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Volumn 2, Issue 2, 2004, Pages 137-147

Thymidylate synthase gene in pharmacogenetics

Author keywords

Anti metabolite; Cancer chemotherapy; Gene polymorphism; Pharmacogenetics; Thymidylate synthase

Indexed keywords

ANTINEOPLASTIC AGENT; CAPECITABINE; FLUOROPYRIMIDINE; FLUOROURACIL; FOLIC ACID; FOLINIC ACID; IRINOTECAN; MESSENGER RNA; METHOTREXATE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); OXALIPLATIN; PEMETREXED; RALTITREXED; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR;

EID: 3042661971     PISSN: 15701603     EISSN: None     Source Type: Journal    
DOI: 10.2174/1570160043377628     Document Type: Review
Times cited : (7)

References (79)
  • 1
    • 0031725620 scopus 로고    scopus 로고
    • Thymine Metabolism and Thymineless Death in Prokaryotes and Eukaryotes
    • Ahmad, S. I.; Kirk, S. H. and Eisenstark, A. (1998) Thymine Metabolism and Thymineless Death in Prokaryotes and Eukaryotes. Annu. Rev. Microbiol. 52, 591-625.
    • (1998) Annu. Rev. Microbiol. , vol.52 , pp. 591-625
    • Ahmad, S.I.1    Kirk, S.H.2    Eisenstark, A.3
  • 3
    • 0027081148 scopus 로고
    • A Naturally Occurring Tyrosine to Histidine Replacement at Residue 33 of Human Thymidylate Synthase Confers Resistance to 5-fluoro-2′-deoxyuridine in Mammalian and Bacterial Cells
    • Barbour, K. W.; Hoganson, D. K.; Berger, S. H. and Berger, F. G. (1992) A Naturally Occurring Tyrosine to Histidine Replacement at Residue 33 of Human Thymidylate Synthase Confers Resistance to 5-fluoro-2′-deoxyuridine in Mammalian and Bacterial Cells. Mol. Pharmacol. 42, 242-248.
    • (1992) Mol. Pharmacol. , vol.42 , pp. 242-248
    • Barbour, K.W.1    Hoganson, D.K.2    Berger, S.H.3    Berger, F.G.4
  • 4
    • 0022344622 scopus 로고
    • Thymidylate Synthase Overproduction and Gene Amplification in Fluorodeoxyuridine-resistant Human Cells
    • Berger, S. H.; Jenh, C. H.; Johnson, L. F. and Berger, F. G. (1985) Thymidylate Synthase Overproduction and Gene Amplification in Fluorodeoxyuridine-resistant Human Cells. Mol. Pharmacol. 28, 461-467.
    • (1985) Mol. Pharmacol. , vol.28 , pp. 461-467
    • Berger, S.H.1    Jenh, C.H.2    Johnson, L.F.3    Berger, F.G.4
  • 5
    • 0037386688 scopus 로고    scopus 로고
    • Is the Measurement of Thymidylate Synthase to Determine Suitability for Treatment with 5-fluoropyrimidines Ready for Prime Time?
    • Bertino, J. R. and Banerjee, D. (2003) Is the Measurement of Thymidylate Synthase to Determine Suitability for Treatment with 5-fluoropyrimidines Ready for Prime Time? Clin. Cancer Res. 9, 1235-1239.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1235-1239
    • Bertino, J.R.1    Banerjee, D.2
  • 9
    • 0023111335 scopus 로고
    • Thymidylate Synthase Gene Amplification in a Colon Tumor Resistant to Fluoropyrimidine Chemotherapy
    • Clark, J. L.; Berger, S. H.; Mittelman, A. and Berger, F. G. (1987) Thymidylate Synthase Gene Amplification in a Colon Tumor Resistant to Fluoropyrimidine Chemotherapy. Cancer Treat. Rep. 71, 261-265.
    • (1987) Cancer Treat. Rep. , vol.71 , pp. 261-265
    • Clark, J.L.1    Berger, S.H.2    Mittelman, A.3    Berger, F.G.4
  • 10
    • 0037990003 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate Reductase Polymorphism in Advanced Colorectal Cancer: A Novel Genomic Predictor of Clinical Response to Fluoropyrimidine-based Chemotherapy
    • Cohen, V.; Panet-Raymond, V.; Sabbaghian, N.; Morin, I.; Batist, G. and Rozen, R. (2003) Methylenetetrahydrofolate Reductase Polymorphism in Advanced Colorectal Cancer: A Novel Genomic Predictor of Clinical Response to Fluoropyrimidine-based Chemotherapy. Clin. Cancer Res. 9, 1611-1615.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1611-1615
    • Cohen, V.1    Panet-Raymond, V.2    Sabbaghian, N.3    Morin, I.4    Batist, G.5    Rozen, R.6
  • 11
    • 0029052988 scopus 로고
    • Thymidylate Synthase Gene Amplification in Human Colon Cancer Cell Lines Resistant to 5-fluorouracil
    • Copur, S.; Aiba, K.; Drake, J. C.; Allegra, C. J. and Chu, E. (1995) Thymidylate Synthase Gene Amplification in Human Colon Cancer Cell Lines Resistant to 5-fluorouracil. Biochem. Pharmacol. 49, 1419-1426.
    • (1995) Biochem. Pharmacol. , vol.49 , pp. 1419-1426
    • Copur, S.1    Aiba, K.2    Drake, J.C.3    Allegra, C.J.4    Chu, E.5
  • 12
    • 0141426676 scopus 로고    scopus 로고
    • The Influence of Cyclin D1 (CCND1) 870A>G Polymorphism and CCND1-thymidylate Synthase (TS) Gene-gene Interaction on the Outcome of Childhood Acute Lymphoblastic Leukaemia
    • Costea, I.; Moghrabi, A. and Krajinovic, M. (2003) The Influence of Cyclin D1 (CCND1) 870A>G Polymorphism and CCND1-thymidylate Synthase (TS) Gene-gene Interaction on the Outcome of Childhood Acute Lymphoblastic Leukaemia. Pharmacogenetics 13, 577-580.
    • (2003) Pharmacogenetics , vol.13 , pp. 577-580
    • Costea, I.1    Moghrabi, A.2    Krajinovic, M.3
  • 13
    • 0017716458 scopus 로고
    • Thymidylate Synthetase - A Target Enzyme in Cancer Chemotherapy
    • Danenberg, P. V. (1977) Thymidylate Synthetase - A Target Enzyme in Cancer Chemotherapy. Biochim. Biophys. Acta 473, 73-92.
    • (1977) Biochim. Biophys. Acta , vol.473 , pp. 73-92
    • Danenberg, P.V.1
  • 15
    • 0027214923 scopus 로고
    • Variation in Human Thymidylate Synthase is Associated with Resistance to 5-fluoro-2′-deoxyuridine
    • Davis, S. T. and Berger, S. H. (1993) Variation in Human Thymidylate Synthase is Associated with Resistance to 5-fluoro-2′-deoxyuridine. Mol. Pharmacol. 43, 702-708.
    • (1993) Mol. Pharmacol. , vol.43 , pp. 702-708
    • Davis, S.T.1    Berger, S.H.2
  • 16
    • 0023007963 scopus 로고
    • Structure of the Gene for Mouse Thymidylate Synthase. Locations of Introns and Multiple Transcriptional Start Sites
    • Deng, T. L.; Li, D. W.; Jenh, C. H. and Johnson, L. F. (1986) Structure of the Gene for Mouse Thymidylate Synthase. Locations of Introns and Multiple Transcriptional Start Sites. J. Biol. Chem. 261, 16000-16005.
    • (1986) J. Biol. Chem. , vol.261 , pp. 16000-16005
    • Deng, T.L.1    Li, D.W.2    Jenh, C.H.3    Johnson, L.F.4
  • 17
    • 0036939857 scopus 로고    scopus 로고
    • Evaluation of Thymidylate Synthase Protein Expression by Western Blotting and Immunohistochemistry on Human Colon Carcinoma Xenografts in Nude Mice
    • Derenzini, M.; Montanaro, L.; Chilla, A.; Tosti, E.; Ceccarelli, C.; Dall'Olio, F.; Ofner, D. and Trere, D. (2002) Evaluation of Thymidylate Synthase Protein Expression by Western Blotting and Immunohistochemistry on Human Colon Carcinoma Xenografts in Nude Mice. J. Histochem. Cytochem. 50, 1633-1640.
    • (2002) J. Histochem. Cytochem. , vol.50 , pp. 1633-1640
    • Derenzini, M.1    Montanaro, L.2    Chilla, A.3    Tosti, E.4    Ceccarelli, C.5    Dall'Olio, F.6    Ofner, D.7    Trere, D.8
  • 18
    • 0037317435 scopus 로고    scopus 로고
    • Prognosis After Rectal Cancer in Blacks and Whites Participating in Adjuvant Therapy Randomized Trials
    • Dignam, J. J.; Ye, Y.; Colangelo, L.; Smith, R.; Mamounas, E. P.; Wieand, H. S. and Wolmark, N. (2003) Prognosis After Rectal Cancer in Blacks and Whites Participating in Adjuvant Therapy Randomized Trials. J. Clin. Oncol. 21, 413-420.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 413-420
    • Dignam, J.J.1    Ye, Y.2    Colangelo, L.3    Smith, R.4    Mamounas, E.P.5    Wieand, H.S.6    Wolmark, N.7
  • 22
    • 0037946769 scopus 로고    scopus 로고
    • Associations Between Polymorphisms in the Thymidylate Synthase and Serine Hydroxymethyltransferase Genes and Susceptibility to Malignant Lymphoma
    • Hishida, A.; Matsuo, K.; Hamajima, N.; Ito, H.; Ogura, M.; Kagami, Y.; Taji, H.; Morishima, Y.; Emi, N. and Tajima, K. (2003) Associations Between Polymorphisms in the Thymidylate Synthase and Serine Hydroxymethyltransferase Genes and Susceptibility to Malignant Lymphoma. Haematologica 88, 159-166.
    • (2003) Haematologica , vol.88 , pp. 159-166
    • Hishida, A.1    Matsuo, K.2    Hamajima, N.3    Ito, H.4    Ogura, M.5    Kagami, Y.6    Taji, H.7    Morishima, Y.8    Emi, N.9    Tajima, K.10
  • 23
    • 0021802395 scopus 로고
    • Assignment of Human Gene Encoding Thymidylate Synthase to Chromosome 18 Using Interspecific Cell Hybrids Between Thymidylate Synthase-negative Mouse Mutant Cells and Human Diploid Fibroblasts
    • Hori, T.; Ayusawa, D.; Shimizu, K.; Koyama, H. and Seno, T. (1985) Assignment of Human Gene Encoding Thymidylate Synthase to Chromosome 18 Using Interspecific Cell Hybrids Between Thymidylate Synthase-negative Mouse Mutant Cells and Human Diploid Fibroblasts. Somat. Cell Mol. Genet. 11, 277-283.
    • (1985) Somat. Cell Mol. Genet. , vol.11 , pp. 277-283
    • Hori, T.1    Ayusawa, D.2    Shimizu, K.3    Koyama, H.4    Seno, T.5
  • 24
    • 0025083351 scopus 로고
    • Regional Assignment of the Human Thymidylate Synthase (TS) Gene to Chromosome Band 18p11.32 by Nonisotopic In Situ Hybridization
    • Hori, T.; Takahashi, E.; Ayusawa, D.; Takeishi, K.; Kaneda, S. and Seno, T. (1990) Regional Assignment of the Human Thymidylate Synthase (TS) Gene to Chromosome Band 18p11.32 by Nonisotopic In Situ Hybridization. Hum. Genet. 85, 576-580.
    • (1990) Hum. Genet. , vol.85 , pp. 576-580
    • Hori, T.1    Takahashi, E.2    Ayusawa, D.3    Takeishi, K.4    Kaneda, S.5    Seno, T.6
  • 25
    • 0027729193 scopus 로고
    • Characterization of Regulatory Sequences and Nuclear Factors that Function in Cooperation with the Promoter of the Human Thymidylate Synthase Gene
    • Horie, N.; Chimoto, M.; Nozawa, R. and Takeishi, K. (1993) Characterization of Regulatory Sequences and Nuclear Factors that Function in Cooperation with the Promoter of the Human Thymidylate Synthase Gene. Biochim. Biophys. Acta 1216, 409-416.
    • (1993) Biochim. Biophys. Acta , vol.1216 , pp. 409-416
    • Horie, N.1    Chimoto, M.2    Nozawa, R.3    Takeishi, K.4
  • 26
    • 0029122937 scopus 로고
    • Functional Analysis and DNA Polymorphism of the Tandemly Repeated Sequences in the 5′-terminal Regulatory Region of the Human Gene for Thymidylate Synthase
    • Horie, N.; Aiba, H.; Oguro, K.; Hojo, H. and Takeishi, K. (1995) Functional Analysis and DNA Polymorphism of the Tandemly Repeated Sequences in the 5′-terminal Regulatory Region of the Human Gene for Thymidylate Synthase. Cell Struct. Funct. 20, 191-197.
    • (1995) Cell Struct. Funct. , vol.20 , pp. 191-197
    • Horie, N.1    Aiba, H.2    Oguro, K.3    Hojo, H.4    Takeishi, K.5
  • 27
    • 0030750738 scopus 로고    scopus 로고
    • Identification of Functional Elements in the Promoter Region of the Human Gene for Thymidylate Synthase and Nuclear Factors that Regulate the Expression of the Gene
    • Horie, N. and Takeishi, K. (1997) Identification of Functional Elements in the Promoter Region of the Human Gene for Thymidylate Synthase and Nuclear Factors that Regulate the Expression of the Gene. J. Biol. Chem. 272, 18375-18381.
    • (1997) J. Biol. Chem. , vol.272 , pp. 18375-18381
    • Horie, N.1    Takeishi, K.2
  • 28
    • 0031733821 scopus 로고    scopus 로고
    • Cloning and Characterization of the Promoter Region of Monkey Thymidylate Synthase Gene
    • Horie, N.; Wakabayashi, M.; Katai, H. and Takeishi, K. (1998) Cloning and Characterization of the Promoter Region of Monkey Thymidylate Synthase Gene. Biol. Pharm. Bull. 21, 1020-1023.
    • (1998) Biol. Pharm. Bull. , vol.21 , pp. 1020-1023
    • Horie, N.1    Wakabayashi, M.2    Katai, H.3    Takeishi, K.4
  • 29
    • 0035207084 scopus 로고    scopus 로고
    • Characterization of Nuclear Factors that Bind to the Human Thymidylate Synthase Gene in HL-60 Cells Differentiated by All-trans Retinoic Acid Treatment
    • Horie, N.; Komada, Y.; Ueta, Y.; Suzuki, T.; Nozawa, R. and Takeishi, K. (2001) Characterization of Nuclear Factors that Bind to the Human Thymidylate Synthase Gene in HL-60 Cells Differentiated by All-trans Retinoic Acid Treatment. Biol. Pharm. Bull. 24, 1351-1355.
    • (2001) Biol. Pharm. Bull. , vol.24 , pp. 1351-1355
    • Horie, N.1    Komada, Y.2    Ueta, Y.3    Suzuki, T.4    Nozawa, R.5    Takeishi, K.6
  • 31
    • 0035860142 scopus 로고    scopus 로고
    • A Polymorphism in the Enhancer Region of the Thymidylate Synthase Promoter Influences the Survival of Colorectal Cancer Patients Treated with 5-fluorouracil
    • Iacopetta, B.; Grieu, F.; Joseph, D. and Elsaleh, H. (2001) A Polymorphism in the Enhancer Region of the Thymidylate Synthase Promoter Influences the Survival of Colorectal Cancer Patients Treated with 5-fluorouracil. Br. J. Cancer 85, 827-830.
    • (2001) Br. J. Cancer , vol.85 , pp. 827-830
    • Iacopetta, B.1    Grieu, F.2    Joseph, D.3    Elsaleh, H.4
  • 32
    • 0036765664 scopus 로고    scopus 로고
    • Association of Thymidylate Synthase Gene Polymorphism with its mRNA and Protein Expression and With Prognosis in Gastric Cancer
    • Ishida, Y.; Kawakami, K.; Tanaka, Y.; Kanehira, E.; Omura, K. and Watanabe, G. (2002) Association of Thymidylate Synthase Gene Polymorphism with its mRNA and Protein Expression and With Prognosis in Gastric Cancer. Anticancer Res. 22, 2805-2809.
    • (2002) Anticancer Res. , vol.22 , pp. 2805-2809
    • Ishida, Y.1    Kawakami, K.2    Tanaka, Y.3    Kanehira, E.4    Omura, K.5    Watanabe, G.6
  • 33
    • 0026335113 scopus 로고
    • Production and Characterization of Monoclonal Antibodies that Localize Human Thymidylate Synthase in the Cytoplasm of Human Cells and Tissue
    • Johnston, P. G.; Liang, C. M.; Henry, S.; Chabner, B. A. and Allegra, C. J. (1991) Production and Characterization of Monoclonal Antibodies that Localize Human Thymidylate Synthase in the Cytoplasm of Human Cells and Tissue. Cancer Res. 51, 6668-6676.
    • (1991) Cancer Res. , vol.51 , pp. 6668-6676
    • Johnston, P.G.1    Liang, C.M.2    Henry, S.3    Chabner, B.A.4    Allegra, C.J.5
  • 34
    • 0023134446 scopus 로고
    • Role in Translation of a Triple Tandemly Repeated Sequence in the 5′- Untranslated Region of Human Thymidylate Synthase mRNA
    • Kaneda, S.; Takeishi, K.; Ayusawa, D.; Shimizu, K.; Seno, T. and Altman, S. (1987) Role in Translation of a Triple Tandemly Repeated Sequence in the 5′- Untranslated Region of Human Thymidylate Synthase mRNA. Nucleic Acids Res. 15, 1259-1270.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 1259-1270
    • Kaneda, S.1    Takeishi, K.2    Ayusawa, D.3    Shimizu, K.4    Seno, T.5    Altman, S.6
  • 38
    • 0033427561 scopus 로고    scopus 로고
    • Polymorphic Tandem Repeats in the Thymidylate Synthase Gene is Associated with its Protein Expression in Human Gastrointestinal Cancers
    • Kawakami, K.; Omura, K.; Kanehira, E. and Watanabe, Y. (1999) Polymorphic Tandem Repeats in the Thymidylate Synthase Gene is Associated with its Protein Expression in Human Gastrointestinal Cancers. Anticancer Res. 19, 3249-3252.
    • (1999) Anticancer Res. , vol.19 , pp. 3249-3252
    • Kawakami, K.1    Omura, K.2    Kanehira, E.3    Watanabe, Y.4
  • 39
    • 0035064464 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate Reductase Polymorphism is Associated with Folate Pool in Gastrointestinal Cancer Tissue
    • Kawakami, K.; Omura, K.; Kanehira, E. and Watanabe, G. (2001a) Methylenetetrahydrofolate Reductase Polymorphism is Associated with Folate Pool in Gastrointestinal Cancer Tissue. Anticancer Res. 21, 285-289.
    • (2001) Anticancer Res. , vol.21 , pp. 285-289
    • Kawakami, K.1    Omura, K.2    Kanehira, E.3    Watanabe, G.4
  • 40
    • 0035671827 scopus 로고    scopus 로고
    • Different Lengths of a Polymorphic Repeat Sequence in the Thymidylate Synthase Gene Affect Translational Efficiency but not its Gene Expression
    • Kawakami, K.; Salonga, D.; Park, J. M.; Danenberg, K. D.; Uetake, H.; Brabender, J.; Omura, K.; Watanabe, G. and Danenberg, P. V. (2001b) Different Lengths of a Polymorphic Repeat Sequence in the Thymidylate Synthase Gene Affect Translational Efficiency but not its Gene Expression. Clin. Cancer Res. 7, 4096-4101.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 4096-4101
    • Kawakami, K.1    Salonga, D.2    Park, J.M.3    Danenberg, K.D.4    Uetake, H.5    Brabender, J.6    Omura, K.7    Watanabe, G.8    Danenberg, P.V.9
  • 41
    • 0036868961 scopus 로고    scopus 로고
    • Functional Polymorphism of the Thymidylate Synthase Gene in Colorectal Cancer Accompanied by Frequent Loss of Heterozygosity
    • Kawakami, K.; Ishida, Y.; Danenberg, K. D.; Omura, K.; Watanabe, G. and Danenberg, P. V. (2002) Functional Polymorphism of the Thymidylate Synthase Gene in Colorectal Cancer Accompanied by Frequent Loss of Heterozygosity. Jpn. J. Cancer Res. 93, 1221-1229.
    • (2002) Jpn. J. Cancer Res. , vol.93 , pp. 1221-1229
    • Kawakami, K.1    Ishida, Y.2    Danenberg, K.D.3    Omura, K.4    Watanabe, G.5    Danenberg, P.V.6
  • 42
    • 0141507954 scopus 로고    scopus 로고
    • Identification and Functional Analysis of Single Nucleotide Polymorphism in the Tandem Repeat Sequence of Thymidylate Synthase Gene
    • Kawakami, K. and Watanabe, G. (2003a) Identification and Functional Analysis of Single Nucleotide Polymorphism in the Tandem Repeat Sequence of Thymidylate Synthase Gene. Cancer Res. 63, 6004-6007.
    • (2003) Cancer Res. , vol.63 , pp. 6004-6007
    • Kawakami, K.1    Watanabe, G.2
  • 43
    • 0346103808 scopus 로고    scopus 로고
    • The Folate Pool in Colorectal Cancers is Associated with DNA Hypermethylation and with a Polymorphism in Methylenetetrahydrofolate Reductase
    • Kawakami, K.; Ruszkiewicz, A.; Bennett, G.; Moore, J.; Watanabe, G. and Iacopetta, B. (2003b) The Folate Pool in Colorectal Cancers is Associated with DNA Hypermethylation and with a Polymorphism in Methylenetetrahydrofolate Reductase. Clin. Cancer Res. 9, 5860-5865.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 5860-5865
    • Kawakami, K.1    Ruszkiewicz, A.2    Bennett, G.3    Moore, J.4    Watanabe, G.5    Iacopetta, B.6
  • 44
    • 0037161062 scopus 로고    scopus 로고
    • Polymorphism of the Thymidylate Synthase Gene and Outcome of Acute Lymphoblastic Leukaemia
    • Krajinovic, M., Costea, I. and Chiasson, S. (2002) Polymorphism of the Thymidylate Synthase Gene and Outcome of Acute Lymphoblastic Leukaemia. Lancet 359, 1033-1034.
    • (2002) Lancet , vol.359 , pp. 1033-1034
    • Krajinovic, M.1    Costea, I.2    Chiasson, S.3
  • 45
    • 0037346011 scopus 로고    scopus 로고
    • Thymidylate Synthase Gene Polymorphism and its Association with Relapse in Childhood B-cell Precursor Acute Lymphoblastic Leukemia
    • Lauten, M.; Asgedom, G.; Welte, K., Schrappe, M. and Stanulla, M. (2003) Thymidylate Synthase Gene Polymorphism and its Association with Relapse in Childhood B-cell Precursor Acute Lymphoblastic Leukemia. Haematologica 88, 353-354.
    • (2003) Haematologica , vol.88 , pp. 353-354
    • Lauten, M.1    Asgedom, G.2    Welte, K.3    Schrappe, M.4    Stanulla, M.5
  • 46
    • 0038387494 scopus 로고    scopus 로고
    • 5-fluorouracil: Mechanisms of Action and Clinical Strategies
    • Longley, D. B.; Harkin, D. P. and Johnston, P. G. (2003) 5-fluorouracil: Mechanisms of Action and Clinical Strategies. Nat. Rev. Cancer 3, 330-338.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 330-338
    • Longley, D.B.1    Harkin, D.P.2    Johnston, P.G.3
  • 47
    • 0036102129 scopus 로고    scopus 로고
    • Length Polymorphism of Thymidylate Synthase Regulatory Region in Chinese Populations and Evolution of the Novel Alleles
    • Luo, H. R.; Lu, X. M.; Yao, Y. G.; Horie, N., Takeishi, K.; Jorde, L. B. and Zhang, Y. P. (2002) Length Polymorphism of Thymidylate Synthase Regulatory Region in Chinese Populations and Evolution of the Novel Alleles. Biochem. Genet. 40, 41-51.
    • (2002) Biochem. Genet. , vol.40 , pp. 41-51
    • Luo, H.R.1    Lu, X.M.2    Yao, Y.G.3    Horie, N.4    Takeishi, K.5    Jorde, L.B.6    Zhang, Y.P.7
  • 48
    • 0037567591 scopus 로고    scopus 로고
    • A Novel Single Nucleotide Polymorphism within the 5′ Tandem Repeat Polymorphism of the Thymidylate Synthase Gene Abolishes USF-1 Binding and Alters Transcriptional Activity
    • Mandola, M.V.; Stoehlmacher, J.; Muller-Weeks, S.; Cesarone, G.; Yu, M. C.; Lenz, H. J.; Ladner, R. D. (2003) A Novel Single Nucleotide Polymorphism within the 5′ Tandem Repeat Polymorphism of the Thymidylate Synthase Gene Abolishes USF-1 Binding and Alters Transcriptional Activity. Cancer Res. 63, 2898-2904.
    • (2003) Cancer Res. , vol.63 , pp. 2898-2904
    • Mandola, M.V.1    Stoehlmacher, J.2    Muller-Weeks, S.3    Cesarone, G.4    Yu, M.C.5    Lenz, H.J.6    Ladner, R.D.7
  • 49
    • 0033564283 scopus 로고    scopus 로고
    • Ethnic Variation in the Thymidylate Synthase Enhancer Region Polymorphism Among Caucasian and Asian Populations
    • Marsh, S.; Collie Duguid, E. S.; Li, T.; Liu, X. and McLeod, H. L. (1999) Ethnic Variation in the Thymidylate Synthase Enhancer Region Polymorphism Among Caucasian and Asian Populations. Genomics 58, 310-312.
    • (1999) Genomics , vol.58 , pp. 310-312
    • Marsh, S.1    Collie Duguid, E.S.2    Li, T.3    Liu, X.4    McLeod, H.L.5
  • 51
    • 0035430487 scopus 로고    scopus 로고
    • Polymorphism in the Thymidylate Synthase Promoter Enhancer Region in Colorectal Cancer
    • Marsh, S.; McKay, J. A.; Cassidy, J. and McLeod, H. L. (2001) Polymorphism in the Thymidylate Synthase Promoter Enhancer Region in Colorectal Cancer. Int. J. Oncol. 19, 383-386.
    • (2001) Int. J. Oncol. , vol.19 , pp. 383-386
    • Marsh, S.1    McKay, J.A.2    Cassidy, J.3    McLeod, H.L.4
  • 52
    • 0037036689 scopus 로고    scopus 로고
    • Outcomes and Toxicity in African-american and Caucasian Patients in a Randomized Adjuvant Chemotherapy Trial for Colon Cancer
    • McCollum, A. D.; Catalano, P. J.; Haller, D. G.; Mayer, R. J.; Macdonald, J. S.; Benson, A. B., 3rd and Fuchs, C. S. (2002) Outcomes and Toxicity in African-american and Caucasian Patients in a Randomized Adjuvant Chemotherapy Trial for Colon Cancer. J. Natl. Cancer Inst. 94, 1160-1167.
    • (2002) J. Natl. Cancer Inst. , vol.94 , pp. 1160-1167
    • McCollum, A.D.1    Catalano, P.J.2    Haller, D.G.3    Mayer, R.J.4    Macdonald, J.S.5    Benson III, A.B.6    Fuchs, C.S.7
  • 55
    • 0035864968 scopus 로고    scopus 로고
    • Genetic Changes in Colorectal Carcinoma Tumors with Liver Metastases Analyzed by Comparative Genomic Hybridization and DNA Ploidy
    • Nakao, K.; Shibusawa, M.; Ishihara, A.; Yoshizawa, H.; Tsunoda, A.; Kusano, M.; Kurose, A.; Makita, T. and Sasaki, K. (2001) Genetic Changes in Colorectal Carcinoma Tumors with Liver Metastases Analyzed by Comparative Genomic Hybridization and DNA Ploidy. Cancer 91, 721-726.
    • (2001) Cancer , vol.91 , pp. 721-726
    • Nakao, K.1    Shibusawa, M.2    Ishihara, A.3    Yoshizawa, H.4    Tsunoda, A.5    Kusano, M.6    Kurose, A.7    Makita, T.8    Sasaki, K.9
  • 56
    • 0029149035 scopus 로고
    • The Number of 5-fluoro-2′-deoxyuridine-5′-monophosphate Binding Sites and Reduced Folate Pool in Human Colorectal Carcinoma Tissues: Changes After Tegafur and Uracil Treatment
    • Omura, K.; Kawakami, K.; Kanehira, E.; Nagasato, A.; Kawashima, S.; Tawaraya, K.; Watanabe, S.; Hirano, K.; Shirasaka, T. and Watanabe, Y. (1995) The Number of 5-fluoro-2′-deoxyuridine-5′-monophosphate Binding Sites and Reduced Folate Pool in Human Colorectal Carcinoma Tissues: Changes After Tegafur and Uracil Treatment. Cancer Res. 55, 3897-3901.
    • (1995) Cancer Res. , vol.55 , pp. 3897-3901
    • Omura, K.1    Kawakami, K.2    Kanehira, E.3    Nagasato, A.4    Kawashima, S.5    Tawaraya, K.6    Watanabe, S.7    Hirano, K.8    Shirasaka, T.9    Watanabe, Y.10
  • 57
    • 0036355046 scopus 로고    scopus 로고
    • Thymidylate Synthase Gene Polymorphism Predicts Response to Capecitabine in Advanced Colorectal Cancer
    • Park, D. J.; Stoehlmacher, J.; Zhang, W.; Tsao-Wei, D.; Groshen, S. and Lenz, H. J. (2002) Thymidylate Synthase Gene Polymorphism Predicts Response to Capecitabine in Advanced Colorectal Cancer. Int. J. Colorectal Dis. 17, 46-49.
    • (2002) Int. J. Colorectal Dis. , vol.17 , pp. 46-49
    • Park, D.J.1    Stoehlmacher, J.2    Zhang, W.3    Tsao-Wei, D.4    Groshen, S.5    Lenz, H.J.6
  • 59
    • 0032533513 scopus 로고    scopus 로고
    • Comparative Genomic Hybridization Analysis of Chromosomal Alterations Induced by the Development of Resistance to Thymidylate Synthase Inhibitors
    • Rooney, P. H.; Stevenson, D. A.; Marsh, S.; Johnston, P. G.; Haites, N. E.; Cassidy, J. and McLeod, H. L. (1998) Comparative Genomic Hybridization Analysis of Chromosomal Alterations Induced by the Development of Resistance to Thymidylate Synthase Inhibitors. Cancer Res. 58, 5042-5045.
    • (1998) Cancer Res. , vol.58 , pp. 5042-5045
    • Rooney, P.H.1    Stevenson, D.A.2    Marsh, S.3    Johnston, P.G.4    Haites, N.E.5    Cassidy, J.6    McLeod, H.L.7
  • 62
    • 0034484473 scopus 로고    scopus 로고
    • Failure of Detection of the Tyrosine to Histidine Substitution at the Residue 33 of Thymidylate Synthase in Human Colorectal Cancer. A Preliminary Study
    • Sanguedolce, R.; Alessandro, R.; De Leo, G.; Gullotti, L.; Sanguedolce, F.; Vultaggio, G.; Diana, G.; Cirello, B. and Rausa, L. (2000) Failure of Detection of the Tyrosine to Histidine Substitution at the Residue 33 of Thymidylate Synthase in Human Colorectal Cancer. A Preliminary Study. Anticancer Res. 20, 4347-4350.
    • (2000) Anticancer Res. , vol.20 , pp. 4347-4350
    • Sanguedolce, R.1    Alessandro, R.2    De Leo, G.3    Gullotti, L.4    Sanguedolce, F.5    Vultaggio, G.6    Diana, G.7    Cirello, B.8    Rausa, L.9
  • 63
  • 64
    • 0021428547 scopus 로고
    • Molecular Cloning of Genomic DNA Segments Partially Coding for Human Thymidylate Synthase from the Mouse Cell Transformant
    • Takeishi, K.; Ayusawa, D.; Kaneda, S.; Shimizu, K. and Seno, T. (1984) Molecular Cloning of Genomic DNA Segments Partially Coding for Human Thymidylate Synthase from the Mouse Cell Transformant. J. Biochem. 95, 1477-1483.
    • (1984) J. Biochem. , vol.95 , pp. 1477-1483
    • Takeishi, K.1    Ayusawa, D.2    Kaneda, S.3    Shimizu, K.4    Seno, T.5
  • 66
    • 0024437529 scopus 로고
    • Human Thymidylate Synthase Gene: Isolation of Phage Clones which Cover a Functionally Active Gene and Structural Analysis of the Region Upstream from the Translation Initiation Codon
    • Takeishi, K.; Kaneda, S.; Ayusawa, D.; Shimizu, K.; Gotoh, O. and Seno, T. (1989) Human Thymidylate Synthase Gene: Isolation of Phage Clones which Cover a Functionally Active Gene and Structural Analysis of the Region Upstream from the Translation Initiation Codon. J. Biochem. 106, 575-583.
    • (1989) J. Biochem. , vol.106 , pp. 575-583
    • Takeishi, K.1    Kaneda, S.2    Ayusawa, D.3    Shimizu, K.4    Gotoh, O.5    Seno, T.6
  • 67
    • 0032585642 scopus 로고    scopus 로고
    • Novel Regions of Allelic Deletion on Chromosome 18p in Tumors of the Lung, Brain and Breast
    • Tran, Y.; Benbatoul, K.; Gorse, K.; Rempel, S.; Futreal, A.; Green, M. and Newsham, I. (1998) Novel Regions of Allelic Deletion on Chromosome 18p in Tumors of the Lung, Brain and Breast. Oncogene 17, 3499-3505.
    • (1998) Oncogene , vol.17 , pp. 3499-3505
    • Tran, Y.1    Benbatoul, K.2    Gorse, K.3    Rempel, S.4    Futreal, A.5    Green, M.6    Newsham, I.7
  • 68
    • 0036765747 scopus 로고    scopus 로고
    • Thymidylate Synthase: A Novel Genetic Determinant of Plasma Homocysteine and Folate Levels
    • Trinh, B. N.; Ong, C. N.; Coetzee, G. A.; Yu, M. C. and Laird, P. W. (2002) Thymidylate Synthase: A Novel Genetic Determinant of Plasma Homocysteine and Folate Levels. Hum. Genet. 111, 299-302.
    • (2002) Hum. Genet. , vol.111 , pp. 299-302
    • Trinh, B.N.1    Ong, C.N.2    Coetzee, G.A.3    Yu, M.C.4    Laird, P.W.5
  • 70
    • 0842268401 scopus 로고    scopus 로고
    • Loss of Heterozygosity at the Thymidylate Synthase Locus on Chromosome 18 Affects Tumor Response and Survival in Individuals Heterozygous for a 28-bp Polymorphism in the TS Gene
    • Uchida, K.; Hayashi, K.; Kawakami, K; Schneider, S.; Yochim, J.M.; Kuramochi, H.; Takasaki, K.; Danenberg, K.D. and Danenberg, P.V. (2004) Loss of Heterozygosity at the Thymidylate Synthase Locus on Chromosome 18 Affects Tumor Response and Survival in Individuals Heterozygous for a 28-bp Polymorphism in the TS Gene. Clin. Cancer Res. 10, 433-439.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 433-439
    • Uchida, K.1    Hayashi, K.2    Kawakami, K.3    Schneider, S.4    Yochim, J.M.5    Kuramochi, H.6    Takasaki, K.7    Danenberg, K.D.8    Danenberg, P.V.9
  • 71
    • 0034518362 scopus 로고    scopus 로고
    • Searching Expressed Sequence Tag Databases: Discovery and Confirmation of a Common Polymorphism in the Thymidylate Synthase Gene
    • Ulrich, C. M.; Bigler, J.; Velicer, C. M.; Greene, E. A.; Farin, F. M. and Potter, J. D. (2000) Searching Expressed Sequence Tag Databases: Discovery and Confirmation of a Common Polymorphism in the Thymidylate Synthase Gene. Cancer Epidemiol. Biomarkers Prev. 9, 1381-1385.
    • (2000) Cancer Epidemiol. Biomarkers Prev. , vol.9 , pp. 1381-1385
    • Ulrich, C.M.1    Bigler, J.2    Velicer, C.M.3    Greene, E.A.4    Farin, F.M.5    Potter, J.D.6
  • 72
    • 0037096858 scopus 로고    scopus 로고
    • Thymidylate Synthase Promoter Polymorphism, Interaction with Folate Intake and Risk of Colorectal Adenomas
    • Ulrich, C. M.; Bigler, J.; Bostick, R.; Fosdick, L. and Potter, J. D. (2002) Thymidylate Synthase Promoter Polymorphism, Interaction with Folate Intake and Risk of Colorectal Adenomas. Cancer Res. 62, 3361-3364.
    • (2002) Cancer Res. , vol.62 , pp. 3361-3364
    • Ulrich, C.M.1    Bigler, J.2    Bostick, R.3    Fosdick, L.4    Potter, J.D.5
  • 73
    • 0041524111 scopus 로고    scopus 로고
    • CpG Island Methylator Phenotype is an Independent Predictor of Survival Benefit from 5-fluorouracil in Stage III Colorectal Cancer
    • Van Rijnsoever, M.; Elsaleh, H.; Joseph, D.; McCaul, K. and Iacopetta, B. (2003) CpG Island Methylator Phenotype is an Independent Predictor of Survival Benefit from 5-fluorouracil in Stage III Colorectal Cancer. Clin. Cancer Res. 9, 2898-2903.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 2898-2903
    • Van Rijnsoever, M.1    Elsaleh, H.2    Joseph, D.3    McCaul, K.4    Iacopetta, B.5
  • 74
    • 0032868050 scopus 로고    scopus 로고
    • Thymidylate Synthase: A Target for Combination Therapy and Determinant of Chemotherapeutic Response in Colorectal Cancer
    • Van Triest, B. and Peters, G. J. (1999) Thymidylate Synthase: A Target for Combination Therapy and Determinant of Chemotherapeutic Response in Colorectal Cancer. Oncology 57, 179-194.
    • (1999) Oncology , vol.57 , pp. 179-194
    • Van Triest, B.1    Peters, G.J.2
  • 77
    • 0037451804 scopus 로고    scopus 로고
    • Cancer Pharmacogenomics: Current and Future Applications
    • Watters, J. W. and McLeod, H. L. (2003) Cancer Pharmacogenomics: Current and Future Applications. Biochim. Biophys. Acta 1603, 99-111.
    • (2003) Biochim. Biophys. Acta , vol.1603 , pp. 99-111
    • Watters, J.W.1    McLeod, H.L.2
  • 78
    • 0034805118 scopus 로고    scopus 로고
    • Structural Analysis of cDNA Encoding Thymidylate Synthase in Hepatic Metastases of Human Colorectal Tumors
    • Yousef, A. M.; Davis, R. A.; Sticca, R. P. and Berger, S. H. (2001) Structural Analysis of cDNA Encoding Thymidylate Synthase in Hepatic Metastases of Human Colorectal Tumors. Int. J. Colorectal Dis. 16, 318-325.
    • (2001) Int. J. Colorectal Dis. , vol.16 , pp. 318-325
    • Yousef, A.M.1    Davis, R.A.2    Sticca, R.P.3    Berger, S.H.4


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