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Volumn 10, Issue 7, 2009, Pages 1095-1108

Genotype-based therapeutic approach for colorectal cancer: State of the art and future perspectives

Author keywords

Anticancer drugs; Colorectal cancer; Personalized therapy; Pharmacogenetics; Polymorphism

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CETUXIMAB; CISPLATIN; DIHYDROPYRIMIDINE DEHYDROGENASE; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUOROURACIL; FOLINIC ACID; GLUCOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE P1; IRINOTECAN; MERCAPTOPURINE; OXALIPLATIN; PANITUMUMAB; TAMOXIFEN; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE; URIDINE DIPHOSPHATE GLUCOSYLTRANSFERASE 1A1;

EID: 67649497365     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656560902889775     Document Type: Review
Times cited : (9)

References (128)
  • 1
    • 33847638137 scopus 로고    scopus 로고
    • Estimates of the cancer incidence and mortality in Europe in 2006
    • Ferlay J, Autier P, Boniol M, et al. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007;18:581-592
    • (2007) Ann Oncol , vol.18 , pp. 581-592
    • Ferlay, J.1    Autier, P.2    Boniol, M.3
  • 2
    • 67650109317 scopus 로고    scopus 로고
    • Available from: Last accessed 29 Mar 2009
    • Cancer Facts and Figures. American Cancer Society, 2008. Available from: www.cancer.org/downloads/ STT/2008CAFFfinalsecured.pdf. [Last accessed 29 Mar 2009]
    • (2008)
  • 3
    • 0035425225 scopus 로고    scopus 로고
    • Pharmacogenetic determinants of anti-cancer drug activity and toxicity
    • DOI 10.1016/S0165-6147(00)01742-9, PII S0165614700017429
    • Danesi R, De Braud F, Fogli S, et al. Pharmacogenetic determinants of anti-cancer drug activity and toxicity. Trends Pharmacol Sci 2001;22:420-426 •• This article focuses on the application of pharmacogenetics in the characterization of differences in the pharmacokinetics and pharmacodynamics of anticancer agents among individuals. (Pubitemid 32718634)
    • (2001) Trends in Pharmacological Sciences , vol.22 , Issue.8 , pp. 420-426
    • Danesi, R.1    De Braud, F.2    Fogli, S.3    Di Paolo, A.4    Del Tacca, M.5
  • 4
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics - Drug disposition, drug targets, and side effects
    • DOI 10.1056/NEJMra020526
    • Evans WE, McLeod HL. Pharmacogenomics-drug disposition, drug targets, and side effects. N Engl J Med 2003;348:538-549 (Pubitemid 36159890)
    • (2003) New England Journal of Medicine , vol.348 , Issue.6 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2
  • 5
    • 84934436050 scopus 로고    scopus 로고
    • Pharmacogenomics of drug-metabolizing enzymes and drug transporters in chemotherapy
    • Bosch TM. Pharmacogenomics of drug-metabolizing enzymes and drug transporters in chemotherapy. Methods Mol Biol 2008;448:63-76
    • (2008) Methods Mol Biol , vol.448 , pp. 63-76
    • Bosch, T.M.1
  • 6
    • 0037339858 scopus 로고    scopus 로고
    • Interethnic difference in the allelic distribution of human epidermal growth factor receptor intron 1 polymorphism
    • Liu W, Innocenti F, Chen P, et al. Interethnic difference in the allelic distribution of human epidermal growth factor receptor intron 1 polymorphism. Clin Cancer Res 2003;9:1009-1012 (Pubitemid 36323704)
    • (2003) Clinical Cancer Research , vol.9 , Issue.3 , pp. 1009-1012
    • Liu, W.1    Innocenti, F.2    Chen, P.3    Das, S.4    Cook Jr., E.H.5    Ratain, M.J.6
  • 7
    • 43749114271 scopus 로고    scopus 로고
    • Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: A prospective clinical trial by the German 5-FU Toxicity Study Group
    • Schwab M, Zanger UM, Marx C, et al. Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group. J Clin Oncol 2008;26:2131-2138
    • (2008) J Clin Oncol , vol.26 , pp. 2131-2138
    • Schwab, M.1    Zanger, U.M.2    Marx, C.3
  • 8
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans WE, Relling MV. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 1999;286:487-491
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 9
    • 35348983887 scopus 로고    scopus 로고
    • International HapMap Consortium
    • Frazer KA, Ballinger DG, et al. International HapMap Consortium. Nature 2007;449:851-861
    • (2007) Nature , vol.449 , pp. 851-861
    • Frazer, K.A.1    Ballinger, D.G.2
  • 10
    • 0033783056 scopus 로고    scopus 로고
    • Mechanism of action of fluoropyrimidines: Relevance to the new developments in colorectal cancer chemotherapy
    • Sobrero A, Guglielmi A, Grossi F, et al. Mechanism of action of fluoropyrimidines: relevance to the new developments in colorectal cancer chemotherapy. Semin Oncol 2000;27(Suppl 10):72-77 (Pubitemid 30781969)
    • (2000) Seminars in Oncology , vol.27 , Issue.5 SUPPL. 10 , pp. 72-77
    • Sobrero, A.1    Guglielmi, A.2    Grossi, F.3    Puglisi, F.4    Aschele, C.5
  • 11
    • 0026540496 scopus 로고
    • Modulation of fluoropyrimidines: Role of dose and schedule of leucovorin administration
    • Zhang ZG, Harstrick A, Rustum YM. Modulation of fluoropyrimidines: role of dose and schedule of leucovorin administration. Semin Oncol 1992;19(Suppl 3):10-15
    • (1992) Semin Oncol , vol.19 , Issue.SUPPL. 3 , pp. 10-15
    • Zhang, Z.G.1    Harstrick, A.2    Rustum, Y.M.3
  • 15
    • 4644252335 scopus 로고    scopus 로고
    • Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: An updated meta-analysis
    • Thirion P, Michiels S, Pignon JP, et al. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: an updated meta-analysis. J Clin Oncol 2004;22:3766-3775
    • (2004) J Clin Oncol , vol.22 , pp. 3766-3775
    • Thirion, P.1    Michiels, S.2    Pignon, J.P.3
  • 19
    • 0032729240 scopus 로고    scopus 로고
    • Clinical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes' B and C carcinoma of the colon: Results from National Surgical Adjuvant Breast and Bowel Project C-04
    • Wolmark N, Rockette H, Mamounas E, et al. Clinical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes' B and C carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project C-04. J Clin Oncol 1999;17:3553-3559 (Pubitemid 29517927)
    • (1999) Journal of Clinical Oncology , vol.17 , Issue.11 , pp. 3553-3559
    • Wolmark, N.1    Rockette, H.2    Mamounas, E.3    Jones, J.4    Wieand, S.5    Wickerham, D.L.6    Bear, H.D.7    Atkins, J.N.8    Dimitrov, N.V.9    Glass, A.G.10    Fisher, E.R.11    Fisher, B.12
  • 20
    • 2542563257 scopus 로고    scopus 로고
    • Pooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: Who benefits and by how much?
    • Gill S, Loprinzi CL, Sargent DJ, et al. Pooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: who benefits and by how much? J Clin Oncol 2004;22:1797-1806
    • (2004) J Clin Oncol , vol.22 , pp. 1797-1806
    • Gill, S.1    Loprinzi, C.L.2    Sargent, D.J.3
  • 22
    • 15744377355 scopus 로고    scopus 로고
    • Phase III Southwest Oncology Group 9415/intergroup 0153 randomized trial of fluorouracil, leucovorin, and levamisole versus fluorouracil continuous infusion and levamisole for adjuvant treatment of stage III and high-risk stage II colon cancer
    • DOI 10.1200/JCO.2005.04.169
    • Poplin EA, Benedetti JK, Estes NC, et al. Phase III Southwest Oncology Group 9415/Intergroup 0153 randomized trial of fluorouracil, leucovorin, and levamisole versus fluorouracil continuous infusion and levamisole for adjuvant treatment of stage III and high-risk stage II colon cancer. J Clin Oncol 2005;23:1819-1825 (Pubitemid 46211360)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.9 , pp. 1819-1825
    • Poplin, E.A.1    Benedetti, J.K.2    Estes, N.C.3    Haller, D.G.4    Mayer, R.J.5    Goldberg, R.M.6    Weiss, G.R.7    Rivkin, S.E.8    Macdonald, J.S.9
  • 23
  • 24
    • 0036875812 scopus 로고    scopus 로고
    • The rational development of capecitabine from the laboratory to the clinic
    • Pentheroudakis G, Twelves C. The rational development of capecitabine from the laboratory to the clinic. Anticancer Res 2002;22:3589-3596 (Pubitemid 36132834)
    • (2002) Anticancer Research , vol.22 , Issue.6 B , pp. 3589-3596
    • Pentheroudakis, G.1    Twelves, C.2
  • 32
    • 0031741679 scopus 로고    scopus 로고
    • Oxaliplatin: A review of preclinical and clinical studies
    • DOI 10.1023/A:1008213732429
    • Raymond E, Chaney SG, Taamma A, Cvitkovic E. Oxaliplatin: a review of preclinical and clinical studies. Ann Oncol 1998;9:1053-1071 (Pubitemid 28518143)
    • (1998) Annals of Oncology , vol.9 , Issue.10 , pp. 1053-1071
    • Raymond, E.1    Chaney, S.G.2    Taamma, A.3    Cvitkovic, E.4
  • 33
    • 0000460127 scopus 로고    scopus 로고
    • Oxaliplatin, tetraplatin, cisplatin, and carboplatin: Spectrum of activity in drug-resistant cell lines and in the cell lines of the National Cancer Institute's Anticancer Drug Screen panel
    • DOI 10.1016/S0006-2952(97)81490-6, PII S0006295296005618
    • Rixe O, Ortuzar W, Alvarez M, et al. Oxaliplatin, tetraplatin, cisplatin, and carboplatin: spectrum of activity in drug-resistant cell lines and in the cell lines of the National Cancer Institute's Anticancer Drug Screen panel. Biochem Pharmacol 1996;52:1855-1865 (Pubitemid 26419675)
    • (1996) Biochemical Pharmacology , vol.52 , Issue.12 , pp. 1855-1865
    • Rixe, O.1    Ortuzar, W.2    Alvarez, M.3    Parker, R.4    Reed, E.5    Paull, K.6    Fojo, T.7
  • 34
    • 0036052558 scopus 로고    scopus 로고
    • Cellular and molecular pharmacology of oxaliplatin
    • Raymond E, Faivre S, Chaney S, et al. Cellular and molecular pharmacology of oxaliplatin. Mol Cancer Ther 2002;1:227-235
    • (2002) Mol Cancer Ther , vol.1 , pp. 227-235
    • Raymond, E.1    Faivre, S.2    Chaney, S.3
  • 35
    • 0344783805 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients. Digestive Group of French Federation of Cancer Centers
    • Becouarn Y, Ychou M, Ducreux M, et al. Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients. Digestive Group of French Federation of Cancer Centers. J Clin Oncol 1998;16:2739-2744
    • (1998) J Clin Oncol , vol.16 , pp. 2739-2744
    • Becouarn, Y.1    Ychou, M.2    Ducreux, M.3
  • 41
    • 21244450226 scopus 로고    scopus 로고
    • Oxaliplatin/5FU/LV in the adjuvant treatment of stage II and stage III colon cancer: Efficacy results with a median follow-up of 4 years
    • de Gramont A, Boni C, Navarro M, et al. Oxaliplatin/5FU/LV in the adjuvant treatment of stage II and stage III colon cancer: efficacy results with a median follow-up of 4 years. Proc Am Soc Clin Oncol 2005;23:3501
    • (2005) Proc Am Soc Clin Oncol , vol.23 , pp. 3501
    • De Gramont, A.1    Boni, C.2    Navarro, M.3
  • 42
    • 44449091598 scopus 로고    scopus 로고
    • Colon cancer: Update on adjuvant therapy
    • DOI 10.3816/CCC.2008.n.023
    • Mano MS, Duhoux F. Colon cancer: update on adjuvant therapy. Clin Colorectal Cancer 2008;7:178-183 (Pubitemid 351758147)
    • (2008) Clinical Colorectal Cancer , vol.7 , Issue.3 , pp. 178-183
    • Mano, M.S.1    Duhoux, F.2
  • 43
    • 24344476396 scopus 로고    scopus 로고
    • A phase III trial comparing FULV to FULV + oxaliplatin in stage II or III carcinoma of the colon: Results of NSABP protocol C-07
    • abstract 3500
    • Wolmark N, Wieand HS, Keubler JP, et al. A phase III trial comparing FULV to FULV + oxaliplatin in stage II or III carcinoma of the colon: results of NSABP protocol C-07 [abstract 3500]. J Clin Oncol 2005;23:16s
    • (2005) J Clin Oncol , vol.23
    • Wolmark, N.1    Wieand, H.S.2    Keubler, J.P.3
  • 45
    • 0036362181 scopus 로고    scopus 로고
    • Why the epidermal growth factor receptor? the rationale for cancer therapy
    • Baselga J. Why the epidermal growth factor receptor? The rationale for cancer therapy. Oncologist 2002;7(Suppl 4):2-8 (Pubitemid 34977157)
    • (2002) Oncologist , vol.7 , Issue.SUPPL. 4 , pp. 2-8
    • Baselga, J.1
  • 46
    • 0031800885 scopus 로고    scopus 로고
    • EGF, TGF-alpha, and EGF-R in human colorectal adenocarcinoma
    • Messa C, Russo F, Caruso MG, Di Leo A. EGF, TGF-alpha, and EGF-R in human colorectal adenocarcinoma. Acta Oncol 1998;37:285-289
    • (1998) Acta Oncol , vol.37 , pp. 285-289
    • Messa, C.1    Russo, F.2    Caruso, M.G.3    Di Leo, A.4
  • 47
    • 0343819997 scopus 로고    scopus 로고
    • Expression of the tyrosine kinase activity growth factor receptors (EGFR, ERB B2, ERB B3) in colorectal adenocarcinomas and adenomas
    • Porebska I, Harlozinska A, Bojarowski T. Expression of the tyrosine kinase activity growth factor receptors (EGFR, ERBB2, ERBB3) in colorectal adenocarcinomas and adenomas. Tumour Biol 2000;21:105-115 (Pubitemid 30114656)
    • (2000) Tumor Biology , vol.21 , Issue.2 , pp. 105-115
    • Porebska, I.1    Harlozinska, A.2    Bojarowski, T.3
  • 48
    • 0027415146 scopus 로고
    • The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer
    • Mayer A, Takimoto M, Fritz E, et al. The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer. Cancer 1993;71:2454-2460 (Pubitemid 23100476)
    • (1993) Cancer , vol.71 , Issue.8 , pp. 2454-2460
    • Mayer, A.1    Takimoto, M.2    Fritz, E.3    Schellander, G.4    Kofler, K.5    Ludwig, H.6
  • 49
    • 20444421216 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-targeted treatment for advanced colorectal carcinoma
    • DOI 10.1002/cncr.21123
    • Venook AP. Epidermal growth factor receptor-targeted treatment for advanced colorectal carcinoma. Cancer 2005;103:2435-2446 (Pubitemid 40800520)
    • (2005) Cancer , vol.103 , Issue.12 , pp. 2435-2446
    • Venook, A.P.1
  • 51
    • 24944518101 scopus 로고    scopus 로고
    • Gefitinib in colorectal cancer: If wishes were horses
    • DOI 10.1200/JCO.2005.05.904
    • Blanke CD. Gefitinib in colorectal cancer: if wishes were horses. J Clin Oncol 2005;23:5446-5449 (Pubitemid 46300133)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.24 , pp. 5446-5449
    • Blanke, C.D.1
  • 52
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • DOI 10.1200/JCO.2004.10.182
    • Saltz LB, Meropol NJ, Loehrer PJ Sr, et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004;22:1201-1208 (Pubitemid 41079832)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.7 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer Sr., P.J.3    Needle, M.N.4    Kopit, J.5    Mayer, R.J.6
  • 54
    • 34447264101 scopus 로고    scopus 로고
    • Randomized phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (mCRC): The CRYSTAL trial
    • abstract 4000
    • Van Cutsem E, Nowacki M, Lang S. Randomized phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (mCRC): the CRYSTAL trial [abstract 4000]. J Clin Oncol 2007;25:18s
    • (2007) J Clin Oncol , vol.25
    • Van Cutsem, E.1    Nowacki, M.2    Lang, S.3
  • 55
    • 36348990562 scopus 로고    scopus 로고
    • Cetuximab plus 5-FU/FA/oxaliplatin (FOLFOX-4) versus FOLFOX-4 in the first-line treatment of metastatic colorectal cancer (mCRC): OPUS, a randomized phase II study
    • Bokemeyer C, Bondarenko I, Makhson A, et al. Cetuximab plus 5-FU/FA/oxaliplatin (FOLFOX-4) versus FOLFOX-4 in the first-line treatment of metastatic colorectal cancer (mCRC): OPUS, a randomized phase II study. Proc Am Soc Clin Oncol 2007;25:4035
    • (2007) Proc Am Soc Clin Oncol , vol.25 , pp. 4035
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3
  • 56
    • 34748844791 scopus 로고    scopus 로고
    • Cetuximab (C), oxaliplatin (Ox) and fluoropyrimidine (Fp): Toxicity during the first 12 weeks of treatment for the first 804 patients entered into the MRC COIN (CR10) trial
    • abstract 4070
    • Maughan T. Cetuximab (C), oxaliplatin (Ox) and fluoropyrimidine (Fp): toxicity during the first 12 weeks of treatment for the first 804 patients entered into the MRC COIN (CR10) trial [abstract 4070]. J Clin Oncol 2007;25:18s
    • (2007) J Clin Oncol , vol.25
    • Maughan, T.1
  • 57
    • 23844454976 scopus 로고    scopus 로고
    • Safety and efficacy of panitumumab monotherapy in patients with metastatic colorectal cancer
    • abstract 3520
    • Malik I, Hecht JR, Patnaik A, et al. Safety and efficacy of panitumumab monotherapy in patients with metastatic colorectal cancer [abstract 3520]. J Clin Oncol 2005;23:251s
    • (2005) J Clin Oncol , vol.23
    • Malik, I.1    Hecht, J.R.2    Patnaik, A.3
  • 58
    • 67650164152 scopus 로고    scopus 로고
    • A phase 3, multicenter, randomized controlled trial of panitumamab plus best supportive care versus best supportive care alone in patients with metastatic colorectal cancer
    • abstract CP-1 Paper presented at the
    • Peeters M, Van Cutsem E, Siena S, et al. A phase 3, multicenter, randomized controlled trial of panitumamab plus best supportive care versus best supportive care alone in patients with metastatic colorectal cancer [abstract CP-1]. Paper presented at the American Association for Cancer Research (AACR) Meeting April 1-5, 2006, Washington, DC, USA
    • American Association for Cancer Research (AACR) Meeting April 1-5, 2006, Washington, DC, USA
    • Peeters, M.1    Van Cutsem, E.2    Siena, S.3
  • 59
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-1186
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 60
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • DOI 10.1038/nm0603-669
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9:669-676 (Pubitemid 36749215)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.-P.2    Lecouter, J.3
  • 61
    • 67650177717 scopus 로고    scopus 로고
    • Available from: Last accessed 29 Mar 2009
    • AVASTIN™ (Bevacizumab). FDA labelling information. FDA/Center for Drug Evaluation and Research, 2004. Available from: www.fda.gov/cder/foi/ label/2004/125085lbl.pdf. [Last accessed 29 Mar 2009]
    • (2004)
  • 63
    • 21244481589 scopus 로고    scopus 로고
    • High-dose bevacizumab improves survival when combined with FOLFOX4 in previously treated advanced colorectal cancer: Results from the Eastern Cooperative Oncology Group (ECOG) study E3200
    • abstract 2
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al. High-dose bevacizumab improves survival when combined with FOLFOX4 in previously treated advanced colorectal cancer: results from the Eastern Cooperative Oncology Group (ECOG) study E3200 [abstract 2]. Proc Am Soc Clin Oncol 2005;23:1s
    • (2005) Proc Am Soc Clin Oncol , vol.23
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 65
    • 33644586050 scopus 로고    scopus 로고
    • Reversible posterior leukoencephalopathy syndrome and bevacizumab [20]
    • DOI 10.1056/NEJMc052954
    • Glusker P, Recht L, Lane B. Reversible posterior leukoencephalopathy syndrome and bevacizumab. N Engl J Med 2006;354:980-982 (Pubitemid 43313687)
    • (2006) New England Journal of Medicine , vol.354 , Issue.9 , pp. 980-981
    • Glusker, P.1    Recht, L.2    Lane, B.3
  • 66
    • 0038387494 scopus 로고    scopus 로고
    • 5-Fluorouracil: Mechanisms of action and clinical strategies
    • DOI 10.1038/nrc1074
    • Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 2003;3:330-338 (Pubitemid 37328853)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.5 , pp. 330-338
    • Longley, D.B.1    Harkin, D.P.2    Johnston, P.G.3
  • 67
    • 0035750549 scopus 로고    scopus 로고
    • Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy
    • Pullarkat ST, Stoehlmacher J, Ghaderi V, et al. Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy. Pharmacogenomics J 2001;1:65-70 (Pubitemid 33757985)
    • (2001) Pharmacogenomics Journal , vol.1 , Issue.1 , pp. 65-70
    • Pullarkat, S.T.1    Lenz, H.-J.2
  • 68
    • 33646240610 scopus 로고    scopus 로고
    • Thymidylate synthase messenger RNA expression in plasma from patients with colon cancer: Prognostic potential
    • Garcia V, García JM, Peña C, et al. Thymidylate synthase messenger RNA expression in plasma from patients with colon cancer: prognostic potential. Clin Cancer Res 2006;12:2095-2100
    • (2006) Clin Cancer Res , vol.12 , pp. 2095-2100
    • Garcia, V.1    García, J.M.2    Peña, C.3
  • 70
    • 0028940399 scopus 로고
    • Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
    • Johnston PG, Lenz HJ, Leichman CG, et al. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 1995;55:1407-1412
    • (1995) Cancer Res , vol.55 , pp. 1407-1412
    • Johnston, P.G.1    Lenz, H.J.2    Leichman, C.G.3
  • 73
    • 14944380124 scopus 로고    scopus 로고
    • Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity
    • DOI 10.1200/JCO.2005.06.219
    • Jakobsen A, Nielsen JN, Gyldenkerne N, et al. Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity. J Clin Oncol 2005;23:1365-1369 (Pubitemid 46260023)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.7 , pp. 1365-1369
    • Jakobsen, A.1    Nielsen, J.N.2    Gyldenkerne, N.3    Lindeberg, J.4
  • 75
    • 0141507954 scopus 로고    scopus 로고
    • Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene
    • Kawakami K, Watanabe G. Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene. Cancer Res 2003;63:6004-6007 • Discusses the relevance of the double polymorphism in the TS tandem repeat sequence, the SNP and the VNTR, in predicting the clinical outcome of 5-fluorouracil-based chemotherapy. (Pubitemid 37187503)
    • (2003) Cancer Research , vol.63 , Issue.18 , pp. 6004-6007
    • Kawakami, K.1    Watanabe, G.2
  • 76
    • 7244258790 scopus 로고    scopus 로고
    • Single nucleotide polymorphism in the 5′ tandem repeat sequences of Thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients
    • DOI 10.1002/ijc.20487
    • Marcuello E, Altés A, del Rio E, et al. Single nucleotide polymorphism in the 5′ tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients. Int J Cancer 2004;112:733-737 (Pubitemid 39435256)
    • (2004) International Journal of Cancer , vol.112 , Issue.5 , pp. 733-737
    • Marcuello, E.1    Altes, A.2    Del Rio, E.3    Cesar, A.4    Menoyo, A.5    Baiget, M.6
  • 79
    • 50249189069 scopus 로고    scopus 로고
    • Liver-only metastatic colorectal cancer patients and thymidylate synthase polymorphisms for predicting response to 5-fluorouracil-based chemotherapy
    • Graziano F, Ruzzo A, Loupakis F, et al. Liver-only metastatic colorectal cancer patients and thymidylate synthase polymorphisms for predicting response to 5-fluorouracil-based chemotherapy. Br J Cancer 2008;99:716-721
    • (2008) Br J Cancer , vol.99 , pp. 716-721
    • Graziano, F.1    Ruzzo, A.2    Loupakis, F.3
  • 80
    • 3042661971 scopus 로고    scopus 로고
    • Thymidylate synthase gene in pharmacogenetics
    • DOI 10.2174/1570160043377628
    • Kawakami K. Thymidylate synthase gene in pharmacogenetics. Curr Pharmacogenomics 2004;2:137-147 (Pubitemid 38842547)
    • (2004) Current Pharmacogenomics , vol.2 , Issue.2 , pp. 137-147
    • Kawakami, K.1
  • 81
    • 2442480694 scopus 로고    scopus 로고
    • A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels
    • DOI 10.1097/00008571-200405000-00007
    • Mandola MV, Stoehlmacher J, Zhang W, et al. A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels. Pharmacogenet 2004;14:319-327 (Pubitemid 38638919)
    • (2004) Pharmacogenetics , vol.14 , Issue.5 , pp. 319-327
    • Mandola, M.V.1    Stoehlmacher, J.2    Zhang, W.3    Groshen, S.4    Yu, M.C.5    Iqbal, S.6    Lenz, H.-J.7    Ladner, R.D.8
  • 83
    • 44449170247 scopus 로고    scopus 로고
    • Pharmacogenetic approach for capecitabine or 5-fluorouracil selection to be combined with oxaliplatin as first-line chemotherapy in advanced colorectal cancer
    • Martinez-Balibrea E, Abad A, Aranda E, et al. Pharmacogenetic approach for capecitabine or 5-fluorouracil selection to be combined with oxaliplatin as first-line chemotherapy in advanced colorectal cancer. Eur J Cancer 2008;44:1229-1237
    • (2008) Eur J Cancer , vol.44 , pp. 1229-1237
    • Martinez-Balibrea, E.1    Abad, A.2    Aranda, E.3
  • 84
    • 0345596364 scopus 로고    scopus 로고
    • Toxicity of fluorouracil in patients with advanced colorectal cancer: Effect of administration schedule and prognostic factors
    • Meta-analysis Group in Cancer
    • Meta-analysis Group in Cancer. Toxicity of fluorouracil in patients with advanced colorectal cancer: effect of administration schedule and prognostic factors. J Clin Oncol 1998;16:3537-3541
    • (1998) J Clin Oncol , vol.16 , pp. 3537-3541
  • 85
    • 33745927137 scopus 로고    scopus 로고
    • How may anticancer chemotherapy with fluorouracil be individualised?
    • Ploylearmsaeng SA, Fuhr U, Jetter A. How may anticancer chemotherapy with fluorouracil be individualised? Clin Pharmacokinet 2006;45:567-592
    • (2006) Clin Pharmacokinet , vol.45 , pp. 567-592
    • Ploylearmsaeng, S.A.1    Fuhr, U.2    Jetter, A.3
  • 86
    • 1942453306 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil
    • DOI 10.1016/j.ejca.2003.12.004, PII S0959804903010694
    • van Kuilenburg AB. Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil. Eur J Cancer 2004;40:939-950 (Pubitemid 38496249)
    • (2004) European Journal of Cancer , vol.40 , Issue.7 , pp. 939-950
    • Van Kuilenburg, A.B.P.1
  • 87
    • 33845219798 scopus 로고    scopus 로고
    • Clinical relevance of different dihydropyrimidine dehydrogenase gene single nucleotide polymorphisms on 5-fluorouracil tolerance
    • DOI 10.1158/1535-7163.MCT-06-0327
    • Morel A, Boisdron-Celle M, Fey L, et al. Clinical relevance of different dihydropyrimidine dehydrogenase gene single nucleotide polymorphisms on 5-fluorouracil tolerance. Mol Cancer Ther 2006;5:2895-2904 • Evaluation of frequencies and effects of several DPYD SNPs on 5-FU tolerance. (Pubitemid 44849017)
    • (2006) Molecular Cancer Therapeutics , vol.5 , Issue.11 , pp. 2895-2904
    • Morel, A.1    Boisdron-Celle, M.2    Fey, L.3    Soulie, P.4    Craipeau, M.C.5    Traore, S.6    Gamelin, E.7
  • 88
    • 33845804384 scopus 로고    scopus 로고
    • Identification of a novel mutation in the dihydropyrimidine dehydrogenase gene in a patient with a lethal outcome following 5-fluorouracil administration and the determination of its frequency in a population of 500 patients with colorectal carcinoma
    • DOI 10.1016/j.clinbiochem.2006.07.012, PII S000991200600244X
    • Morel A, Boisdron-Celle M, Fey L, et al. Identification of a novel mutation in the dihydropyrimidine dehydrogenase gene in a patient with a lethal outcome following 5-fluorouracil administration and the determination of its frequency in a population of 500 patients with colorectal carcinoma. Clin Biochem 2007;40:11-17 (Pubitemid 46014150)
    • (2007) Clinical Biochemistry , vol.40 , Issue.1-2 , pp. 11-17
    • Morel, A.1    Boisdron-Celle, M.2    Fey, L.3    Laine-Cessac, P.4    Gamelin, E.5
  • 89
    • 1042292043 scopus 로고    scopus 로고
    • Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cell to 5-fluorouracil and methotrexate
    • Sohn KJ, Croxford R, Yates Z, et al. Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. J Natl Cancer Inst 2004;96:134-144 (Pubitemid 38195904)
    • (2004) Journal of the National Cancer Institute , vol.96 , Issue.2 , pp. 134-144
    • Sohn, K.-J.1    Croxford, R.2    Yates, Z.3    Lucock, M.4    Kim, Y.-I.5
  • 90
    • 14944380124 scopus 로고    scopus 로고
    • Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity
    • DOI 10.1200/JCO.2005.06.219
    • Jakobsen A, Nielsen JN, Gyldenkerne N, et al. Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity. J Clin Oncol 2005;23:1365-1369 (Pubitemid 46260023)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.7 , pp. 1365-1369
    • Jakobsen, A.1    Nielsen, J.N.2    Gyldenkerne, N.3    Lindeberg, J.4
  • 91
    • 0037213983 scopus 로고    scopus 로고
    • Cellular determinants of oxaliplatin sensitivity in colon cancer cell lines
    • DOI 10.1016/S0959-8049(02)00411-2, PII S0959804902004112
    • Arnould S, Hennebelle I, Canal P, et al. Cellular determinants of oxaliplatin sensitivity in colon cancer cell lines. Eur J Cancer 2003;39:112-119 (Pubitemid 36005433)
    • (2003) European Journal of Cancer , vol.39 , Issue.1 , pp. 112-119
    • Arnould, S.1    Hennebelle, I.2    Canal, P.3    Bugat, R.4    Guichard, S.5
  • 92
    • 24344479165 scopus 로고    scopus 로고
    • ERCC1 codon 118 polymorphism is a predictive factor for the tumor response to oxaliplatin/5-fluorouracil combination chemotherapy in patients with advanced colorectal cancer
    • DOI 10.1158/1078-0432.CCR-04-2216
    • Viguier J, Boige V, Miquel C, et al. ERCC1 codon 118 polymorphism is a predictive factor for the tumor response to oxaliplatin/5-fluorouracil combination chemotherapy in patients with advanced colorectal cancer. Clin Cancer Res 2005;11:6212-6217 (Pubitemid 41262950)
    • (2005) Clinical Cancer Research , vol.11 , Issue.17 , pp. 6212-6217
    • Viguier, J.1    Boige, V.2    Miquel, C.3    Pocard, M.4    Giraudeau, B.5    Sabourin, J.-C.6    Ducreux, M.7    Sarasin, A.8    Praz, F.9
  • 93
    • 4143107582 scopus 로고    scopus 로고
    • ERCC1 gene polymorphism as a predictor for clinical outcome in advanced colorectal cancer patients treated with platinum-based chemotherapy
    • Park DJ, Zhang W, Stoehlmacher J, et al. ERCC1 gene polymorphism as a predictor for clinical outcome in advanced colorectal cancer patients treated with platinum-based chemotherapy. Clin Adv Hematol Oncol 2003;1:162-166
    • (2003) Clin Adv Hematol Oncol , vol.1 , pp. 162-166
    • Park, D.J.1    Zhang, W.2    Stoehlmacher, J.3
  • 94
    • 3843130823 scopus 로고    scopus 로고
    • A multivariate analysis of genomic polymorphisms: Prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer
    • Stoehlmacher J, Park DJ, Zhang W, et al. A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer. Br J Cancer 2004;91:344-354 (Pubitemid 39037082)
    • (2004) British Journal of Cancer , vol.91 , Issue.2 , pp. 344-354
    • Stoehlmacher, J.1    Park, D.J.2    Zhang, W.3    Yang, D.4    Groshen, S.5    Zahedy, S.6    Lenz, H.-J.7
  • 96
    • 37649009185 scopus 로고    scopus 로고
    • Determination of ERCC2 Lys751Gln and GSTP1 Ile105Val gene polymorphisms in colorectal cancer patients: Relationships with treatment outcome
    • Le Morvan V, Smith D, Laurand A, et al. Determination of ERCC2 Lys751Gln and GSTP1 Ile105Val gene polymorphisms in colorectal cancer patients: relationships with treatment outcome. Pharmacogenomics 2007;8:1693-1703
    • (2007) Pharmacogenomics , vol.8 , pp. 1693-1703
    • Le Morvan, V.1    Smith, D.2    Laurand, A.3
  • 97
    • 39049168449 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in nucleotide excision repair genes XPA, XPD, XPG and ERCC1 in advanced colorectal cancer patients treated with first-line oxaliplatin/fluoropyrimidine
    • DOI 10.1159/000113534
    • Monzo M, Moreno I, Navarro A, et al. Single nucleotide polymorphisms in nucleotide excision repair genes XPA, XPD, XPG and ERCC1 in advanced colorectal cancer patients treated with first-line oxaliplatin/fluoropyrimidine. Oncology 2007;72:364-370 (Pubitemid 351238151)
    • (2007) Oncology , vol.72 , Issue.5-6 , pp. 364-370
    • Monzo, M.1    Moreno, I.2    Navarro, A.3    Ibeas, R.4    Artells, R.5    Gel, B.6    Martinez, F.7    Moreno, J.8    Hernandez, R.9    Navarro-Vigo, M.10
  • 98
    • 33645111448 scopus 로고    scopus 로고
    • Glutathione S-transferase polymorphisms: Cancer incidence and therapy
    • McIlwain CC, Townsend DM, Tew KD. Glutathione S-transferase polymorphisms: cancer incidence and therapy. Oncogene 2006;25:1639-1648
    • (2006) Oncogene , vol.25 , pp. 1639-1648
    • McIlwain, C.C.1    Townsend, D.M.2    Tew, K.D.3
  • 100
    • 53849100996 scopus 로고    scopus 로고
    • GSTP1 Ile105Val polymorphism correlates with progression-free survival in MCRC patients treated with or without irinotecan: A study of the Dutch Colorectal Cancer Group
    • Discusses the impact of the GSTP1 codon 105 polymorphism on the response to irinotecan-based chemotherapy in patients with metastatic CRC
    • Kweekel DM, Koopman M, Antonini NF, et al. GSTP1 Ile105Val polymorphism correlates with progression-free survival in MCRC patients treated with or without irinotecan: a study of the Dutch Colorectal Cancer Group. Br J Cancer 2008;99:1316-1321 • Discusses the impact of the GSTP1 codon 105 polymorphism on the response to irinotecan-based chemotherapy in patients with metastatic CRC.
    • (2008) Br J Cancer , vol.99 , pp. 1316-1321
    • Kweekel, D.M.1    Koopman, M.2    Antonini, N.F.3
  • 101
    • 31444431779 scopus 로고    scopus 로고
    • Polymorphisms of glutathione S-transferases (GST) and thymidylate synthase (TS) - Novel predictors for response and survival in gastric cancer patients
    • DOI 10.1038/sj.bjc.6602891, PII 6602891
    • Goekkurt E, Hoehn S, Wolschke C, et al. Polymorphisms of glutathione S-transferases (GST) and thymidylate synthase (TS)-novel predictors for response and survival in gastric cancer patients. Br J Cancer 2006;94:281-286 (Pubitemid 43151548)
    • (2006) British Journal of Cancer , vol.94 , Issue.2 , pp. 281-286
    • Goekkurt, E.1    Hoehn, S.2    Wolschke, C.3    Wittmer, C.4    Stueber, C.5    Hossfeld, D.K.6    Stoehlmacher, J.7
  • 105
    • 41549134617 scopus 로고    scopus 로고
    • Gilbert's syndrome and irinotecan toxicity: Combination with UDP-glucuronosyltransferase 1A7 variants increases risk
    • Lankisch TO, Schulz C, Zwingers T, et al. Gilbert's syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk. Cancer Epidemiol Biomarkers Prev 2008;17:695-701
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 695-701
    • Lankisch, T.O.1    Schulz, C.2    Zwingers, T.3
  • 106
    • 41549141441 scopus 로고    scopus 로고
    • Irinotecan pharmacogenetics: Influence of pharmacodynamic genes
    • Hoskins JM, Marcuello E, Altes A, et al. Irinotecan pharmacogenetics: influence of pharmacodynamic genes. Clin Cancer Res 2008;14:1788-1796
    • (2008) Clin Cancer Res , vol.14 , pp. 1788-1796
    • Hoskins, J.M.1    Marcuello, E.2    Altes, A.3
  • 107
    • 41149140325 scopus 로고    scopus 로고
    • Pharmacogenetic profiling for cetuximab plus irinotecan therapy in patients with refractory advanced colorectal cancer
    • Graziano F, Ruzzo A, Loupakis F, et al. Pharmacogenetic profiling for cetuximab plus irinotecan therapy in patients with refractory advanced colorectal cancer. J Clin Oncol 2008;26:1427-1434
    • (2008) J Clin Oncol , vol.26 , pp. 1427-1434
    • Graziano, F.1    Ruzzo, A.2    Loupakis, F.3
  • 110
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008;359:1757-1765
    • (2008) N Engl J Med , vol.359 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 111
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado RG, Wolf M, Peeters M, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008;26:1626-1634
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 113
    • 48249145381 scopus 로고    scopus 로고
    • UGT1A1*28 genotype and irinotecan dosage in patients with metastatic colorectal cancer: A Dutch Colorectal Cancer Group study
    • Kweekel DM, Gelderblom H, Van der Straaten T, et al. UGT1A1*28 genotype and irinotecan dosage in patients with metastatic colorectal cancer: a Dutch Colorectal Cancer Group study. Br J Cancer 2008;99:275-282
    • (2008) Br J Cancer , vol.99 , pp. 275-282
    • Kweekel, D.M.1    Gelderblom, H.2    Van Der Straaten, T.3
  • 114
    • 28444480186 scopus 로고    scopus 로고
    • Concordance of pharmacogenetic markers in germline and colorectal tumor DNA
    • DOI 10.2217/14622416.6.8.873
    • Marsh S, Mallon MA, Goodfellow P, et al. Concordance of pharmacogenetic markers in germline and colorectal tumor DNA. Pharmacogenomics 2005;6:873-877 (Pubitemid 41724361)
    • (2005) Pharmacogenomics , vol.6 , Issue.8 , pp. 873-877
    • Marsh, S.1    Mallon, M.A.2    Goodfellow, P.3    McLeod, H.L.4
  • 115
    • 0842268401 scopus 로고    scopus 로고
    • Loss of Heterozygosity at the Thymidylate Synthase (TS) Locus on Chromosome 18 Affects Tumor Response and Survival in Individuals Heterozygous for a 28-bp Polymorphism in the TS Gene
    • DOI 10.1158/1078-0432.CCR-0200-03
    • Uchida K, Hayashi K, Kawakami K, et al. Loss of heterozygosity at the thymidylate synthase (TS) locus on chromosome 18 affects tumor response and survival in individuals heterozygous for a 28-bp polymorphism in the TS gene. Clin Cancer Res 2004;10:433-439 (Pubitemid 38173979)
    • (2004) Clinical Cancer Research , vol.10 , Issue.2 , pp. 433-439
    • Uchida, K.1    Hayashi, K.2    Kawakami, K.3    Schneider, S.4    Yochim, J.M.5    Kuramochi, H.6    Takasaki, K.7    Danenberg, K.D.8    Danenberg, P.V.9
  • 116
    • 0028940399 scopus 로고
    • Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
    • Johnston PG, Lenz HJ, Leichman CG, et al. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 1995;55:1407-1412
    • (1995) Cancer Res , vol.55 , pp. 1407-1412
    • Johnston, P.G.1    Lenz, H.J.2    Leichman, C.G.3
  • 117
    • 45749127481 scopus 로고    scopus 로고
    • Predictive biomarkers of chemotherapy efficacy in colorectal cancer: Results from the UK MRC FOCUS trial
    • Braun MS, Richman SD, Quirke P, et al. Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial. J Clin Oncol 2008;26:2690-2698
    • (2008) J Clin Oncol , vol.26 , pp. 2690-2698
    • Braun, M.S.1    Richman, S.D.2    Quirke, P.3
  • 118
    • 29344443013 scopus 로고    scopus 로고
    • Methylation of the DPYD promoter: An alternative mechanism for dihydropyrimidine dehydrogenase deficiency in cancer patients
    • DOI 10.1158/1078-0432.CCR-05-1520
    • Ezzeldin HH, Lee AM, Mattison LK, et al. Methylation of the DPYD promoter: an alternative mechanism for dihydropyrimidine dehydrogenase deficiency in cancer patients. Clin Cancer Res 2005;11:8699-8705 (Pubitemid 43005919)
    • (2005) Clinical Cancer Research , vol.11 , Issue.24 , pp. 8699-8705
    • Ezzeldin, H.H.1    Lee, A.M.2    Mattison, L.K.3    Diasio, R.B.4
  • 119
    • 33947587702 scopus 로고    scopus 로고
    • Suppression of DPYD expression in RKO Cells via DNA methylation in the regulatory region of the DPYD promoter: A potentially important epigenetic mechanism regulating DPYD expression
    • DOI 10.1139/O07-009
    • Zhang X, Soong R, Wang K, et al. Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression. Biochem Cell Biol 2007;85:337-346 (Pubitemid 47025913)
    • (2007) Biochemistry and Cell Biology , vol.85 , Issue.3 , pp. 337-346
    • Zhang, X.1    Soong, R.2    Wang, K.3    Li, L.4    Davie, J.R.5    Guarcello, V.6    Diasio, R.B.7
  • 120
    • 1442290323 scopus 로고    scopus 로고
    • Thymidylate-synthase expression and prognosis in colorectal cancer: A systematic review and meta-analysis
    • DOI 10.1200/JCO.2004.05.064
    • Popat S, Matakidou A, Houlston RS. Thymidylate synthase expression and prognosis in colorectal cancer: a systematic review and meta-analysis. J Clin Oncol 2004;22:529-536 (Pubitemid 41079782)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.3 , pp. 529-536
    • Popat, S.1    Matakidou, A.2    Houlston, R.S.3
  • 122
    • 59149099636 scopus 로고    scopus 로고
    • Designing pharmacogenetic projects in industry: Practical design perspectives from the Industry Pharmacogenomics Working Group
    • Bromley CM, Close S, Cohen N, et al. Designing pharmacogenetic projects in industry: practical design perspectives from the Industry Pharmacogenomics Working Group. Pharmacogenomics J 2009;9:14-22
    • (2009) Pharmacogenomics J , vol.9 , pp. 14-22
    • Bromley, C.M.1    Close, S.2    Cohen, N.3
  • 123
    • 4544244965 scopus 로고    scopus 로고
    • SNP discovery and typing technologies for pharmacogenomics
    • Twyman RM. SNP discovery and typing technologies for pharmacogenomics. Curr Top Med Chem 2004;4:1423-1431 (Pubitemid 39242883)
    • (2004) Current Topics in Medicinal Chemistry , vol.4 , Issue.13 , pp. 1423-1431
    • Twyman, R.M.1
  • 124
    • 4544367874 scopus 로고    scopus 로고
    • Technology platforms for pharmacogenomic diagnostic assays
    • DOI 10.1038/nrd1496
    • Koch WH. Technology platforms for pharmacogenomic diagnostic assays. Nat Rev Drug Discov 2004;3:749-761 (Pubitemid 39242827)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.9 , pp. 749-761
    • Koch, W.H.1
  • 125
    • 33745962246 scopus 로고    scopus 로고
    • Microelectronic array system for molecular diagnostic genotyping: Nanogen NanoChip 400 and Molecular Biology Workstation
    • DOI 10.1586/14737159.6.3.287
    • Keen-Kim D, Grody WW, Richards CS. Microelectronic array system for molecular diagnostic genotyping: NanogenNanoChip 400 and molecular biology workstation. Expert Rev Mol Diagn 2006;6:287-294 (Pubitemid 44174335)
    • (2006) Expert Review of Molecular Diagnostics , vol.6 , Issue.3 , pp. 287-294
    • Keen-Kim, D.1    Grody, W.W.2    Richards, C.S.3
  • 127
    • 34547590995 scopus 로고    scopus 로고
    • QuickSNP: An automated web server for selection of tagSNPs
    • Grover D, Woodfield AS, Verma R, et al. QuickSNP: an automated web server for selection of tagSNPs. Nucleic Acids Res 2007;35(Web Server issue):W115-20
    • (2007) Nucleic Acids Res , vol.35 , Issue.WEB SERVER ISSUE
    • Grover, D.1    Woodfield, A.S.2    Verma, R.3


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