-
2
-
-
0033824263
-
Cytogenetic evidence of clonality in cutaneous benign fibrous histiocytomas: A report of the CHAMP study group
-
Vanni R, Fletcher CD, Sciot R, et al. Cytogenetic evidence of clonality in cutaneous benign fibrous histiocytomas: a report of the CHAMP study group. Histopathology 2000;37:212-7.
-
(2000)
Histopathology
, vol.37
, pp. 212-217
-
-
Vanni, R.1
Fletcher, C.D.2
Sciot, R.3
-
3
-
-
0030459428
-
Frequent clones of p53-mutated keratinocytes in normal human skin
-
Jonason AS, Kunala S, Price GJ, et al. Frequent clones of p53-mutated keratinocytes in normal human skin. Proc Natl Acad Sci U S A 1996;93:14025-9.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 14025-14029
-
-
Jonason, A.S.1
Kunala, S.2
Price, G.J.3
-
4
-
-
17244367849
-
DNA damage response as a candidate anticancer barrier in early human tumorigenesis
-
Bartkova J, Horejsi Z, Koed K, et al. DNA damage response as a candidate anticancer barrier in early human tumorigenesis. Nature 2005;434:864-70.
-
(2005)
Nature
, vol.434
, pp. 864-870
-
-
Bartkova, J.1
Horejsi, Z.2
Koed, K.3
-
5
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
Gorgoulis VG, Vassiliou LV, Karakaidos P, et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005;434:907-13.
-
(2005)
Nature
, vol.434
, pp. 907-913
-
-
Gorgoulis, V.G.1
Vassiliou, L.V.2
Karakaidos, P.3
-
6
-
-
24144443517
-
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
-
Gasser S, Orsulic S, Brown EJ, Raulet DH. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 2005;436:1186-90.
-
(2005)
Nature
, vol.436
, pp. 1186-1190
-
-
Gasser, S.1
Orsulic, S.2
Brown, E.J.3
Raulet, D.H.4
-
7
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997;88:593-602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
8
-
-
0038457477
-
Human melanocyte senescence and melanoma susceptibility genes
-
Bennett DC. Human melanocyte senescence and melanoma susceptibility genes. Oncogene 2003;22:3063-9.
-
(2003)
Oncogene
, vol.22
, pp. 3063-3069
-
-
Bennett, D.C.1
-
9
-
-
33747161409
-
Pathogenesis of melanocytic naevi: Growth arrest linked with cellular senescence?
-
Mooi WJ, Peeper DS. Pathogenesis of melanocytic naevi: growth arrest linked with cellular senescence? Histopathology 2002;41:Suppl 2:139-43.
-
(2002)
Histopathology
, vol.41
, Issue.2 SUPPL.
, pp. 139-143
-
-
Mooi, W.J.1
Peeper, D.S.2
-
10
-
-
0035500487
-
Cellular senescence as a tumor-suppressor mechanism
-
Campisi J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol 2001;11:S27-S31.
-
(2001)
Trends Cell Biol
, vol.11
-
-
Campisi, J.1
-
11
-
-
0034028836
-
Tumor suppressors and oncogenes in cellular senescence
-
Bringold F, Serrano M. Tumor suppressors and oncogenes in cellular senescence. Exp Gerontol 2000;35:317-29.
-
(2000)
Exp Gerontol
, vol.35
, pp. 317-329
-
-
Bringold, F.1
Serrano, M.2
-
12
-
-
0037309326
-
Tumor suppression by Ink4a-Arf: Progress and puzzles
-
Lowe SW, Sherr CJ. Tumor suppression by Ink4a-Arf: progress and puzzles. Curr Opin Genet Dev 2003;13:77-83.
-
(2003)
Curr Opin Genet Dev
, vol.13
, pp. 77-83
-
-
Lowe, S.W.1
Sherr, C.J.2
-
13
-
-
23244461708
-
Oncogene-induced senescence as an initial barrier in lymphoma development
-
Braig M, Lee S, Loddenkemper C, et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 2005;436:660-5.
-
(2005)
Nature
, vol.436
, pp. 660-665
-
-
Braig, M.1
Lee, S.2
Loddenkemper, C.3
-
14
-
-
23244460597
-
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
-
Chen Z, Trotman LC, Shaffer D, et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 2005;436:725-30.
-
(2005)
Nature
, vol.436
, pp. 725-730
-
-
Chen, Z.1
Trotman, L.C.2
Shaffer, D.3
-
15
-
-
23244447893
-
Tumour biology: Senescence in premalignant tumours
-
Collado M, Gil J, Efeyan A, et al. Tumour biology: senescence in premalignant tumours. Nature 2005;436:642.
-
(2005)
Nature
, vol.436
, pp. 642
-
-
Collado, M.1
Gil, J.2
Efeyan, A.3
-
16
-
-
23244447037
-
BRAFE600-associated senescence-like cell cycle arrest of human naevi
-
Michaloglou C, Vredeveld LC, Soengas MS, et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 2005;436:720-4.
-
(2005)
Nature
, vol.436
, pp. 720-724
-
-
Michaloglou, C.1
Vredeveld, L.C.2
Soengas, M.S.3
-
17
-
-
50549218525
-
The limited in vitro lifetime of human diploid cell strains
-
Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965;37:614-36.
-
(1965)
Exp Cell Res
, vol.37
, pp. 614-636
-
-
Hayflick, L.1
-
18
-
-
33646946746
-
Senescence-associated beta-galactosidase is lysosomal beta-galactosidase
-
Lee BY, Han JA, Im JS, et al. Senescence-associated beta-galactosidase is lysosomal beta-galactosidase. Aging Cell 2006;5:187-95.
-
(2006)
Aging Cell
, vol.5
, pp. 187-195
-
-
Lee, B.Y.1
Han, J.A.2
Im, J.S.3
-
19
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 1995;92:9363-7.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
-
20
-
-
0037667702
-
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
-
Narita M, Nunez S, Heard E, et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 2003;113:703-16.
-
(2003)
Cell
, vol.113
, pp. 703-716
-
-
Narita, M.1
Nunez, S.2
Heard, E.3
-
21
-
-
0034304960
-
Hayf lick, his limit, and cellular ageing
-
Shay JW, Wright WE. Hayf lick, his limit, and cellular ageing. Nat Rev Mol Cell Biol 2000;1:72-6.
-
(2000)
Nat Rev Mol Cell Biol
, vol.1
, pp. 72-76
-
-
Shay, J.W.1
Wright, W.E.2
-
22
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990;345:458-60.
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
23
-
-
0030745448
-
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
-
Meyerson M, Counter CM, Eaton EN, et al. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 1997;90:785-95.
-
(1997)
Cell
, vol.90
, pp. 785-795
-
-
Meyerson, M.1
Counter, C.M.2
Eaton, E.N.3
-
24
-
-
18444374159
-
Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis
-
Wiemann SU, Satyanarayana A, Tsahuridu M, et al. Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. FASEB J 2002;16:935-42.
-
(2002)
FASEB J
, vol.16
, pp. 935-942
-
-
Wiemann, S.U.1
Satyanarayana, A.2
Tsahuridu, M.3
-
25
-
-
0043026840
-
Telomere shortening impairs organ regeneration by inhibiting cell cycle reentry of a subpopulation of cells
-
Satyanarayana A, Wiemann SU, Buer J, et al. Telomere shortening impairs organ regeneration by inhibiting cell cycle reentry of a subpopulation of cells. EMBO J 2003;22:4003-13.
-
(2003)
EMBO J
, vol.22
, pp. 4003-4013
-
-
Satyanarayana, A.1
Wiemann, S.U.2
Buer, J.3
-
27
-
-
27744527486
-
The first molecular details of ALT in human tumor cells
-
Muntoni A, Reddel RR. The first molecular details of ALT in human tumor cells. Hum Mol Genet 2005;14:Spec No. 2: R191-T196.
-
(2005)
Hum Mol Genet
, vol.14
, Issue.2 SPEC. NO.
-
-
Muntoni, A.1
Reddel, R.R.2
-
28
-
-
0343228751
-
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis
-
Gonzalez-Suarez E, Samper E, Flores JM, Blasco MA. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat Genet 2000;26:114-7.
-
(2000)
Nat Genet
, vol.26
, pp. 114-117
-
-
Gonzalez-Suarez, E.1
Samper, E.2
Flores, J.M.3
Blasco, M.A.4
-
29
-
-
0033614998
-
Creation of human tumour cells with defined genetic elements
-
Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA. Creation of human tumour cells with defined genetic elements. Nature 1999;400:464-8.
-
(1999)
Nature
, vol.400
, pp. 464-468
-
-
Hahn, W.C.1
Counter, C.M.2
Lundberg, A.S.3
Beijersbergen, R.L.4
Brooks, M.W.5
Weinberg, R.A.6
-
30
-
-
0022486653
-
In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes
-
Franza BR Jr, Maruyama K, Garrels JI, Ruley HE. In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes. Cell 1986;44:409-18.
-
(1986)
Cell
, vol.44
, pp. 409-418
-
-
Franza Jr., B.R.1
Maruyama, K.2
Garrels, J.I.3
Ruley, H.E.4
-
31
-
-
0020520516
-
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
-
Land H, Parada LF, Weinberg RA. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 1983;304:596-602.
-
(1983)
Nature
, vol.304
, pp. 596-602
-
-
Land, H.1
Parada, L.F.2
Weinberg, R.A.3
-
32
-
-
0029009926
-
Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds
-
Gruis NA, van der Velden PA, Sandkuijl LA, et al. Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds. Nat Genet 1995;10:351-3.
-
(1995)
Nat Genet
, vol.10
, pp. 351-353
-
-
Gruis, N.A.1
Van Der Velden, P.A.2
Sandkuijl, L.A.3
-
33
-
-
0028121279
-
A cell cycle regulator potentially involved in genesis of many tumor types
-
Kamb A, Gruis NA, Weaver-Feldhaus J, et al. A cell cycle regulator potentially involved in genesis of many tumor types. Science 1994;264:436-40.
-
(1994)
Science
, vol.264
, pp. 436-440
-
-
Kamb, A.1
Gruis, N.A.2
Weaver-Feldhaus, J.3
-
34
-
-
0028978274
-
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
-
Wolfel T, Hauer M, Schneider J, et al. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 1995;269:1281-4.
-
(1995)
Science
, vol.269
, pp. 1281-1284
-
-
Wolfel, T.1
Hauer, M.2
Schneider, J.3
-
35
-
-
0035170850
-
A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family
-
Randerson-Moor JA, Harland M, Williams S, et al. A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family. Hum Mol Genet 2001;10:55-62.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 55-62
-
-
Randerson-Moor, J.A.1
Harland, M.2
Williams, S.3
-
36
-
-
0035817722
-
A melanoma-associated germline mutation in exon 1beta inactivates p14ARF
-
Rizos H, Puig S, Badenas C, et al. A melanoma-associated germline mutation in exon 1beta inactivates p14ARF. Oncogene 2001;20:5543-7.
-
(2001)
Oncogene
, vol.20
, pp. 5543-5547
-
-
Rizos, H.1
Puig, S.2
Badenas, C.3
-
37
-
-
0032504784
-
p19ARF links the tumour suppressor p53 to Ras
-
Palmero I, Pantoja C, Serrano M. p19ARF links the tumour suppressor p53 to Ras. Nature 1998;395:125-6.
-
(1998)
Nature
, vol.395
, pp. 125-126
-
-
Palmero, I.1
Pantoja, C.2
Serrano, M.3
-
38
-
-
0028276685
-
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor
-
Tanaka N, Ishihara M, Kitagawa M, et al. Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-Cell 1994;77:829-39.
-
(1994)
IRF-Cell
, vol.77
, pp. 829-839
-
-
Tanaka, N.1
Ishihara, M.2
Kitagawa, M.3
-
39
-
-
0035156849
-
Escape from premature senescence is not sufficient for oncogenic transformation by Ras
-
Peeper DS, Dannenberg JH, Douma S, te Riele H, Bernards R. Escape from premature senescence is not sufficient for oncogenic transformation by Ras. Nat Cell Biol 2001;3:198-203.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 198-203
-
-
Peeper, D.S.1
Dannenberg, J.H.2
Douma, S.3
Te Riele, H.4
Bernards, R.5
-
40
-
-
0033635597
-
Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions
-
Dannenberg JH, van Rossum A, Schuijff L, te Riele H. Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev 2000;14:3051-64.
-
(2000)
Genes Dev
, vol.14
, pp. 3051-3064
-
-
Dannenberg, J.H.1
Van Rossum, A.2
Schuijff, L.3
Te Riele, H.4
-
41
-
-
0033637086
-
Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization
-
Sage J, Mulligan GJ, Attardi LD, et al. Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev 2000;14:3037-50.
-
(2000)
Genes Dev
, vol.14
, pp. 3037-3050
-
-
Sage, J.1
Mulligan, G.J.2
Attardi, L.D.3
-
42
-
-
0001510491
-
The RB and p53 pathways in cancer
-
Sherr CJ, McCormick F. The RB and p53 pathways in cancer. Cancer Cell 2002;2:103-12.
-
(2002)
Cancer Cell
, vol.2
, pp. 103-112
-
-
Sherr, C.J.1
McCormick, F.2
-
43
-
-
12144289681
-
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
-
Berns K, Hijmans EM, Mullenders J, et al. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 2004;428:431-7.
-
(2004)
Nature
, vol.428
, pp. 431-437
-
-
Berns, K.1
Hijmans, E.M.2
Mullenders, J.3
-
44
-
-
0036167650
-
A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence
-
Peeper DS, Shvarts A, Brummelkamp T, et al. A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence. Nat Cell Biol 2002;4:148-53.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 148-153
-
-
Peeper, D.S.1
Shvarts, A.2
Brummelkamp, T.3
-
45
-
-
30144440248
-
The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene
-
Rowland BD, Bernards R, Peeper DS. The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat Cell Biol 2005;7:1074-82.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 1074-1082
-
-
Rowland, B.D.1
Bernards, R.2
Peeper, D.S.3
-
46
-
-
0034682721
-
Cellular senescence: Mitotic clock or culture shock?
-
Sherr CJ, DePinho RA. Cellular senescence: mitotic clock or culture shock? Cell 2000;102:407-10.
-
(2000)
Cell
, vol.102
, pp. 407-410
-
-
Sherr, C.J.1
DePinho, R.A.2
-
47
-
-
15044351968
-
Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland
-
Lazzerini Denchi E, Attwooll C, Pasini D, Helin K. Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland. Mol Cell Biol 2005;25:2660-72.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 2660-2672
-
-
Lazzerini Denchi, E.1
Attwooll, C.2
Pasini, D.3
Helin, K.4
-
48
-
-
0041883654
-
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context
-
Guerra C, Mijimolle N, Dhawahir A, et al. Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell 2003;4:111-20.
-
(2003)
Cancer Cell
, vol.4
, pp. 111-120
-
-
Guerra, C.1
Mijimolle, N.2
Dhawahir, A.3
-
49
-
-
4043163497
-
High BRAF mutation frequency does not characterize all melanocytic tumor types
-
Saldanha G, Purnell D, Fletcher A, Potter L, Gillies A, Pringle JH. High BRAF mutation frequency does not characterize all melanocytic tumor types. Int J Cancer 2004;111:705-10.
-
(2004)
Int J Cancer
, vol.111
, pp. 705-710
-
-
Saldanha, G.1
Purnell, D.2
Fletcher, A.3
Potter, L.4
Gillies, A.5
Pringle, J.H.6
-
50
-
-
0034491067
-
Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features
-
Bastian BC, LeBoit PE, Pinkel D. Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features. Am J Pathol 2000;157:967-72.
-
(2000)
Am J Pathol
, vol.157
, pp. 967-972
-
-
Bastian, B.C.1
LeBoit, P.E.2
Pinkel, D.3
-
51
-
-
0141816881
-
Suppression of BRAF(V599E) in human melanoma abrogates transformation
-
Hingorani SR, Jacobetz MA, Robertson GP, Herlyn M, Tuveson DA. Suppression of BRAF(V599E) in human melanoma abrogates transformation. Cancer Res 2003;63:5198-202.
-
(2003)
Cancer Res
, vol.63
, pp. 5198-5202
-
-
Hingorani, S.R.1
Jacobetz, M.A.2
Robertson, G.P.3
Herlyn, M.4
Tuveson, D.A.5
-
52
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002;417:949-54.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
53
-
-
0042885906
-
BRAF as a potential therapeutic target in melanoma and other malignancies
-
Tuveson DA, Weber BL, Herlyn M. BRAF as a potential therapeutic target in melanoma and other malignancies. Cancer Cell 2003;4:95-8.
-
(2003)
Cancer Cell
, vol.4
, pp. 95-98
-
-
Tuveson, D.A.1
Weber, B.L.2
Herlyn, M.3
-
54
-
-
1942469306
-
Mechanisms of cell-cycle arrest in Spitz nevi with constitutive activation of the MAP-kinase pathway
-
Maldonado JL, Timmerman L, Fridlyand J, Bastian BC. Mechanisms of cell-cycle arrest in Spitz nevi with constitutive activation of the MAP-kinase pathway. Am J Pathol 2004;164:1783-7.
-
(2004)
Am J Pathol
, vol.164
, pp. 1783-1787
-
-
Maldonado, J.L.1
Timmerman, L.2
Fridlyand, J.3
Bastian, B.C.4
-
56
-
-
0031595666
-
p16 and p21WAF1 protein expression in melanocytic tumors by immunohistochemistry
-
Sparrow LE, Eldon MJ, English DR, Heenan PJ. p16 and p21WAF1 protein expression in melanocytic tumors by immunohistochemistry. Am J Dermatopathol 1998;20:255-61.
-
(1998)
Am J Dermatopathol
, vol.20
, pp. 255-261
-
-
Sparrow, L.E.1
Eldon, M.J.2
English, D.R.3
Heenan, P.J.4
-
57
-
-
0030040533
-
Immunohistochemical detection of CDK4 and p16INK4 proteins in cutaneous malignant melanoma
-
Wang YL, Uhara H, Yamazaki Y, Nikaido T, Saida T. Immunohistochemical detection of CDK4 and p16INK4 proteins in cutaneous malignant melanoma. Br J Dermatol 1996;134:269-75.
-
(1996)
Br J Dermatol
, vol.134
, pp. 269-275
-
-
Wang, Y.L.1
Uhara, H.2
Yamazaki, Y.3
Nikaido, T.4
Saida, T.5
-
58
-
-
0036277964
-
Quantitative in situ evaluation of telomeres in fluorescence in situ hybridization-processed sections of cutaneous melanocytic lesions and correlation with telomerase activity
-
Miracco C, Margherita De Santi M, Schurfeld K, et al. Quantitative in situ evaluation of telomeres in fluorescence in situ hybridization-processed sections of cutaneous melanocytic lesions and correlation with telomerase activity. Br J Dermatol 2002;146:399-408.
-
(2002)
Br J Dermatol
, vol.146
, pp. 399-408
-
-
Miracco, C.1
Margherita De Santi, M.2
Schurfeld, K.3
-
59
-
-
33747192833
-
Cellular senescence in naevi and immortalisation in melanoma: A role for p16?
-
in press
-
Gray-Schopfer VC, Cheong SC, Chong H, et al. Cellular senescence in naevi and immortalisation in melanoma: a role for p16? Br J Cancer (in press).
-
Br J Cancer
-
-
Gray-Schopfer, V.C.1
Cheong, S.C.2
Chong, H.3
-
60
-
-
0041966056
-
Reversal of human cellular senescence: Roles of the p53 and p16 pathways
-
Beausejour CM, Krtolica A, Galimi F, et al. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 2003;22:4212-22.
-
(2003)
EMBO J
, vol.22
, pp. 4212-4222
-
-
Beausejour, C.M.1
Krtolica, A.2
Galimi, F.3
-
61
-
-
0030729474
-
Cooperative effects of INK4a and ras in melanoma susceptibility in vivo
-
Chin L, Pomerantz J, Polsky D, et al. Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes Dev 1997;11:2822-34.
-
(1997)
Genes Dev
, vol.11
, pp. 2822-2834
-
-
Chin, L.1
Pomerantz, J.2
Polsky, D.3
-
62
-
-
0032533594
-
Malignant melanoma: Modern black plague and genetic black box
-
Chin L, Merlino G, DePinho RA. Malignant melanoma: modern black plague and genetic black box. Genes Dev 1998;12:3467-81.
-
(1998)
Genes Dev
, vol.12
, pp. 3467-3481
-
-
Chin, L.1
Merlino, G.2
DePinho, R.A.3
-
63
-
-
0035817687
-
Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
-
Krimpenfort P, Quon KC, Mooi WJ, Loonstra A, Berns A. Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. Nature 2001;413:83-6.
-
(2001)
Nature
, vol.413
, pp. 83-86
-
-
Krimpenfort, P.1
Quon, K.C.2
Mooi, W.J.3
Loonstra, A.4
Berns, A.5
-
64
-
-
0035817688
-
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
-
Sharpless NE, Bardeesy N, Lee KH, et al. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 2001;413:86-91.
-
(2001)
Nature
, vol.413
, pp. 86-91
-
-
Sharpless, N.E.1
Bardeesy, N.2
Lee, K.H.3
-
65
-
-
13444258032
-
BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma
-
Patton EE, Widlund HR, Kutok JL, et al. BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol 2005;15:249-54.
-
(2005)
Curr Biol
, vol.15
, pp. 249-254
-
-
Patton, E.E.1
Widlund, H.R.2
Kutok, J.L.3
-
66
-
-
22844445932
-
Use of human tissue to assess the oncogenic activity of melanoma-associated mutations
-
Chudnovsky Y, Adams AE, Robbins PB, Lin Q, Khavari PA. Use of human tissue to assess the oncogenic activity of melanoma-associated mutations. Nat Genet 2005;37:745-9.
-
(2005)
Nat Genet
, vol.37
, pp. 745-749
-
-
Chudnovsky, Y.1
Adams, A.E.2
Robbins, P.B.3
Lin, Q.4
Khavari, P.A.5
-
67
-
-
0027970713
-
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
-
Di Leonardo A, Linke SP, Clarkin K, Wahl GM. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev 1994;8:2540-51.
-
(1994)
Genes Dev
, vol.8
, pp. 2540-2551
-
-
Di Leonardo, A.1
Linke, S.P.2
Clarkin, K.3
Wahl, G.M.4
-
68
-
-
18444418797
-
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability
-
McGill GG, Horstmann M, Widlund HR, et al. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 2002;109:707-18.
-
(2002)
Cell
, vol.109
, pp. 707-718
-
-
McGill, G.G.1
Horstmann, M.2
Widlund, H.R.3
-
69
-
-
0029023626
-
Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved
-
Wang E. Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. Cancer Res 1995;55:2284-92.
-
(1995)
Cancer Res
, vol.55
, pp. 2284-2292
-
-
Wang, E.1
-
70
-
-
0037013154
-
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
-
Schmitt CA, Fridman JS, Yang M, et al. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 2002;109:335-46.
-
(2002)
Cell
, vol.109
, pp. 335-346
-
-
Schmitt, C.A.1
Fridman, J.S.2
Yang, M.3
-
71
-
-
25844508786
-
The melanocyte differentiation program predisposes to metastasis after neoplastic transformation
-
Gupta PB, Kuperwasser C, Brunet JP, et al. The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Nat Genet 2005;37:1047-54.
-
(2005)
Nat Genet
, vol.37
, pp. 1047-1054
-
-
Gupta, P.B.1
Kuperwasser, C.2
Brunet, J.P.3
-
72
-
-
27744547091
-
Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma
-
Wu WS, Heinrichs S, Xu D, et al. Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 2005;123:641-53.
-
(2005)
Cell
, vol.123
, pp. 641-653
-
-
Wu, W.S.1
Heinrichs, S.2
Xu, D.3
-
73
-
-
30444461024
-
Comprehensive analysis of the p53 status in mucosal and cutaneous melanomas
-
Gwosdz C, Scheckenbach K, Lieven O, et al. Comprehensive analysis of the p53 status in mucosal and cutaneous melanomas. Int J Cancer 2006;118:577-82.
-
(2006)
Int J Cancer
, vol.118
, pp. 577-582
-
-
Gwosdz, C.1
Scheckenbach, K.2
Lieven, O.3
-
74
-
-
9244224723
-
Intrinsic tumour suppression
-
Lowe SW, Cepero E, Evan G. Intrinsic tumour suppression. Nature 2004;432:307-15.
-
(2004)
Nature
, vol.432
, pp. 307-315
-
-
Lowe, S.W.1
Cepero, E.2
Evan, G.3
-
75
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
-
Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005;120:513-22.
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
77
-
-
12344273381
-
Variation in the human TP53 gene affects old age survival and cancer mortality
-
Van Heemst D, Mooijaart SP, Beekman M, et al. Variation in the human TP53 gene affects old age survival and cancer mortality. Exp Gerontol 2005;40:11-5.
-
(2005)
Exp Gerontol
, vol.40
, pp. 11-15
-
-
Van Heemst, D.1
Mooijaart, S.P.2
Beekman, M.3
-
78
-
-
0037011958
-
p53 Mutant mice that display early ageing-associated phenotypes
-
Tyner SD, Venkatachalam S, Choi J, et al. p53 Mutant mice that display early ageing-associated phenotypes. Nature 2002;415:45-53.
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
-
79
-
-
0035834121
-
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
-
Krtolica A, Parrinello S, Lockett S, Desprez PY, Campisi J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci U S A 2001;98:12072-7.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 12072-12077
-
-
Krtolica, A.1
Parrinello, S.2
Lockett, S.3
Desprez, P.Y.4
Campisi, J.5
-
81
-
-
0035406393
-
High-resolution chromosome 3p allelotyping of breast carcinomas and precursor lesions demonstrates frequent loss of heterozygosity and a discontinuous pattern of allele loss
-
Maitra A, Wistuba II, Washington C, et al. High-resolution chromosome 3p allelotyping of breast carcinomas and precursor lesions demonstrates frequent loss of heterozygosity and a discontinuous pattern of allele loss. Am J Pathol 2001;159:119-30.
-
(2001)
Am J Pathol
, vol.159
, pp. 119-130
-
-
Maitra, A.1
Wistuba, I.I.2
Washington, C.3
-
82
-
-
0037086268
-
DNA damage is able to induce senescence in tumor cells in vitro and in vivo
-
te Poele RH, Okorokov AL, Jardine L, Cummings J, Joel SP. DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res 2002;62:1876-83.
-
(2002)
Cancer Res
, vol.62
, pp. 1876-1883
-
-
Te Poele, R.H.1
Okorokov, A.L.2
Jardine, L.3
Cummings, J.4
Joel, S.P.5
-
83
-
-
0037686707
-
Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53
-
Dirac AM, Bernards R. Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53. J Biol Chem 2003;278:11731-4.
-
(2003)
J Biol Chem
, vol.278
, pp. 11731-11734
-
-
Dirac, A.M.1
Bernards, R.2
-
84
-
-
0038342441
-
Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
-
Sage J, Miller AL, Perez-Mancera PA, Wysocki JM, Jacks T. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 2003;424:223-8.
-
(2003)
Nature
, vol.424
, pp. 223-228
-
-
Sage, J.1
Miller, A.L.2
Perez-Mancera, P.A.3
Wysocki, J.M.4
Jacks, T.5
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