ATM - A key determinant of multiple cellular responses to irradiation

Acta Oncologica

Volumn 40, Issue 6, 2001, Pages 686-688

  Kastan, M B ^a   Lim, D S ^a   Kim, S T ^a   Yang, D ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; IRRADIATION; PHYSIOLOGY; PROTEINS; RADIOTHERAPY; TUMORS;

NEURODEGENERATION;

CELLS;

ATM PROTEIN; GENE PRODUCT;

ATAXIA; CANCER INCIDENCE; CARCINOGENESIS; CONFERENCE PAPER; HUMAN; IMMUNE DEFICIENCY; IN VITRO STUDY; IN VIVO STUDY; INFERTILITY; IONIZING RADIATION; NERVE DEGENERATION; PRIORITY JOURNAL; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; TELANGIECTASIA;

ATAXIA TELANGIECTASIA; CELL CYCLE PROTEINS; CELL SURVIVAL; DNA DAMAGE; DNA-BINDING PROTEINS; HUMANS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 0035189448     PISSN: 0284186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/02841860152619089     Document Type: Conference Paper

References (20)

1. Cell cycle control and cancer
2. Tumor-suppressor p53: Implications for tumor development and prognosis
3. The complexity of p53 modulation: Emerging patterns from divergent signals
4. DNA strand breaks: The DNA template alterations that trigger p53-dependent DNA damage response pathways
5. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
6. 1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
7. DNA damage activates p53 through a phosphorylation-acetylation cascade
8. DNA damage induces phosphorylation of the amino terminus of p53
9. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
10. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
11. Enhanced phosphorylation of p53 by ATM in response to DNA damage
12. Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis
13. A single ataxia telangiectasia gene with a product similar to PI-3 kinase
14. p53 and ATM: Cell cycle, cell death and cancer
15. Fragments of ATM which have dominant-negative or complementing activity
16. Influence of ATM function on telomere metabolism
17. ATM binds to β-adaptin in cytoplasmic vesicles
18. Substrate specificities and identification of putative substrates of ATM kinase family members
19. Ionizing radiation activates the ATM kinase throughout the cell cycle
20. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway