochondria: Implications for oxidative stress, aging and disease: A novel etiological classification of mitochondrial proteolytic disorders
    • DA Bota KJA Davies 2001 Protein degradation in mitochondria: implications for oxidative stress, aging and disease: a novel etiological classification of mitochondrial proteolytic disorders Mitochondrion 1 33 49
    • (2001) Mitochondrion , vol.1 , pp. 33-49
    • Bota, D.A.1    Davies, K.J.A.2
  • 137
    • 33749265862 scopus 로고    scopus 로고
    • Formation of elongated giant mitochondria in DFO-induced cellular senescence: Involvement of enhanced fusion process through modulation of Fis1
    • YS Yoon DS Yoon IK Lim SH Yoon HY Chung M Rojo F Malka MJ Jou JC Martinou G Yoon 2006 Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1 J Cell Physiol 209 468 480
    • (2006) J Cell Physiol , vol.209 , pp. 468-480
    • Yoon, Y.S.1    Yoon, D.S.2    Lim, I.K.3    Yoon, S.H.4    Chung, H.Y.5    Rojo, M.6    Malka, F.7    Jou, M.J.8    Martinou, J.C.9    Yoon, G.10
  • 139
    • 53149087460 scopus 로고    scopus 로고
    • Mitochondrial alterations in Parkinson's disease: New clues
    • DRCP Miquel Vila 2008 Mitochondrial alterations in Parkinson's disease: new clues J Neurochem 107 317 328
    • (2008) J Neurochem , vol.107 , pp. 317-328
    • Vila Drcp, M.1
  • 140
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • D Narendra A Tanaka D-F Suen RJ Youle 2008 Parkin is recruited selectively to impaired mitochondria and promotes their autophagy J Cell Biol 183 795 803
    • (2008) J Cell Biol , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.-F.3    Youle, R.J.4
  • 141
    • 0034613294 scopus 로고    scopus 로고
    • Age-related decline in chaperone-mediated autophagy
    • AM Cuervo JF Dice 2000 Age-related decline in chaperone-mediated autophagy J Biol Chem 275 31505 31513
    • (2000) J Biol Chem , vol.275 , pp. 31505-31513
    • Cuervo, A.M.1    Dice, J.F.2
  • 142
    • 35948982621 scopus 로고    scopus 로고
    • The role of autophagy in aging: Its essential part in the anti-aging mechanism of caloric restriction
    • E Bergamini G Cavallini A Donati Z Gori 2007 The role of autophagy in aging: its essential part in the anti-aging mechanism of caloric restriction Ann N Y Acad Sci 1114 69 78
    • (2007) Ann N y Acad Sci , vol.1114 , pp. 69-78
    • Bergamini, E.1    Cavallini, G.2    Donati, A.3    Gori, Z.4
  • 143
    • 57049186623 scopus 로고    scopus 로고
    • How to live long and prosper: Autophagy, mitochondria, and aging
    • WL Yen DJ Klionsky 2008 How to live long and prosper: autophagy, mitochondria, and aging Physiology 23 248 262
    • (2008) Physiology , vol.23 , pp. 248-262
    • Yen, W.L.1    Klionsky, D.J.2
  • 144
    • 0029560552 scopus 로고
    • The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes
    • A Terman 1995 The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes Gerontology 41 319 326
    • (1995) Gerontology , vol.41 , pp. 319-326
    • Terman, A.1
  • 146
    • 33746704943 scopus 로고    scopus 로고
    • Stimulation of macroautophagy can rescue older cells from 8-OHdG mtDNA accumulation: A safe and easy way to meet goals in the SENS agenda
    • A Donati M Taddei G Cavallini E Bergamini 2006 Stimulation of macroautophagy can rescue older cells from 8-OHdG mtDNA accumulation: a safe and easy way to meet goals in the SENS agenda Rejuvenation Res 9 408 412
    • (2006) Rejuvenation Res , vol.9 , pp. 408-412
    • Donati, A.1    Taddei, M.2    Cavallini, G.3    Bergamini, E.4
  • 147
    • 33748306003 scopus 로고    scopus 로고
    • Nicotinamide extends replicative lifespan of human cells
    • HT Kang HI Lee ES Hwang 2006 Nicotinamide extends replicative lifespan of human cells Aging Cell 5 423 436
    • (2006) Aging Cell , vol.5 , pp. 423-436
    • Kang, H.T.1    Lee, H.I.2    Hwang, E.S.3
  • 149
    • 0036346816 scopus 로고    scopus 로고
    • Effects of establishing cell cultures and cell culture conditions on the proliferative life span of human fibroblasts isolated from different tissues and donors of different ages
    • AK Balin AJ Fisher M Anzelone I Leong RG Allen 2002 Effects of establishing cell cultures and cell culture conditions on the proliferative life span of human fibroblasts isolated from different tissues and donors of different ages Exp Cell Res 274 275 287
    • (2002) Exp Cell Res , vol.274 , pp. 275-287
    • Balin, A.K.1    Fisher, A.J.2    Anzelone, M.3    Leong, I.4    Allen, R.G.5
  • 150
    • 38049001556 scopus 로고    scopus 로고
    • Low oxygen delays fibroblast senescence despite shorter telomeres
    • D Betts S Perrault W King 2008 Low oxygen delays fibroblast senescence despite shorter telomeres Biogerontology 9 19 31
    • (2008) Biogerontology , vol.9 , pp. 19-31
    • Betts, D.1    Perrault, S.2    King, W.3
  • 151
    • 35448962513 scopus 로고    scopus 로고
    • A continuous correlation between oxidative stress and telomere shortening in fibroblasts
    • T Richter T Zglinicki 2007 A continuous correlation between oxidative stress and telomere shortening in fibroblasts Exp Gerontol 42 1039 1042
    • (2007) Exp Gerontol , vol.42 , pp. 1039-1042
    • Richter, T.1    Zglinicki, T.2
  • 153
    • 34249689057 scopus 로고    scopus 로고
    • Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission
    • N Taguchi N Ishihara A Jofuku T Oka K Mihara 2007 Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission J Biol Chem 282 11521 11529
    • (2007) J Biol Chem , vol.282 , pp. 11521-11529
    • Taguchi, N.1    Ishihara, N.2    Jofuku, A.3    Oka, T.4    Mihara, K.5
  • 154
    • 0034881326 scopus 로고    scopus 로고
    • Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA
    • K Nakada K Inoue T Ono K Isobe A Ogura Y-I Goto I Nonaka J-I Hayashi 2001 Inter-mitochondrial complementation: mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA Nat Med 7 934 940
    • (2001) Nat Med , vol.7 , pp. 934-940
    • Nakada, K.1    Inoue, K.2    Ono, T.3    Isobe, K.4    Ogura, A.5    Goto, Y.-I.6    Nonaka, I.7    Hayashi, J.-I.8
  • 155
    • 0034938453 scopus 로고    scopus 로고
    • Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria
    • T Ono K Isobe K Nakada J-I Hayashi 2001 Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria Nat Genet 28 272 275
    • (2001) Nat Genet , vol.28 , pp. 272-275
    • Ono, T.1    Isobe, K.2    Nakada, K.3    Hayashi, J.-I.4
  • 156
    • 4644343220 scopus 로고    scopus 로고
    • In vivo interaction between mitochondria carrying mtDNAs from different mouse species
    • A Sato K Nakada H Shitara H Yonekawa J-I Hayashi 2004 In vivo interaction between mitochondria carrying mtDNAs from different mouse species Genetics 167 1855 1861
    • (2004) Genetics , vol.167 , pp. 1855-1861
    • Sato, A.1    Nakada, K.2    Shitara, H.3    Yonekawa, H.4    Hayashi, J.-I.5
  • 158
    • 0016711140 scopus 로고
    • The effect of age on mitochondrial ultrastructure
    • PD Wilson LM Franks 1975 The effect of age on mitochondrial ultrastructure Gerontologia 21 81 94
    • (1975) Gerontologia , vol.21 , pp. 81-94
    • Wilson, P.D.1    Franks, L.M.2
  • 159
    • 0016708787 scopus 로고
    • The formation of enlarged and giant mitochondria in the aging process of human hepatic cells
    • T Sato H Tauchi 1975 The formation of enlarged and giant mitochondria in the aging process of human hepatic cells Acta Pathol Jpn 25 403 412
    • (1975) Acta Pathol Jpn , vol.25 , pp. 403-412
    • Sato, T.1    Tauchi, H.2
  • 160
    • 0030897739 scopus 로고    scopus 로고
    • Genetic and functional changes in mitochondria associated with aging
    • T Ozawa 1997 Genetic and functional changes in mitochondria associated with aging Physiol Rev 77 425 464
    • (1997) Physiol Rev , vol.77 , pp. 425-464
    • Ozawa, T.1
  • 161
    • 0017751995 scopus 로고
    • Ultrastructure of the aging myocardium: A morphometric approach
    • HG Sachs JA Colgan ML Lazarus 1977 Ultrastructure of the aging myocardium: a morphometric approach Am J Anat 150 63 71
    • (1977) Am J Anat , vol.150 , pp. 63-71
    • Sachs, H.G.1    Colgan, J.A.2    Lazarus, M.L.3
  • 165
    • 0031574362 scopus 로고    scopus 로고
    • Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging
    • A Barrientos J Casademont F Cardellach X Estivill A Urbano-Marquez V Nunes 1997 Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with aging Mol Brain Res 52 284 289
    • (1997) Mol Brain Res , vol.52 , pp. 284-289
    • Barrientos, A.1    Casademont, J.2    Cardellach, F.3    Estivill, X.4    Urbano-Marquez, A.5    Nunes, V.6
  • 166
    • 0032429396 scopus 로고    scopus 로고
    • Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lung
    • H-C Lee C-Y Lu H-J Fahn Y-H Wei 1998 Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lung FEBS Lett 441 292 296
    • (1998) FEBS Lett , vol.441 , pp. 292-296
    • Lee, H.-C.1    Lu, C.-Y.2    Fahn, H.-J.3    Wei, Y.-H.4
  • 168
    • 0036236006 scopus 로고    scopus 로고
    • The mitochondrial-lysosomal axis theory of aging: Accumulation of damaged mitochondria as a result of imperfect autophagocytosis
    • UT Brunk A Terman 2002 The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis Eur J Biochem 269 1996 2002
    • (2002) Eur J Biochem , vol.269 , pp. 1996-2002
    • Brunk, U.T.1    Terman, A.2
  • 169
    • 0141483496 scopus 로고    scopus 로고
    • Marked aging-related decline in efficiency of oxidative phosphorylation in human skin fibroblasts
    • M Greco G Villani F Mazzucchelli N Bresolin S Papa G Attardi 2003 Marked aging-related decline in efficiency of oxidative phosphorylation in human skin fibroblasts FASEB J 17 1706 1708
    • (2003) FASEB J , vol.17 , pp. 1706-1708
    • Greco, M.1    Villani, G.2    Mazzucchelli, F.3    Bresolin, N.4    Papa, S.5    Attardi, G.6
  • 170
    • 10344238130 scopus 로고    scopus 로고
    • Ageing and subcellular distribution of mitochondria: Role of mitochondrial DNA deletions and energy production
    • B Drew C Leeuwenburgh 2004 Ageing and subcellular distribution of mitochondria: role of mitochondrial DNA deletions and energy production Acta Physiol Scand 182 333 341
    • (2004) Acta Physiol Scand , vol.182 , pp. 333-341
    • Drew, B.1    Leeuwenburgh, C.2
  • 171
    • 0034691680 scopus 로고    scopus 로고
    • Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys
    • ME Lopez NL Van Zeeland DB Dahl R Weindruch JM Aiken 2000 Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys Mutat Res 452 123 138
    • (2000) Mutat Res , vol.452 , pp. 123-138
    • Lopez, M.E.1    Van Zeeland, N.L.2    Dahl, D.B.3    Weindruch, R.4    Aiken, J.M.5
  • 176
    • 34147143631 scopus 로고    scopus 로고
    • Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci
    • X Ye B Zerlanko R Zhang N Somaiah M Lipinski P Salomoni PD Adams 2007 Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci Mol Cell Biol 27 2452 2465
    • (2007) Mol Cell Biol , vol.27 , pp. 2452-2465
    • Ye, X.1    Zerlanko, B.2    Zhang, R.3    Somaiah, N.4    Lipinski, M.5    Salomoni, P.6    Adams, P.D.7
  • 177
    • 33947236204 scopus 로고    scopus 로고
    • Molecular dissection of formation of senescence-associated heterochromatin foci
    • R Zhang W Chen PD Adams 2007 Molecular dissection of formation of senescence-associated heterochromatin foci Mol Cell Biol 27 2343 2358
    • (2007) Mol Cell Biol , vol.27 , pp. 2343-2358
    • Zhang, R.1    Chen, W.2    Adams, P.D.3
  • 184
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • H Takai A Smogorzewska T de Lange 2003 DNA damage foci at dysfunctional telomeres Curr Biol 13 1549 1556
    • (2003) Curr Biol , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    De Lange, T.3
  • 185
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • EP Rogakou C Boon C Redon WM Bonner 1999 Megabase chromatin domains involved in DNA double-strand breaks in vivo J Cell Biol 146 905 916
    • (1999) J Cell Biol , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 187
    • 2442511752 scopus 로고    scopus 로고
    • Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a
    • U Herbig WA Jobling BPC Chen DJ Chen JM Sedivy 2004 Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a Mol Cell 14 501 513
    • (2004) Mol Cell , vol.14 , pp. 501-513
    • Herbig, U.1    Jobling, W.A.2    Chen, B.P.C.3    Chen, D.J.4    Sedivy, J.M.5
  • 189
    • 2342458205 scopus 로고    scopus 로고
    • Aging and nuclear organization: Lamins and progeria
    • LC Mounkes CL Stewart 2004 Aging and nuclear organization: lamins and progeria Curr Opin Cell Biol 16 322 327
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 322-327
    • Mounkes, L.C.1    Stewart, C.L.2
  • 191
    • 17644373758 scopus 로고    scopus 로고
    • Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome
    • P Scaffidi T Misteli 2005 Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome Nat Med 11 440 445
    • (2005) Nat Med , vol.11 , pp. 440-445
    • Scaffidi, P.1    Misteli, T.2
  • 192
    • 33845699084 scopus 로고    scopus 로고
    • DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A
    • Y Liu A Rusinol M Sinensky Y Wang Y Zou 2006 DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A J Cell Sci 119 4644 4649
    • (2006) J Cell Sci , vol.119 , pp. 4644-4649
    • Liu, Y.1    Rusinol, A.2    Sinensky, M.3    Wang, Y.4    Zou, Y.5
  • 193
    • 33646745137 scopus 로고    scopus 로고
    • Lamin A-dependent nuclear defects in human aging
    • P Scaffidi T Misteli 2006 Lamin A-dependent nuclear defects in human aging Science 312 1059 1063
    • (2006) Science , vol.312 , pp. 1059-1063
    • Scaffidi, P.1    Misteli, T.2
  • 194
    • 33745931074 scopus 로고    scopus 로고
    • Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
    • WC Hallows S Lee JM Denu 2006 Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases Proc Natl Acad Sci USA 103 10230 10235
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 10230-10235
    • Hallows, W.C.1    Lee, S.2    Denu, J.M.3
  • 195
    • 33745889628 scopus 로고    scopus 로고
    • Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
    • B Schwer J Bunkenborg RO Verdin JS Andersen E Verdin 2006 Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2 Proc Natl Acad Sci USA 103 10224 10229
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 10224-10229
    • Schwer, B.1    Bunkenborg, J.2    Verdin, R.O.3    Andersen, J.S.4    Verdin, E.5
  • 199
    • 50549087736 scopus 로고    scopus 로고
    • Growth stimulation leads to cellular senescence when the cell cycle is blocked
    • ZN Demidenko MV Blagosklonny 2008 Growth stimulation leads to cellular senescence when the cell cycle is blocked Cell Cycle 7 3355 3361
    • (2008) Cell Cycle , vol.7 , pp. 3355-3361
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 200
    • 56349105542 scopus 로고    scopus 로고
    • Immunohistochemical analysis of lens cells on formation of different types of age-related cataract in humans
    • N Korsakova V Sergeeva S Petrov 2008 Immunohistochemical analysis of lens cells on formation of different types of age-related cataract in humans Neurosci Behav Physiol 38 887 890
    • (2008) Neurosci Behav Physiol , vol.38 , pp. 887-890
    • Korsakova, N.1    Sergeeva, V.2    Petrov, S.3
  • 201
    • 0032579473 scopus 로고    scopus 로고
    • On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes
    • A Terman UT Brunk 1998 On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes Mech Ageing Dev 100 145 156
    • (1998) Mech Ageing Dev , vol.100 , pp. 145-156
    • Terman, A.1    Brunk, U.T.2
  • 202
  • 203
    • 16244383882 scopus 로고    scopus 로고
    • Dinstinct ROS and biochemical profiles in cells undergoing DNA damage-induced senescence and apoptosis
    • YS Song BY Lee ES Hwang 2005 Dinstinct ROS and biochemical profiles in cells undergoing DNA damage-induced senescence and apoptosis Mech Ageing Dev 126 580 590
    • (2005) Mech Ageing Dev , vol.126 , pp. 580-590
    • Song, Y.S.1    Lee, B.Y.2    Hwang, E.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.