Methylation of the DPYD promoter: An alternative mechanism for dihydropyrimidine dehydrogenase deficiency in cancer patients

Clinical Cancer Research

Volumn 11, Issue 24, 2005, Pages 8699-8705

  Ezzeldin, Hany H ^a   Lee, Adam M ^a   Mattison, Lori K ^a   Diasio, Robert B ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL;

ALLELE; ARTICLE; BLOOD SAMPLING; CANCER PATIENT; DENATURING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; DPYD GENE; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME DEGRADATION; ENZYME MECHANISM; GENE; GENE LOCATION; GENE SEQUENCE; GENOTYPE; HUMAN; HUMAN CELL; METHYLATION; PHARMACOGENETICS; PRIORITY JOURNAL; PROMOTER REGION;

ADULT; ANTIMETABOLITES, ANTINEOPLASTIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CPG ISLANDS; DIHYDROURACIL DEHYDROGENASE (NADP); DNA METHYLATION; DOWN-REGULATION; FEMALE; FLUOROURACIL; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MUTATION; NEOPLASMS; NUCLEIC ACID DENATURATION; PHENOTYPE; PROMOTER REGIONS (GENETICS);

EID: 29344443013     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-05-1520     Document Type: Article

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