메뉴 건너뛰기




Volumn 45, Issue 6, 2006, Pages 567-592

How may anticancer chemotherapy with fluorouracil be individualised?

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; CISPLATIN; CYCLOPHOSPHAMIDE; DIHYDROFLUOROURACIL; DIHYDROPYRIMIDINE DEHYDROGENASE; DOXORUBICIN; EPIRUBICIN; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; METHOTREXATE; OXALIPLATIN; PLATINUM DERIVATIVE;

EID: 33745927137     PISSN: 03125963     EISSN: 03125963     Source Type: Journal    
DOI: 10.2165/00003088-200645060-00002     Document Type: Review
Times cited : (44)

References (127)
  • 1
    • 0031023815 scopus 로고    scopus 로고
    • Pharmacogenetics: A laboratory tool for optimizing therapeutic efficacy
    • Linder MW, Prough RA, Valdes RJ. Pharmacogenetics: a laboratory tool for optimizing therapeutic efficacy. Clin Chem 1997; 43: 254-66
    • (1997) Clin Chem , vol.43 , pp. 254-266
    • Linder, M.W.1    Prough, R.A.2    Valdes, R.J.3
  • 2
    • 0033403326 scopus 로고    scopus 로고
    • Technologies for detecting genetic polymorphism in pharmacogenomics
    • Shi MM, Bleavins VR, de la Iglesia FA. Technologies for detecting genetic polymorphism in pharmacogenomics. Mol Diagn 1999; 4: 343-51
    • (1999) Mol Diagn , vol.4 , pp. 343-351
    • Shi, M.M.1    Bleavins, V.R.2    De La Iglesia, F.A.3
  • 3
    • 0031742831 scopus 로고    scopus 로고
    • Relevance of pheno- and genotyping in clinical drug development
    • Zühlsdorf MT. Relevance of pheno- and genotyping in clinical drug development. Int J Clin Pharmacol Ther 1998; 36: 607-12
    • (1998) Int J Clin Pharmacol Ther , vol.36 , pp. 607-612
    • Zühlsdorf, M.T.1
  • 5
    • 0038600607 scopus 로고    scopus 로고
    • Current treatments and future perspectives in colorectal and gastric cancer
    • Wilke HJ, van Cutsem E. Current treatments and future perspectives in colorectal and gastric cancer. Ann Oncol 2003; 14 Suppl. 2: ii49-55
    • (2003) Ann Oncol , vol.14 , Issue.2 SUPPL.
    • Wilke, H.J.1    Van Cutsem, E.2
  • 6
    • 1842639490 scopus 로고    scopus 로고
    • New systemic frontline treatment for metastatic colorectal carcinoma
    • Braun AH, Achterrath W, Wilke H, et al. New systemic frontline treatment for metastatic colorectal carcinoma. Cancer 2004; 100: 1558-77
    • (2004) Cancer , vol.100 , pp. 1558-1577
    • Braun, A.H.1    Achterrath, W.2    Wilke, H.3
  • 7
    • 0242475354 scopus 로고    scopus 로고
    • Oesophageal cancer: New developments in systemic therapy
    • Ilson DH. Oesophageal cancer: new developments in systemic therapy. Cancer Treat Rev 2003; 21: 525-32
    • (2003) Cancer Treat Rev , vol.21 , pp. 525-532
    • Ilson, D.H.1
  • 8
    • 2942648695 scopus 로고    scopus 로고
    • Four decades of continuing innovation with fluorouracil: Current and future approaches to fluorouracil chemoradiation therapy
    • Rich TA, Shepard RC, Mosley ST. Four decades of continuing innovation with fluorouracil: current and future approaches to fluorouracil chemoradiation therapy. J Clin Oncol 2004; 22: 2214-32
    • (2004) J Clin Oncol , vol.22 , pp. 2214-2232
    • Rich, T.A.1    Shepard, R.C.2    Mosley, S.T.3
  • 9
    • 1842293351 scopus 로고    scopus 로고
    • Drugs of choice for cancer chemotherapy
    • Anonymous. Drugs of choice for cancer chemotherapy. Med Lett Drugs Ther 1997; 39: 21-8
    • (1997) Med Lett Drugs Ther , vol.39 , pp. 21-28
  • 10
    • 0023904924 scopus 로고
    • Dose versus pharmacokinetics for predicting tolerance to 5-day continuous infusion of 5-FU
    • Milano G, Roman P, Khater P, et al. Dose versus pharmacokinetics for predicting tolerance to 5-day continuous infusion of 5-FU. Int J Cancer 1988; 41: 537-41
    • (1988) Int J Cancer , vol.41 , pp. 537-541
    • Milano, G.1    Roman, P.2    Khater, P.3
  • 11
    • 0022630996 scopus 로고
    • Clinical pharmacokinetic study of 5-FU in continuous 5-day infusions for head and neck cancer
    • Thyss A, Milano G, Renëe N, et al. Clinical pharmacokinetic study of 5-FU in continuous 5-day infusions for head and neck cancer. Cancer Chemother Pharmacol 1986; 16: 64-6
    • (1986) Cancer Chemother Pharmacol , vol.16 , pp. 64-66
    • Thyss, A.1    Milano, G.2    Renëe, N.3
  • 12
    • 13344269002 scopus 로고    scopus 로고
    • Relationship between 5-fluorouracil (5-FU) dose intensity and therapeutic response in patients with advanced colorectal cancer receiving infusional therapy containing 5-FU
    • Gamelin EC, Danquechin-Dorval EM, Dumesnil YF, et al. Relationship between 5-fluorouracil (5-FU) dose intensity and therapeutic response in patients with advanced colorectal cancer receiving infusional therapy containing 5-FU. Cancer 1996; 77: 441-51
    • (1996) Cancer , vol.77 , pp. 441-451
    • Gamelin, E.C.1    Danquechin-Dorval, E.M.2    Dumesnil, Y.F.3
  • 13
    • 1242329822 scopus 로고    scopus 로고
    • Platinum-based chemotherapy in metastatic breast cancer: Current status
    • Decatris MP, Sundar S, O'Byrne KJ. Platinum-based chemotherapy in metastatic breast cancer: current status. Cancer Treat Rev 2004; 30: 53-81
    • (2004) Cancer Treat Rev , vol.30 , pp. 53-81
    • Decatris, M.P.1    Sundar, S.2    O'Byrne, K.J.3
  • 14
    • 0033834414 scopus 로고    scopus 로고
    • Dose and time dependencies of 5-fluorouracil pharmacokinetics
    • Terret C, Erdociain E, Guimbaud R, et al. Dose and time dependencies of 5-fluorouracil pharmacokinetics. Clin Pharmacol Ther 2000; 68: 270-9
    • (2000) Clin Pharmacol Ther , vol.68 , pp. 270-279
    • Terret, C.1    Erdociain, E.2    Guimbaud, R.3
  • 15
    • 6344247602 scopus 로고    scopus 로고
    • Important role of the dihydrouracil/uracil ratio in marked interpatient variations of fluoropyrimidine pharmacokinetics and pharmacodynamics
    • Jiang H, Lu J, Jiang J, et al. Important role of the dihydrouracil/uracil ratio in marked interpatient variations of fluoropyrimidine pharmacokinetics and pharmacodynamics. J Clin Pharmacol 2004; 44: 1260-72
    • (2004) J Clin Pharmacol , vol.44 , pp. 1260-1272
    • Jiang, H.1    Lu, J.2    Jiang, J.3
  • 16
    • 0035793817 scopus 로고    scopus 로고
    • 5-fluorouracil steady state pharmacokinetics and outcome in patients receiving protracted venous infusion for advanced colorectal cancer
    • Jodrell DI, Stewart M, Aird R, et al. 5-fluorouracil steady state pharmacokinetics and outcome in patients receiving protracted venous infusion for advanced colorectal cancer. Br J Cancer 2001; 84: 600-3
    • (2001) Br J Cancer , vol.84 , pp. 600-603
    • Jodrell, D.I.1    Stewart, M.2    Aird, R.3
  • 17
    • 0030033602 scopus 로고    scopus 로고
    • Measurement of plasma 5-fluorouracil by high-performance liquid chromatography with comparison of results to tissue drug levels observed using in vivo 19F magnetic resonance spectroscopy in patients on a protracted venous infusion with or without interferon-alpha
    • Findlay MP, Raynaud F, Cunningham D, et al. Measurement of plasma 5-fluorouracil by high-performance liquid chromatography with comparison of results to tissue drug levels observed using in vivo 19F magnetic resonance spectroscopy in patients on a protracted venous infusion with or without interferon-alpha. Ann Oncol 1996; 7: 47-53
    • (1996) Ann Oncol , vol.7 , pp. 47-53
    • Findlay, M.P.1    Raynaud, F.2    Cunningham, D.3
  • 18
    • 0025737565 scopus 로고
    • Relative importance of dose, body surface area, sex, and age for 5-fluorouracil clearance
    • Port RE, Daniel B, Ding RW, et al. Relative importance of dose, body surface area, sex, and age for 5-fluorouracil clearance. Oncology 1991; 48: 277-81
    • (1991) Oncology , vol.48 , pp. 277-281
    • Port, R.E.1    Daniel, B.2    Ding, R.W.3
  • 19
    • 0026636184 scopus 로고
    • Influence of sex and age on fluorouracil clearance
    • Milano G, Etienne MC, Cassuto-Viguier E, et al. Influence of sex and age on fluorouracil clearance. J Clin Oncol 1992; 10: 1171-5
    • (1992) J Clin Oncol , vol.10 , pp. 1171-1175
    • Milano, G.1    Etienne, M.C.2    Cassuto-Viguier, E.3
  • 20
    • 0028805308 scopus 로고
    • Population characteristics of hepatic dihydropyrimidine dehydrogenase activity, a key metabolic enzyme in 5-fluorouracil chemotherapy
    • Lu Z, Zhang R, Diasio RB. Population characteristics of hepatic dihydropyrimidine dehydrogenase activity, a key metabolic enzyme in 5-fluorouracil chemotherapy. Clin Pharacol Ther 1995; 58: 512-22
    • (1995) Clin Pharacol Ther , vol.58 , pp. 512-522
    • Lu, Z.1    Zhang, R.2    Diasio, R.B.3
  • 21
    • 0037087563 scopus 로고    scopus 로고
    • Women experience greater toxicity with fluorouracil-based chemotherapy for colorectal cancer
    • Sloan JA, Goldberg RM, Sargent DJ, et al. Women experience greater toxicity with fluorouracil-based chemotherapy for colorectal cancer. J Clin Oncol 2002; 20: 1491-8
    • (2002) J Clin Oncol , vol.20 , pp. 1491-1498
    • Sloan, J.A.1    Goldberg, R.M.2    Sargent, D.J.3
  • 22
    • 0031890613 scopus 로고    scopus 로고
    • Co-variables influencing 5-fluorouracil clearance during continuous venous infusion: A NONMEM analysis
    • Etienne MC, Chatelut E, Pivot X, et al. Co-variables influencing 5-fluorouracil clearance during continuous venous infusion: a NONMEM analysis. Eur J Cancer 1998; 34: 92-7
    • (1998) Eur J Cancer , vol.34 , pp. 92-97
    • Etienne, M.C.1    Chatelut, E.2    Pivot, X.3
  • 23
    • 0026709718 scopus 로고
    • No effect of dose, hepatic function, or nutritional status on 5-FU clearance following continuous (5-days), 5-FU infusion
    • Fleming RA, Milano GA, Etienne MC, et al. No effect of dose, hepatic function, or nutritional status on 5-FU clearance following continuous (5-days), 5-FU infusion. Br J Cancer 1992; 66: 668-72
    • (1992) Br J Cancer , vol.66 , pp. 668-672
    • Fleming, R.A.1    Milano, G.A.2    Etienne, M.C.3
  • 24
    • 0037328454 scopus 로고    scopus 로고
    • Extensive hepatic replacement due to liver metastases has no effect on 5-fluorouracil pharmacokinetics
    • Maring JG, Piersma H, van Dalen A, et al. Extensive hepatic replacement due to liver metastases has no effect on 5-fluorouracil pharmacokinetics. Cancer Chemother Pharmacol 2003; 51: 167-73
    • (2003) Cancer Chemother Pharmacol , vol.51 , pp. 167-173
    • Maring, J.G.1    Piersma, H.2    Van Dalen, A.3
  • 25
    • 0043202914 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of 24-hour infusion 5-fluorouracil and leucovorin in patients with organ dysfunction
    • Fleming GF, Schilsky RL, Schumm LP, et al. Phase I and pharmacokinetic study of 24-hour infusion 5-fluorouracil and leucovorin in patients with organ dysfunction. Ann Oncol 2003; 14: 1142-7
    • (2003) Ann Oncol , vol.14 , pp. 1142-1147
    • Fleming, G.F.1    Schilsky, R.L.2    Schumm, L.P.3
  • 26
    • 17144449953 scopus 로고    scopus 로고
    • 19F nuclear magnetic resonance spectroscopy for a patient on chronic hemodialysis
    • 19F nuclear magnetic resonance spectroscopy for a patient on chronic hemodialysis. Am J Kidney Dis 2002; 39: 1-7
    • (2002) Am J Kidney Dis , vol.39 , pp. 1-7
    • Rengelshausen, J.1    Hull, W.E.2    Schwenger, V.3
  • 27
    • 33646828703 scopus 로고    scopus 로고
    • Effect of hemodialysis on the metabolic clearance of 5-fluorouracil in a patient with end-stage renal failure
    • Gusella M, Rebeschini M, Cartei G, et al. Effect of hemodialysis on the metabolic clearance of 5-fluorouracil in a patient with end-stage renal failure. Ther Drug Monit 2005; 27: 816-8
    • (2005) Ther Drug Monit , vol.27 , pp. 816-818
    • Gusella, M.1    Rebeschini, M.2    Cartei, G.3
  • 29
    • 0028559551 scopus 로고
    • Potential importance of dihydropyrimidine dehydrogenase (DPD) in cancer chemotherapy
    • Milano G, Etienne MC. Potential importance of dihydropyrimidine dehydrogenase (DPD) in cancer chemotherapy. Pharmacogenetics 1994; 4: 301-6
    • (1994) Pharmacogenetics , vol.4 , pp. 301-306
    • Milano, G.1    Etienne, M.C.2
  • 30
    • 0029973215 scopus 로고    scopus 로고
    • Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity
    • Wei X, McLeod HL, McMurroug JL, et al. Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity. J Clin Invest 1996; 3: 610-5
    • (1996) J Clin Invest , vol.3 , pp. 610-615
    • Wei, X.1    McLeod, H.L.2    McMurroug, J.L.3
  • 31
    • 0029133354 scopus 로고
    • Diagnosis analysis, clinical importance and molecular basis of dihydropyrimidine dehydrogenase deficiency
    • Gonzalez FJ, Fernandez-Salguero P. Diagnosis analysis, clinical importance and molecular basis of dihydropyrimidine dehydrogenase deficiency. Trend Pharmacol Sci 1995; 16: 325-7
    • (1995) Trend Pharmacol Sci , vol.16 , pp. 325-327
    • Gonzalez, F.J.1    Fernandez-Salguero, P.2
  • 32
    • 0028006858 scopus 로고
    • Population study of dihydropyrimidine dehydrogenase in cancer patients
    • Etienne MC, Lagrange JL, Dassoville O, et al. Population study of dihydropyrimidine dehydrogenase in cancer patients. J Clin Oncol 1994; 12: 2248-53
    • (1994) J Clin Oncol , vol.12 , pp. 2248-2253
    • Etienne, M.C.1    Lagrange, J.L.2    Dassoville, O.3
  • 33
    • 0027496582 scopus 로고
    • Severe fluorouracil toxicity in a patient with dihydropyrimidine dehydrogenase deficiency
    • Houyau P, Gay C, Chatelut E, et al. Severe fluorouracil toxicity in a patient with dihydropyrimidine dehydrogenase deficiency. J Natl Cancer Inst 1993; 85: 1602-3
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1602-1603
    • Houyau, P.1    Gay, C.2    Chatelut, E.3
  • 34
    • 0025990479 scopus 로고
    • Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency
    • Harris B, Carpenter JT, Diasio RB. Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. Cancer 1991; 68: 499-501
    • (1991) Cancer , vol.68 , pp. 499-501
    • Harris, B.1    Carpenter, J.T.2    Diasio, R.B.3
  • 35
    • 0027409335 scopus 로고
    • Severe 5-fluorouracil toxicity in a patient with decreased dihydropyrimidine dehydrogenase activity
    • Lyss AP, Lilenbaum RC, Harris BE, et al. Severe 5-fluorouracil toxicity in a patient with decreased dihydropyrimidine dehydrogenase activity. Cancer Invest 1993; 11: 239-40
    • (1993) Cancer Invest , vol.11 , pp. 239-240
    • Lyss, A.P.1    Lilenbaum, R.C.2    Harris, B.E.3
  • 36
    • 0023902287 scopus 로고
    • Familial deficiency of dihydropyrimidine dehydrogenase: Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity
    • Diasio RB, Beavers TL, Carpenter JT. Familial deficiency of dihydropyrimidine dehydrogenase: biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity. J Clin Invest 1988; 81: 47-51
    • (1988) J Clin Invest , vol.81 , pp. 47-51
    • Diasio, R.B.1    Beavers, T.L.2    Carpenter, J.T.3
  • 37
    • 0027945196 scopus 로고
    • Dihydropyrimidine dehydrogenase activity and fluorouracil chemotherapy
    • Diasio RB, Lu Z. Dihydropyrimidine dehydrogenase activity and fluorouracil chemotherapy. J Clin Oncol 1994; 12: 2239-42
    • (1994) J Clin Oncol , vol.12 , pp. 2239-2242
    • Diasio, R.B.1    Lu, Z.2
  • 38
    • 0023187085 scopus 로고
    • Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile
    • Heggie GD, Sommadossi JP, Cross DS, et al. Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile. Cancer Res 1987; 16: 2203-6
    • (1987) Cancer Res , vol.16 , pp. 2203-2206
    • Heggie, G.D.1    Sommadossi, J.P.2    Cross, D.S.3
  • 39
    • 1842453897 scopus 로고    scopus 로고
    • Circadian rhythm of dihydrouracil/uracil ratios in biological fluids: A potential biomarker for dihydropyfluorouracil rimidine dehydrogenase levels
    • Jiang H, Lu J, Ji J. Circadian rhythm of dihydrouracil/uracil ratios in biological fluids: a potential biomarker for dihydropyfluorouracil rimidine dehydrogenase levels. Br J Pharmacol 2004; 141: 616-23
    • (2004) Br J Pharmacol , vol.141 , pp. 616-623
    • Jiang, H.1    Lu, J.2    Ji, J.3
  • 40
    • 0025058867 scopus 로고
    • Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion
    • Harris BE, Song R, Soong SJ, et al. Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion. Cancer Res 1990; 50: 197-201
    • (1990) Cancer Res , vol.50 , pp. 197-201
    • Harris, B.E.1    Song, R.2    Soong, S.J.3
  • 41
    • 0026753035 scopus 로고
    • Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients
    • Fleming RA, Milano G, Thyss A, et al. Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients. Cancer Res 1992; 52: 2899-902
    • (1992) Cancer Res , vol.52 , pp. 2899-2902
    • Fleming, R.A.1    Milano, G.2    Thyss, A.3
  • 42
    • 0031010583 scopus 로고    scopus 로고
    • Inter- and intraindividual variation in dihydropyrimidine dehydrogenase activity in pefluorouracil ripheral blood mononuclear cells
    • Grem JL, Yee LK, Venzon DJ, et al. Inter- and intraindividual variation in dihydropyrimidine dehydrogenase activity in pefluorouracil ripheral blood mononuclear cells. Cancer Chemother Pharmacol 1997; 40: 117-25
    • (1997) Cancer Chemother Pharmacol , vol.40 , pp. 117-125
    • Grem, J.L.1    Yee, L.K.2    Venzon, D.J.3
  • 43
    • 0008816682 scopus 로고
    • Plasma concentration of 5-fluorouracil and mononuclear cell dihydropyrimidine dehydrogenase activity in patients treated with different chronomodulated schedules
    • abstract no. 135
    • Langouët AM, Metzger G, Comisso M, et al. Plasma concentration of 5-fluorouracil and mononuclear cell dihydropyrimidine dehydrogenase activity in patients treated with different chronomodulated schedules [abstract no. 135]. Biol Rhythm Res 1995; 26: 409
    • (1995) Biol Rhythm Res , vol.26 , pp. 409
    • Langouët, A.M.1    Metzger, G.2    Comisso, M.3
  • 44
    • 0023686205 scopus 로고
    • Sources of variability of dihydropyrimidine dehydrogenase activity in human blood mononuclear cells
    • Tuchman M, von Roemeling R, Lanning RM, et al. Sources of variability of dihydropyrimidine dehydrogenase activity in human blood mononuclear cells. Annu Rev Chronopharmacol 1988; 5: 399-402
    • (1988) Annu Rev Chronopharmacol , vol.5 , pp. 399-402
    • Tuchman, M.1    Von Roemeling, R.2    Lanning, R.M.3
  • 45
    • 0031832980 scopus 로고    scopus 로고
    • No circadian variation of dihydropyrimidine dehydrogenase, uridine phosphorylase, beta-alanine, and 5-fluorouracil during continuous infusion of 5-fluorouracil
    • Van Kuilenburg AB, Poorter RL, Peters GL, et al. No circadian variation of dihydropyrimidine dehydrogenase, uridine phosphorylase, beta-alanine, and 5-fluorouracil during continuous infusion of 5-fluorouracil. Adv Exp Med Biol 1998; 431: 811-6
    • (1998) Adv Exp Med Biol , vol.431 , pp. 811-816
    • Van Kuilenburg, A.B.1    Poorter, R.L.2    Peters, G.L.3
  • 46
    • 20444403412 scopus 로고    scopus 로고
    • Dihydropyrimidine deshydrogenase (DPD): Rhythm and consequences
    • Paris
    • Barrat-Petit MA, Naulin-Ifi C, Mahler P, et al. Dihydropyrimidine deshydrogenase (DPD): rhythm and consequences. Pathol Biol (Paris) 2005; 53: 261-4
    • (2005) Pathol Biol , vol.53 , pp. 261-264
    • Barrat-Petit, M.A.1    Naulin-Ifi, C.2    Mahler, P.3
  • 47
    • 0028036652 scopus 로고
    • Chronomodulated versus fixed-infusion-rate delivery of ambulatory chemotherapy with oxaliplatin, fluorouracil, and folinic acid (leucovorin) in patients with colorectal cancer metastases: A randomized multi-institutional trial
    • Lévi FA, Zidani R, Vannetzel JM, et al. Chronomodulated versus fixed-infusion-rate delivery of ambulatory chemotherapy with oxaliplatin, fluorouracil, and folinic acid (leucovorin) in patients with colorectal cancer metastases: a randomized multi-institutional trial. J Natl Cancer Inst 1994; 86: 1608-17
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1608-1617
    • Lévi, F.A.1    Zidani, R.2    Vannetzel, J.M.3
  • 48
    • 0041055512 scopus 로고    scopus 로고
    • Randomised muticentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer
    • Lévi F, Zidani R, Misset JL, et al. Randomised muticentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer. Lancet 1997; 350: 681-6
    • (1997) Lancet , vol.350 , pp. 681-686
    • Lévi, F.1    Zidani, R.2    Misset, J.L.3
  • 49
    • 0027932318 scopus 로고
    • Spontaneous or imposed circadian changes in plasma concentrations of 5-fluorouracil coadministered with folinic acid and oxaliplatin: Relationship with mucosal toxicity in patients with cancer
    • Metzger G, Massari C, Etienne MC, et al. Spontaneous or imposed circadian changes in plasma concentrations of 5-fluorouracil coadministered with folinic acid and oxaliplatin: relationship with mucosal toxicity in patients with cancer. Clin Pharmacol Ther 1994; 56: 190-201
    • (1994) Clin Pharmacol Ther , vol.56 , pp. 190-201
    • Metzger, G.1    Massari, C.2    Etienne, M.C.3
  • 50
    • 0038234812 scopus 로고    scopus 로고
    • Pharmacokinetics of oxaliplatin during chronomodulated infusion in metastatic gastrointestinal cancer patients: A pilot investigation with preliminary results
    • Merkel U, Wedding U, Roskos M, et al. Pharmacokinetics of oxaliplatin during chronomodulated infusion in metastatic gastrointestinal cancer patients: a pilot investigation with preliminary results. Exp Toxicol Pathol 2003; 54: 475-9
    • (2003) Exp Toxicol Pathol , vol.54 , pp. 475-479
    • Merkel, U.1    Wedding, U.2    Roskos, M.3
  • 51
    • 0242720707 scopus 로고    scopus 로고
    • Pharmacokinetic study of oxaliplatin iv chronomodulated infusion combined with 5-fluorouracil iv continuous infusion in the treatment of advanced colorectal cancer
    • Cattel L, La Grotta G, Infante L, et al. Pharmacokinetic study of oxaliplatin iv chronomodulated infusion combined with 5-fluorouracil iv continuous infusion in the treatment of advanced colorectal cancer. Farmaco 2003; 58: 1333-8
    • (2003) Farmaco , vol.58 , pp. 1333-1338
    • Cattel, L.1    La Grotta, G.2    Infante, L.3
  • 52
    • 3042568991 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interaction between 5-fluorouracil and oxaliplatin
    • Joel SP, Papamichael D, Richards F, et al. Lack of pharmacokinetic interaction between 5-fluorouracil and oxaliplatin. Clin Pharmacol Ther 2004; 76: 45-54
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 45-54
    • Joel, S.P.1    Papamichael, D.2    Richards, F.3
  • 53
    • 0024512054 scopus 로고
    • 5-FU therapeutic monitoring with dose adjustment leads to an improved therapeutic index in head and neck cancer
    • Santini J, Milano G, Thyss A, et al. 5-FU therapeutic monitoring with dose adjustment leads to an improved therapeutic index in head and neck cancer. Br J Cancer 1989; 59: 287-90
    • (1989) Br J Cancer , vol.59 , pp. 287-290
    • Santini, J.1    Milano, G.2    Thyss, A.3
  • 54
    • 0031901763 scopus 로고    scopus 로고
    • Long-term weekly treatment of colorectal metastatic cancer with fluorouracil and leucovorin: Results of a multicentric prospective trial of fluorouracil dosage optimization by pharmacokinetic monitoring in 152 patients
    • Gamelin E, Boisdron-Celle M, Delva R, et al. Long-term weekly treatment of colorectal metastatic cancer with fluorouracil and leucovorin: results of a multicentric prospective trial of fluorouracil dosage optimization by pharmacokinetic monitoring in 152 patients. J Clin Oncol 1998; 16: 1470-8
    • (1998) J Clin Oncol , vol.16 , pp. 1470-1478
    • Gamelin, E.1    Boisdron-Celle, M.2    Delva, R.3
  • 55
    • 0025171495 scopus 로고
    • Clinical significance of monitoring serum levels of 5-fluorouracil by continuous infusion in patients with advanced colonic cancer
    • Yoshida T, Araki E, Iigo M, et al. Clinical significance of monitoring serum levels of 5-fluorouracil by continuous infusion in patients with advanced colonic cancer. Cancer Chemother Pharmacol 1990; 26: 352-4
    • (1990) Cancer Chemother Pharmacol , vol.26 , pp. 352-354
    • Yoshida, T.1    Araki, E.2    Iigo, M.3
  • 56
    • 0028357629 scopus 로고
    • Relationship between fluorouracil systemic exposure and tumor response and patient survival
    • Milano G, Etienne MC, Renée N, et al. Relationship between fluorouracil systemic exposure and tumor response and patient survival. J Clin Oncol 1994; 12: 1291-5
    • (1994) J Clin Oncol , vol.12 , pp. 1291-1295
    • Milano, G.1    Etienne, M.C.2    Renée, N.3
  • 57
    • 0018222094 scopus 로고
    • Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion
    • Hillcoat BL, McCulloch PB, Figueredo AT, et al. Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion. Br J Cancer 1978; 38: 719-24
    • (1978) Br J Cancer , vol.38 , pp. 719-724
    • Hillcoat, B.L.1    McCulloch, P.B.2    Figueredo, A.T.3
  • 58
    • 0034782963 scopus 로고    scopus 로고
    • Relationship between 5-pefluorouracil disposition, toxicity, and dihydropyrimidine dehydrogenase activity in cancer patients
    • Di Paolo A, Danesi R, Falcone A, et al. Relationship between 5-pefluorouracil disposition, toxicity, and dihydropyrimidine dehydrogenase activity in cancer patients. Ann Oncol 2001; 12: 1301-6
    • (2001) Ann Oncol , vol.12 , pp. 1301-1306
    • Di Paolo, A.1    Danesi, R.2    Falcone, A.3
  • 59
    • 0036785124 scopus 로고    scopus 로고
    • Relationship between plasma concentrations of 5-fluorouracil and 5-fluoro-5,6-dihydrouracil and toxicity of 5-fluorouracil infusion in cancer patients
    • Di Paolo A, Ibrahim T, Danesi R, et al. Relationship between plasma concentrations of 5-fluorouracil and 5-fluoro-5,6-dihydrouracil and toxicity of 5-fluorouracil infusion in cancer patients. Ther Drug Monit 2002; 24: 588-93
    • (2002) Ther Drug Monit , vol.24 , pp. 588-593
    • Di Paolo, A.1    Ibrahim, T.2    Danesi, R.3
  • 60
    • 0242361685 scopus 로고    scopus 로고
    • Individual 5-FU dose adaptation in metastatic colorectal cancer: Results of a phase II study using a bimonthly pharmacokinetically intensified LV5FU2 regimen
    • Ychou M, Duffour J, Kramar A, et al. Individual 5-FU dose adaptation in metastatic colorectal cancer: results of a phase II study using a bimonthly pharmacokinetically intensified LV5FU2 regimen. Cancer Chemother Pharmacol 2003; 52: 282-90
    • (2003) Cancer Chemother Pharmacol , vol.52 , pp. 282-290
    • Ychou, M.1    Duffour, J.2    Kramar, A.3
  • 61
    • 0027525386 scopus 로고
    • Development and validation of a limited sampling strategy for 5-fluorouracil given by bolus intravenous administration
    • Moore MJ, Bunting P, Yuan S, et al. Development and validation of a limited sampling strategy for 5-fluorouracil given by bolus intravenous administration. Ther Drug Monit 1993; 15: 394-9
    • (1993) Ther Drug Monit , vol.15 , pp. 394-399
    • Moore, M.J.1    Bunting, P.2    Yuan, S.3
  • 62
    • 0025891191 scopus 로고
    • Pharmacokinetics of 5-fluorouracil after short systemic infusion: Plasma level at the end of the distribution phase as an indicator of the total area under the plasma concentration-time curve
    • Port RE, Edler L, Herrmann R, et al. Pharmacokinetics of 5-fluorouracil after short systemic infusion: plasma level at the end of the distribution phase as an indicator of the total area under the plasma concentration-time curve. Ther Drug Monit 1991; 13: 96-102
    • (1991) Ther Drug Monit , vol.13 , pp. 96-102
    • Port, R.E.1    Edler, L.2    Herrmann, R.3
  • 63
    • 0036001247 scopus 로고    scopus 로고
    • New limited sampling strategy for determining 5-fluorouracil area under the concentration-time curve after rapid intravenous bolus
    • Gusella M, Ferrazzi E, Ferrari M, et al. New limited sampling strategy for determining 5-fluorouracil area under the concentration-time curve after rapid intravenous bolus. Ther Drug Monit 2002; 24: 425-31
    • (2002) Ther Drug Monit , vol.24 , pp. 425-431
    • Gusella, M.1    Ferrazzi, E.2    Ferrari, M.3
  • 64
    • 0036913715 scopus 로고    scopus 로고
    • Limited sampling model for the analysis of 5-fluorouracil pharmacokinetics in adjuvant chemotherapy for colorectal cancer
    • Di Paolo A, Danesi R, Vannozzi F, et al. Limited sampling model for the analysis of 5-fluorouracil pharmacokinetics in adjuvant chemotherapy for colorectal cancer. Clin Pharmacol Ther 2002; 72: 627-37
    • (2002) Clin Pharmacol Ther , vol.72 , pp. 627-637
    • Di Paolo, A.1    Danesi, R.2    Vannozzi, F.3
  • 65
    • 33745888380 scopus 로고    scopus 로고
    • Multicentric randomized trial comparing in weekly treatment of advanced colorectal cancer (CRC) intensified 5-fluorouracil and folinic acid (FA) with 5-FU pharmacokinetic monitoring to a constant dose calculated with body surface area
    • abstract no. 1039 Alexandria (VA)
    • Gamelin E, Jacob J, Danquechin-Dorval E, et al. Multicentric randomized trial comparing in weekly treatment of advanced colorectal cancer (CRC) intensified 5-fluorouracil and folinic acid (FA) with 5-FU pharmacokinetic monitoring to a constant dose calculated with body surface area [abstract no. 1039]. Annual Meeting of American Society of Clinical Oncology; 1998; Alexandria (VA)
    • (1998) Annual Meeting of American Society of Clinical Oncology
    • Gamelin, E.1    Jacob, J.2    Danquechin-Dorval, E.3
  • 66
    • 0031696544 scopus 로고    scopus 로고
    • Clinical impact of pharmacokinetically-guided dose adaptation of 5-fluorouracil: Results from a multicentric randomized trial in patients with locally advanced head and neck carcinomas
    • Fety R, Rolland F, Barberi-Heyob M, et al. Clinical impact of pharmacokinetically-guided dose adaptation of 5-fluorouracil: results from a multicentric randomized trial in patients with locally advanced head and neck carcinomas. Clin Cancer Res 1998; 4: 2039-45
    • (1998) Clin Cancer Res , vol.4 , pp. 2039-2045
    • Fety, R.1    Rolland, F.2    Barberi-Heyob, M.3
  • 67
    • 0028568929 scopus 로고
    • Clinical randomized study of 5FU monitoring versus standard dose in patients with head and neck cancer: Preliminary results
    • Fety R, Rolland F, Barberi-Heyob M, et al. Clinical randomized study of 5FU monitoring versus standard dose in patients with head and neck cancer: preliminary results. Anticancer Res 1994; 14: 2347-52
    • (1994) Anticancer Res , vol.14 , pp. 2347-2352
    • Fety, R.1    Rolland, F.2    Barberi-Heyob, M.3
  • 68
    • 0031790577 scopus 로고    scopus 로고
    • The role of dihydropyrimidine dehydrogenase (DPD) modulation in 5-FU pharmacology
    • Diasio RB. The role of dihydropyrimidine dehydrogenase (DPD) modulation in 5-FU pharmacology. Oncology 1998; 12 Suppl. 7: 23-7
    • (1998) Oncology , vol.12 , Issue.7 SUPPL. , pp. 23-27
    • Diasio, R.B.1
  • 69
    • 0041303650 scopus 로고    scopus 로고
    • Clinical implication of dihydropyrimidine dehydrogenase (DPD) activity in 5-FU-based chemotherapy: Mutations in the DPD gene, and DPD inhibitory fluoropyrimidines
    • Omura K. Clinical implication of dihydropyrimidine dehydrogenase (DPD) activity in 5-FU-based chemotherapy: mutations in the DPD gene, and DPD inhibitory fluoropyrimidines. Int J Clin Oncol 2003; 8: 132-8
    • (2003) Int J Clin Oncol , vol.8 , pp. 132-138
    • Omura, K.1
  • 70
    • 0029830640 scopus 로고    scopus 로고
    • Individualizing therapy with 5-fluorouracil related to dihydropyrimidine dehydrogenase: Theory and limits
    • Milano G, Etienne MC. Individualizing therapy with 5-fluorouracil related to dihydropyrimidine dehydrogenase: theory and limits. Ther Drug Monit 1996; 18: 335-40
    • (1996) Ther Drug Monit , vol.18 , pp. 335-340
    • Milano, G.1    Etienne, M.C.2
  • 71
    • 0037041639 scopus 로고    scopus 로고
    • Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene
    • Maring JG, van Kuilenburg ABP, Haasjes J, et al. Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene. Br J Cancer 2002; 86: 1028-33
    • (2002) Br J Cancer , vol.86 , pp. 1028-1033
    • Maring, J.G.1    Van Kuilenburg, A.B.P.2    Haasjes, J.3
  • 72
    • 0034488052 scopus 로고    scopus 로고
    • Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: Identification of new mutations in DPD gene
    • Van Kuilenburg AB, Haasjes J, Richel DF, et al. Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in DPD gene. Clin Cancer Res 2000; 6: 4705-12
    • (2000) Clin Cancer Res , vol.6 , pp. 4705-4712
    • Van Kuilenburg, A.B.1    Haasjes, J.2    Richel, D.F.3
  • 73
    • 0035750549 scopus 로고    scopus 로고
    • Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy
    • Pullarkat ST, Stoehlmacher J, Ghaderi V, et al. Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy. Pharmacogenomics J 2001; 1: 65-70
    • (2001) Pharmacogenomics J , vol.1 , pp. 65-70
    • Pullarkat, S.T.1    Stoehlmacher, J.2    Ghaderi, V.3
  • 74
    • 0035430487 scopus 로고    scopus 로고
    • Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer
    • Marsh S, McKay JA, Cassidy J, et al. Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer. Int J Oncol 2001; 19: 383-6
    • (2001) Int J Oncol , vol.19 , pp. 383-386
    • Marsh, S.1    McKay, J.A.2    Cassidy, J.3
  • 75
    • 4444339951 scopus 로고    scopus 로고
    • Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy
    • Lecomte T, Ferraz JM, Zinzindohoue F, et al. Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. Clin Cancer Res 2004; 10: 5880-8
    • (2004) Clin Cancer Res , vol.10 , pp. 5880-5888
    • Lecomte, T.1    Ferraz, J.M.2    Zinzindohoue, F.3
  • 76
    • 0035209477 scopus 로고    scopus 로고
    • Thymidylate synthase expression in stage II and III colon cancer: A retrospective review
    • Tomiak A, Vincent M, Earle CC, et al. Thymidylate synthase expression in stage II and III colon cancer: a retrospective review. Am J Clin Oncol 2001; 24: 597-602
    • (2001) Am J Clin Oncol , vol.24 , pp. 597-602
    • Tomiak, A.1    Vincent, M.2    Earle, C.C.3
  • 77
    • 27144456276 scopus 로고    scopus 로고
    • Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients
    • Westra JL, Hollema H, Schaapveld M, et al. Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients. Ann Oncol 2005; 16: 1646-53
    • (2005) Ann Oncol , vol.16 , pp. 1646-1653
    • Westra, J.L.1    Hollema, H.2    Schaapveld, M.3
  • 78
    • 0032765994 scopus 로고    scopus 로고
    • MTHFR (C677T) polymorphisms and stage III colon cancer: Response to therapy
    • Wisotzkey JD, Toman J, Bell T, et al. MTHFR (C677T) polymorphisms and stage III colon cancer: response to therapy. Mol Diagn 1999; 4: 95-9
    • (1999) Mol Diagn , vol.4 , pp. 95-99
    • Wisotzkey, J.D.1    Toman, J.2    Bell, T.3
  • 79
    • 19944428095 scopus 로고    scopus 로고
    • Methylenete-trahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients
    • Etienne MC, Formento JL, Chazal M, et al. Methylenete-trahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients. Pharmacogenetics 2004; 14: 785-92
    • (2004) Pharmacogenetics , vol.14 , pp. 785-792
    • Etienne, M.C.1    Formento, J.L.2    Chazal, M.3
  • 80
    • 23644459261 scopus 로고    scopus 로고
    • Genetic factors includencing pyrimidine-antagonist chemotherapy
    • Maring JG, Groen HJM, Wachters FM, et al. Genetic factors includencing pyrimidine-antagonist chemotherapy. Pharmacogenomics J 2005; 5: 226-43
    • (2005) Pharmacogenomics J , vol.5 , pp. 226-243
    • Maring, J.G.1    Groen, H.J.M.2    Wachters, F.M.3
  • 81
    • 0030981029 scopus 로고    scopus 로고
    • Structure organization of the human dihydropyrimidine dehydrogenase gene
    • Johnson MR, Wang K, Tillmanns S, et al. Structure organization of the human dihydropyrimidine dehydrogenase gene. Cancer Res 1997; 57: 1660-3
    • (1997) Cancer Res , vol.57 , pp. 1660-1663
    • Johnson, M.R.1    Wang, K.2    Tillmanns, S.3
  • 82
    • 0032143631 scopus 로고    scopus 로고
    • Characterization of the human dihydropyrimidine dehydrogenase gene
    • Wei X, Elizondo G, Sapone A, et al. Characterization of the human dihydropyrimidine dehydrogenase gene. Genomics 1998; 51: 391-400
    • (1998) Genomics , vol.51 , pp. 391-400
    • Wei, X.1    Elizondo, G.2    Sapone, A.3
  • 83
    • 0028813120 scopus 로고
    • Human polymorphism in drug metabolism: Mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uraciluria
    • Meinsma R, Fernandez-Salguero P, van Kuilenburg AB, et al. Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uraciluria. DNA Cell Biol 1995; 14: 1-6
    • (1995) DNA Cell Biol , vol.14 , pp. 1-6
    • Meinsma, R.1    Fernandez-Salguero, P.2    Van Kuilenburg, A.B.3
  • 84
    • 0028027180 scopus 로고
    • cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria
    • Yokota H, Fernandez-Salguero P, Furuya H, et al. cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria. J Biol Chem 1994; 269: 23192-6
    • (1994) J Biol Chem , vol.269 , pp. 23192-23196
    • Yokota, H.1    Fernandez-Salguero, P.2    Furuya, H.3
  • 85
    • 1942453306 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluororuracil
    • Van Kuilenburg ABP. Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluororuracil. Eur J Cancer 2004; 40: 939-50
    • (2004) Eur J Cancer , vol.40 , pp. 939-950
    • Van Kuilenburg, A.B.P.1
  • 86
    • 0032974922 scopus 로고    scopus 로고
    • Genotype and phenotype in patients with dihydropyrimidine dehydrogenase deficiency
    • Van Kuilenburg ABP, Vreken P, Abeling NGGM, et al. Genotype and phenotype in patients with dihydropyrimidine dehydrogenase deficiency. Hum Genet 1999; 104: 1-9
    • (1999) Hum Genet , vol.104 , pp. 1-9
    • Van Kuilenburg, A.B.P.1    Vreken, P.2    Abeling, N.G.G.M.3
  • 87
    • 0036798968 scopus 로고    scopus 로고
    • High prevalence of the IVS14 + 1G>A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicity
    • Van Kuilenburg ABP, Meinsma R, Zoetekouw L, et al. High prevalence of the IVS14 + 1G>A mutation in the dihydropyrimidine dehydrogenase gene of patients with severe 5-fluorouracil-associated toxicity. Pharmacogenetics 2002; 12: 555-8
    • (2002) Pharmacogenetics , vol.12 , pp. 555-558
    • Van Kuilenburg, A.B.P.1    Meinsma, R.2    Zoetekouw, L.3
  • 88
    • 0034901306 scopus 로고    scopus 로고
    • Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: Frequency of the common IVS14 + 1G>A mutation causing DPD deficiency
    • Van Kuilenburg AB, Muller EW, Haasjes J, et al. Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14 + 1G>A mutation causing DPD deficiency. Clin Cancer Res 2001; 7: 1149-53
    • (2001) Clin Cancer Res , vol.7 , pp. 1149-1153
    • Van Kuilenburg, A.B.1    Muller, E.W.2    Haasjes, J.3
  • 89
    • 0034050905 scopus 로고    scopus 로고
    • Known variant DPYD alleles do not explain dihydropyrimidine dehydrogenase deficiency in cancer patients
    • Collie-Duguid ES, Etienne MC, Milano G, et al. Known variant DPYD alleles do not explain dihydropyrimidine dehydrogenase deficiency in cancer patients. Pharmacogenetics 2000; 10: 217-23
    • (2000) Pharmacogenetics , vol.10 , pp. 217-223
    • Collie-Duguid, E.S.1    Etienne, M.C.2    Milano, G.3
  • 90
    • 0031948047 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase deficiency: A novel mutation and expression of missense mutations in E. coli
    • published erratum appears in J Inherit Metab Dis 1998; 21: 623
    • Vreken P, van Kuilenburg AB, Meinsma R, et al. Dihydropyrimidine dehydrogenase deficiency: a novel mutation and expression of missense mutations in E. coli. [published erratum appears in J Inherit Metab Dis 1998; 21: 623]. J Inherit Metab Dis 1998; 21: 276-9
    • (1998) J Inherit Metab Dis , vol.21 , pp. 276-279
    • Vreken, P.1    Van Kuilenburg, A.B.2    Meinsma, R.3
  • 91
    • 10844254584 scopus 로고    scopus 로고
    • Multiple organ failure due to 5-fluorouracil chemotherapy in a patient with a rare dihydropyrimidine dehydrogenase gene variant
    • Lazar A, Mau-Holzmann UA, Kolb H, et al. Multiple organ failure due to 5-fluorouracil chemotherapy in a patient with a rare dihydropyrimidine dehydrogenase gene variant. Onkologie 2004; 27: 559-62
    • (2004) Onkologie , vol.27 , pp. 559-562
    • Lazar, A.1    Mau-Holzmann, U.A.2    Kolb, H.3
  • 92
    • 0345700864 scopus 로고    scopus 로고
    • Lethal 5-fluorouracil toxicity associated with a novel mutation in the dihydropyrimidine dehydrogenase gene
    • Van Kuilenburg ABP, Baars JW, Meinsma R, et al. Lethal 5-fluorouracil toxicity associated with a novel mutation in the dihydropyrimidine dehydrogenase gene. Ann Oncol 2003; 14: 341-2
    • (2003) Ann Oncol , vol.14 , pp. 341-342
    • Van Kuilenburg, A.B.P.1    Baars, J.W.2    Meinsma, R.3
  • 93
    • 0032422075 scopus 로고    scopus 로고
    • Identification of novel mutations in the dihydropyrimidine dehydrogenase gene in a Japanese patient with 5-fluorouracil toxicity
    • Kouwaki M, Hamajima N, Sumi S, et al. Identification of novel mutations in the dihydropyrimidine dehydrogenase gene in a Japanese patient with 5-fluorouracil toxicity. Clin Cancer Res 1998; 4: 2999-3004
    • (1998) Clin Cancer Res , vol.4 , pp. 2999-3004
    • Kouwaki, M.1    Hamajima, N.2    Sumi, S.3
  • 94
    • 0035074119 scopus 로고    scopus 로고
    • Germline mutation of dihydropyrimidine dehydrogenase gene among a japanese population in relation to toxicity to 5-FU
    • Yamaguchi K, Arai Y, Kanda Y, et al. Germline mutation of dihydropyrimidine dehydrogenase gene among a japanese population in relation to toxicity to 5-FU. Jpn J Cancer Res 2001; 92: 337-42
    • (2001) Jpn J Cancer Res , vol.92 , pp. 337-342
    • Yamaguchi, K.1    Arai, Y.2    Kanda, Y.3
  • 95
    • 0031462149 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase (DPD) deficiency: Identification and expression of missense mutations C29R, R886H and R235W
    • Vreken P, van Kuilenburg AB, Meinsma R, et al. Dihydropyrimidine dehydrogenase (DPD) deficiency: identification and expression of missense mutations C29R, R886H and R235W. Hum Genet 1997; 101: 333-8
    • (1997) Hum Genet , vol.101 , pp. 333-338
    • Vreken, P.1    Van Kuilenburg, A.B.2    Meinsma, R.3
  • 96
    • 0036303541 scopus 로고    scopus 로고
    • Profound dihydropyrimidine dehydrogenase deficiency resulting from a novel compound heterozygote genotype
    • Johnson MR, Wang K, Diasio RB. Profound dihydropyrimidine dehydrogenase deficiency resulting from a novel compound heterozygote genotype. Clin Cancer Res 2002; 8: 768-74
    • (2002) Clin Cancer Res , vol.8 , pp. 768-774
    • Johnson, M.R.1    Wang, K.2    Diasio, R.B.3
  • 97
    • 0037093447 scopus 로고    scopus 로고
    • Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure
    • Van Kuilenburg ABP, Dobritzsch D, Meinsma R, et al. Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure. Biochem J 2002; 364: 157-63
    • (2002) Biochem J , vol.364 , pp. 157-163
    • Van Kuilenburg, A.B.P.1    Dobritzsch, D.2    Meinsma, R.3
  • 98
    • 0042525899 scopus 로고    scopus 로고
    • Denaturing high performance liquid chromatography analysis of the DPYD gene in patients with 5-fluorouracil toxicity
    • Ezzeldin H, Johnson MR, Okamoto Y, et al. Denaturing high performance liquid chromatography analysis of the DPYD gene in patients with 5-fluorouracil toxicity. Clin Cancer Res 2003; 9: 3021-8
    • (2003) Clin Cancer Res , vol.9 , pp. 3021-3028
    • Ezzeldin, H.1    Johnson, M.R.2    Okamoto, Y.3
  • 99
    • 0031807488 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase deficiency: Identification of two novel mutations and expression of missense mutations in E. coli
    • Vreken P, van Kuilenburg AB, Meinsma R, et al. Dihydropyrimidine dehydrogenase deficiency: identification of two novel mutations and expression of missense mutations in E. coli. Adv Exp Med Biol 1998; 431: 341-6
    • (1998) Adv Exp Med Biol , vol.431 , pp. 341-346
    • Vreken, P.1    Van Kuilenburg, A.B.2    Meinsma, R.3
  • 100
    • 25144509570 scopus 로고    scopus 로고
    • Identification of three novel mutations in the dihydropyrimidine dehydrogenase gene associated with altered pre-mRNA splicing or protein function
    • Van Kuilenburg AB, Meinsma R, Beke E, et al. Identification of three novel mutations in the dihydropyrimidine dehydrogenase gene associated with altered pre-mRNA splicing or protein function. Biol Chem 2005; 386: 319-24
    • (2005) Biol Chem , vol.386 , pp. 319-324
    • Van Kuilenburg, A.B.1    Meinsma, R.2    Beke, E.3
  • 101
    • 22344435797 scopus 로고    scopus 로고
    • Duhydropyrimidine dehydrogenase actibity in 150 healthy Japanese volunteers and identification of novel mutations
    • Ogura K, Ohnuma T, Minamide Y, et al. Duhydropyrimidine dehydrogenase actibity in 150 healthy Japanese volunteers and identification of novel mutations. Clin Cancer Res 2005; 11: 5067-8
    • (2005) Clin Cancer Res , vol.11 , pp. 5067-5068
    • Ogura, K.1    Ohnuma, T.2    Minamide, Y.3
  • 102
    • 23844456590 scopus 로고    scopus 로고
    • Analysis of the DPYD gene implication in 5-fluorouracil catabolism in a cohort of Caucasian individuals
    • Seck K, Riemer S, Kates R, et al. Analysis of the DPYD gene implication in 5-fluorouracil catabolism in a cohort of Caucasian individuals. Clin Cancer Res 2005; 11: 5886-92
    • (2005) Clin Cancer Res , vol.11 , pp. 5886-5892
    • Seck, K.1    Riemer, S.2    Kates, R.3
  • 103
    • 7344249042 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects
    • Ridge SA, Sludden J, Brown O, et al. Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects. Br J Clin Pharmacol 1998; 46: 151-6
    • (1998) Br J Clin Pharmacol , vol.46 , pp. 151-156
    • Ridge, S.A.1    Sludden, J.2    Brown, O.3
  • 104
    • 15144351973 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer
    • Ridge SA, Sludden J, Wei X, et al. Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer. Br J Cancer 1998; 77: 497-500
    • (1998) Br J Cancer , vol.77 , pp. 497-500
    • Ridge, S.A.1    Sludden, J.2    Wei, X.3
  • 105
    • 0000989026 scopus 로고    scopus 로고
    • Possible prediction of adverse reactions to fluorouracil by the measurement of urinary dihydrothymine and thymine
    • Sumi S, Kidouchi K, Kondou M, et al. Possible prediction of adverse reactions to fluorouracil by the measurement of urinary dihydrothymine and thymine. Int J Mol Med 1998; 2: 477-82
    • (1998) Int J Mol Med , vol.2 , pp. 477-482
    • Sumi, S.1    Kidouchi, K.2    Kondou, M.3
  • 106
    • 0030758197 scopus 로고    scopus 로고
    • Identification of novel point mutations in the dihydropyrimidine dehydrogenase gene
    • Vreken P, Van Kuilenburg AB, Meinsma R, et al. Identification of novel point mutations in the dihydropyrimidine dehydrogenase gene. J Inherit Metab Dis 1997; 20: 335-8
    • (1997) J Inherit Metab Dis , vol.20 , pp. 335-338
    • Vreken, P.1    Van Kuilenburg, A.B.2    Meinsma, R.3
  • 107
    • 0032795865 scopus 로고    scopus 로고
    • Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil
    • Johnson MR, Hageboutros A, Wang K, et al. Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil. Clin Cancer Res 1999; 5: 2006-11
    • (1999) Clin Cancer Res , vol.5 , pp. 2006-2011
    • Johnson, M.R.1    Hageboutros, A.2    Wang, K.3
  • 108
    • 0034808681 scopus 로고    scopus 로고
    • Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5′-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls
    • Raida M, Schwabe W, Häusler P, et al. Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5′-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls. Clin Cancer Res 2001; 7: 2832-9
    • (2001) Clin Cancer Res , vol.7 , pp. 2832-2839
    • Raida, M.1    Schwabe, W.2    Häusler, P.3
  • 109
    • 0031836751 scopus 로고    scopus 로고
    • Heterozygosity for point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity
    • Van Kuilenburg AB, Vreken P, Beex LV, et al. Heterozygosity for point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity. Adv Exp Med Biol 1998; 431: 293-8
    • (1998) Adv Exp Med Biol , vol.431 , pp. 293-298
    • Van Kuilenburg, A.B.1    Vreken, P.2    Beex, L.V.3
  • 110
    • 12244262239 scopus 로고    scopus 로고
    • Pharmacogenetics and clinical aspects of dihydropyrimidine dehydrogenase deficiency
    • Van Kuilenburg BP, De Abreu RA, van Gennip AH. Pharmacogenetics and clinical aspects of dihydropyrimidine dehydrogenase deficiency. Ann Clin Biochem 2003; 40: 41-5
    • (2003) Ann Clin Biochem , vol.40 , pp. 41-45
    • Van Kuilenburg, B.P.1    De Abreu, R.A.2    Van Gennip, A.H.3
  • 111
    • 33745907502 scopus 로고    scopus 로고
    • Association between mutations in the dihydropyrimidine dehydrogenase gene and severe toxicity of treatment with 5-fluorouracil: A prospective multicenter study
    • Kollmannsberger C, Bokemeyer C, Marx C, et al. Association between mutations in the dihydropyrimidine dehydrogenase gene and severe toxicity of treatment with 5-fluorouracil: a prospective multicenter study [abstract]. Onkologie 2001; 24 Suppl. 6: 101
    • (2001) Onkologie , vol.24 , Issue.6 SUPPL. , pp. 101
    • Kollmannsberger, C.1    Bokemeyer, C.2    Marx, C.3
  • 112
    • 29344443013 scopus 로고    scopus 로고
    • Methylation of the DPYD promoter: An alternative mechanism for dihydropyrimidine dehydrogenase deficiency in cancer patients
    • Ezzeldin HH, Lee AM, Mattison LK, et al. Methylation of the DPYD promoter: an alternative mechanism for dihydropyrimidine dehydrogenase deficiency in cancer patients. Clin Cancer Res 2005; 11: 8699-705
    • (2005) Clin Cancer Res , vol.11 , pp. 8699-8705
    • Ezzeldin, H.H.1    Lee, A.M.2    Mattison, L.K.3
  • 113
    • 0025083351 scopus 로고
    • Regional assignment of the human thymidylate synthase (TS) gene to chromosome band 18p11.32 by nonisotopic in situ hybridization
    • Hori T, Takahashi E, Ayusawa D, et al. Regional assignment of the human thymidylate synthase (TS) gene to chromosome band 18p11.32 by nonisotopic in situ hybridization. Hum Genet 1990; 85: 576-80
    • (1990) Hum Genet , vol.85 , pp. 576-580
    • Hori, T.1    Takahashi, E.2    Ayusawa, D.3
  • 114
    • 0035868667 scopus 로고    scopus 로고
    • Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer
    • Villafranca E, Okruzhnov Y, Dominguez MA, et al. Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer. J Clin Oncol 2001; 19: 1779-86
    • (2001) J Clin Oncol , vol.19 , pp. 1779-1786
    • Villafranca, E.1    Okruzhnov, Y.2    Dominguez, M.A.3
  • 115
    • 0037567591 scopus 로고    scopus 로고
    • A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity
    • Mandola MV, Stoehlmacher J, Muller-Weeks S, et al. A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity. Cancer Res 2003; 63: 2898-904
    • (2003) Cancer Res , vol.63 , pp. 2898-2904
    • Mandola, M.V.1    Stoehlmacher, J.2    Muller-Weeks, S.3
  • 116
    • 7244258790 scopus 로고    scopus 로고
    • Single nucleotide polymorphism in the 5́ tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients
    • Marcuello E, Altés A, del Rio E, et al. Single nucleotide polymorphism in the 5́ tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients. Int J Cancer 2004; 112: 733-7
    • (2004) Int J Cancer , vol.112 , pp. 733-737
    • Marcuello, E.1    Altés, A.2    Del Rio, E.3
  • 117
    • 0027426408 scopus 로고
    • Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: Population characteristics newly identified deficient patients and clinical implication in 5-fluorouracil chemotherapy
    • Lu Z, Zhang R, Diasio RB. Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics newly identified deficient patients and clinical implication in 5-fluorouracil chemotherapy. Cancer Res 1993; 53: 5433-8
    • (1993) Cancer Res , vol.53 , pp. 5433-5438
    • Lu, Z.1    Zhang, R.2    Diasio, R.B.3
  • 118
    • 0030885948 scopus 로고    scopus 로고
    • Semi-automated radioassay for determination of dihydropyrimidine dehydrogenase (DPD) activity: Screening cancer patients for DPD deficiency, a condition associated with 5-fluorouracil toxicity
    • Johnson MR, Yan J, Shao L, et al. Semi-automated radioassay for determination of dihydropyrimidine dehydrogenase (DPD) activity: screening cancer patients for DPD deficiency, a condition associated with 5-fluorouracil toxicity. J Chromatogr B 1997; 696: 183-91
    • (1997) J Chromatogr B , vol.696 , pp. 183-191
    • Johnson, M.R.1    Yan, J.2    Shao, L.3
  • 119
    • 0022263834 scopus 로고
    • Familial pyrimidinemia and pyrimidinuria associated with severe fluorouracil toxicity
    • Tuchman M, Stoeckeler JS, Kiang DT, et al. Familial pyrimidinemia and pyrimidinuria associated with severe fluorouracil toxicity. N Engl J Med 1985; 313: 245-9
    • (1985) N Engl J Med , vol.313 , pp. 245-249
    • Tuchman, M.1    Stoeckeler, J.S.2    Kiang, D.T.3
  • 120
    • 0034984031 scopus 로고    scopus 로고
    • Importance of dihydropyrimidine dehydrogenase (DPD) deficiency in patients exhibiting toxicity following treatment with 5-fluorouracil
    • Johnson MR, Diasio RB. Importance of dihydropyrimidine dehydrogenase (DPD) deficiency in patients exhibiting toxicity following treatment with 5-fluorouracil. Adv Enzyme Regul 2001; 41: 151-7
    • (2001) Adv Enzyme Regul , vol.41 , pp. 151-157
    • Johnson, M.R.1    Diasio, R.B.2
  • 121
    • 0032940053 scopus 로고    scopus 로고
    • Correlation between uracil and dihydrouracil plasma ratio, fluorouracil (5-FU) pharmacokinetic parameters, and tolerance in patients with advanced colorectal cancer: A potential interest for predicting 5-FU toxicity and determining optimal 5-FU dosage
    • Gamelin E, Boisdron-Celle M, Guérin-Meyer V, et al. Correlation between uracil and dihydrouracil plasma ratio, fluorouracil (5-FU) pharmacokinetic parameters, and tolerance in patients with advanced colorectal cancer: a potential interest for predicting 5-FU toxicity and determining optimal 5-FU dosage. J Clin Oncol 1999; 17: 1105-10
    • (1999) J Clin Oncol , vol.17 , pp. 1105-1110
    • Gamelin, E.1    Boisdron-Celle, M.2    Guérin-Meyer, V.3
  • 122
    • 0031807939 scopus 로고    scopus 로고
    • Urinary screening for pyrimidine metabolism disorders: Reference ranges for dihydrouracil, uracil and dihydrouracil/uracil ratio
    • Sumi S, Kidouchi K, Hayashi K, et al. Urinary screening for pyrimidine metabolism disorders: reference ranges for dihydrouracil, uracil and dihydrouracil/uracil ratio. Adv Exp Med Biol 1998; 431: 191-5
    • (1998) Adv Exp Med Biol , vol.431 , pp. 191-195
    • Sumi, S.1    Kidouchi, K.2    Hayashi, K.3
  • 123
    • 0024781839 scopus 로고
    • Comparative study of thymine and uracil metabolism in healthy persons and in a patients with dihydropyrimidine dehydrogenase deficiency
    • Van Gennip AH, Abeling NG, Elzinga-Zoetekouw L, et al. Comparative study of thymine and uracil metabolism in healthy persons and in a patients with dihydropyrimidine dehydrogenase deficiency. Adv Exp Med Biol 1989; 253A: 111-8
    • (1989) Adv Exp Med Biol , vol.253 A , pp. 111-118
    • Van Gennip, A.H.1    Abeling, N.G.2    Elzinga-Zoetekouw, L.3
  • 124
    • 0033783745 scopus 로고    scopus 로고
    • Urinary pyrimidine analysis in healthy newborns, infants, children, adults and patients with congenital metabolic disease
    • Asai M, Sumi S, Kidouchi K, et al. Urinary pyrimidine analysis in healthy newborns, infants, children, adults and patients with congenital metabolic disease. Pediatr Int 2000; 42: 499-503
    • (2000) Pediatr Int , vol.42 , pp. 499-503
    • Asai, M.1    Sumi, S.2    Kidouchi, K.3
  • 125
    • 0030469777 scopus 로고    scopus 로고
    • Possible prediction of adverse reactions to pyrimidine chemotherapy from urinary pyrimidine levels and a case of asymptomatic adult dihydropyrimidinuria
    • Hayashi K, Kidouchi K, Sumi S, et al. Possible prediction of adverse reactions to pyrimidine chemotherapy from urinary pyrimidine levels and a case of asymptomatic adult dihydropyrimidinuria. Clin Cancer Res 1996; 2: 1937-41
    • (1996) Clin Cancer Res , vol.2 , pp. 1937-1941
    • Hayashi, K.1    Kidouchi, K.2    Sumi, S.3
  • 126
    • 0033870677 scopus 로고    scopus 로고
    • Comparative pharmacokinetic analysis of 5-fluorouracil and its major metabolite 5-fluoro-5,6-dihydrouracil after conventional and of duced test dose in cancer patients
    • Bocci G, Danesi R, Di Paolo A, et al. Comparative pharmacokinetic analysis of 5-fluorouracil and its major metabolite 5-fluoro-5,6-dihydrouracil after conventional and of duced test dose in cancer patients. Clin Cancer Res 2000; 6: 3032-7
    • (2000) Clin Cancer Res , vol.6 , pp. 3032-3037
    • Bocci, G.1    Danesi, R.2    Di Paolo, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.