Controlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer

Journal of Clinical Oncology

Volumn 15, Issue 1, 1997, Pages 246-250

  O'Connell, M J ^a   Mailliard, J A ^a   Kahn, M J ^a   Macdonald, J S ^a   Haller, D G ^a   Mayer, R J ^a   Wieand, H S ^a  

^a North Central Cancer Treatment Group Rochester   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; FOLINIC ACID;

ADULT; AGED; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER ADJUVANT THERAPY; CANCER SURGERY; CANCER SURVIVAL; CLINICAL TRIAL; COLON CANCER; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MULTIMODALITY CANCER THERAPY; PRIORITY JOURNAL;

EID: 0031022988     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1997.15.1.246     Document Type: Article

References (21)

1. Keyomarsi K, Moran RG: Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells. Cancer Res 46:5229-5235, 1986
2. Rustum YM, Trave F, Zakrzewski SF, et al: Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin. NCI Monogr 5:165-170, 1987
3. Park J, Collins JM, Gazdar AF, et al: Enhancement of fluorinated pyrimidine-induced cytotoxicity by leucovorin in human colorectal carcinoma cell lines. J Natl Cancer Inst 80:1560-1564, 1988
4. Erlichman C, Fine S, Wong A, et al: A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma. J Clin Oncol 6:469-475, 1988
5. Poon MA, O'Connell MJ, Moertel CG, Wieand HS, et al: Biochemical modulation of fluorouracil: Evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. J Clin Oncol 7:1407-1418, 1989
6. Doroshow JH, Bertrand M, Multhauf P, et al: Prospective randomized trial comparing 5-FU versus 5-FU and high dose folinic acid for treatment of advanced colorectal cancer. Proc Am Soc Clin Oncol 6:96, 1987 (abstr)
7. Petrelli N, Herrera L, Rustum Y, et al: A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma. J Clin Oncol 5:1559-1565, 1987
8. Gastrointestinal Tumor Study Group: The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: A prospective randomized phase III. J Clin Oncol 7:1419-1426, 1989
9. Moertel CG, Fleming TR, Macdonald JS, et al: Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med 322:352, 1990
10. O'Connell MJ, Mailliard J, Macdonald JS, et al: An intergroup trial of intensive course 5FU and low-dose leucovorin as surgical adjuvant therapy for high-risk colon cancer. Proc Am Soc Clin Oncol 12:190, 1993 (abstr)
11. Becker R, Chambers J, Wilks A: The New S Language. Wadsworth & Brooks/Cole, Pacific Grove, CA, 1988
12. SAS/STAT User's Guide. Version 6 ed, vol 2. Cary, NC, SAS Institute, 1990
13. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481, 1958
14. Mantel N, Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22:719-748, 1959
15. Cox DR: Regression models and life-tables. J R Stat Soc B 34:187-220, 1972
16. Poon MA, O'Connell MJ, Wieand HS, et al: Biochemical modulation of fluorouracil with leucovorin: Confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer. J Clin Oncol 9:1967-1972, 1991
17. Advanced Colorectal Cancer Meta-Analysis Project: Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate. J Clin Oncol 10:896-903, 1992
18. Buroker TR, O'Connell MJ, Wieand, et al: Randomized comparison of two schedules of fluorouracil and leucovcrin in the treatment of advanced colorectal cancer. J Clin Oncol 12:14-20, 1994
19. Wolmark N, Rockette H, Fisher B, et al: The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: Results from National Surgical Adjuvant Breast and Bowel Project protocol C-03. J Clin Oncol 11:1879-1887, 1993
20. International Multicentre Pooled Analysis of Colon Cancer Trials (IMPACT) investigators: Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. Lancet 345:939-944, 1995
21. Mahood DJ, Dose AM, Loprinzi CL, et al: Inhibition of 5-fluorouracil-induced mucositis by oral cryotherapy. J Clin Oncol 9:449-452, 1991