메뉴 건너뛰기




Volumn 5, Issue 9, 2007, Pages 698-706

Translation of pharmacogenetic knowledge into cancer therapeutics

Author keywords

Cancer therapeutics; Chemotherapy; Pharmacogenetics; Polymorphisms

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER C2; ANTINEOPLASTIC AGENT; ASPARAGINASE; BREAST CANCER RESISTANCE PROTEIN; CISPLATIN; CYTOCHROME P450 2D6; DAUNORUBICIN; DIHYDROPYRIMIDINE DEHYDROGENASE; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; ETOPOSIDE; FLUOROURACIL; FOLINIC ACID; GEFITINIB; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A9; IRINOTECAN; K RAS PROTEIN; MERCAPTOPURINE; MULTIDRUG RESISTANCE PROTEIN 1; PLACEBO; PREDNISOLONE; SULFOTRANSFERASE 1A1; TAMOXIFEN; THIOPURINE METHYLTRANSFERASE; VINCRISTINE; ANTINEMATODAL AGENT;

EID: 38449109707     PISSN: 15430790     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (9)

References (116)
  • 1
    • 43949124373 scopus 로고    scopus 로고
    • Cancer pharmacogenomics: Germline DNA, tumor DNA, or both?
    • In press
    • Cerri E, Falcone A, Innocenti F. Cancer pharmacogenomics: germline DNA, tumor DNA, or both? Pharmacogenomics. In press.
    • Pharmacogenomics
    • Cerri, E.1    Falcone, A.2    Innocenti, F.3
  • 2
    • 0042196122 scopus 로고    scopus 로고
    • Itinorecan pathway genotype analysis to predict pharmacokinetics
    • Mathijssen RH, Marsh S, Karlsson MO, et al. Itinorecan pathway genotype analysis to predict pharmacokinetics. Clin Cancer Res. 2003;9:3246-3253.
    • (2003) Clin Cancer Res , vol.9 , pp. 3246-3253
    • Mathijssen, R.H.1    Marsh, S.2    Karlsson, M.O.3
  • 3
    • 0032748555 scopus 로고    scopus 로고
    • Pharmacogenetics and pharmacogenomics: Why is this relevant to the clinical geneticist?
    • Nebert DW. Pharmacogenetics and pharmacogenomics: why is this relevant to the clinical geneticist? Clin Genet. 1999;56:247-258.
    • (1999) Clin Genet , vol.56 , pp. 247-258
    • Nebert, D.W.1
  • 4
    • 0000616920 scopus 로고
    • Enzymatic deficiency in primaquine-sensitive erythrocytes
    • Carson PE, Alving AS, Flanagan CL, Ickes CE. Enzymatic deficiency in primaquine-sensitive erythrocytes. Science, 1956; 124(3220):484-485.
    • (1956) Science , vol.124 , Issue.3220 , pp. 484-485
    • Carson, P.E.1    Alving, A.S.2    Flanagan, C.L.3    Ickes, C.E.4
  • 5
    • 34250943612 scopus 로고
    • (Enzymatic inactivation of isonicetinic acid hydrizide in human and animal organism
    • Bonicke R, Reif W. (Enzymatic inactivation of isonicetinic acid hydrizide in human and animal organism. J. Naunyn Schmiedeberes Arch Exp Pathol Pharmakol. 1953;220:321-323.
    • (1953) J. Naunyn Schmiedeberes Arch Exp Pathol Pharmakol , vol.220 , pp. 321-323
    • Bonicke, R.1    Reif, W.2
  • 6
    • 49749223413 scopus 로고
    • The familial incidence of low pseudochollnesterase level
    • Lehmann H, Ryan E. The familial incidence of low pseudochollnesterase level Lancet. 1956;271(6934):124.
    • (1956) Lancet , vol.271 , Issue.6934 , pp. 124
    • Lehmann, H.1    Ryan, E.2
  • 7
    • 0006948626 scopus 로고
    • Metabolism of Isoniazid in man as related to the occurrence of peripheral neuritis
    • Hughes HB, Biehl JP, Jones AP, Schmidt LH. Metabolism of Isoniazid in man as related to the occurrence of peripheral neuritis. Am Rev Tuberc. 1954;70:266-273.
    • (1954) Am Rev Tuberc , vol.70 , pp. 266-273
    • Hughes, H.B.1    Biehl, J.P.2    Jones, A.P.3    Schmidt, L.H.4
  • 8
    • 0027409335 scopus 로고
    • Severe 5-fluorourac toxicity in a patient with decreased dihydropyrimidine dehydrogenase activity
    • Lyss AP, Lilenbaum RC, Harris BE, Diasio RB. Severe 5-fluorourac toxicity in a patient with decreased dihydropyrimidine dehydrogenase activity. Cancer Invest. 1993;11:239-240.
    • (1993) Cancer Invest , vol.11 , pp. 239-240
    • Lyss, A.P.1    Lilenbaum, R.C.2    Harris, B.E.3    Diasio, R.B.4
  • 9
    • 0023902287 scopus 로고
    • Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity
    • Diasio RB, Beavers TL, Carpenter JT: Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity. J Clin Invest. 1988;81:47-51.
    • (1988) J Clin Invest , vol.81 , pp. 47-51
    • Diasio, R.B.1    Beavers, T.L.2    Carpenter, J.T.3
  • 10
    • 0025837127 scopus 로고
    • Altered metcaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia
    • Evans WE, Horner M, Chu YQ, Kalwinsky D, Roberts WM. Altered metcaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia. J Pediatr. 1991;119:985-989.
    • (1991) J Pediatr , vol.119 , pp. 985-989
    • Evans, W.E.1    Horner, M.2    Chu, Y.Q.3    Kalwinsky, D.4    Roberts, W.M.5
  • 11
    • 0035871560 scopus 로고    scopus 로고
    • Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine
    • Evans WE, Hon YY, Bomgaars L, et al, Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine. J Clin Oncol. 2001;19:2293-2301.
    • (2001) J Clin Oncol , vol.19 , pp. 2293-2301
    • Evans, W.E.1    Hon, Y.Y.2    Bomgaars, L.3
  • 12
    • 0033486029 scopus 로고    scopus 로고
    • Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus
    • Relling MV, Hancock ML, Rivera GK, et al. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus. J Natl Cancer Inst. 1999;91:2001-2008.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 2001-2008
    • Relling, M.V.1    Hancock, M.L.2    Rivera, G.K.3
  • 13
    • 0018822866 scopus 로고
    • Mercaptopurine Pharmacogenerics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
    • Weinshilboum RM, Sladek SL. Mercaptopurine Pharmacogenerics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet. 1990;32:651-662.
    • (1990) Am J Hum Genet , vol.32 , pp. 651-662
    • Weinshilboum, R.M.1    Sladek, S.L.2
  • 14
    • 0031661579 scopus 로고    scopus 로고
    • UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan
    • Ando Y, Saka H, Asai G, Sugiura S, Shimokata K, Kamataki T. UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan. Ann Oncol. 1998;9:845-847.
    • (1998) Ann Oncol , vol.9 , pp. 845-847
    • Ando, Y.1    Saka, H.2    Asai, G.3    Sugiura, S.4    Shimokata, K.5    Kamataki, T.6
  • 15
    • 0030716924 scopus 로고    scopus 로고
    • Severe CPT-11 toxicity in patients with Gilbert's syndrome: Two case reports
    • Wasserman E, Myara A, Lokiec F, et al. Severe CPT-11 toxicity in patients with Gilbert's syndrome: two case reports. Ann Oncol. 1997;8:1049-1051.
    • (1997) Ann Oncol , vol.8 , pp. 1049-1051
    • Wasserman, E.1    Myara, A.2    Lokiec, F.3
  • 16
    • 2342459714 scopus 로고    scopus 로고
    • Genetic variants in the UDP-glucutonosyltransferase 1A1 gene predict die risk of severe neutropenia of irinotecan
    • Innocenti F, Undevia SD, Iyer L, et al. Genetic variants in the UDP-glucutonosyltransferase 1A1 gene predict die risk of severe neutropenia of irinotecan. J Clin Oncol. 2004:22:1382-1388.
    • (2004) J Clin Oncol , vol.22 , pp. 1382-1388
    • Innocenti, F.1    Undevia, S.D.2    Iyer, L.3
  • 17
    • 0035865322 scopus 로고    scopus 로고
    • A map ofhurnan genome sequence variation containing 1.42 million single nucleotide polymorphisms
    • Sachidanandam R, Weissman D, Schmidt SC, et al. A map ofhurnan genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 2001;409:928-933.
    • (2001) Nature , vol.409 , pp. 928-933
    • Sachidanandam, R.1    Weissman, D.2    Schmidt, S.C.3
  • 18
    • 19944434201 scopus 로고    scopus 로고
    • CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment
    • Ji Y, Desta Z, Stearns V, et al. CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. J Natl Cancer Inst 2005;97:30-39.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 30-39
    • Ji, Y.1    Desta, Z.2    Stearns, V.3
  • 19
    • 33847034287 scopus 로고    scopus 로고
    • The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen
    • Goetz MP, Knox SK, Suman VJ, et al. The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen. Breast Cancer Res Treat. 2007;101:113-121.
    • (2007) Breast Cancer Res Treat , vol.101 , pp. 113-121
    • Goetz, M.P.1    Knox, S.K.2    Suman, V.J.3
  • 20
    • 27644561365 scopus 로고    scopus 로고
    • Genomics: Understanding human diversity
    • Goldstein DB, Cavalleri GL. Genomics: understanding human diversity. Nature 2005;437(7063):1241-1242.
    • (2005) Nature , vol.437 , Issue.7063 , pp. 1241-1242
    • Goldstein, D.B.1    Cavalleri, G.L.2
  • 21
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome, 7063:1299-1320
    • A haplotype map of the human genome. Nature. 2005;437(7063):1299-1320.
    • (2005) Nature , pp. 437
  • 22
    • 33646429761 scopus 로고    scopus 로고
    • p53 mutation and cyclin D1 amplification correlate with cisplatin sensitivity in xenografted human squamous cell carcinomas from head and neck
    • Henriksson E, Baldetorp B, Borg A, et al. p53 mutation and cyclin D1 amplification correlate with cisplatin sensitivity in xenografted human squamous cell carcinomas from head and neck. Acta Oncol. 2006:45:300-305.
    • (2006) Acta Oncol , vol.45 , pp. 300-305
    • Henriksson, E.1    Baldetorp, B.2    Borg, A.3
  • 23
    • 20544434063 scopus 로고    scopus 로고
    • Murine candidate bleomycin induced pulmonary fibrosis susceptibility genes identified by gene expression and sequence analysis of linkage regions
    • Haston CK, Tomko TG, Godin N. Kerckhoff L, Hallett MT: Murine candidate bleomycin induced pulmonary fibrosis susceptibility genes identified by gene expression and sequence analysis of linkage regions. J Med Genet. 2005;42: 464-473.
    • (2005) J Med Genet , vol.42 , pp. 464-473
    • Haston, C.K.1    Tomko, T.G.2    Godin, N.3    Kerckhoff, L.4    Hallett, M.T.5
  • 24
    • 3543054544 scopus 로고    scopus 로고
    • Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment
    • Holleman A, Cheok MH, den Boer ML, et al. Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment. N Engl J Med. 2004;351:533-542.
    • (2004) N Engl J Med , vol.351 , pp. 533-542
    • Holleman, A.1    Cheok, M.H.2    den Boer, M.L.3
  • 25
    • 20244377046 scopus 로고    scopus 로고
    • Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia
    • Lugthart S, Cheok MH, den Boer ML, et al. Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia. Cancer Cell. 2005;7:375-386.
    • (2005) Cancer Cell , vol.7 , pp. 375-386
    • Lugthart, S.1    Cheok, M.H.2    den Boer, M.L.3
  • 26
    • 33644542448 scopus 로고    scopus 로고
    • Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia
    • Schmidt S, Rainer J, Riml S, et al. Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia. Blood. 2006;107:2061-2069.
    • (2006) Blood , vol.107 , pp. 2061-2069
    • Schmidt, S.1    Rainer, J.2    Riml, S.3
  • 28
    • 3042616025 scopus 로고    scopus 로고
    • Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity
    • Dolan ME, Newbold KG, Nagasubramanian R, et al. Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity. Cancer Res. 2004;64:4353-4356.
    • (2004) Cancer Res , vol.64 , pp. 4353-4356
    • Dolan, M.E.1    Newbold, K.G.2    Nagasubramanian, R.3
  • 29
    • 21844478747 scopus 로고    scopus 로고
    • Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
    • Garraway LA, Widlund HR, Rubin MA, et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature. 2005;436(7047):117-122.
    • (2005) Nature , vol.436 , Issue.7047 , pp. 117-122
    • Garraway, L.A.1    Widlund, H.R.2    Rubin, M.A.3
  • 30
    • 33846883741 scopus 로고    scopus 로고
    • Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays
    • Pfeifer D, Pantic M, Skarulla I, et al. Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays. Blood. 2007;109:1202-1210.
    • (2007) Blood , vol.109 , pp. 1202-1210
    • Pfeifer, D.1    Pantic, M.2    Skarulla, I.3
  • 31
    • 33748190743 scopus 로고    scopus 로고
    • Integration of global SNP-based mapping and expression arrays reveals key regions, mechanisms, and genes important in the pathogenesis of multiple myeloma
    • Walker BA, Leone PE, Jenner MW, et al. Integration of global SNP-based mapping and expression arrays reveals key regions, mechanisms, and genes important in the pathogenesis of multiple myeloma. Blood, 2006;108:1733-1743.
    • (2006) Blood , vol.108 , pp. 1733-1743
    • Walker, B.A.1    Leone, P.E.2    Jenner, M.W.3
  • 32
    • 21344437734 scopus 로고    scopus 로고
    • Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis
    • Zhao X, Weir BA, LaFramboise T, et al. Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis. Cancer Res. 2005;65:5561-5570.
    • (2005) Cancer Res , vol.65 , pp. 5561-5570
    • Zhao, X.1    Weir, B.A.2    LaFramboise, T.3
  • 33
    • 0033519986 scopus 로고    scopus 로고
    • High incidence of secondary brain tumours after radiotherapy and antimetabolites
    • Relling MV, Rubnitz JE, Rivera GK, et al. High incidence of secondary brain tumours after radiotherapy and antimetabolites. Lancet. 1999;354:34-39.
    • (1999) Lancet , vol.354 , pp. 34-39
    • Relling, M.V.1    Rubnitz, J.E.2    Rivera, G.K.3
  • 34
    • 0031884608 scopus 로고    scopus 로고
    • Etoposide and antimetabolite pharmacology in patients who develop secondary acute mycloid leukemia
    • Relling MV, Yanishevski Y, Nemec J, et al. Etoposide and antimetabolite pharmacology in patients who develop secondary acute mycloid leukemia. Leukemia. 1998:12:346-352.
    • (1998) Leukemia , vol.12 , pp. 346-352
    • Relling, M.V.1    Yanishevski, Y.2    Nemec, J.3
  • 35
    • 0033135738 scopus 로고    scopus 로고
    • Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia
    • Reing MV, Hancock ML, Boyett JM, Pui CH, Evans WE. Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia. Blood. 1999;93:2817-2823.
    • (1999) Blood , vol.93 , pp. 2817-2823
    • Reing, M.V.1    Hancock, M.L.2    Boyett, J.M.3    Pui, C.H.4    Evans, W.E.5
  • 36
    • 0025331198 scopus 로고
    • Genetic variation in response to 6-mercaptopurine for childhood adute lymphoblastic leukaemia
    • Lennard L, Lilleyman JS, Van Loon J, Weinshilboum RM. Genetic variation in response to 6-mercaptopurine for childhood adute lymphoblastic leukaemia. Lancet. 1990;336:225-229.
    • (1990) Lancet , vol.336 , pp. 225-229
    • Lennard, L.1    Lilleyman, J.S.2    Van Loon, J.3    Weinshilboum, R.M.4
  • 37
    • 20144365645 scopus 로고    scopus 로고
    • Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia
    • Stanulla M, Schaeffeler E, Flohr T, et al. Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia. JAMA. 2005;293:1485-1489.
    • (2005) JAMA , vol.293 , pp. 1485-1489
    • Stanulla, M.1    Schaeffeler, E.2    Flohr, T.3
  • 38
    • 0036009619 scopus 로고    scopus 로고
    • The thiopurine S-methyltransferase gene locus: Implications for clinical pharmacogenomics
    • McLeod HL, Siva C. The thiopurine S-methyltransferase gene locus: implications for clinical pharmacogenomics. Pharmacogenomics. 2002;3:89-98.
    • (2002) Pharmacogenomics , vol.3 , pp. 89-98
    • McLeod, H.L.1    Siva, C.2
  • 39
    • 3242762099 scopus 로고    scopus 로고
    • Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants
    • Schaeffeler E, Fischer C, Brockmeier D, et al. Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants. Pharma-cogenetics. 2004;14:407-417.
    • (2004) Pharma-cogenetics , vol.14 , pp. 407-417
    • Schaeffeler, E.1    Fischer, C.2    Brockmeier, D.3
  • 40
    • 0032693405 scopus 로고    scopus 로고
    • Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferasce (TPMT) in mammalian cells: Mechanism for TPMT protein deficiency inherited by TPMT*2, TPMT*3A, TPMT*3B or TPMT*3C
    • Tai HL, Fessing MY, Bonten EJ, et al. Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferasce (TPMT) in mammalian cells: mechanism for TPMT protein deficiency inherited by TPMT*2, TPMT*3A, TPMT*3B or TPMT*3C. Pharmacogenetics. 1999;9:641-650.
    • (1999) Pharmacogenetics , vol.9 , pp. 641-650
    • Tai, H.L.1    Fessing, M.Y.2    Bonten, E.J.3
  • 41
    • 0030986251 scopus 로고    scopus 로고
    • Enhanced proteolysis of chiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*,3A, TPMT*2): Mechanisms for the genetic polymorphism of TPMT activity
    • Tai HL, Krynetski EY, Schuetz EG, Yanishevski Y, Evans WE. Enhanced proteolysis of chiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*,3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity. Proc Natl Acad Sci U S A. 1997;94:6444-6449.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 6444-6449
    • Tai, H.L.1    Krynetski, E.Y.2    Schuetz, E.G.3    Yanishevski, Y.4    Evans, W.E.5
  • 42
    • 0028826952 scopus 로고
    • Higher activity of polymorphic thiopurine S-methyltransferase in erythrocytes from neonates compared to adults
    • McLeod HL, Krynetski EY, Wilimas JA, Evans WE. Higher activity of polymorphic thiopurine S-methyltransferase in erythrocytes from neonates compared to adults. Pharmacogenetics. 1995;5:281-286.
    • (1995) Pharmacogenetics , vol.5 , pp. 281-286
    • McLeod, H.L.1    Krynetski, E.Y.2    Wilimas, J.A.3    Evans, W.E.4
  • 43
    • 0034162687 scopus 로고    scopus 로고
    • Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2
    • Humerickhouse R, Lohrbarch K, Li L, Boston WF, Dolan ME. Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2. Cancer Res. 2000;60:1189-1192.
    • (2000) Cancer Res , vol.60 , pp. 1189-1192
    • Humerickhouse, R.1    Lohrbarch, K.2    Li, L.3    Boston, W.F.4    Dolan, M.E.5
  • 44
    • 0028867826 scopus 로고
    • The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome
    • Bosma PJ, Chowdbury JR, Bakker C, et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome, N Engl J Med. 1995;333:1171-1175.
    • (1995) N Engl J Med , vol.333 , pp. 1171-1175
    • Bosma, P.J.1    Chowdbury, J.R.2    Bakker, C.3
  • 45
    • 0032519431 scopus 로고    scopus 로고
    • Genetic predisposition i to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes
    • Iyer L, King CD, Whitington PF, et al. Genetic predisposition i to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. J Clin Invest. 1998;101:847-854.
    • (1998) J Clin Invest , vol.101 , pp. 847-854
    • Iyer, L.1    King, C.D.2    Whitington, P.F.3
  • 46
    • 0030030762 scopus 로고    scopus 로고
    • Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome
    • Monaghan G, Ryan M, Seddon R, Hume R, Burchell B. Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome. Lancet. 1996;347:578-581.
    • (1996) Lancet , vol.347 , pp. 578-581
    • Monaghan, G.1    Ryan, M.2    Seddon, R.3    Hume, R.4    Burchell, B.5
  • 47
    • 0032493441 scopus 로고    scopus 로고
    • Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: A balanced polymorphism for regulation of bilirubin metabolism?
    • Beutler E, Gelbart T, Demina A. Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? Proc Natl Acad Sci U S A. 1998;95:8170-8174.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8170-8174
    • Beutler, E.1    Gelbart, T.2    Demina, A.3
  • 48
    • 0035897912 scopus 로고    scopus 로고
    • Genetic determinants of jaundice and gallstones, in haemoglobin E beta thalassaemia
    • Premawardhena A, Fisher CA, Fathiu F, et al. Genetic determinants of jaundice and gallstones, in haemoglobin E beta thalassaemia. Lancet. 2001:357:1945-1946.
    • (2001) Lancet , vol.357 , pp. 1945-1946
    • Premawardhena, A.1    Fisher, C.A.2    Fathiu, F.3
  • 49
    • 0038351780 scopus 로고    scopus 로고
    • The global distribution of length polymorphisms of the promoters of the glucuronosyltransferase 1 gene (UGT1A1): Hematologic and evolutionary implications
    • Premawardhena A, Fisher CA, Liu YT, et al. The global distribution of length polymorphisms of the promoters of the glucuronosyltransferase 1 gene (UGT1A1): hematologic and evolutionary implications. Blood Cells Mol Dis. 2003;31:98-101.
    • (2003) Blood Cells Mol Dis , vol.31 , pp. 98-101
    • Premawardhena, A.1    Fisher, C.A.2    Liu, Y.T.3
  • 51
    • 0032718482 scopus 로고    scopus 로고
    • Variability at the uridine diphosphate glucuronosyltransferase 1A1 promoter in human populations and primates
    • Hall D, Ybazeta G, Destro-Bisol G, Petzi-Erler M, Di Rienzo A. Variability at the uridine diphosphate glucuronosyltransferase 1A1 promoter in human populations and primates. Pharmacogenetics. 1999;9:591-599.
    • (1999) Pharmacogenetics , vol.9 , pp. 591-599
    • Hall, D.1    Ybazeta, G.2    Destro-Bisol, G.3    Petzi-Erler, M.4    Di Rienzo, A.5
  • 52
    • 12244271026 scopus 로고    scopus 로고
    • Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups
    • Innocenti F, Grimsley C, Das S, et al. Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups. Pharmacogenetics. 2002;12:725-733.
    • (2002) Pharmacogenetics , vol.12 , pp. 725-733
    • Innocenti, F.1    Grimsley, C.2    Das, S.3
  • 53
    • 0038275905 scopus 로고    scopus 로고
    • Glucuroniidation of 7-ethyl10-hydroxycamprothecin (SN-38), an active metabolite of irinotecan (CPT-11), by human UGT1A1 variants, G71R, P229Q, and Y486D
    • Jinno H, Tanaka-Kagawa T, Hanioka N, et al. Glucuroniidation of 7-ethyl10-hydroxycamprothecin (SN-38), an active metabolite of irinotecan (CPT-11), by human UGT1A1 variants, G71R, P229Q, and Y486D. Drug Metab Dispos. 2003;31:108-113.
    • (2003) Drug Metab Dispos , vol.31 , pp. 108-113
    • Jinno, H.1    Tanaka-Kagawa, T.2    Hanioka, N.3
  • 54
    • 0031719562 scopus 로고    scopus 로고
    • Neonatal hyperbilirubinemia and mutation of the bilirubin uridine diphosphate-glocuronosyltransferase gene: A common missense mutation among Japanese, Koreans and Chinese
    • Akaba K, Kimura T, Sasaki A, et al. Neonatal hyperbilirubinemia and mutation of the bilirubin uridine diphosphate-glocuronosyltransferase gene: a common missense mutation among Japanese, Koreans and Chinese. Biochem Mol Biol Int. 1998;46:21-26.
    • (1998) Biochem Mol Biol Int , vol.46 , pp. 21-26
    • Akaba, K.1    Kimura, T.2    Sasaki, A.3
  • 55
    • 0033816138 scopus 로고    scopus 로고
    • Variations of the bilirubin uridine-diphosphoglucuronosyl transferase 1A1 gene in healthy Taiwanese
    • Huang CS, Luo GA, Huang ML, Yu SC, Yang SS. Variations of the bilirubin uridine-diphosphoglucuronosyl transferase 1A1 gene in healthy Taiwanese. Pharmacogenetics 2000;10:539-544.
    • (2000) Pharmacogenetics , vol.10 , pp. 539-544
    • Huang, C.S.1    Luo, G.A.2    Huang, M.L.3    Yu, S.C.4    Yang, S.S.5
  • 56
    • 2942527225 scopus 로고    scopus 로고
    • UGT1A1 haplotypes associated with reduced glucuronidation mid increased serum bilirubin in irinotecan-administered Japanese patients with cancer
    • Sai K, Saeki M, Saito Y, et al. UGT1A1 haplotypes associated with reduced glucuronidation mid increased serum bilirubin in irinotecan-administered Japanese patients with cancer. Clin Pharmacol Ther. 2004;75:501-515.
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 501-515
    • Sai, K.1    Saeki, M.2    Saito, Y.3
  • 57
    • 0028022585 scopus 로고
    • Metabolic fate of irinotecan in humans: Correlation of glucuronidation with diarrhea
    • Gupta E, Lestingi TM, Mick R, Ramirez J, Vokes EE, Retain MJ. Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea. Cancer Res. 1994;54:3723-3725.
    • (1994) Cancer Res , vol.54 , pp. 3723-3725
    • Gupta, E.1    Lestingi, T.M.2    Mick, R.3    Ramirez, J.4    Vokes, E.E.5    Retain, M.J.6
  • 58
    • 0032934383 scopus 로고    scopus 로고
    • Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism
    • Iyer L, Hall D, Das S, et al. Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism. Clin Pharmacol Ther. 1999;65: 576-582.
    • (1999) Clin Pharmacol Ther , vol.65 , pp. 576-582
    • Iyer, L.1    Hall, D.2    Das, S.3
  • 59
    • 0036025450 scopus 로고    scopus 로고
    • UGT1A1 *28 polymorphism as a determinant of irinotecan disposition and toxicity
    • Iyer L, Das S, Janisch L, et al. UGT1A1 *28 polymorphism as a determinant of irinotecan disposition and toxicity. Pharmacogenomics J. 2002;2:43-47.
    • (2002) Pharmacogenomics J , vol.2 , pp. 43-47
    • Iyer, L.1    Das, S.2    Janisch, L.3
  • 60
    • 7244258790 scopus 로고    scopus 로고
    • Single nucleotide polymorphism in the 5′ tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients
    • Marcuello E, Altes A, del Rio E, Cesar A, Menoyo A, Baiget M. Single nucleotide polymorphism in the 5′ tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients. Int J Cancer. 2004; 112:733-737.
    • (2004) Int J Cancer , vol.112 , pp. 733-737
    • Marcuello, E.1    Altes, A.2    del Rio, E.3    Cesar, A.4    Menoyo, A.5    Baiget, M.6
  • 61
    • 4143101374 scopus 로고    scopus 로고
    • Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: A molecular and clinical study of 75 patients
    • Rouits E, Boisdron-Celle M, Dumont A, Guerin O, Morel A, Gamelin E. Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: a molecular and clinical study of 75 patients. Clin Cancer Res. 2004;10:5151-5159.
    • (2004) Clin Cancer Res , vol.10 , pp. 5151-5159
    • Rouits, E.1    Boisdron-Celle, M.2    Dumont, A.3    Guerin, O.4    Morel, A.5    Gamelin, E.6
  • 62
    • 33745972934 scopus 로고    scopus 로고
    • The role of UGT1A1*28 polymorphism in the pharmacodynamics and pharmacokinetics of irinotecan in patients with metastatic colorectal cancer
    • Toffoli G, Cecchin E, Corona G, et al. The role of UGT1A1*28 polymorphism in the pharmacodynamics and pharmacokinetics of irinotecan in patients with metastatic colorectal cancer. J Clin Oncol. 2006;24:3061-3068.
    • (2006) J Clin Oncol , vol.24 , pp. 3061-3068
    • Toffoli, G.1    Cecchin, E.2    Corona, G.3
  • 63
    • 3242743744 scopus 로고    scopus 로고
    • Rapid detection of UGT1A1 gene polymorphisms by newly developed Invader assay
    • Hasegawa Y, Sarashina T, Ando M, et al. Rapid detection of UGT1A1 gene polymorphisms by newly developed Invader assay. Clin Chem. 2004;50: 1479-1480.
    • (2004) Clin Chem , vol.50 , pp. 1479-1480
    • Hasegawa, Y.1    Sarashina, T.2    Ando, M.3
  • 64
    • 0032998425 scopus 로고    scopus 로고
    • Polymorphism identification and quantitative detection of genomic DNA by invasive cleavage of oligonucleotide probes
    • Lyamichev V, Mast AL, Hall JG, et al. Polymorphism identification and quantitative detection of genomic DNA by invasive cleavage of oligonucleotide probes. Nat Biotechnol. 1999;17:292-296.
    • (1999) Nat Biotechnol , vol.17 , pp. 292-296
    • Lyamichev, V.1    Mast, A.L.2    Hall, J.G.3
  • 65
    • 0036765309 scopus 로고    scopus 로고
    • Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38)
    • Gagne JF, Montminy V, Belanger P, Journault K. Gaucher G, Guillemette C. Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). Mol Pharmacol. 2002;62:608-617.
    • (2002) Mol Pharmacol , vol.62 , pp. 608-617
    • Gagne, J.F.1    Montminy, V.2    Belanger, P.3    Journault, K.4    Gaucher, G.5    Guillemette, C.6
  • 66
    • 0033600191 scopus 로고    scopus 로고
    • Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus
    • Ciotti M. Basu N, Brangi M, Owens IS. Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus. Biochem Biophys Res Commun. 1999;260:199-202.
    • (1999) Biochem Biophys Res Commun , vol.260 , pp. 199-202
    • Ciotti, M.1    Basu, N.2    Brangi, M.3    Owens, I.S.4
  • 67
    • 0034128936 scopus 로고    scopus 로고
    • Human UDP-glucuronosyltransferases: Metabolism, expression, and disease
    • Tukey RH, Strassburg CP. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol. 2000;40:581-616.
    • (2000) Annu Rev Pharmacol Toxicol , vol.40 , pp. 581-616
    • Tukey, R.H.1    Strassburg, C.P.2
  • 68
    • 12944329893 scopus 로고    scopus 로고
    • UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan
    • Carlini LE, Meropol NJ, Bever J, et al. UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. Clin Cancer Res. 2005;11:1226-1236.
    • (2005) Clin Cancer Res , vol.11 , pp. 1226-1236
    • Carlini, L.E.1    Meropol, N.J.2    Bever, J.3
  • 69
    • 33744804311 scopus 로고    scopus 로고
    • Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinorecan and cisplatin
    • Han JY, Lim HS, Shin ES, et al. Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinorecan and cisplatin. J Clin Oncol. 2006;24:2237-2244.
    • (2006) J Clin Oncol , vol.24 , pp. 2237-2244
    • Han, J.Y.1    Lim, H.S.2    Shin, E.S.3
  • 71
    • 43949104698 scopus 로고    scopus 로고
    • Innocenti F. Undevia S, Chen X, et al. Pharmacogenetic analysis of inter-individual irinotecan (CPT-11) phamacokinetic (PK) variability: evidence for a functional variant of ABCC2. J Clin Oncol. 2004:22(14s):2010.
    • Innocenti F. Undevia S, Chen X, et al. Pharmacogenetic analysis of inter-individual irinotecan (CPT-11) phamacokinetic (PK) variability: evidence for a functional variant of ABCC2. J Clin Oncol. 2004:22(14s):2010.
  • 72
    • 33846012498 scopus 로고    scopus 로고
    • Irinotecan-induced diarrhea: Functional significance of the polymorphic ABCC2 transporter protein
    • de Jong FA, Scott-Horton TJ, Kroetz DL, et al. Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein. Clin Pharmacol Ther. 2007;81:42-49.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 42-49
    • de Jong, F.A.1    Scott-Horton, T.J.2    Kroetz, D.L.3
  • 73
    • 12144286615 scopus 로고    scopus 로고
    • Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan
    • Sai K, Kaniwa N, Itoda M, et al. Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan. Pharmacogenetics. 2003;13:741-757.
    • (2003) Pharmacogenetics , vol.13 , pp. 741-757
    • Sai, K.1    Kaniwa, N.2    Itoda, M.3
  • 74
    • 17144413348 scopus 로고    scopus 로고
    • Pharmacogenctic Profiling across the irinotecan pathway in Asian patients with cancer
    • Zhou Q, Sparreboom A, Tan EH, et al. Pharmacogenctic Profiling across the irinotecan pathway in Asian patients with cancer. Br J Clin Pharmacol. 2005;59:415-424.
    • (2005) Br J Clin Pharmacol , vol.59 , pp. 415-424
    • Zhou, Q.1    Sparreboom, A.2    Tan, E.H.3
  • 75
    • 0031031421 scopus 로고    scopus 로고
    • Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to die 4-hydroxylation of tamoxifen by human liver microsomes
    • Crewe HK, Ellis SW, Lennard MS, Tucker GT. Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to die 4-hydroxylation of tamoxifen by human liver microsomes. Biochem Pharmacol. 1997;53:171-178.
    • (1997) Biochem Pharmacol , vol.53 , pp. 171-178
    • Crewe, H.K.1    Ellis, S.W.2    Lennard, M.S.3    Tucker, G.T.4
  • 76
    • 0038697813 scopus 로고    scopus 로고
    • Quantification of tamoxifen and three metabolites in plasma by high-performance liquid chromatography with fluorescence detection: Application to a clinical tria1
    • Lee KH, Ward BA, Desta Z, Flockhart DA, Jones DR. Quantification of tamoxifen and three metabolites in plasma by high-performance liquid chromatography with fluorescence detection: application to a clinical tria1. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;791:245-253.
    • (2003) J Chromatogr B Analyt Technol Biomed Life Sci , vol.791 , pp. 245-253
    • Lee, K.H.1    Ward, B.A.2    Desta, Z.3    Flockhart, D.A.4    Jones, D.R.5
  • 77
    • 0037094334 scopus 로고    scopus 로고
    • Reverse geometrical selecuvity in glucuronidation and sulfation of cis and trans-4-hydroxytamoxifens by human liver UDP-glucuronosyltransferases and sulfotransferases
    • Nishiyama T, Ogura & Nakano H, et al. Reverse geometrical selecuvity in glucuronidation and sulfation of cis and trans-4-hydroxytamoxifens by human liver UDP-glucuronosyltransferases and sulfotransferases. Biochem Pharmacol. 2002;63:1817-1830.
    • (2002) Biochem Pharmacol , vol.63 , pp. 1817-1830
    • Nishiyama, T.1    Ogura2    Nakano, H.3
  • 78
    • 33344467530 scopus 로고    scopus 로고
    • Sulfation of raloxifene arid 4-hydroxytamoxifen by human cytosolic sulfotransferases
    • Falany JL, Pilloff DE, Leyh TS, Falany CN. Sulfation of raloxifene arid 4-hydroxytamoxifen by human cytosolic sulfotransferases. Drug Metab Dispos. 2006;34:361-368.
    • (2006) Drug Metab Dispos , vol.34 , pp. 361-368
    • Falany, J.L.1    Pilloff, D.E.2    Leyh, T.S.3    Falany, C.N.4
  • 79
    • 0346602691 scopus 로고    scopus 로고
    • Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine
    • Stearns V, Johnson MD, Rae JM, et al. Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. J Natl Cancer Inst. 2003;95:1758-1764.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 1758-1764
    • Stearns, V.1    Johnson, M.D.2    Rae, J.M.3
  • 80
    • 0025168860 scopus 로고
    • Genetic polymorphism of sparteine/debrisoquine oxidation: A reappraisal
    • Lennard MS. Genetic polymorphism of sparteine/debrisoquine oxidation: a reappraisal. Pharmacol Toxicol. 1990;67:273-283.
    • (1990) Pharmacol Toxicol , vol.67 , pp. 273-283
    • Lennard, M.S.1
  • 81
    • 0036124107 scopus 로고    scopus 로고
    • CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
    • Bradford LD. CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics. 2002;3:229-243.
    • (2002) Pharmacogenomics , vol.3 , pp. 229-243
    • Bradford, L.D.1
  • 82
    • 0033461165 scopus 로고    scopus 로고
    • Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data
    • Gaedigk A, Gotschall RR, Forbes NS, Simon SD, Kearns GL, Leeder JS. Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data. Pharmacogenetics. 1999;9:669-682.
    • (1999) Pharmacogenetics , vol.9 , pp. 669-682
    • Gaedigk, A.1    Gotschall, R.R.2    Forbes, N.S.3    Simon, S.D.4    Kearns, G.L.5    Leeder, J.S.6
  • 83
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
    • Sachse C, Brockmoller J, Bauer S, Roots I. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet. 1997;60:284-295.
    • (1997) Am J Hum Genet , vol.60 , pp. 284-295
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3    Roots, I.4
  • 84
    • 21344467511 scopus 로고    scopus 로고
    • Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
    • Nowell SA, Ahn J, Rae JM, et al. Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients. Breast Cancer Res Treat. 2005:91:249-258.
    • (2005) Breast Cancer Res Treat , vol.91 , pp. 249-258
    • Nowell, S.A.1    Ahn, J.2    Rae, J.M.3
  • 85
    • 29144491089 scopus 로고    scopus 로고
    • Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients
    • Wegman R Vainikka L, Stal O, et al. Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients. Breast Cancer Res. 2005;7:284-290.
    • (2005) Breast Cancer Res , vol.7 , pp. 284-290
    • Wegman, R.1    Vainikka, L.2    Stal, O.3
  • 86
    • 0037032497 scopus 로고    scopus 로고
    • Association between sulfotransferase 1A1 genotype and survival of breast cancer patients receiving tamoxifen therapy
    • Nowell S, Sweeney C, Winters M, et al. Association between sulfotransferase 1A1 genotype and survival of breast cancer patients receiving tamoxifen therapy. J Natl Cancer Inst. 2002; 94:1635-1640.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1635-1640
    • Nowell, S.1    Sweeney, C.2    Winters, M.3
  • 87
    • 33747045564 scopus 로고    scopus 로고
    • Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: Data from the Italian Tamoxifen Trial
    • author reply 3709
    • Bonanni B, Macis D, Maisonneuve P et al. Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: data from the Italian Tamoxifen Trial. J Clin Oncol. 2006;24:3708-3709; author reply 3709.
    • (2006) J Clin Oncol , vol.24 , pp. 3708-3709
    • Bonanni, B.1    Macis, D.2    Maisonneuve, P.3
  • 88
    • 33644639136 scopus 로고    scopus 로고
    • Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes
    • Goetz MP, Rae JM, Suman VJ, et al. Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol. 2005;23:9312-9318.
    • (2005) J Clin Oncol , vol.23 , pp. 9312-9318
    • Goetz, M.P.1    Rae, J.M.2    Suman, V.J.3
  • 89
    • 34248208754 scopus 로고    scopus 로고
    • Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer
    • Wegman P, Elingarami S, Carstensen J, Stal O, Nordenskjold B, Wingren S. Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer. Breast Cancer Res. 2007; 9:R7.
    • (2007) Breast Cancer Res , vol.9
    • Wegman, P.1    Elingarami, S.2    Carstensen, J.3    Stal, O.4    Nordenskjold, B.5    Wingren, S.6
  • 90
    • 38349001998 scopus 로고    scopus 로고
    • SPORE Study Provides New Guidelines for Tamoxifen Use
    • Reynolds S. SPORE Study Provides New Guidelines for Tamoxifen Use. NCI Cancer Bulletin. 2006;3:1-2.
    • (2006) NCI Cancer Bulletin , vol.3 , pp. 1-2
    • Reynolds, S.1
  • 91
    • 0027418152 scopus 로고
    • Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: Polymorphism in RFLP and DNA sequence of CYP2D6
    • Wang SL, Huang JD, Lai MD, Liu BH, Lai ML. Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: polymorphism in RFLP and DNA sequence of CYP2D6. Clin Pharmacol Ther. 1993;53:410-418.
    • (1993) Clin Pharmacol Ther , vol.53 , pp. 410-418
    • Wang, S.L.1    Huang, J.D.2    Lai, M.D.3    Liu, B.H.4    Lai, M.L.5
  • 92
    • 0036339071 scopus 로고    scopus 로고
    • Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans
    • Gaedigk A, Bradford LD, Marcucci KA, Leeder JS. Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans. Clin Pharmacol Ther 2002;72:76-89.
    • (2002) Clin Pharmacol Ther , vol.72 , pp. 76-89
    • Gaedigk, A.1    Bradford, L.D.2    Marcucci, K.A.3    Leeder, J.S.4
  • 93
    • 0027965620 scopus 로고
    • Genetic analysis of the Chinese cytochrome P4502D locus: Characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation
    • Johansson I, Oscarson M, Yue QY, Bertilsson L, Sjoqvist F, Ingelman-Sundberg M. Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. Mol Pharmacol. 1994;46:452-459.
    • (1994) Mol Pharmacol , vol.46 , pp. 452-459
    • Johansson, I.1    Oscarson, M.2    Yue, Q.Y.3    Bertilsson, L.4    Sjoqvist, F.5    Ingelman-Sundberg, M.6
  • 95
    • 0037106273 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor for cancer therapy
    • Mendelsohn J. Targeting the epidermal growth factor receptor for cancer therapy. J Clin Oncol. 2002;201S-13S.
    • (2002) J Clin Oncol
    • Mendelsohn, J.1
  • 96
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • Thatcher N, Chang A, Parikh R et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet. 2005;366(9496):1527-1537.
    • (2005) Lancet , vol.366 , Issue.9496 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, R.3
  • 97
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell cancer to gefitinib. N Engl J Med. 2004;350:2129-2139.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 98
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer correlation with clinical response to gefitinib therapy. Science. 2004;304:1497-1500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 99
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are pommon in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are pommon in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A. 2004;101:13306-13311.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 100
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]
    • Fukuoka M, Yano S, Giaccone G, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]. J Clin Oncol. 2003;21:2237-2246.
    • (2003) J Clin Oncol , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 101
    • 20244388126 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence
    • Mitsudomi T, Kosaka T, Endoh H, et al. Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. J Clin Oncol. 2005;23:2513-2520.
    • (2005) J Clin Oncol , vol.23 , pp. 2513-2520
    • Mitsudomi, T.1    Kosaka, T.2    Endoh, H.3
  • 102
    • 20244389188 scopus 로고    scopus 로고
    • Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell rung cancer patients treated with gefitinib
    • Han SW Kim TY, Hwang PG, et al. Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell rung cancer patients treated with gefitinib. J Clin Oncol. 2005;23:2493-2501.
    • (2005) J Clin Oncol , vol.23 , pp. 2493-2501
    • Han, S.W.1    Kim, T.Y.2    Hwang, P.G.3
  • 103
    • 24344459713 scopus 로고    scopus 로고
    • Epidermal growth factor receptor activating mutations in Spanish gefitinib-treated non-small-cell lung cancer patients
    • Cortes-Funes H, Gomez C, Rosell R, et al. Epidermal growth factor receptor activating mutations in Spanish gefitinib-treated non-small-cell lung cancer patients. Ann Oncol. 2005;16:1081-1086.
    • (2005) Ann Oncol , vol.16 , pp. 1081-1086
    • Cortes-Funes, H.1    Gomez, C.2    Rosell, R.3
  • 104
    • 23844490782 scopus 로고    scopus 로고
    • Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas
    • Taron M, Ichinose Y. Rosell R, et al. Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas. Clin Cancer Res. 2005; 11:5878-5885.
    • (2005) Clin Cancer Res , vol.11 , pp. 5878-5885
    • Taron, M.1    Ichinose, Y.2    Rosell, R.3
  • 105
    • 33845262077 scopus 로고    scopus 로고
    • Gefitinib for non-small-cell lung cancer patients with epidermal growth factor receptor gene mutations screened by peptide nucleic acid-locked nucleic acid PCR clamp
    • Sutani A, Nagai Y, Udagawa K, et al. Gefitinib for non-small-cell lung cancer patients with epidermal growth factor receptor gene mutations screened by peptide nucleic acid-locked nucleic acid PCR clamp. Br J Cancer. 2006;95:1483-1489.
    • (2006) Br J Cancer , vol.95 , pp. 1483-1489
    • Sutani, A.1    Nagai, Y.2    Udagawa, K.3
  • 106
    • 33746789922 scopus 로고    scopus 로고
    • Prospective phase II study of gefitinib for chemotheraphy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations
    • Inoue A, Suzuki T, Pukuhara T, et al. Prospective phase II study of gefitinib for chemotheraphy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations. J Clin Oncol. 2006;24: 3340-3346.
    • (2006) J Clin Oncol , vol.24 , pp. 3340-3346
    • Inoue, A.1    Suzuki, T.2    Pukuhara, T.3
  • 107
    • 33750205340 scopus 로고    scopus 로고
    • A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations
    • Asahina H, Yamazaki K, Kinoshita I, et al. A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations. Br J Cancer. 2006;95:998-1004.
    • (2006) Br J Cancer , vol.95 , pp. 998-1004
    • Asahina, H.1    Yamazaki, K.2    Kinoshita, I.3
  • 108
    • 27244451321 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer
    • Takano T, Ohe Y, Sakamoto H, et al. Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer. J Clin Oncol. 2005;23:6829-6837.
    • (2005) J Clin Oncol , vol.23 , pp. 6829-6837
    • Takano, T.1    Ohe, Y.2    Sakamoto, H.3
  • 109
    • 20444498630 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
    • Cappuzzo F, Hirsch FR, Rossi E, et al. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst. 2005;97:643-655.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 643-655
    • Cappuzzo, F.1    Hirsch, F.R.2    Rossi, E.3
  • 110
    • 33750962024 scopus 로고    scopus 로고
    • Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer
    • Hirsch FR, Varella-Garcia M, Bunn PA, Jr., et al. Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer. J Clin Oncol. 2006;24:5034-5042.
    • (2006) J Clin Oncol , vol.24 , pp. 5034-5042
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn Jr., P.A.3
  • 111
    • 13844317894 scopus 로고    scopus 로고
    • EQFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • Kobayashi S, Boggon TJ, Dayaram T, et al. EQFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med. 2005;352:786-792.
    • (2005) N Engl J Med , vol.352 , pp. 786-792
    • Kobayashi, S.1    Boggon, T.J.2    Dayaram, T.3
  • 112
    • 15744372810 scopus 로고    scopus 로고
    • KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
    • Pao W, Wang TY, Riely GJ, et al. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med. 2005;2:e17.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Wang, T.Y.2    Riely, G.J.3
  • 113
  • 114
    • 43949093319 scopus 로고    scopus 로고
    • A genotype-directed phase I study of irinotecan in advanced cancer patients
    • Innocenti F, Janisch L, Das S, et al. A genotype-directed phase I study of irinotecan in advanced cancer patients. J Clin Oncol 2007;25(185):2502.
    • (2007) J Clin Oncol , vol.25 , Issue.185 , pp. 2502
    • Innocenti, F.1    Janisch, L.2    Das, S.3
  • 115
    • 43949143051 scopus 로고    scopus 로고
    • A phase I dose escalation study of irinotecan (CPT-11), oxaliplatin (Oxal), and capecitabine (Cap) within three UGT1A1 TA promoter cohorts (6/6, 617, and 7/7)
    • Goetz MP, Safgren S, Goldberg RM, et al. A phase I dose escalation study of irinotecan (CPT-11), oxaliplatin (Oxal), and capecitabine (Cap) within three UGT1A1 TA promoter cohorts (6/6, 617, and 7/7). J Clin Oncol. 2005;23(16S):2014.
    • (2005) J Clin Oncol , vol.23 , Issue.16 S , pp. 2014
    • Goetz, M.P.1    Safgren, S.2    Goldberg, R.M.3
  • 116
    • 43949125733 scopus 로고    scopus 로고
    • Individual genotyping to optimize chemotheraphy in metastatic colorectal cancer (MCRC): The COLOGEN trial
    • Falandry C, You B, Milano G, et al. Individual genotyping to optimize chemotheraphy in metastatic colorectal cancer (MCRC): the COLOGEN trial. J Clin Oncol. 2007;25(18S):2510.
    • (2007) J Clin Oncol , vol.25 , Issue.18 S , pp. 2510
    • Falandry, C.1    You, B.2    Milano, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.