The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women

Human Molecular Genetics

Volumn 17, Issue 22, 2008, Pages 3502-3508

  Qi, Lu ^a,b   Kraft, Peter ^a,b   Hunter, David J ^a,b   Hu, Frank B ^a,b  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELANOCORTIN 4 RECEPTOR;

ADULT; AGE; AGED; ALLELE; ARTICLE; BODY MASS; CALORIC INTAKE; COHORT ANALYSIS; CONTROLLED STUDY; DIABETES MELLITUS; DIETARY INTAKE; ENERGY BALANCE; FAT INTAKE; FEMALE; FOOD INTAKE; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; INHERITANCE; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN INTAKE; REGULATORY MECHANISM; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; WEIGHT CHANGE;

ADULT; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; DIETARY FATS; EATING; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MIDDLE AGED; MULTIVARIATE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, MELANOCORTIN, TYPE 4; RISK FACTORS; WEIGHT GAIN;

EID: 54949113309     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddn242     Document Type: Article

References (32)

1. Tao, Y.X. (2005) Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity. Mol. Cell. Endocrinol., 239, 1-14.
2. Branson, R., Potoczna, N., Kral, J.G., Lentes, K.U., Hoehe, M.R. and Horber, F.F. (2003) Binge eating as a major phenotype of melanocortin 4 receptor gene mutations. N. Engl. J. Med., 348, 1096-1103.
3. Adan, R.A., Tiesjema, B., Hillebrand, J.J., la Fleur, S.E., Kas, M.J. and de Krom, M. (2006) The MC4 receptor and control of appetite. Br. J. Pharmacol., 149, 815-827.
4. Mergen, M., Mergen, H., Ozata, M., Oner, R. and Oner, C. (2001) A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity. J. Clin. Endocrinol. Metab., 86, 3448.
5. Chambers, J.C., Elliott, P., Zabaneh, D., Zhang, W., Li, Y., Froguel, P., Balding, D., Scott, J. and Kooner, J.S. (2008) Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat. Genet., 40, 716-718.
6. Loos, R.J., Lindgren, C.M., Li, S., Wheeler, E., Zhao, J.H., Prokopenko, I., Inouye, M., Freathy, R.M., Attwood, A.P., Beckmann, J.S. et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat. Genet., 40, 768-775.
7. Santoro, N., Rankinen, T., Perusse, L., Loos, R.J. and Bouchard, C. (2005) MC4R marker associated with stature in children and young adults: a longitudinal study. J. Pediatr. Endocrinol. Metab., 18, 859-863.
8. Huszar, D., Lynch, C.A., Fairchild-Huntress, V., Dunmore, J.H., Fang, Q., Berkemeier, L.R., Gu, W., Kesterson, R.A., Boston, B.A., Cone, R.D. et al. (1997) Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell, 88, 131-141.
9. Zeggini, E., Scott, L.J., Saxena, R., Voight, B.F., Marchini, J.L., Hu, T., de Bakker, P.I., Abecasis, G.R., Almgren, P., Andersen, G. et al. (2008) Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat. Genet., 40, 638-645.
10. Chen, A.S., Metzger, J.M., Trumbauer, M.E., Guan, X.M., Yu, H., Frazier, E.G., Marsh, D.J., Forrest, M.J., Gopal-Truter, S., Fisher, J. et al. (2000) Role of the melanocortin-4 receptor in metabolic rate and food intake in mice. Transgenic Res., 9, 145-154.
11. Heid, I.M., Vollmert, C., Kronenberg, F., Huth, C., Ankerst, D.P., Luchner, A., Hinney, A., Bronner, G., Wichmann, H.E., Illig, T. et al. (2008) Association of the MC4R V103I polymorphism with the metabolic syndrome: The KORA Study. Obesity (Silver Spring), 16 369-376.
12. Samama, P., Rumennik, L. and Grippo, J.F. (2003) The melanocortin receptor MCR4 controls fat consumption. Regul. Pept., 113, 85-88.
13. Hagan, M.M., Rushing, P.A., Benoit, S.C., Woods, S.C. and Seeley, R.J. (2001) Opioid receptor involvement in the effect of AgRP-(83-132) on food intake and food selection. Am. J. Physiol. Regul. Integr. Comp. Physiol., 280, R814-R821.
14. Cai, G., Cole, S.A., Bastarrachea, R.A., Maccluer, J.W., Blangero, J. and Comuzzie, A.G. (2004) Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22. Am. J. Clin. Nutr., 80, 1410-1414.
15. Perusse, L., Tremblay, A., Leblanc, C., Cloninger, C.R., Reich, T., Rice, J. and Bouchard, C. (1988) Familial resemblance in energy intake: contribution of genetic and environmental factors. Am. J. Clin. Nutr. 47, 629-635.
16. Mitchell, B.D., Rainwater, D.L., Hsueh, W.C., Kennedy, A.J., Stern, M.P. and Maccluer, J.W. (2003) Familial aggregation of nutrient intake and physical activity: Results from the San Antonio Family Heart Study. Ann. Epidemiol., 13, 128-135.
17. Thomasson, H.R., Edenberg, H.J., Crabb, D.W., Mai, X.L., Jerome, R.E., Li, T.K., Wang, S.P., Lin, Y.T., Lu, R.B. and Yin, S.J. (1991) Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am. J. Hum. Genet., 48, 677-681.
18. Bierut, L.J., Cubells, J.F., Iacono, W.G., Li, M.D., Madden, P.A., Nelson, E.C., Pollock, J.D., Rutter, J.L., Swan, G.E. and Vanyukov, M. (2007) Genetic research and smoking behavior. JAMA, 297, 810.
19. Balthasar, N., Dalgaard, L.T., Lee, C.E., Yu, J., Funahashi, H., Williams, T., Ferreira, M., Tang, V., McGovern, R.A., Kenny, C.D. et al. (2005) Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell, 123, 493-505.
20. Lissner, L. (2002) Measuring food intake in studies of obesity. Public Health Nutr., 5, 889-892.
21. Willett, W., Stampfer, M.J., Bain, C., Lipnick, R., Speizer, F.E., Rosner, B., Cramer, D. and Hennekens, C.H. (1983) Cigarette smoking, relative weight, and menopause. Am. J. Epidemiol., 117, 651-658.
22. Rimm, E.B., Stampfer, M.J., Colditz, G.A., Chute, C.G., Litin, L.B. and Willett, W.C. (1990) Validity of self-reported waist and hip circumferences in men and women. Epidemiology, 1, 466-473.
23. Hu, F.B., Willett, W.C., Li, T., Stampfer, M.J., Colditz, G.A. and Manson, J.E. (2004) Adiposity as compared with physical activity in predicting mortality among women. N. Engl. J. Med., 351, 2694-2703.
24. Hu, F.B., Manson, J.E., Stampfer, M.J., Colditz, G., Liu, S., Solomon, C.G. and Willett, W.C. (2001) Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N. Engl. J. Med., 345, 790-797.
25. Manson, J.E., Colditz, G.A., Stampfer, M.J., Willett, W.C., Rosner, B., Monson, R.R., Speizer, F.E. and Hennekens, C.H. (1990) A prospective study of obesity and risk of coronary heart disease in women. N. Engl. J. Med., 322, 882-889.
26. Colditz, G.A., Manson, J.E. and Hankinson, S.E. (1997) The Nurses' Health Study: 20-year contribution to the understanding of health among women. J. Womens Health, 6, 49-62.
27. Qi, L., Meigs, J., Manson, J.E., Ma, J., Hunter, D., Rifai, N. and Hu, F.B. (2005) HFE genetic variability, body iron stores, and the risk of type 2 diabetes in U.S. women. Diabetes, 54, 3567-3572.
28. Qi, L., van Dam, R.M., Meigs, J.B., Manson, J.E., Hunter, D. and Hu, F.B. (2006) Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis. Hum. Mol. Genet., 15, 1914-1920.
29. (1979) Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. National Diabetes Data Group. Diabetes, 28, 1039-1057.
30. (1997) Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care, 20, 1183-1197.
31. Hu, F.B., Stampfer, M.J., Manson, J.E., Rimm, E., Colditz, G.A., Rosner, B.A., Hennekens, C.H. and Willett, W.C. (1997) Dietary fat intake and the risk of coronary heart disease in women. N. Engl. J. Med., 337, 1491-1499.
32. Willett, W. (1998) Nutritional Epidemiology, 2nd edn. Oxford University Press, New York.