Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation

Aging Cell

Volumn 7, Issue 6, 2008, Pages 894-907

  Seo, Yong Hak ^a   Jung, Hyun Jung ^a   Shin, Hyun Taek ^a   Kim, You Mie ^a   Yim, Hyunee ^a   Chung, Hae Young ^b   Lim, In Kyoung ^a   Yoon, Gyesoon ^a  

^a Ajou University School of Medicine   (South Korea)

^b Pusan National University   (South Korea)

Author keywords

Aging; Cellular senescence; Glycogenesis; Glycogensynthase; GSK3; Reactive oxygen species

Indexed keywords

2 (3 CHLORO 4 HYDROXYANILINO) 3 (2 NITROPHENYL)MALEIMIDE; GLYCOGEN; GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; LITHIUM CHLORIDE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA;

AGING; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FISCHER 344 RAT; GLYCOGEN SYNTHESIS; HUMAN; HUMAN CELL; IMMUNOMODULATION; LIVER; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; RAT; RNA INTERFERENCE; SENESCENCE;

AGE FACTORS; AMINOPHENOLS; ANIMALS; CELL AGING; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOGEN; GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MALE; MALEIMIDES; RATS; RATS, INBRED F344;

RATTUS;

EID: 56849096570     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2008.00436.x     Document Type: Article

References (56)

1. Ames BN, Shigenaga MK, Hagen TM (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA 90, 7915-7922.
2. Ban KC, Singh H, Krishnan R, Seow HF (2003) GSK-3beta phosphorylation of FKHR transcription factor as a prognostic variable in acute myeloid leukemia. Leuk. Res. 27, 1159-1162.
3. Bartke A (2001) Mutations prolong life in flies; implications for aging in mammals. Trends Endocrinol. Metab. 12, 233-234.
4. Bollen M, Keppens S, Stalmans W (1998) Specific features of glycogen metabolism in the liver. Biochem. J. 336, 19-31.
5. Campisi J, d'Adda di Fagagna F (2007) Cellular senescence: When bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 8, 729-740.
6. Cline GW, Rothman DL, Magnusson I, Katz LD, Shulman GI (1994) 13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus. J. Clin. Inv. 94, 2369-2376.
7. Coghlan MP, Culbert AA, Cross DA, Corcoran SL, Yates JW, Pearce NJ, Rausch OL, Murphy GJ, Carter PS, Cox LR, Mills D, Brown MJ, Haigh D, Ward RW, Smith DG, Murray KJ, Reith AD, Holder JC (2000) Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem. Biol. 7, 793-803.
8. Cohen P, Frame S (2001) The renaissance of GSK3. Nature Rev. Mol Cell Biol. 2, 769-776.
9. Dall'Aglio E, Chang H, Reaven GM, Azhar S (1987) Age-related changes in rat muscle glycogen synthase. J. Gerontol. 42, 168-172.
10. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, Peacocke M, Campisi J (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 92, 9363-9367.
11. Dominguez I, Itoh K, Sokol SY (1995) Role of glycogen synthase kinase 3β as a negative regulator of dorsoventral axis formation in Xenopus embryos. Proc. Natl. Acad. Sci. USA 92, 8498-8502.
12. Eldar-Finkelman H, Ilouz R (2003) Challenges and oppotunities with glycogen synthase kinase-3 inhibitors for insulin resistance and Type 2 diabetes treatment. Expert Opin. Investig. Drugs 12, 1511-1519.
13. Embi N, Rylatt DB, Cohen P (1980) Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic AMP-dependent protein kinase and phosphorylase kinase. Eur. J. Biochem. 107, 519-527.
14. Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408, 239-247.
15. Forde JE, Dale TC (2007) Glycogen synthase kinase 3: A key regulator of cellular fate. Cell Mol. Life Sci. 64, 1930-1944.
16. Frame S, Cohen P (2001) GSK3 takes centre stage more than 20 years after its discovery. Biochem. J. 359, 1-16.
17. Gertz HJ, Cervos-Navarro J, Frydl V, Schultz F (1985) Glycogen accumulation of the aging human brain. Mech. Ageing. Dev. 31, 25-35.
18. Harris RA (2006) Carbohydrate metabolism I: Major metabolic pathways and their control. In Textbook of Biochemistry with Clinical Correlation (Devlin TM, ed.). New Jergy: Hoboken, Wiley-Liss, pp. 581-635.
19. Hayflick L (1965) The limited in vitro lifetime of human diploid cell strains. Exp. Cell. Res. 37, 614-636.
20. Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR (2000) Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 406, 86-90.
21. Holzenberger M, Dupont J, Ducos B, Leneuve P, Géloën A, Even PC, Cervera P, Le Bouc Y (2003) IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421, 182-187.
22. Huang W, Chang HY, Fei T, Wu H, Chen YG (2007) GSK3β mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene 26, 2471-2482.
23. Jope RS, Yuskaitis CJ, Beurel E (2007) Glycogen synthase kinase-3 (GSK3): Inflammation, diseases, and therapeutics. Neurochem. Res. 32, 577-595.
24. Kenyon C (2005) The plasticity of aging: Insights from long-lived mutants. Cell 120, 449-460.
25. Khandelwal RL, Enno TL, Narayanan N (1984) Effects of age on glycogen synthase and phosphorylase activities in rat liver. Mech. Ageing Dev. 28, 13-22.
26. Kim HS, Song MC, Kwak IH, Park TJ, Lim IK (2003) Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence. J. Biol. Chem. 278, 37497-37510.
27. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G (1997) Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277, 942-946.
28. Kortlever RM, Higgins PJ, Bernards R (2006) Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat. Cell Biol. 8, 877-884.
29. Kurokawa T, Ozaki N, Sato E, Ishibashi S (1997) Rapid decrease of glycogen concentration in the hearts of senescence-accelarated mice during aging. Mech. Ageing. Dev. 97, 227-236.
30. Liao X, Zhang L, Thrasher JB, Du J, Li B (2003) Glycogen synthase kinase-3beta suppression eliminates tumor necrosis factor-related apoptosis-inducing ligand resistance in prostate cancer. Mol. Cancer Ther. 2, 1215-1222.
31. Locher R, Brandes RP, Vetter W, Barton M (2002) Native LDL induces proliferation of human vascular smooth muscle cells via redox-mediated activation of ERK 1/2 mitogen-activated protein kinases. Hypertension 39, 645-650.
32. MacAulay K, Blair AS, Hajduch E, Terashima T, Baba O, Sutherland C, Hundal HS (2005) Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells. J. Biol. Chem. 280, 9509-9518.
33. Matsumura T, Zerrudo Z, Hayflick L (1979) Senescent human diploid cells in culture: Survival, DNA synthesis and morphology. J. Gerontol. 34, 328-334.
34. Miyauchi H, Minamino T, Tateno K, Kunieda T, Toko H, Komuro I (2004) Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J. 23, 212-220.
35. Moore SA, Peterson RG, Felten DL, O'Connor BL (1981) Glycogen accumulation in tibial nerves of experimentally diabetic and aging control rats. J. Neurol. Sci. 52, 289-303.
36. Mysliwski A, Kmiec Z (1992) Effect of aging on glycogen synthesis in liver of starved-refed rats. Arch. Gerontol. Geriatr. 14, 85-92.
37. Pagliassotti MJ, Cherrington AD (1992) Regulation of net hepatic glucose uptake in vivo. Ann. Rev. Physiol. 54, 847-860.
38. Pagliassotti MJ, Holste LC, Moore MC, Neal DW, Cherrington AD (1996) Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. J. Clin. Invest. 97, 81-91.
39. Pelicano H, Xu RH, Du M, Feng L, Sasaki R, Carew JS, Hu Y, Ramdas L, Hu L, Keating MJ, Zhang W, Plunkett W, Huang P (2006) Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism. J. Cell Biol. 175, 913-923.
40. Robbins E, Levine EM, Eagle H (1970) Morphologic changes accompanying senescence of cultured human diploid cells. J. Exp. Med. 131, 1211-1222.
41. Rottmann S, Wang Y, Nasoff M, Deveraux QL, Quon KC (2005) A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function. Proc. Natl. Acad. Sci. USA 102, 15195-15200.
42. Rylatt DB, Aitken A, Bilham T, Condon GD, Embi N, Cohen P (1980) Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase. Eur. J. Biochem. 107, 529-537.
43. Schwabe RF, Brenner DA (2002) Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am. J. Physiol. Gastrointest. Liver Physiol. 283, G204-G211.
44. Shakoori A, Ougolkov A, Yu ZW, Zhang B, Modarressi MH, Billadeau DD, Mai M, Takahashi Y, Minamoto T (2005) Deregulated GSK3beta activity in colorectal cancer: Its association with tumor cell survival and proliferation. Biochem. Biophys. Res. Commun. 334, 1365-1373.
45. Shulman GI, Rothman DL, Jue T, Stein P, DeFronzo RA, Shulman RG (1990) Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. New Engl. J. Med. 322, 223-228.
46. Sutherland C, Leighton IA, Cohen P (1993) Inactivation of glycogen synthase kinase-3 beta by phosphorylation: New kinase connections in insulin and growth-factor signaling. Biochem. J. 296, 15-19.
47. Takashima A (2006) GSK-3 is essential in the pathogenesis of Alzheimer's disease. J. Alzheimers. Dis. 9, 309-317.
48. Tater M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS (2001) A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292, 107-110.
49. Tissenbaum HA, Ruvkun G (1998) An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics 148, 703-717.
50. Wang X, Janmaat M, Beugnet A, Paulin FE, Proud CG (2002) Evidence that the dephosphorylation of Ser 535 in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is sufficient for the activation of eIF2B by insulin. Biochem. J. 367, 475-481.
51. Wang Q, Zhou Y, Wang X, Evers BM (2006) Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase. Oncogene 25, 43-50.
52. Ye X, Zerlanko B, Kennedy A, Banumathy G, Zhang R, Adams PD (2007) Downregulation of Wnt singnaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Mol. Cell. 27, 183-196.
53. Yoon G, Kim HJ, Yoon YS, Cho H, Lim IK, Lee JH (2002) Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: Association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression. Biochem. J. 366, 613-621.
54. Yoon YS, Lee JH, Hwang SC, Choi KS, Yoon G (2005) TGF β1 induces prolonged mitochondrial ROS generation through decreased complex IV activity with senescent arrest in Mv1Lu cells. Oncogene 24, 1895-1903.
55. Yoon YS, Yoon DS, Lim IK, Yoon SH, Chung HY, Rojo M, Malka F, Jou MJ, Martinou JC, Yoon G (2006) Formation of elongated giant mitochondria in DFO-induced cellular senescence: Involvement of enhanced fusion process through modulation of Fis1. J. Cell Phys. 209, 468-480.
56. Zmijewski JW, Jope RS (2004) Nuclear accumulation of glycogen synthase kinase-3 during replicative senescence of human fibroblasts. Aging Cell 3, 309-317.