The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis

Journal of Lipid Research

Volumn 49, Issue 3, 2008, Pages 607-611

  Wåhlén, Kerstin ^a   Sjölin, Eva ^a   Hoffstedt, Johan ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Adipocyte; Lipid and glucose metabolism; Messenger RNA; Single nucleotide polymorphism

Indexed keywords

GLYCEROL; HORMONE SENSITIVE LIPASE; INSULIN; MESSENGER RNA; PERILIPIN; TRIACYLGLYCEROL LIPASE; FTO PROTEIN, HUMAN; PROTEIN;

ADIPOCYTE; ADIPOSE TISSUE; ADULT; AGED; ALLELE; ARTICLE; BIOPSY; BODY MASS; BODY WEIGHT; CELL DIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; FAT MASS AND OBESITY ASSOCIATED GENE; FEMALE; GENE; GENE EXPRESSION; GENETIC VARIABILITY; GENOTYPE; GLYCEROL BLOOD LEVEL; HUMAN; LIPID METABOLISM; LIPOGENESIS; LIPOLYSIS; NORMAL HUMAN; OBESITY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SUBCUTANEOUS FAT; GENETICS; METABOLISM;

ADIPOCYTES; BODY MASS INDEX; FEMALE; GENOTYPE; GLYCEROL; HUMANS; LIPOLYSIS; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; RNA, MESSENGER;

EID: 42949102733     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M700448-JLR200     Document Type: Article

References (16)

1. Frayling, T. M., N. J. Timpson, M. N. Weedon, E. Zeggini, R. M. Freathy, C. M. Lindgren, J. R. Perry, K. S. Elliott, H. Lango, N. W. Rayner, et al. 2007. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 316: 889-894.
2. Dina, C., D. Meyre, S. Gallina, E. Durand, A. Korner, P. Jacobson, L. M. Carlsson, W. Kiess, V. Vatin, C. Lecoeur, et al. 2007. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat. Genet. 39: 724-726.
3. Scuteri, A., S. Sanna, W-M. Chen, M. Uda, G. Albai, J. Strait, S. Najjar, R. Nagaraja, M. Orrú, G. Usala, et al. 2007. Genomewide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 3: e115.
4. Matthews, D. R., J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, and R. C. Turner. 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28: 412-419.
5. Gallagher, D., M. Visser, D. Sepulveda, R. N. Pierson, T. Harris, and S. B. Heymsfield. 1996. How useful is body mass index for comparison of body fatness across age, sex, and ethnic groups? Am. J. Epidemiol. 143: 228-239.
6. Dahlman, I., A. Dicker, H. Jiao, J. Kere, L. Blomqvist, V. van Harmelen, J. Hoffstedt, K. Borch-Johnsen, T. Jorgensen, T. Hansen, et al. 2007. A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis. Am. J. Hum. Genet. 80: 1115-1124.
7. Lofgren, P., J. Hoffstedt, E. Naslund, M. Wiren, and P. Arner. 2005. Prospective and controlled studies of the actions of insulin and catecholamine in fat cells of obese women following weight reduction. Diabetologia. 48: 2334-2342.
8. Mairal, A., D. Langin, P. Arner, and J. Hoffstedt. 2006. Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity. Diabetologia. 49: 1629-1636.
9. Ryden, M., E. Arvidsson, L. Blomqvist, L. Perbeck, A. Dicker, and P. Arner. 2004. Targets for TNF-alpha-induced lipolysis in human adipocytes. Biochem. Biophys. Res. Commun. 318: 168-175.
10. van Harmelen, V., M. Ryden, E. Sjolin, and J. Hoffstedt. 2007. A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression. J. Lipid Res. 48: 201-206.
11. Groop, L. 2007. From fused toes in mice to human obesity. Nat. Genet. 39: 706-707.
12. Blaak, E. 2001. Gender differences in fat metabolism. Curr. Opin. Clin. Nutr. Metab. Care. 4: 499-502.
13. Lafontan, M., and M. Berlan. 2003. Do regional differences in adipocyte biology provide new pathophysiological insights? Trends Pharmacol. Sci. 24: 276-283.
14. Arner, P., and D. Langin. 2007. The role of neutral lipases in human adipose tissue lipolysis. Curr. Opin. Lipidol. 18: 246-250.
15. Martinez-Botas, J., J. B. Anderson, D. Tessier, A. Lapillonne, B. H-J. Chang, M. J. Quast, D. Gorenstein, K-H. Chen, and L. Chan. 2000. Absence of perilipin results in leanness and reverses obesity in Leprdb/db mice. Nat. Genet. 26: 474-479.
16. Tansey, J. T., C. Sztalryd, J. Gruia-Gray, D. L. Roush, J. V. Zee, O. Gavrilova, M. L. Reitman, C-X. Deng, C. Li, A. R. Kimmel, et al. 2002. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc. Natl. Acad. Sci. USA. 98: 6494-6499.