-
1
-
-
0037421584
-
Inheritance and drug response
-
Weinshilboum, R. Inheritance and drug response. N. Engl. J. Med. 348, 529-537 (2003).
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 529-537
-
-
Weinshilboum, R.1
-
2
-
-
2642570170
-
Moving towards individualized medicine with pharmacogenomics
-
Evans, W. E. & Relling, M. V. Moving towards individualized medicine with pharmacogenomics. Nature 429, 464-468 (2004).
-
(2004)
Nature
, vol.429
, pp. 464-468
-
-
Evans, W.E.1
Relling, M.V.2
-
3
-
-
0032793249
-
Polymorphic human cytochrome P450 enzymes: An opportunity for individualized drug treatment
-
Ingelman-Sundberg, M., Oscarson, M. & McLellan, R. A. Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment. Trends Pharmacol. Sci. 20, 342-349 (1999).
-
(1999)
Trends Pharmacol. Sci.
, vol.20
, pp. 342-349
-
-
Ingelman-Sundberg, M.1
Oscarson, M.2
McLellan, R.A.3
-
4
-
-
0034792584
-
Clinical relevance of genetic polymorphisms in the human CYP2C subfamily
-
Goldstein, J. A. Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. Br. J. Clin. Pharmacol. 52, 349-355 (2001).
-
(2001)
Br. J. Clin. Pharmacol.
, vol.52
, pp. 349-355
-
-
Goldstein, J.A.1
-
5
-
-
0036394942
-
Clinical significance of the cytochrome P450 2C19 genetic polymorphism
-
Desta, Z., Zhao, X., Shin, J. G. & Flockhart, D. A. Clinical significance of the cytochrome P450 2C19 genetic polymorphism. Clin. Pharmacokinet. 41, 913-958 (2002).
-
(2002)
Clin. Pharmacokinet.
, vol.41
, pp. 913-958
-
-
Desta, Z.1
Zhao, X.2
Shin, J.G.3
Flockhart, D.A.4
-
6
-
-
0012304444
-
-
(ed. Pacifici, G. M. & Pelkonen, O.) (Taylor and Francis, London and New York,)
-
Levy, G. N. & Weber W.W. in Interindividual Variability in Human Drug Metabolism (ed. Pacifici, G. M. & Pelkonen, O.) 333-357 (Taylor and Francis, London and New York, 2001).
-
(2001)
Interindividual Variability in Human Drug Metabolism
, pp. 333-357
-
-
Levy, G.N.1
Weber, W.W.2
-
7
-
-
0032921854
-
Methylation pharmacogenetics: Catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase
-
Weinshilboum, R. M., Otterness, D. M. & Szumlanski, C. L. Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Annu. Rev. Pharmacol. Toxicol. 39, 19-52 (1999).
-
(1999)
Annu. Rev. Pharmacol. Toxicol.
, vol.39
, pp. 19-52
-
-
Weinshilboum, R.M.1
Otterness, D.M.2
Szumlanski, C.L.3
-
8
-
-
0038345017
-
Cancer drugs, genetic variation and the glutathione-S-transferase gene family
-
Townsend, D. & Tew, K. Cancer drugs, genetic variation and the glutathione-S-transferase gene family. Am. J. Pharmacogenomics 3, 157-172 (2003).
-
(2003)
Am. J. Pharmacogenomics
, vol.3
, pp. 157-172
-
-
Townsend, D.1
Tew, K.2
-
9
-
-
0242469218
-
Pharmacogenetics of cytochrome p4502D6: Genetic background and clinical implication
-
Cascorbi, I. Pharmacogenetics of cytochrome p4502D6: genetic background and clinical implication. Eur. J. Clin. Invest. 33 (Suppl. 2), 17-22 (2003).
-
(2003)
Eur. J. Clin. Invest.
, vol.33
, Issue.SUPPL. 2
, pp. 17-22
-
-
Cascorbi, I.1
-
10
-
-
0042326159
-
Pharmacogenomic applications in clinical drug development
-
Dracopoli, N. C. Pharmacogenomic applications in clinical drug development. Cancer Chemother. Pharmacol. 52 (Suppl 1), S57-S60 (2003).
-
(2003)
Cancer Chemother. Pharmacol.
, vol.52
, Issue.SUPPL. 1
-
-
Dracopoli, N.C.1
-
11
-
-
4544312232
-
Pharmacogenomics
-
Ross, J. S. et. al. Pharmacogenomics. Adv. Anat. Pathol. 11, 211-220 (2004).
-
(2004)
Adv. Anat. Pathol.
, vol.11
, pp. 211-220
-
-
Ross, J.S.1
-
12
-
-
3543054544
-
Gene-expression patterns in drug resistant acute lymphoblastic leukemia cells and response to treatment
-
Holleman, A. et. al. Gene-expression patterns in drug resistant acute lymphoblastic leukemia cells and response to treatment. N. Engl. J. Med. 351, 533-542 (2004).
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 533-542
-
-
Holleman, A.1
-
13
-
-
0024605518
-
Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS)
-
Newton, C. R. et. al. Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS). Nucleic Acids Res. 17, 2503-2516 (1989).
-
(1989)
Nucleic Acids Res.
, vol.17
, pp. 2503-2516
-
-
Newton, C.R.1
-
14
-
-
0025861818
-
Detection of specific polymerase chain reaction product by utilizing the 5′ - 3′ exonuclease activity of Thermus aquaticus DNA polymerase
-
Holland, P. M., Abramson, R. D., Watson, R. & Gelfand, D. H. Detection of specific polymerase chain reaction product by utilizing the 5′ - 3′ exonuclease activity of Thermus aquaticus DNA polymerase. Proc. Natl Acad. Sci. USA 88, 7276-7280 (1991).
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 7276-7280
-
-
Holland, P.M.1
Abramson, R.D.2
Watson, R.3
Gelfand, D.H.4
-
15
-
-
0032998425
-
Polymorphism identification and quantitative detection of genomic DNA by invasive cleavage of oligonucleotide probes
-
Lyamichev, V. et. al. Polymorphism identification and quantitative detection of genomic DNA by invasive cleavage of oligonucleotide probes. Nature Biotechnol. 17, 292-296 (1999).
-
(1999)
Nature Biotechnol.
, vol.17
, pp. 292-296
-
-
Lyamichev, V.1
-
16
-
-
0025650533
-
A primer-guided nucleotide incorporation assay in the genotyping of apolipoprotein E
-
Syvanen, A. C., Aalto-Setala, K., Harju, L., Kontula, K. & Soderlund, H. A primer-guided nucleotide incorporation assay in the genotyping of apolipoprotein E. Genomics 8, 684-692 (1990).
-
(1990)
Genomics
, vol.8
, pp. 684-692
-
-
Syvanen, A.C.1
Aalto-Setala, K.2
Harju, L.3
Kontula, K.4
Soderlund, H.5
-
17
-
-
0026056970
-
Genetic disease detection and DNA amplification using cloned thermostable ligase
-
Barany, F. Genetic disease detection and DNA amplification using cloned thermostable ligase. Proc. Natl Acad. Sci. USA 1, 189-193 (1991).
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.1
, pp. 189-193
-
-
Barany, F.1
-
18
-
-
0033936872
-
Parallel genotyping of human SNPs using generic high-density oligonucleotide tag arrays
-
Fan, J. B. et. al. Parallel genotyping of human SNPs using generic high-density oligonucleotide tag arrays. Genome Res. 10, 853-860 (2000).
-
(2000)
Genome Res.
, vol.10
, pp. 853-860
-
-
Fan, J.B.1
-
19
-
-
0030890116
-
Single-nucleotide polymorphism identification assays using a thermostable DNA polymerase and delayed extraction MALDI-TOF mass spectrometry
-
Haff, L. A. & Smirnov, I. P. Single-nucleotide polymorphism identification assays using a thermostable DNA polymerase and delayed extraction MALDI-TOF mass spectrometry. Genome Res. 7, 378-388 (1997).
-
(1997)
Genome Res.
, vol.7
, pp. 378-388
-
-
Haff, L.A.1
Smirnov, I.P.2
-
20
-
-
0028001030
-
A method for typing polymorphism at the HLA-A locus using PCR amplification and immobilized oligonucleotide probes
-
Bugawan, T. L., Apple, R. & Erlich, H. A. A method for typing polymorphism at the HLA-A locus using PCR amplification and immobilized oligonucleotide probes. Tissue Antigens 44, 137-147 (1994).
-
(1994)
Tissue Antigens
, vol.44
, pp. 137-147
-
-
Bugawan, T.L.1
Apple, R.2
Erlich, H.A.3
-
21
-
-
0029915406
-
Cystic fibrosis mutation detection by hybridization to light-generated DNA probe arrays
-
Cronin, M. T. et al. Cystic fibrosis mutation detection by hybridization to light-generated DNA probe arrays. Hum Mutat. 7, 244-255 (1996).
-
(1996)
Hum. Mutat.
, vol.7
, pp. 244-255
-
-
Cronin, M.T.1
-
22
-
-
0034212298
-
Suspension arrays for high throughput, multiplexed single nucleotide polymorphism genotyping
-
Armstrong, B., Stewart, M. & Mazumder, A. Suspension arrays for high throughput, multiplexed single nucleotide polymorphism genotyping. Cytometry 40, 102-108 (2000).
-
(2000)
Cytometry
, vol.40
, pp. 102-108
-
-
Armstrong, B.1
Stewart, M.2
Mazumder, A.3
-
23
-
-
0034783988
-
CYP2D6 genotyping with oligonucleotide microarrays and nortriptyline concentrations in geriatric depression
-
Murphy, G. M. Jr et al. CYP2D6 genotyping with oligonucleotide microarrays and nortriptyline concentrations in geriatric depression. Neuropsychopharmacology 25, 737-743 (2001).
-
(2001)
Neuropsychopharmacology
, vol.25
, pp. 737-743
-
-
Murphy Jr., G.M.1
-
24
-
-
0037380942
-
Comparison of two CYP2D6 genotyping methods and assessment of genotype-phenotype relationships
-
Chou, W. H. et. al. Comparison of two CYP2D6 genotyping methods and assessment of genotype-phenotype relationships. Clin Chem. 49, 542-551 (2003).
-
(2003)
Clin. Chem.
, vol.49
, pp. 542-551
-
-
Chou, W.H.1
-
25
-
-
0029748326
-
Parallel human genome analysis: Microarray-based expression monitoring of 1000 genes
-
Schena, M. et al. Parallel human genome analysis: microarray-based expression monitoring of 1000 genes. Proc. Natl Acad. Sci. USA 93, 10614-10619 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 10614-10619
-
-
Schena, M.1
-
26
-
-
0029852580
-
Use of a cDNA microarray to analyse gene expression patterns in human cancer
-
DeRisi, J. et. al. Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nature Genet. 14, 457-460 (1996).
-
(1996)
Nature Genet.
, vol.14
, pp. 457-460
-
-
DeRisi, J.1
-
27
-
-
0034088857
-
A gene expression database for the molecular pharmacology of cancer
-
Scherf, U. et. al. A gene expression database for the molecular pharmacology of cancer. Nature Genet. 24, 236-244 (2000).
-
(2000)
Nature Genet.
, vol.24
, pp. 236-244
-
-
Scherf, U.1
-
28
-
-
0034303643
-
Molecular profiling of human cancer
-
Liotta L. & Petricoin, E. Molecular profiling of human cancer. Nature Rev. Genet. 1, 48-56 (2000).
-
(2000)
Nature Rev. Genet.
, vol.1
, pp. 48-56
-
-
Liotta, L.1
Petricoin, E.2
-
29
-
-
0029782373
-
Genetic tests which identify the principal defects in CYP2C19 responsible for the polymorphism in mephenytoin metabolism
-
Goldstein, J. A. & Blaisdell, J. Genetic tests which identify the principal defects in CYP2C19 responsible for the polymorphism in mephenytoin metabolism. Methods Enzymol. 272, 210-218 (1996).
-
(1996)
Methods Enzymol.
, vol.272
, pp. 210-218
-
-
Goldstein, J.A.1
Blaisdell, J.2
-
30
-
-
0035202021
-
Rapid detection of the C-1496G polymorphism in the CYP2D62 allele
-
Claassen, J. D., Pascoe, N., Schatzberg, A. F. & Murphy, G. M. Jr. Rapid detection of the C-1496G polymorphism in the CYP2D62 allele. Clin. Chem. 47, 2153-2155 (2001).
-
(2001)
Clin. Chem.
, vol.47
, pp. 2153-2155
-
-
Claassen, J.D.1
Pascoe, N.2
Schatzberg, A.F.3
Murphy Jr., G.M.4
-
31
-
-
14744306436
-
Simultaneous amplification and detection of specific DNA sequences
-
Higuchi, R., Dollinger, G., Walsh, P. S. & Griffith, R. Simultaneous amplification and detection of specific DNA sequences. Biotechnology NY 10, 413-417 (1992).
-
(1992)
Biotechnology NY
, vol.10
, pp. 413-417
-
-
Higuchi, R.1
Dollinger, G.2
Walsh, P.S.3
Griffith, R.4
-
32
-
-
0028911538
-
Quantitative detection of reverse transcriptase-PCR products by means of a novel and sensitive DNA stain
-
Schneeberger, C., Speiser, P., Kury, F. & Zeillinger, R. Quantitative detection of reverse transcriptase-PCR products by means of a novel and sensitive DNA stain. PCR Methods Appl. 4, 234-238 (1995).
-
(1995)
PCR Methods Appl.
, vol.4
, pp. 234-238
-
-
Schneeberger, C.1
Speiser, P.2
Kury, F.3
Zeillinger, R.4
-
33
-
-
0033006003
-
Allelic discrimination using fluorogenic probes and the 5′ nuclease assay
-
Livak, K. J. Allelic discrimination using fluorogenic probes and the 5′ nuclease assay. Genet Anal. 14, 143-149 (1999).
-
(1999)
Genet. Anal.
, vol.14
, pp. 143-149
-
-
Livak, K.J.1
-
34
-
-
0033608466
-
Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and disk of bleeding complications
-
Aithal, G. P., Day, C. P., Kesteven, P. J. & Daly, A. K. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and disk of bleeding complications. Lancet 353, 717-719 (1999).
-
(1999)
Lancet
, vol.353
, pp. 717-719
-
-
Aithal, G.P.1
Day, C.P.2
Kesteven, P.J.3
Daly, A.K.4
-
35
-
-
0035043035
-
Fluorescence-based detection of the CETP TaqIB polymorphism: False positives with the TaqMan-based exonuclease assay attributable to a previously unknown gene variant
-
Teupser, D., Rupprecht, W., Lohse, F. & Thiery, J. Fluorescence-based detection of the CETP TaqIB polymorphism: false positives with the TaqMan-based exonuclease assay attributable to a previously unknown gene variant. Clin Chem. 47, 852-857 (2001).
-
(2001)
Clin. Chem.
, vol.47
, pp. 852-857
-
-
Teupser, D.1
Rupprecht, W.2
Lohse, F.3
Thiery, J.4
-
36
-
-
0031451539
-
Real-time fluorescence genotyping of factor V Leiden during rapid-cycle PCR
-
Lay, M. J. & Wittwer, C. T. Real-time fluorescence genotyping of factor V Leiden during rapid-cycle PCR. Clin Chem. 43, 2262-2267 (1997).
-
(1997)
Clin. Chem.
, vol.43
, pp. 2262-2267
-
-
Lay, M.J.1
Wittwer, C.T.2
-
37
-
-
0031695438
-
Homogeneous multiplex genotyping of hemochromatosis mutations with fluorescent hybridization probes
-
Bernard, P. S., Ajioka, R. S., Kushner, J. P. & Wittwer, C. T. Homogeneous multiplex genotyping of hemochromatosis mutations with fluorescent hybridization probes. Am. J. Pathol. 153, 1055-1061 (1998).
-
(1998)
Am. J. Pathol.
, vol.153
, pp. 1055-1061
-
-
Bernard, P.S.1
Ajioka, R.S.2
Kushner, J.P.3
Wittwer, C.T.4
-
38
-
-
0036434235
-
Validation of a new fluorogenic real-time PCR assay for detection of CYP2C9 allelic variants and CYP2C9 allelic distribution in a German population
-
Burian, M., Grosch, S., Tegeder, I. & Geisslinger, G. Validation of a new fluorogenic real-time PCR assay for detection of CYP2C9 allelic variants and CYP2C9 allelic distribution in a German population. Br. J. Clin. Pharmacol. 54, 518-521 (2002).
-
(2002)
Br. J. Clin. Pharmacol.
, vol.54
, pp. 518-521
-
-
Burian, M.1
Grosch, S.2
Tegeder, I.3
Geisslinger, G.4
-
39
-
-
17744376645
-
Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility
-
Wikman, H. et al. Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility. Pharmacogenetics 11, 157-168 (2001).
-
(2001)
Pharmacogenetics
, vol.11
, pp. 157-168
-
-
Wikman, H.1
-
40
-
-
1842781740
-
Thiopurine S-methyltransferase polymorphisms: Efficient screening method for patients considering taking thiopurine drugs
-
Wusk, B. et al. Thiopurine S-methyltransferase polymorphisms: efficient screening method for patients considering taking thiopurine drugs. Eur. J. Clin. Pharmacol. 60, 5-10 (2004).
-
(2004)
Eur. J. Clin. Pharmacol.
, vol.60
, pp. 5-10
-
-
Wusk, B.1
-
41
-
-
0036707748
-
Detection of a novel point mutation of the prothrombin gene at position 20209
-
Warshawsky, I. et al. Detection of a novel point mutation of the prothrombin gene at position 20209. Diagn. Mol. Pathol. 11, 152-156 (2002).
-
(2002)
Diagn. Mol. Pathol.
, vol.11
, pp. 152-156
-
-
Warshawsky, I.1
-
42
-
-
0034783455
-
An unusual melting curve profile in LightCycler multiplex genotyping of the hemochromatosis H63D/C282Y gene mutations
-
Tag, C. G., Gressner, A. M. & Weiskirchen, R. An unusual melting curve profile in LightCycler multiplex genotyping of the hemochromatosis H63D/C282Y gene mutations. Clin. Biochem. 34, 511-515 (2001).
-
(2001)
Clin. Biochem.
, vol.34
, pp. 511-515
-
-
Tag, C.G.1
Gressner, A.M.2
Weiskirchen, R.3
-
43
-
-
12244289276
-
Detection of Francisella tularensis within infected mouse tissues by using a hand-held PCR thermocycler
-
Emanuel, P. A. et al. Detection of Francisella tularensis within infected mouse tissues by using a hand-held PCR thermocycler. J. Clin. Microbiol. 41, 689-693 (2003).
-
(2003)
J. Clin. Microbiol.
, vol.41
, pp. 689-693
-
-
Emanuel, P.A.1
-
44
-
-
0033428098
-
Clinical, genetic, and pharmacogenetic applications of the Invader assay
-
Kwiatkowski, R. W., Lyamichev, V., de Arruda, M. & Neri, B. Clinical, genetic, and pharmacogenetic applications of the Invader assay. Mol. Diagn. 4, 353-364 (1999).
-
(1999)
Mol. Diagn.
, vol.4
, pp. 353-364
-
-
Kwiatkowski, R.W.1
Lyamichev, V.2
de Arruda, M.3
Neri, B.4
-
45
-
-
0036713570
-
Invader technology for DNA and RNA analysis: Principles and applications
-
de Arruda, M, et al. Invader technology for DNA and RNA analysis: principles and applications. Expert Rev. Mol. Diagn. 2, 487-496 (2002).
-
(2002)
Expert Rev. Mol. Diagn.
, vol.2
, pp. 487-496
-
-
de Arruda, M.1
-
46
-
-
0036597896
-
Characterization of cytochrome P450 2D6 alleles using the Invader system
-
Neville, M, et al. Characterization of cytochrome P450 2D6 alleles using the Invader system. Biotechniques. 34 (Suppl.), 40-43 (2002).
-
(2002)
Biotechniques
, vol.34
, Issue.SUPPL.
, pp. 40-43
-
-
Neville, M.1
-
47
-
-
0023022499
-
Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes
-
Saiki, R. K., Bugawan, T. L., Horn, G. T., Mullis, K. B. & Erlich, H. A. Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes. Nature 324, 163-166 (1986).
-
(1986)
Nature
, vol.324
, pp. 163-166
-
-
Saiki, R.K.1
Bugawan, T.L.2
Horn, G.T.3
Mullis, K.B.4
Erlich, H.A.5
-
48
-
-
0035071595
-
Fluorescent microsphere-based readout technology for multiplexed human single nucleotide polymorphism analysis and bacterial identification
-
Ye, F. et al. Fluorescent microsphere-based readout technology for multiplexed human single nucleotide polymorphism analysis and bacterial identification. Hum. Mutat. 17, 305-316 (2001).
-
(2001)
Hum. Mutat.
, vol.17
, pp. 305-316
-
-
Ye, F.1
-
49
-
-
0032892409
-
Single nucleotide polymorphic discrimination by an electronic dot blot assay on semiconductor microchips
-
Gilles, P. N., Wu, D. J., Foster, C. B., Dillon, P. J. & Chanock, S. J. Single nucleotide polymorphic discrimination by an electronic dot blot assay on semiconductor microchips. Nature Biotechnol. 17, 365-370 (1999).
-
(1999)
Nature Biotechnol.
, vol.17
, pp. 365-370
-
-
Gilles, P.N.1
Wu, D.J.2
Foster, C.B.3
Dillon, P.J.4
Chanock, S.J.5
-
50
-
-
84984933234
-
High density synthetic oligonucleotide arrays
-
Lipshutz, R. J., Fodor, S. P., Gingeras, T. R. & Lockhart, D. J. High density synthetic oligonucleotide arrays. Nature Genet. 21 (Suppl. 1), 20-24 (1999).
-
(1999)
Nature Genet.
, vol.21
, Issue.SUPPL. 1
, pp. 20-24
-
-
Lipshutz, R.J.1
Fodor, S.P.2
Gingeras, T.R.3
Lockhart, D.J.4
-
51
-
-
0035092024
-
Flow cytometric platform for high-throughput single nucleotide polymorphism analysis
-
661-666
-
Taylor, J. D. et al. Flow cytometric platform for high-throughput single nucleotide polymorphism analysis. Biotechniques 30, 661-666, 668-669 (2001).
-
(2001)
Biotechniques
, vol.30
, pp. 668-669
-
-
Taylor, J.D.1
-
52
-
-
12144286180
-
Parallel genotyping of over 10,000 SNPs using a one-primer assay on a high-density oligonucleotide array
-
Matsuzai, H. et al. Parallel genotyping of over 10,000 SNPs using a one-primer assay on a high-density oligonucleotide array. Genome Res. 14, 414-425 (2004).
-
(2004)
Genome Res.
, vol.14
, pp. 414-425
-
-
Matsuzai, H.1
-
53
-
-
10744221619
-
Large-scale genotyping of complex DNA
-
Kennedy, G. C. et al. Large-scale genotyping of complex DNA. Nature Biotechnol. 21, 1233-1237 (2003).
-
(2003)
Nature Biotechnol.
, vol.21
, pp. 1233-1237
-
-
Kennedy, G.C.1
-
54
-
-
0035941029
-
Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21
-
Patil, N. et al. Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science 294, 1719-1723 (2001).
-
(2001)
Science
, vol.294
, pp. 1719-1723
-
-
Patil, N.1
-
55
-
-
84881422579
-
-
(ads Wong, S. H., Linder, M. W. & Valdes, R.) (in the press)
-
Koch, W. H. in Clinical Pharmacogenomics (ads Wong, S. H., Linder, M. W. & Valdes, R.) (in the press).
-
Clinical Pharmacogenomics
-
-
Koch, W.H.1
-
56
-
-
0346881255
-
Update on HIV resistance and resistance testing
-
Sebastian, J. & Faruki, H. Update on HIV resistance and resistance testing. Med. Res. Rev. 24, 115-125 (2004).
-
(2004)
Med. Res. Rev.
, vol.24
, pp. 115-125
-
-
Sebastian, J.1
Faruki, H.2
-
57
-
-
0035751937
-
Assessing TP53 status in human tumours to evaluate clinical outcome
-
Soussi, T. & Beroud, C. Assessing TP53 status in human tumours to evaluate clinical outcome. Nature Rev. Cancer 1, 233-240 (2001).
-
(2001)
Nature Rev. Cancer
, vol.1
, pp. 233-240
-
-
Soussi, T.1
Beroud, C.2
-
58
-
-
0043025622
-
Exploiting the p53 pathway for cancer diagnosis and therapy
-
Woods, Y. L. & Lane, D. P. Exploiting the p53 pathway for cancer diagnosis and therapy. Hematol. J. 4, 233-247 (2003).
-
(2003)
Hematol. J.
, vol.4
, pp. 233-247
-
-
Woods, Y.L.1
Lane, D.P.2
-
59
-
-
0035105560
-
The results of colorectal cancer treatment by p53 status: Treatment-specific overview
-
Petersen, S., Thames, H. D., Nieder, C., Petersen, C. & Baumann, M. The results of colorectal cancer treatment by p53 status: treatment-specific overview. Dis. Colon Rectum 44, 322-333 (2001).
-
(2001)
Dis. Colon Rectum
, vol.44
, pp. 322-333
-
-
Petersen, S.1
Thames, H.D.2
Nieder, C.3
Petersen, C.4
Baumann, M.5
-
60
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev, L. T. et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844-848 (2004).
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
-
61
-
-
0033027744
-
High performance DNA sequencing, and the detection of mutations and polymorphisms, on the Clipper sequencer
-
Yager, T. D. et al. High performance DNA sequencing, and the detection of mutations and polymorphisms, on the Clipper sequencer. Electrophoresis 20, 1280-1300 (1999).
-
(1999)
Electrophoresis
, vol.20
, pp. 1280-1300
-
-
Yager, T.D.1
-
62
-
-
0031833296
-
Rapid sequencing of the p53 gene with a new automated DNA sequencer
-
Bharaj, B. S., Angelopoulou, K. & Diamandis, E. P. Rapid sequencing of the p53 gene with a new automated DNA sequencer. Clin. Chem. 44, 1397-1403 (1998).
-
(1998)
Clin. Chem.
, vol.44
, pp. 1397-1403
-
-
Bharaj, B.S.1
Angelopoulou, K.2
Diamandis, E.P.3
-
63
-
-
15844378825
-
Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays
-
Kozel, M. J. et al. Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays. Nature Med. 2, 753-759 (1996).
-
(1996)
Nature Med.
, vol.2
, pp. 753-759
-
-
Kozel, M.J.1
-
64
-
-
18744366039
-
Clinical application of oligonucleotide probe array for full-length gene sequencing of TP53 in colon cancer
-
Takahashi, Y. et al. Clinical application of oligonucleotide probe array for full-length gene sequencing of TP53 in colon cancer. Oncology 64, 54-60 (2003).
-
(2003)
Oncology
, vol.64
, pp. 54-60
-
-
Takahashi, Y.1
-
65
-
-
0034657333
-
Comparison of TP53 mutations identified by oligonucleotide microarray and conventional DNA sequence analysis
-
Wen, W. H. et al. Comparison of TP53 mutations identified by oligonucleotide microarray and conventional DNA sequence analysis. Cancer Res. 60, 2716-2722 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 2716-2722
-
-
Wen, W.H.1
-
66
-
-
1542290446
-
Expression Profiling - Best practices for data generation and interpretation in clinical trials
-
The Tumor Analysis Best Practices Working Group
-
The Tumor Analysis Best Practices Working Group. Expression Profiling - best practices for data generation and interpretation in clinical trials. Nature Rev. Genet. 5, 229-237 (2004).
-
(2004)
Nature Rev. Genet.
, vol.5
, pp. 229-237
-
-
-
67
-
-
0141871186
-
-
(ads Parmigiani, G., Garrett, E., Irizarry, R. & Zeger, S.) (Springer, New York,)
-
Parmigiani, G., Garrett, E., Irizarry, R. & Zeger, S. in The Analysis of Gene Expression Data, (ads Parmigiani, G., Garrett, E., Irizarry, R. & Zeger, S.) 1-45 (Springer, New York, 2003).
-
(2003)
The Analysis of Gene Expression Data
, pp. 1-45
-
-
Parmigiani, G.1
Garrett, E.2
Irizarry, R.3
Zeger, S.4
-
68
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch, T. J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl J. Med. 350, 2129-2139 (2004).
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
-
69
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez, J. G. et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304, 1497-1500 (2004).
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
-
70
-
-
0141993002
-
Classification of pediatric acute lymphoblastic leukemia by gene expression profiling
-
Ross, M. E. et al. Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood 102, 2951-2959 (2003).
-
(2003)
Blood
, vol.102
, pp. 2951-2959
-
-
Ross, M.E.1
-
71
-
-
0142094497
-
Gene expression profiling as a tool for the diagnosis of acute leukemias
-
Haferlach, T. et al. Gene expression profiling as a tool for the diagnosis of acute leukemias. Semin. Hematol. 40, 281-295 (2003).
-
(2003)
Semin. Hematol.
, vol.40
, pp. 281-295
-
-
Haferlach, T.1
-
72
-
-
2442551001
-
5-Fluorouracil: Identification of novel downstream mediators of tumor response
-
Boyer, J., Maxwell, P. J., Longley, D. B. & Johnston, P. G. 5-Fluorouracil: identification of novel downstream mediators of tumor response. Anticancer Res. 24, 417-423 (2004).
-
(2004)
Anticancer Res.
, vol.24
, pp. 417-423
-
-
Boyer, J.1
Maxwell, P.J.2
Longley, D.B.3
Johnston, P.G.4
-
73
-
-
0042125511
-
Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer
-
Chang, J. C. et al. Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer. Lancet 362, 362-369 (2003).
-
(2003)
Lancet
, vol.362
, pp. 362-369
-
-
Chang, J.C.1
-
74
-
-
2942578063
-
A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen
-
Ma, X. J. et al. A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. Cancer Cell 5, 607-616 (2004).
-
(2004)
Cancer Cell
, vol.5
, pp. 607-616
-
-
Ma, X.J.1
-
75
-
-
1342346660
-
'Draft' Guidance for Industry: Pharmacogenomics Data Submissions
-
US Department of Health and Human Services Food and Drug Administration, Center for Drug Evaluation and Research, Center for Biologics Evaluation and Research & Center for Devices and Radiological Health. (November,)
-
US Department of Health and Human Services Food and Drug Administration, Center for Drug Evaluation and Research, Center for Biologics Evaluation and Research & Center for Devices and Radiological Health. 'Draft' Guidance for Industry: Pharmacogenomics Data Submissions. (November, 2003).
-
(2003)
-
-
-
76
-
-
0036124107
-
CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
-
Bradford, L. D. CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics 3, 229-243 (2002).
-
(2002)
Pharmacogenomics
, vol.3
, pp. 229-243
-
-
Bradford, L.D.1
-
77
-
-
0024796958
-
The human debrisoquine 4-hydroxylase (CYP2D) locus: Sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene
-
Kimura, S., Umeno, M., Skoda, R. C., Meyer, U. A. & Gonzalez, F. J. The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. Am. J. Hum. Genet. 45, 889-904 (1989).
-
(1989)
Am. J. Hum. Genet.
, vol.45
, pp. 889-904
-
-
Kimura, S.1
Umeno, M.2
Skoda, R.C.3
Meyer, U.A.4
Gonzalez, F.J.5
-
78
-
-
0026629691
-
Evolution of a highly polymorphic human cyochrome P450 gene cluster: CYP2D6
-
Heim, M. H. & Meyer, U. A. Evolution of a highly polymorphic human cyochrome P450 gene cluster: CYP2D6. Genomics 14, 49-58 (1992).
-
(1992)
Genomics
, vol.14
, pp. 49-58
-
-
Heim, M.H.1
Meyer, U.A.2
-
79
-
-
1942421701
-
Pharmacogenetics of cytochrome P450 and its applications in drug therapy: The past, present and future
-
Ingelman-Sundberg, M. Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future. Trends Pharmacol. Sci. 25, 193-200 (2004)
-
(2004)
Trends Pharmacol. Sci.
, vol.25
, pp. 193-200
-
-
Ingelman-Sundberg, M.1
-
80
-
-
0031038038
-
Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
-
Sachse, C., Brockmoller, J., Bauer, S. & Roots, I. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am. J. Hum. Genet. 60, 284-295 (1997).
-
(1997)
Am. J. Hum. Genet.
, vol.60
, pp. 284-295
-
-
Sachse, C.1
Brockmoller, J.2
Bauer, S.3
Roots, I.4
-
81
-
-
0029102348
-
Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology
-
Steen, V. M. et al. Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology. Pharmacogenetics 5, 215-223 (1995).
-
(1995)
Pharmacogenetics
, vol.5
, pp. 215-223
-
-
Steen, V.M.1
-
82
-
-
0007293059
-
Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene
-
Lovlie, R., Daly, A. K., Molven, A., Idle, J. R. & Steen, V. M. Ultrarapid metabolizers of debrisoquine: characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene. FEBS Lett. 392, 30-34 (1996).
-
(1996)
FEBS Lett.
, vol.392
, pp. 30-34
-
-
Lovlie, R.1
Daly, A.K.2
Molven, A.3
Idle, J.R.4
Steen, V.M.5
-
83
-
-
0033595018
-
Rapid p53 sequence analysis in primary lung cancer using an oligonucleotide probe array
-
Ahrendt, S. A. et al. Rapid p53 sequence analysis in primary lung cancer using an oligonucleotide probe array. Proc. Natl Acad. Sci. USA 96, 7382-7387 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 7382-7387
-
-
Ahrendt, S.A.1
|