메뉴 건너뛰기




Volumn 16, Issue 3, 2004, Pages 322-327

Aging and nuclear organization: Lamins and progeria

Author keywords

EDMD; Emery Dreifuss muscular dystrophy; familial partial lipodystrophy; FPLD; HGPS; Hutchinson Gilford progeria syndrome; IF; INM; inner nuclear membrane; Ins Igfr; insulin insulin like growth factor; intermediate filament; lamin A gene; LMNA; MAD

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LAMIN A;

EID: 2342458205     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2004.03.009     Document Type: Review
Times cited : (84)

References (50)
  • 2
    • 0036245337 scopus 로고    scopus 로고
    • Mechanisms of ageing: Public or private?
    • Partridge L., Gems D. Mechanisms of ageing: public or private? Nat Rev Genet. 3:2002;165-175
    • (2002) Nat Rev Genet , vol.3 , pp. 165-175
    • Partridge, L.1    Gems, D.2
  • 3
    • 0037312020 scopus 로고    scopus 로고
    • How does calorie restriction work?
    • Koubova J., Guarente L. How does calorie restriction work? Genes Dev. 17:2003;313-321
    • (2003) Genes Dev , vol.17 , pp. 313-321
    • Koubova, J.1    Guarente, L.2
  • 4
    • 0141677687 scopus 로고    scopus 로고
    • Longevity regulation in Saccharomyces cerevisiae: Linking metabolism, genome stability, and heterochromatin
    • Bitterman K.J., Medvedik O., Sinclair D.A. Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiol Mol Biol Rev. 67:2003;376-399
    • (2003) Microbiol Mol Biol Rev , vol.67 , pp. 376-399
    • Bitterman, K.J.1    Medvedik, O.2    Sinclair, D.A.3
  • 6
    • 0037673950 scopus 로고    scopus 로고
    • Recurrent de novo point mutations in lamin a cause Hutchinson-Gilford progeria syndrome
    • These two papers show for the first time that mutations in the LMNA gene are responsible for the rare premature aging disease HGPS.
    • Eriksson M., Brown W.T., Gordon L.B., Glynn M.W., Singer J., Scott L., Erdos M.R., Robbins C.M., Moses T.Y., Berglund P., et al. Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature. 423:2003;293-298 These two papers show for the first time that mutations in the LMNA gene are responsible for the rare premature aging disease HGPS.
    • (2003) Nature , vol.423 , pp. 293-298
    • Eriksson, M.1    Brown, W.T.2    Gordon, L.B.3    Glynn, M.W.4    Singer, J.5    Scott, L.6    Erdos, M.R.7    Robbins, C.M.8    Moses, T.Y.9    Berglund, P.10
  • 7
    • 0035012439 scopus 로고    scopus 로고
    • Hutchinson-Guilford progeria syndrome
    • Sarkar P.K., Shinton R.A. Hutchinson-Guilford progeria syndrome. Postgrad Med J. 77:2001;312-317
    • (2001) Postgrad Med J , vol.77 , pp. 312-317
    • Sarkar, P.K.1    Shinton, R.A.2
  • 8
    • 0034626770 scopus 로고    scopus 로고
    • Lessons from human progeroid syndromes
    • Martin G.M., Oshima J. Lessons from human progeroid syndromes. Nature. 408:2000;263-266
    • (2000) Nature , vol.408 , pp. 263-266
    • Martin, G.M.1    Oshima, J.2
  • 10
    • 0033771208 scopus 로고    scopus 로고
    • The Werner syndrome protein: An update
    • Oshima J. The Werner syndrome protein: an update. Bioessays. 22:2000;894-901
    • (2000) Bioessays , vol.22 , pp. 894-901
    • Oshima, J.1
  • 11
    • 0035062128 scopus 로고    scopus 로고
    • DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders
    • Mohaghegh P., Hickson I.D. DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders. Hum Mol Genet. 10:2001;741-746
    • (2001) Hum Mol Genet , vol.10 , pp. 741-746
    • Mohaghegh, P.1    Hickson, I.D.2
  • 12
    • 0042736696 scopus 로고    scopus 로고
    • LMNA mutations in atypical Werner's syndrome
    • This paper shows that other mutations in the LMNA gene can also result in the rare premature aging disease HGPS. It raises questions as to how the mutant forms of these lamins result in the disease, compared to the more common splicing variant.
    • Chen L., Lee L., Kudlow B.A., Dos Santos H.G., Sletvold O., Shafeghati Y., Botha E.G., Garg A., Hanson N.B., Martin G.M., et al. LMNA mutations in atypical Werner's syndrome. Lancet. 362:2003;440-445 This paper shows that other mutations in the LMNA gene can also result in the rare premature aging disease HGPS. It raises questions as to how the mutant forms of these lamins result in the disease, compared to the more common splicing variant.
    • (2003) Lancet , vol.362 , pp. 440-445
    • Chen, L.1    Lee, L.2    Kudlow, B.A.3    Dos Santos, H.G.4    Sletvold, O.5    Shafeghati, Y.6    Botha, E.G.7    Garg, A.8    Hanson, N.B.9    Martin, G.M.10
  • 13
    • 0031686054 scopus 로고    scopus 로고
    • Nuclear lamins: Their structure, assembly, and interactions
    • Stuurman N., Heins S., Aebi U. Nuclear lamins: their structure, assembly, and interactions. J Struct Biol. 122:1998;42-66
    • (1998) J Struct Biol , vol.122 , pp. 42-66
    • Stuurman, N.1    Heins, S.2    Aebi, U.3
  • 16
    • 0025165401 scopus 로고
    • Characterization of a second highly conserved B-type lamin present in cells previously thought to contain only a single B-type lamin
    • Hoger T.H., Zatloukal K., Waizenegger I., Krohne G. Characterization of a second highly conserved B-type lamin present in cells previously thought to contain only a single B-type lamin. Chromosoma. 99:1990;379-390
    • (1990) Chromosoma , vol.99 , pp. 379-390
    • Hoger, T.H.1    Zatloukal, K.2    Waizenegger, I.3    Krohne, G.4
  • 17
    • 0027257461 scopus 로고
    • Structural organization of the human gene encoding nuclear lamin a and nuclear lamin C
    • Lin F., Worman H.J. Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C. J Biol Chem. 268:1993;16321-16326
    • (1993) J Biol Chem , vol.268 , pp. 16321-16326
    • Lin, F.1    Worman, H.J.2
  • 18
    • 0023646768 scopus 로고
    • Teratocarcinoma stem cells and early mouse embryos contain only a single major lamin polypeptide closely resembling lamin B
    • Stewart C., Burke B. Teratocarcinoma stem cells and early mouse embryos contain only a single major lamin polypeptide closely resembling lamin B. Cell. 51:1987;383-392
    • (1987) Cell , vol.51 , pp. 383-392
    • Stewart, C.1    Burke, B.2
  • 20
    • 0036303235 scopus 로고    scopus 로고
    • Remodelling the walls of the nucleus
    • Burke B., Ellenberg J. Remodelling the walls of the nucleus. Nat Rev Mol Cell Biol. 3:2002;487-497
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 487-497
    • Burke, B.1    Ellenberg, J.2
  • 21
    • 0033636843 scopus 로고    scopus 로고
    • Head and/or CaaX domain deletions of lamin proteins disrupt preformed lamin a and C but not lamin B structure in mammalian cells
    • Izumi M., Vaughan O.A., Hutchison C.J., Gilbert D.M. Head and/or CaaX domain deletions of lamin proteins disrupt preformed lamin A and C but not lamin B structure in mammalian cells. Mol Biol Cell. 11:2000;4323-4337
    • (2000) Mol Biol Cell , vol.11 , pp. 4323-4337
    • Izumi, M.1    Vaughan, O.A.2    Hutchison, C.J.3    Gilbert, D.M.4
  • 23
    • 0036347096 scopus 로고    scopus 로고
    • Life at the edge: The nuclear envelope and human disease
    • Burke B., Stewart C.L. Life at the edge: the nuclear envelope and human disease. Nat Rev Mol Cell Biol. 3:2002;575-585
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 575-585
    • Burke, B.1    Stewart, C.L.2
  • 24
    • 0037673940 scopus 로고    scopus 로고
    • A progeroid syndrome in mice is caused by defects in A-type lamins
    • The derivation of a mouse model for HGPS is described. The mutation causing progeria in the mouse is different from the human mutations, although the similarity in phenotype is striking. The mouse mutation again raises questions as to how the different A-type lamin mutant proteins cause progeria.
    • Mounkes L.C., Kozlov S., Hernandez L., Sullivan T., Stewart C.L. A progeroid syndrome in mice is caused by defects in A-type lamins. Nature. 423:2003;298-301 The derivation of a mouse model for HGPS is described. The mutation causing progeria in the mouse is different from the human mutations, although the similarity in phenotype is striking. The mouse mutation again raises questions as to how the different A-type lamin mutant proteins cause progeria.
    • (2003) Nature , vol.423 , pp. 298-301
    • Mounkes, L.C.1    Kozlov, S.2    Hernandez, L.3    Sullivan, T.4    Stewart, C.L.5
  • 25
    • 0032573157 scopus 로고    scopus 로고
    • A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
    • Lebel M., Leder P. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci U S A. 95:1998;13097-13102
    • (1998) Proc Natl Acad Sci U S a , vol.95 , pp. 13097-13102
    • Lebel, M.1    Leder, P.2
  • 28
    • 0344309291 scopus 로고    scopus 로고
    • Nuclear envelope alterations in fibroblasts from LGMD1B patients carrying nonsense Y259X heterozygous or homozygous mutation in lamin A/C gene
    • Muchir A., van Engelen B.G., Lammens M., Mislow J.M., McNally E., Schwartz K., Bonne G. Nuclear envelope alterations in fibroblasts from LGMD1B patients carrying nonsense Y259X heterozygous or homozygous mutation in lamin A/C gene. Exp Cell Res. 291:2003;352-362
    • (2003) Exp Cell Res , vol.291 , pp. 352-362
    • Muchir, A.1    Van Engelen, B.G.2    Lammens, M.3    Mislow, J.M.4    McNally, E.5    Schwartz, K.6    Bonne, G.7
  • 29
    • 0025612124 scopus 로고
    • A lamin-independent pathway for nuclear envelope assembly
    • Newport J.W., Wilson K.L., Dunphy W.G. A lamin-independent pathway for nuclear envelope assembly. J Cell Biol. 111:1990;2247-2259
    • (1990) J Cell Biol , vol.111 , pp. 2247-2259
    • Newport, J.W.1    Wilson, K.L.2    Dunphy, W.G.3
  • 31
    • 0023894266 scopus 로고
    • The musculoskeletal manifestations of progeria. A literature review
    • Hamer L., Kaplan F., Fallon M. The musculoskeletal manifestations of progeria. A literature review. Orthopedics. 11:1988;763-769
    • (1988) Orthopedics , vol.11 , pp. 763-769
    • Hamer, L.1    Kaplan, F.2    Fallon, M.3
  • 33
    • 0035691915 scopus 로고    scopus 로고
    • Nuclear envelope disorganization in fibroblasts from lipodystrophic patients with heterozygous R482Q/W mutations in the lamin A/C gene
    • Vigouroux C., Auclair M., Dubosclard E., Pouchelet M., Capeau J., Courvalin J.C., Buendia B. Nuclear envelope disorganization in fibroblasts from lipodystrophic patients with heterozygous R482Q/W mutations in the lamin A/C gene. J Cell Sci. 114:2001;4459-4468
    • (2001) J Cell Sci , vol.114 , pp. 4459-4468
    • Vigouroux, C.1    Auclair, M.2    Dubosclard, E.3    Pouchelet, M.4    Capeau, J.5    Courvalin, J.C.6    Buendia, B.7
  • 35
    • 0037959860 scopus 로고    scopus 로고
    • XMAN1, an inner nuclear membrane protein, antagonizes BMP signaling by interacting with Smad1 in Xenopus embryos
    • Osada S., Ohmori S.Y., Taira M. XMAN1, an inner nuclear membrane protein, antagonizes BMP signaling by interacting with Smad1 in Xenopus embryos. Development. 130:2003;1783-1794
    • (2003) Development , vol.130 , pp. 1783-1794
    • Osada, S.1    Ohmori, S.Y.2    Taira, M.3
  • 37
    • 0036537888 scopus 로고    scopus 로고
    • A novel interaction between lamin a and SREBP1: Implications for partial lipodystrophy and other laminopathies
    • Lloyd D.J., Trembath R.C., Shackleton S. A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies. Hum Mol Genet. 11:2002;769-777
    • (2002) Hum Mol Genet , vol.11 , pp. 769-777
    • Lloyd, D.J.1    Trembath, R.C.2    Shackleton, S.3
  • 39
    • 1342284873 scopus 로고    scopus 로고
    • LMNA mutations in atypical Werner's syndrome
    • Bonne G., Levy N. LMNA mutations in atypical Werner's syndrome. Lancet. 362:2003;1585-1586
    • (2003) Lancet , vol.362 , pp. 1585-1586
    • Bonne, G.1    Levy, N.2
  • 40
    • 2342526584 scopus 로고    scopus 로고
    • LMNA mutations in atypical Werner's syndrome
    • Oshima J., Garg A., Martin G.M., Kennedy B.K. LMNA mutations in atypical Werner's syndrome. Lancet. 362:2003;1586
    • (2003) Lancet , vol.362 , pp. 1586
    • Oshima, J.1    Garg, A.2    Martin, G.M.3    Kennedy, B.K.4
  • 43
    • 0036578920 scopus 로고    scopus 로고
    • Defective prelamin a processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice
    • These two papers show that defective post-translational processing of farnesylated proteins, including lamin A, results in mice with multiple pathologies, some of which are shared with the progeric mice. They suggest that processing of the lamins is may partly underlie the molecular basis of the progeric phenotype.
    • Pendas A.M., Zhou Z., Cadinanos J., Freije J.M., Wang J., Hultenby K., Astudillo A., Wernerson A., Rodriguez F., Tryggvason K., et al. Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nat Genet. 31:2002;94-99 These two papers show that defective post-translational processing of farnesylated proteins, including lamin A, results in mice with multiple pathologies, some of which are shared with the progeric mice. They suggest that processing of the lamins is may partly underlie the molecular basis of the progeric phenotype.
    • (2002) Nat Genet , vol.31 , pp. 94-99
    • Pendas, A.M.1    Zhou, Z.2    Cadinanos, J.3    Freije, J.M.4    Wang, J.5    Hultenby, K.6    Astudillo, A.7    Wernerson, A.8    Rodriguez, F.9    Tryggvason, K.10
  • 44
    • 0041919374 scopus 로고    scopus 로고
    • Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia
    • Agarwal A.K., Fryns J.P., Auchus R.J., Garg A. Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia. Hum Mol Genet. 12:2003;1995-2001
    • (2003) Hum Mol Genet , vol.12 , pp. 1995-2001
    • Agarwal, A.K.1    Fryns, J.P.2    Auchus, R.J.3    Garg, A.4
  • 45
    • 0034255236 scopus 로고    scopus 로고
    • Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex
    • Zheng R., Ghirlando R., Lee M.S., Mizuuchi K., Krause M., Craigie R. Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex. Proc Natl Acad Sci U S A. 97:2000;8997-9002
    • (2000) Proc Natl Acad Sci U S a , vol.97 , pp. 8997-9002
    • Zheng, R.1    Ghirlando, R.2    Lee, M.S.3    Mizuuchi, K.4    Krause, M.5    Craigie, R.6
  • 46
    • 0037446880 scopus 로고    scopus 로고
    • MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans
    • Liu J., Lee K.K., Segura-Totten M., Neufeld E., Wilson K.L., Gruenbaum Y. MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 100:2003;4598-4603
    • (2003) Proc Natl Acad Sci U S a , vol.100 , pp. 4598-4603
    • Liu, J.1    Lee, K.K.2    Segura-Totten, M.3    Neufeld, E.4    Wilson, K.L.5    Gruenbaum, Y.6
  • 47
    • 0032526483 scopus 로고    scopus 로고
    • Aneuploidy analysis in fibroblasts of human premature aging syndromes by FISH during in vitro cellular aging
    • Mukherjee A.B., Costello C. Aneuploidy analysis in fibroblasts of human premature aging syndromes by FISH during in vitro cellular aging. Mech Ageing Dev. 103:1998;209-222
    • (1998) Mech Ageing Dev , vol.103 , pp. 209-222
    • Mukherjee, A.B.1    Costello, C.2
  • 49
    • 0042839614 scopus 로고    scopus 로고
    • Mechanism and regulation of human non-homologous DNA end-joining
    • Lieber M.R., Ma Y., Pannicke U., Schwarz K. Mechanism and regulation of human non-homologous DNA end-joining. Nat Rev Mol Cell Biol. 4:2003;712-720
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 712-720
    • Lieber, M.R.1    Ma, Y.2    Pannicke, U.3    Schwarz, K.4
  • 50
    • 0000207650 scopus 로고    scopus 로고
    • Etiology of the Metabolic Syndrome
    • Edited by Bray GA, Bouchard C, James WPT: Dekker Inc.;
    • Björntop P: Etiology of the Metabolic Syndrome. In Handbook of Obesity. Edited by Bray GA, Bouchard C, James WPT: Dekker Inc.; 1998:573-600.
    • (1998) Handbook of Obesity , pp. 573-600
    • Björntop, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.