A common genetic variant is associated with adult and childhood obesity

Science

Volumn 312, Issue 5771, 2006, Pages 279-283

  Herbert, Alan ^a   Gerry, Norman P ^a   McQueen, Matthew B ^b   Heid, Iris M ^c   Pfeufer, Arne ^c,d   Illig, Thomas ^c   Wichmann, H Erich ^c,e   Meitinger, Thomas ^c,d   Hunter, David ^b,f   Hu, Frank B ^b,f   Colditz, Graham ^f   Hinney, Anke ^g   Hebebrand, Johannes ^g   Koberwitz, Kerstin ^d,g   Zhu, Xiaofeng ^h   Cooper, Richard ^h   Ardlie, Kristin ⁱ   Lyon, Helen ^j,k,l   Hirschhorn, Joel N ^j,k,l   Laird, Nan M ^b   Lenburg, Marc E ^a   Lange, Christoph ^f,j   Christman, Michael F ^a   more..

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g UNIVERSITY OF DUISBURG ESSEN   (Germany)

^h LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

ⁱ Genomics Collaborative Inc   (United States)

^j BOSTON CHILDREN S HOSPITAL   (United States)

^k HARVARD MEDICAL SCHOOL   (United States)

^l BROAD INSTITUTE OF MIT AND HARVARD   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DRUG THERAPY; GENES; GENETIC ENGINEERING; PATIENT MONITORING; PATIENT TREATMENT;

COMMON DISEASES; GENETIC POLYMORPHISMS; GENETIC VARIANTS; INSIG2 GENE;

DISEASE CONTROL;

ANCESTRY; CARDIOVASCULAR DISEASE; DIABETES; DNA; GENE; HYPERTENSION;

AFRICAN AMERICAN; ALLELE; ARTICLE; DNA DETERMINATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HEART DISEASE; HUMAN; HUMAN GENOME; HYPERTENSION; INHERITANCE; INSIG2 GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; WESTERN EUROPE;

ADULT; AFRICAN AMERICANS; ALLELES; BODY MASS INDEX; CASE-CONTROL STUDIES; CHILD; COHORT STUDIES; EUROPE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENES, RECESSIVE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LINKAGE DISEQUILIBRIUM; MALE; MEMBRANE PROTEINS; MODELS, GENETIC; OBESITY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; VARIATION (GENETICS);

EURASIA; EUROPE; WESTERN EUROPE;

EID: 33645825830     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1124779     Document Type: Article

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37. The authors thank the participants of the FHS for their contribution and the NHLBI-FH5 investigators for providing DMA samples and phenotypic data for our analysis. This work was supported by a Leadership Award from the Whitaker Foundation (A.M. and M.F.C.); grants from the American Diabetes Association to A.H. and an ADA Smith Family Pinnacle Program Project to J.N.H.; and partially by the following NIH grants: R01GM046877 (M.F.C.), K23DK067288 (H.L), R01HL54485 and R01HL074166 (R.C. and X.Z.), P30DK46200 (principal investigator B. Corkey), and R01MH59532, U01HL65899, and R01HL66289 (N.M.L. and C.L.). A.P., I.H., T.I., T.M., H.-E.W., A. Hi., J. He., and K.K. were supported by the German Ministry of Education and Research (BMBF, grant 031U212C) through the National Genome Research Network (NGFN, grants 01GR0411, N2NV-S31T10, PGE-S04T13, PGE-S15T04, NHK-S19T19, and NHK-S38T01) amd Bioinformatics for the Analysis of Mammalian Genomes (BFAM) and by DFG WI621/12-1. The Nurses Health Study is funded by National Cancer Institute grant CA87969 and thanks C. Guo for data analysis. We thank D. Pellman, N. Levin, and J. Kirkland for comments on the manuscript.