Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functions

Oncogene

Volumn 26, Issue 41, 2007, Pages 6002-6009

  Sakamoto, S ^a,e   Iijima, K ^b   Mochizuki, D ^b   Nakamura, K ^a   Teshigawara, K ^c   Kobayashi, J ^a   Matsuura, S ^d   Tauchi, H ^b   Komatsu, K ^a  

^a KYOTO UNIVERSITY   (Japan)

^b IBARAKI UNIVERSITY   (Japan)

^c Lymphocyte Bank Co Ltd   (Japan)

^d HIROSHIMA UNIVERSITY   (Japan)

^e Microbial Chemistry Research Foundation   (Japan)

Author keywords

ATM; FHA BRCT domains; Homologous recombination; MRE11; NBS1

Indexed keywords

ATM PROTEIN; NIBRIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHROMATID EXCHANGE; CONTROLLED STUDY; FIBROBLAST; GENE CONVERSION; GENE DELETION; GENE MUTATION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; RADIOSENSITIVITY;

ADENINE; CELL CYCLE PROTEINS; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; FIBROBLASTS; GENE FREQUENCY; HUMANS; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RECOMBINATION, GENETIC; THYMINE; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA;

EID: 34548496891     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210428     Document Type: Article

References (27)

1. Bolderson E, Scorah J, Helleday T, Smythe C, Meuth M. (2004). ATM is required for the cellular response to thymidine induced replication fork stress. Hum Mol Genet 13: 2937-2945.
2. Bressan DA, Baxter BK, Petrini JH. (1999). The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae. Mol Cell Biol 19: 7681-7687.
3. Celeste A, Fernandez-Capetillo O, Kruhlak MJ, Pilch DR, Staudt DW, Lee A et al. (2003). Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol 5: 675-679.
4. Cerosaletti KM, Concannon P. (2003). Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation. J Biol Chem 278: 21944-21951.
5. Falck J, Coates J, Jackson SP. (2005). Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434: 605-611.
6. Golding SE, Rosenberg E, Khalil A, McEwen A, Holmes M, Neill S et al. (2004). Double strand break repair by homologous recombination is regulated bycell cycle-independent signaling via ATM in human glioma cells. J Biol Chem 279: 15402-15410.
7. Greenberg RA, Sobhian B, Pathania S, Cantor SB, Nakatani Y, Livingston DM. (2006). Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Genes Dev 20: 34-46.
8. Horejsi Z, Falck J, Bakkenist CJ, Kastan MB, Lukas J, Bartek J. (2004). Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. Oncogene 23: 3122-3127.
9. Jasin M. (2002). Homologous repair of DNA damage and tumorigenesis: the BRCA connection. Oncogene 21: 8981-8993.
10. Kim JS, Krasieva TB, LaMorte V, Taylor AM, Yokomori K. (2002). Specific recruitment of human cohesin to laser-induced DNA damage. J Biol Chem 277: 45149-45153.
11. Kobayashi J, Antoccia A, Tauchi H, Matsuura S, Komatsu K. (2004). NBS1 and its functional role in the DNA damage response. DNA Repair 3: 855-861.
12. Kobayashi J, Tauchi H, Sakamoto S, Nakamura A, Morishima K, Matsuura S et al. (2002). NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain. Curr Biol 12: 1846-1851.
13. Lavin MF. (2004). The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks. DNA Repair 3: 1515-1520.
14. Lim DS, Kim ST, Xu B, Maser RS, Lin J, Petrini JH et al. (2000). ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 404: 613-617.
15. Mirzoeva OK, Petrini JH. (2001). DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol Cell Biol 21: 281-288.
16. Nakanishi K, Yang YG, Pierce AJ, Taniguchi T, Digweed M, D'Andrea AD et al. (2005). Human Fanconi anemia monoubiquitination pathwaypromotes homologous DNA repair. Proc Natl Acad Sci USA 102: 1110-1115.
17. Pierce AJ, Johnson RD, Thompson LH, Jasin M. (1999). XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev 13: 2633-2638.
18. Riballo E, Kuhne M, Rief N, Doherty A, Smith GC, Recio MJ et al. (2004). A pathwayof double-strand break rejoining dependent upon ATM, artemis, and proteins locating to gamma-H2AX foci. Mol Cell 16: 715-724.
19. Shiloh Y. (2003). ATM and related protein kinases: safe-guarding genome integrity. Nat Rev Cancer 3: 155-168.
20. Takao N, Kato H, Mori R, Morrison C, Sonada E, Sun X et al. (1999). Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation. Oncogene 18: 7002-7009.
21. Tauchi H, Kobayashi J, Morishima K, Matsuura S, Nakamura A, Shiraishi T et al. (2001). The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50-hMRE11-NBS1 complex DNA repair activity. J Biol Chem 276: 12-15.
22. Tauchi H, Kobayashi J, Morishima K, van Gent DC, Shiraishi T, Verkaik NS et al. (2002). Nbs1 is essential for DNA repair byhomologous recombination in higher vertebrate cells. Nature 420: 93-98.
23. The International Nijmegen Breakage Syndrome Study Group (2000). Nijmegen breakage syndrome. Arch Dis Child 82: 400-406.
24. Uziel T, Lernthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y. (2003). Requirement of the MRN complex for ATM activation by DNA damage. EMBO J 22: 5612-5621.
25. Xie A, Puget N, Shim I, Odate S, Jarzyna I, Bassing CH et al. (2004). Control of sister chromatid recombination by histone H2AX. Mol Cell 16: 1017-1025.
26. Yamamoto K, Hirano S, Ishiai M, Morishima K, Kitao H, Namikoshi K et al. (2005). Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination. Mol Cell Biol 25: 34-43.
27. Zhao S, Renthal W, Lee EY. (2002). Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses. Nucleic Acids Res 30: 4815-4822.