-
1
-
-
0034605033
-
Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells
-
Abrams JR, Kelley SL, Hayes E, Kikuchi T, Brown MJ, Kang S et al. (2000) Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells. J Exp Med 192:681-94
-
(2000)
J Exp Med
, vol.192
, pp. 681-694
-
-
Abrams, J.R.1
Kelley, S.L.2
Hayes, E.3
Kikuchi, T.4
Brown, M.J.5
Kang, S.6
-
2
-
-
34548125305
-
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
-
Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F (2007a) Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8:942-9
-
(2007)
Nat Immunol
, vol.8
, pp. 942-949
-
-
Acosta-Rodriguez, E.V.1
Napolitani, G.2
Lanzavecchia, A.3
Sallusto, F.4
-
3
-
-
34249079176
-
Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
-
Acosta-Rodriguez EV, Rivino L, Geginat J, Jarrossay D, Gattorno M, Lanzavecchia A et al. (2007b) Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol 8:639-46
-
(2007)
Nat Immunol
, vol.8
, pp. 639-646
-
-
Acosta-Rodriguez, E.V.1
Rivino, L.2
Geginat, J.3
Jarrossay, D.4
Gattorno, M.5
Lanzavecchia, A.6
-
4
-
-
0037449737
-
Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
-
Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL (2003) Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 278:1910-4
-
(2003)
J Biol Chem
, vol.278
, pp. 1910-1914
-
-
Aggarwal, S.1
Ghilardi, N.2
Xie, M.H.3
de Sauvage, F.J.4
Gurney, A.L.5
-
5
-
-
0033911218
-
Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes
-
Albanesi C, , Scarponi C, Cavani A, Federici M, Nasorri F, Girolomoni G (2000) Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes. J Invest Dermatol 115:81-7
-
(2000)
J Invest Dermatol
, vol.115
, pp. 81-87
-
-
Albanesi, C.1
Scarponi, C.2
Cavani, A.3
Federici, M.4
Nasorri, F.5
Girolomoni, G.6
-
6
-
-
18244428735
-
Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency
-
Altare F, Durandy A, Lammas D, Emile JF, Lamhamedi S, Le Deist F et al. (1998) Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science 280:1432-5
-
(1998)
Science
, vol.280
, pp. 1432-1435
-
-
Altare, F.1
Durandy, A.2
Lammas, D.3
Emile, J.F.4
Lamhamedi, S.5
Le Deist, F.6
-
7
-
-
24144477540
-
Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts
-
Andoh A, Zhang Z, Inatomi O, Fujino S, Deguchi Y, Araki Y et al. (2005) Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. Gastroenterology 129:969-84
-
(2005)
Gastroenterology
, vol.129
, pp. 969-984
-
-
Andoh, A.1
Zhang, Z.2
Inatomi, O.3
Fujino, S.4
Deguchi, Y.5
Araki, Y.6
-
8
-
-
34447281733
-
Interleukin 25 promotes the initiation of proallergic type 2 responses
-
Angkasekwinai P, Park H, Wang YH, Chang SH, Corry DB, Liu YJ et al. (2007) Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med 204:1509-17
-
(2007)
J Exp Med
, vol.204
, pp. 1509-1517
-
-
Angkasekwinai, P.1
Park, H.2
Wang, Y.H.3
Chang, S.H.4
Corry, D.B.5
Liu, Y.J.6
-
9
-
-
27644565806
-
Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity
-
Arican O, Aral M, Sasmaz S, Ciragil P (2005) Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. Mediators Inflamm 2005:273-9
-
(2005)
Mediators Inflamm
, vol.2005
, pp. 273-279
-
-
Arican, O.1
Aral, M.2
Sasmaz, S.3
Ciragil, P.4
-
10
-
-
0032729645
-
The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: A type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients
-
Austin LM, Ozawa M, Kikuchi T, Walters IB, Krueger JG (1999) The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients. J Invest Dermatol 113:752-9
-
(1999)
J Invest Dermatol
, vol.113
, pp. 752-759
-
-
Austin, L.M.1
Ozawa, M.2
Kikuchi, T.3
Walters, I.B.4
Krueger, J.G.5
-
11
-
-
33747588291
-
Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
-
Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S et al. (2006) Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 7:929-36
-
(2006)
Nat Immunol
, vol.7
, pp. 929-936
-
-
Batten, M.1
Li, J.2
Yi, S.3
Kljavin, N.M.4
Danilenko, D.M.5
Lucas, S.6
-
12
-
-
0036604062
-
IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells
-
Belladonna ML, RenauldJC, Bianchi R, Vacca C, Fallarino F, Orabona C et al. (2002) IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells. J Immunol 168:5448-54
-
(2002)
J Immunol
, vol.168
, pp. 5448-5454
-
-
Belladonna, M.L.1
Renauld, J.C.2
Bianchi, R.3
Vacca, C.4
Fallarino, F.5
Orabona, C.6
-
13
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M et al. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235-8
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
Korn, T.4
Strom, T.B.5
Oukka, M.6
-
14
-
-
34248572345
-
T(H)-17 cells in the circle of immunity and autoimmunity
-
Bettelli E, Oukka M, Kuchroo VK (2007) T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol 8:345-50
-
(2007)
Nat Immunol
, vol.8
, pp. 345-350
-
-
Bettelli, E.1
Oukka, M.2
Kuchroo, V.K.3
-
15
-
-
42149161160
-
T-helper 17 cells in psoriatic plaques and additional genetic links between IL-23 and psoriasis
-
Blauvelt A (2008) T-helper 17 cells in psoriatic plaques and additional genetic links between IL-23 and psoriasis. J Invest Dermatol 128: 1064-7
-
(2008)
J Invest Dermatol
, vol.128
, pp. 1064-1067
-
-
Blauvelt, A.1
-
16
-
-
36048953799
-
A role for T cell-derived interleukin 22 in psoriatic skin inflammation
-
Boniface K, Guignouard E, Pedretti N, Garcia M, Delwail A, Bernard FX et al. (2007) A role for T cell-derived interleukin 22 in psoriatic skin inflammation. Clin Exp Immunol 150:407-15
-
(2007)
Clin Exp Immunol
, vol.150
, pp. 407-415
-
-
Boniface, K.1
Guignouard, E.2
Pedretti, N.3
Garcia, M.4
Delwail, A.5
Bernard, F.X.6
-
17
-
-
0024521715
-
Predominance of "memory" T cells (CD4+, CDw29+) over "naive" T cells (CD4+, CD45R+) in both normal and diseased human skin
-
Bos JD, Hagenaars C, Das PK, Krieg SR, Voorn WJ, Kapsenberg ML (1989) Predominance of "memory" T cells (CD4+, CDw29+) over "naive" T cells (CD4+, CD45R+) in both normal and diseased human skin. Arch Dermatol Res 281:24-30
-
(1989)
Arch Dermatol Res
, vol.281
, pp. 24-30
-
-
Bos, J.D.1
Hagenaars, C.2
Das, P.K.3
Krieg, S.R.4
Voorn, W.J.5
Kapsenberg, M.L.6
-
18
-
-
1542313881
-
Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha
-
Boyman O, Hefti HP, Conrad C, Nickoloff BJ, Suter M, Nestle FO (2004) Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha. J Exp Med 199:731-6
-
(2004)
J Exp Med
, vol.199
, pp. 731-736
-
-
Boyman, O.1
Hefti, H.P.2
Conrad, C.3
Nickoloff, B.J.4
Suter, M.5
Nestle, F.O.6
-
19
-
-
33645829078
-
IL-22 is increased in active Crohn's disease and promotes proinflamma-tory gene expression and intestinal epithelial cell migration
-
Brand S, Beigel F, Olszak T, Zitzmann K, Eichhorst ST, Otte JM et al. (2006) IL-22 is increased in active Crohn's disease and promotes proinflamma-tory gene expression and intestinal epithelial cell migration. Am J Physiol Gastrointest Liver Physiol 290:G827-38
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
-
-
Brand, S.1
Beigel, F.2
Olszak, T.3
Zitzmann, K.4
Eichhorst, S.T.5
Otte, J.M.6
-
20
-
-
0036884860
-
Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibody
-
Brok HP, van Meurs M, Blezer E, Schantz A, Peritt D, Treacy G et al. (2002) Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibody. J Immunol 169:6554-63
-
(2002)
J Immunol
, vol.169
, pp. 6554-6563
-
-
Brok, H.P.1
van Meurs, M.2
Blezer, E.3
Schantz, A.4
Peritt, D.5
Treacy, G.6
-
21
-
-
33745553245
-
A phase 1/2A trial of STA 5326, an oral interleukin-12/23 inhibitor, in patients with active moderate to severe Crohn's disease
-
Burakoff R, Barish CF, Riff D, Pruitt R, Chey WY, Farraye FA et al. (2006) A phase 1/2A trial of STA 5326, an oral interleukin-12/23 inhibitor, in patients with active moderate to severe Crohn's disease. Inflamm Bowel Dis 12:558-65
-
(2006)
Inflamm Bowel Dis
, vol.12
, pp. 558-565
-
-
Burakoff, R.1
Barish, C.F.2
Riff, D.3
Pruitt, R.4
Chey, W.Y.5
Farraye, F.A.6
-
22
-
-
0036188478
-
Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein
-
Bush KA, Farmer KM, Walker JS, Kirkham BW (2002) Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein. Arthritis Rheum 46:802-5
-
(2002)
Arthritis Rheum
, vol.46
, pp. 802-805
-
-
Bush, K.A.1
Farmer, K.M.2
Walker, J.S.3
Kirkham, B.W.4
-
23
-
-
34547774225
-
Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis
-
Capon F, Di Meglio P, Szaub J, Prescott NJ, Dunster C, Baumber L et al. (2007) Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. Hum Genet 122:201-6
-
(2007)
Hum Genet
, vol.122
, pp. 201-206
-
-
Capon, F.1
Di Meglio, P.2
Szaub, J.3
Prescott, N.J.4
Dunster, C.5
Baumber, L.6
-
24
-
-
33846608131
-
A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes
-
Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP et al. (2007) A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet 80:273-90
-
(2007)
Am J Hum Genet
, vol.80
, pp. 273-290
-
-
Cargill, M.1
Schrodi, S.J.2
Chang, M.3
Garcia, V.E.4
Brandon, R.5
Callis, K.P.6
-
25
-
-
0032939156
-
Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium
-
Chabaud M, Durand JM, Buchs N, Fossiez F, Page G, Frappart L et al. (1999) Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum 42:963-70
-
(1999)
Arthritis Rheum
, vol.42
, pp. 963-970
-
-
Chabaud, M.1
Durand, J.M.2
Buchs, N.3
Fossiez, F.4
Page, G.5
Frappart, L.6
-
26
-
-
33751546237
-
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis
-
Chan JR, Blumenschein W, Murphy E, Diveu C, Wiekowski M, Abbondanzo S et al. (2006) IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med 203:2557-87
-
(2006)
J Exp Med
, vol.203
, pp. 2557-2587
-
-
Chan, J.R.1
Blumenschein, W.2
Murphy, E.3
Diveu, C.4
Wiekowski, M.5
Abbondanzo, S.6
-
27
-
-
0348223787
-
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
-
Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N etal. (2003) Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198:1875-86
-
(2003)
J Exp Med
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
Jin, W.2
Hardegen, N.3
Lei, K.J.4
Li, L.5
Marinos, N.6
-
28
-
-
38949155203
-
Regulation of IL-17 production in human lymphocytes
-
Chen Z, O'Shea JJ (2008) Regulation of IL-17 production in human lymphocytes. Cytokine 41:71-8
-
(2008)
Cytokine
, vol.41
, pp. 71-78
-
-
Chen, Z.1
O'Shea, J.J.2
-
29
-
-
34848821989
-
Distinct regulation of interleukin-17 in human T helper lymphocytes
-
Chen Z, Tato CM, Muul L, Laurence A, O'Shea JJ (2007) Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum 56:2936-46
-
(2007)
Arthritis Rheum
, vol.56
, pp. 2936-2946
-
-
Chen, Z.1
Tato, C.M.2
Muul, L.3
Laurence, A.4
O'Shea, J.J.5
-
30
-
-
33845744729
-
Cyclosporine A inhibits IL-15-induced IL-17 production in CD4+ T cells via down-regulation of PI3K/Akt and NF-kappaB
-
Cho ML, Ju JH, Kim KW, Moon YM, Lee SY, Min SY et al. (2007) Cyclosporine A inhibits IL-15-induced IL-17 production in CD4+ T cells via down-regulation of PI3K/Akt and NF-kappaB. Immunol Lett 108:88-96
-
(2007)
Immunol Lett
, vol.108
, pp. 88-96
-
-
Cho, M.L.1
Ju, J.H.2
Kim, K.W.3
Moon, Y.M.4
Lee, S.Y.5
Min, S.Y.6
-
31
-
-
0037442115
-
CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism
-
Chung DR, Kasper DL, Panzo RJ, Chitnis T, Grusby MJ, Sayegh MH et al. (2003) CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism. J Immunol 170:1958-63
-
(2003)
J Immunol
, vol.170
, pp. 1958-1963
-
-
Chung, D.R.1
Kasper, D.L.2
Panzo, R.J.3
Chitnis, T.4
Grusby, M.J.5
Sayegh, M.H.6
-
32
-
-
34447124969
-
Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis
-
Conrad C, Boyman O, Tonel G, Tun-Kyi A, Laggner U, de Fougerolles A et al. (2007) Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. Nat Med 13:836-42
-
(2007)
Nat Med
, vol.13
, pp. 836-842
-
-
Conrad, C.1
Boyman, O.2
Tonel, G.3
Tun-Kyi, A.4
Laggner, U.5
de Fougerolles, A.6
-
33
-
-
49249135394
-
Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor
-
Cosmi L, De Palma R, Santarlasci V, Maggi L, Capone M, Frosali F et al. (2008) Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor. J Exp Med 205:1903-16
-
(2008)
J Exp Med
, vol.205
, pp. 1903-1916
-
-
Cosmi, L.1
De Palma, R.2
Santarlasci, V.3
Maggi, L.4
Capone, M.5
Frosali, F.6
-
34
-
-
0037434789
-
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
-
Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B et al. (2003) Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421:744-8
-
(2003)
Nature
, vol.421
, pp. 744-748
-
-
Cua, D.J.1
Sherlock, J.2
Chen, Y.3
Murphy, C.A.4
Joyce, B.5
Seymour, B.6
-
35
-
-
46949086109
-
Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells
-
de Beaucoudrey L, Puel A, Filipe-Santos O, Cobat A, Ghandil P, Chrabieh M et al. (2008) Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells. J Exp Med 205:1543-50
-
(2008)
J Exp Med
, vol.205
, pp. 1543-1550
-
-
de Beaucoudrey, L.1
Puel, A.2
Filipe-Santos, O.3
Cobat, A.4
Ghandil, P.5
Chrabieh, M.6
-
36
-
-
0032577295
-
Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients
-
de Jong R, Altare F, Haagen IA, Elferink DG, Boer T, van Breda Vriesman PJ et al. (1998) Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science 280:1435-8
-
(1998)
Science
, vol.280
, pp. 1435-1438
-
-
de Jong, R.1
Altare, F.2
Haagen, I.A.3
Elferink, D.G.4
Boer, T.5
van Breda Vriesman, P.J.6
-
37
-
-
0024840522
-
Further characterization of the "incipient lesion of chronic stationary type psoriasis vulgaris in exacerbation". The CD4-positive lymphocytes are the prominent cell population infiltrating the dermis
-
De Panfilis G, Manara GC, Ferrari C, Torresani C, Zucchi A, Devoto RM (1989) Further characterization of the "incipient lesion of chronic stationary type psoriasis vulgaris in exacerbation". The CD4-positive lymphocytes are the prominent cell population infiltrating the dermis. Acta Derm Venereol Suppl 146:26-30
-
(1989)
Acta Derm Venereol Suppl
, vol.146
, pp. 26-30
-
-
De Panfilis, G.1
Manara, G.C.2
Ferrari, C.3
Torresani, C.4
Zucchi, A.5
Devoto, R.M.6
-
38
-
-
33845340501
-
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
-
Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ et al. (2006) A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314:1461-3
-
(2006)
Science
, vol.314
, pp. 1461-1463
-
-
Duerr, R.H.1
Taylor, K.D.2
Brant, S.R.3
Rioux, J.D.4
Silverberg, M.S.5
Daly, M.J.6
-
39
-
-
43849103451
-
Relation of an interleukin-23 receptor gene polymorphism to graft-versus-host disease after hematopoietic-cell transplantation
-
Elmaagacli AH, Koldehoff M, Landt O, Beelen DW (2008) Relation of an interleukin-23 receptor gene polymorphism to graft-versus-host disease after hematopoietic-cell transplantation. Bone Marrow Transplant 41:821-6
-
(2008)
Bone Marrow Transplant
, vol.41
, pp. 821-826
-
-
Elmaagacli, A.H.1
Koldehoff, M.2
Landt, O.3
Beelen, D.W.4
-
40
-
-
36749081557
-
Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes
-
Evans HG, Suddason T, Jackson I, Taams LS, Lord GM (2007) Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes. Proc Natl Acad Sci USA 104:17034-9
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 17034-17039
-
-
Evans, H.G.1
Suddason, T.2
Jackson, I.3
Taams, L.S.4
Lord, G.M.5
-
41
-
-
38749138182
-
Functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis but not for systemic sclerosis
-
Farago B, Magyari L, Safrany E, Csongei V, Jaromi L, Horvatovich K et al. (2008) Functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis but not for systemic sclerosis. Ann Rheum Dis 67:248-50
-
(2008)
Ann Rheum Dis
, vol.67
, pp. 248-250
-
-
Farago, B.1
Magyari, L.2
Safrany, E.3
Csongei, V.4
Jaromi, L.5
Horvatovich, K.6
-
42
-
-
0033953110
-
CD69, HLA-DR and the IL-2R identify persistently activated T cells in psoriasis vulgaris lesional skin: Blood and skin comparisons by flow cytometry
-
Ferenczi K, Burack L, Pope M, Krueger JG, Austin LM (2000) CD69, HLA-DR and the IL-2R identify persistently activated T cells in psoriasis vulgaris lesional skin: blood and skin comparisons by flow cytometry. J Autoimmun 14:63-78
-
(2000)
J Autoimmun
, vol.14
, pp. 63-78
-
-
Ferenczi, K.1
Burack, L.2
Pope, M.3
Krueger, J.G.4
Austin, L.M.5
-
43
-
-
15844402155
-
T cell interleukin-17 induces stromal cells to produce proin-flammatory and hematopoietic cytokines
-
Fossiez F, Djossou O, Chomarat P, Flores-Romo L, Ait-Yahia S, Maat C et al. (1996) T cell interleukin-17 induces stromal cells to produce proin-flammatory and hematopoietic cytokines. J Exp Med 183:2593-603
-
(1996)
J Exp Med
, vol.183
, pp. 2593-2603
-
-
Fossiez, F.1
Djossou, O.2
Chomarat, P.3
Flores-Romo, L.4
Ait-Yahia, S.5
Maat, C.6
-
44
-
-
0037216498
-
Increased expression of interleukin 17 in inflammatory bowel disease
-
Fujino S, Andoh A, Bamba S, Ogawa A, Hata K, Araki Y et al. (2003) Increased expression of interleukin 17 in inflammatory bowel disease. Gut 52:65-70
-
(2003)
Gut
, vol.52
, pp. 65-70
-
-
Fujino, S.1
Andoh, A.2
Bamba, S.3
Ogawa, A.4
Hata, K.5
Araki, Y.6
-
45
-
-
29744450121
-
Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
-
Fuss IJ, Becker C, Yang Z, Groden C, Hornung RL, Heller F et al. (2006) Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm Bowel Dis 12:9-15
-
(2006)
Inflamm Bowel Dis
, vol.12
, pp. 9-15
-
-
Fuss, I.J.1
Becker, C.2
Yang, Z.3
Groden, C.4
Hornung, R.L.5
Heller, F.6
-
46
-
-
2142711704
-
Alefacept therapy reduces the effector T-cell population in lesional psoriatic epidermis
-
Goedkoop AY, de Rie MA, Picavet DI, Kraan MC, Dinant HJ, van Kuijk AW et al. (2004) Alefacept therapy reduces the effector T-cell population in lesional psoriatic epidermis. Arch Dermatol Res 295:465-73
-
(2004)
Arch Dermatol Res
, vol.295
, pp. 465-473
-
-
Goedkoop, A.Y.1
de Rie, M.A.2
Picavet, D.I.3
Kraan, M.C.4
Dinant, H.J.5
van Kuijk, A.W.6
-
47
-
-
23444432216
-
TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques
-
Gottlieb AB, Chamian F, Masud S, Cardinale I, Abello MV, Lowes MA et al. (2005) TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques. J Immunol 175:2721-9
-
(2005)
J Immunol
, vol.175
, pp. 2721-2729
-
-
Gottlieb, A.B.1
Chamian, F.2
Masud, S.3
Cardinale, I.4
Abello, M.V.5
Lowes, M.A.6
-
48
-
-
34249039292
-
A phase 1, double-blind, placebo-controlled study evaluating single subcutaneous administrations of a human interleukin-12/23 monoclonal antibody in subjects with plaque psoriasis
-
Gottlieb AB, Cooper KD, McCormick TS, Toichi E, Everitt DE, Frederick B et al. (2007) A phase 1, double-blind, placebo-controlled study evaluating single subcutaneous administrations of a human interleukin-12/23 monoclonal antibody in subjects with plaque psoriasis. Curr Med Res Opin 23:1081-92
-
(2007)
Curr Med Res Opin
, vol.23
, pp. 1081-1092
-
-
Gottlieb, A.B.1
Cooper, K.D.2
McCormick, T.S.3
Toichi, E.4
Everitt, D.E.5
Frederick, B.6
-
49
-
-
39149090681
-
Insights into gene modulation by therapeutic TNF and IFNgamma antibodies: TNF regulates IFNgamma production by T cells and TNF- regulated genes linked to psoriasis transcriptome
-
Haider AS, Cohen J, Fei J, Zaba LC, Cardinale I, Toyoko K et al. (2008a) Insights into gene modulation by therapeutic TNF and IFNgamma antibodies: TNF regulates IFNgamma production by T cells and TNF- regulated genes linked to psoriasis transcriptome. J Invest Dermatol 128:655-66
-
(2008)
J Invest Dermatol
, vol.128
, pp. 655-666
-
-
Haider, A.S.1
Cohen, J.2
Fei, J.3
Zaba, L.C.4
Cardinale, I.5
Toyoko, K.6
-
50
-
-
40749156754
-
Identification of cellular pathways of "type 1", Th17 T cells, and TNF- and inducible nitric oxide synthase-producing dendritic cells in autoimmune inflammation through pharmacogenomic study of cyclosporine A in psoriasis
-
Haider AS, Lowes MA, Suarez-Farinas M, Zaba LC, Cardinale I, Khatcherian A et al. (2008b) Identification of cellular pathways of "type 1", Th17 T cells, and TNF- and inducible nitric oxide synthase-producing dendritic cells in autoimmune inflammation through pharmacogenomic study of cyclosporine A in psoriasis. J Immunol 180:1913-20
-
(2008)
J Immunol
, vol.180
, pp. 1913-1920
-
-
Haider, A.S.1
Lowes, M.A.2
Suarez-Farinas, M.3
Zaba, L.C.4
Cardinale, I.5
Khatcherian, A.6
-
51
-
-
27544490377
-
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
-
Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM et al. (2005) Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6:1123-32
-
(2005)
Nat Immunol
, vol.6
, pp. 1123-1132
-
-
Harrington, L.E.1
Hatton, R.D.2
Mangan, P.R.3
Turner, H.4
Murphy, T.L.5
Murphy, K.M.6
-
52
-
-
30944452780
-
Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis
-
Hofstetter HH, Ibrahim SM, Koczan D, Kruse N, Weishaupt A, Toyka KV et al. (2005) Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis. Cell Immunol 237:123-30
-
(2005)
Cell Immunol
, vol.237
, pp. 123-130
-
-
Hofstetter, H.H.1
Ibrahim, S.M.2
Koczan, D.3
Kruse, N.4
Weishaupt, A.5
Toyka, K.V.6
-
53
-
-
0033564323
-
IL-12, independently of IFN-gamma, plays a crucial role in the pathogenesis of a murine psoriasis-like skin disorder
-
Hong K, Chu A, Lùdvìksson BR, Berg EL, Ehrhardt RO (1999) IL-12, independently of IFN-gamma, plays a crucial role in the pathogenesis of a murine psoriasis-like skin disorder. J Immunol 162:7480-91
-
(1999)
J Immunol
, vol.162
, pp. 7480-7491
-
-
Hong, K.1
Chu, A.2
Lùdvìksson, B.R.3
Berg, E.L.4
Ehrhardt, R.O.5
-
54
-
-
3242814586
-
Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice
-
Huang W, Na L, Fidel PL, Schwarzenberger P (2004) Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis 190:624-31
-
(2004)
J Infect Dis
, vol.190
, pp. 624-631
-
-
Huang, W.1
Na, L.2
Fidel, P.L.3
Schwarzenberger, P.4
-
55
-
-
40849119745
-
Interleukin (IL)-23 receptor is a major susceptibility gene for Graves' ophthalmopathy: The IL-23/T-helper 17 axis extends to thyroid auto-immunity
-
Huber AK, Jacobson EM, Jazdzewski K, Concepcion ES, Tomer Y (2008) Interleukin (IL)-23 receptor is a major susceptibility gene for Graves' ophthalmopathy: the IL-23/T-helper 17 axis extends to thyroid auto-immunity. J Clin Endocrinol Metab 93:1077-81
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 1077-1081
-
-
Huber, A.K.1
Jacobson, E.M.2
Jazdzewski, K.3
Concepcion, E.S.4
Tomer, Y.5
-
56
-
-
48249149426
-
TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: A novel in vivo screening model of psoriasis
-
Hvid H, Teige I, Kvist PH, Svensson L, Kemp K (2008) TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis. Int Immunol 20:1097-106
-
(2008)
Int Immunol
, vol.20
, pp. 1097-1106
-
-
Hvid, H.1
Teige, I.2
Kvist, P.H.3
Svensson, L.4
Kemp, K.5
-
57
-
-
17244381180
-
Expression of interleukin-22 in rheumatoid arthritis: Potential role as a proinflammatory cytokine
-
Ikeuchi H, Kuroiwa T, Hiramatsu N, Kaneko Y, Hiromura K, Ueki K et al. (2005) Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine. Arthritis Rheum 52:1037-46
-
(2005)
Arthritis Rheum
, vol.52
, pp. 1037-1046
-
-
Ikeuchi, H.1
Kuroiwa, T.2
Hiramatsu, N.3
Kaneko, Y.4
Hiromura, K.5
Ueki, K.6
-
58
-
-
38049039796
-
3′UTR C2370A allele of the IL-23 receptor gene is associated with relapsing-remitting multiple sclerosis
-
Illes Z, Safrany E, Peterfalvi A, Magyari L, Farago B, Pozsonyi E et al. (2008) 3′UTR C2370A allele of the IL-23 receptor gene is associated with relapsing-remitting multiple sclerosis. Neurosci Lett 431:36-8
-
(2008)
Neurosci Lett
, vol.431
, pp. 36-38
-
-
Illes, Z.1
Safrany, E.2
Peterfalvi, A.3
Magyari, L.4
Farago, B.5
Pozsonyi, E.6
-
60
-
-
33748588423
-
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
-
Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ et al. (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126:1121-33
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
McKenzie, B.S.2
Zhou, L.3
Tadokoro, C.E.4
Lepelley, A.5
Lafaille, J.J.6
-
61
-
-
36148976803
-
Etanercept reduces the serum levels of interleukin-23 and macrophage inflammatory protein-3 alpha in patients with rheumatoid arthritis
-
Kageyama Y, Ichikawa T, Nagafusa T, Torikai E, Shimazu M, Nagano A (2007) Etanercept reduces the serum levels of interleukin-23 and macrophage inflammatory protein-3 alpha in patients with rheumatoid arthritis. Rheumatol Int 28:137-43
-
(2007)
Rheumatol Int
, vol.28
, pp. 137-143
-
-
Kageyama, Y.1
Ichikawa, T.2
Nagafusa, T.3
Torikai, E.4
Shimazu, M.5
Nagano, A.6
-
62
-
-
47049124548
-
IL-12, IL-23, and IL-27 enhance human beta-defensin-2 production in human keratinocytes
-
Kanda N, Watanabe S (2008) IL-12, IL-23, and IL-27 enhance human beta-defensin-2 production in human keratinocytes. Eur J Immunol 38:1287-96
-
(2008)
Eur J Immunol
, vol.38
, pp. 1287-1296
-
-
Kanda, N.1
Watanabe, S.2
-
63
-
-
34247523141
-
Discovery and biology of IL-23 and IL-27: Related but functionally distinct regulators of inflammation
-
Kastelein RA, Hunter CA, Cua DJ (2007) Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol 25:221-42
-
(2007)
Annu Rev Immunol
, vol.25
, pp. 221-242
-
-
Kastelein, R.A.1
Hunter, C.A.2
Cua, D.J.3
-
64
-
-
9744265704
-
A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis
-
Kauffman CL, Aria N, Toichi E, McCormick TE, Cooper KD, Gottlieb AB et al. (2004) A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis. J Invest Dermatol 123:1037-44
-
(2004)
J Invest Dermatol
, vol.123
, pp. 1037-1044
-
-
Kauffman, C.L.1
Aria, N.2
Toichi, E.3
McCormick, T.E.4
Cooper, K.D.5
Gottlieb, A.B.6
-
65
-
-
39649108216
-
Safety and efficacy of ABT-874, a fully human interleukin 12/23 monoclonal antibody, in the treatment of moderate to severe chronic plaque psoriasis: Results of a randomized, placebo-controlled, phase 2 trial
-
Kimball AB, Gordon KB, Langley RG, Menter A, Chartash EK, Valdes J (2008) Safety and efficacy of ABT-874, a fully human interleukin 12/23 monoclonal antibody, in the treatment of moderate to severe chronic plaque psoriasis: results of a randomized, placebo-controlled, phase 2 trial. Arch Dermatol 144:200-7
-
(2008)
Arch Dermatol
, vol.144
, pp. 200-207
-
-
Kimball, A.B.1
Gordon, K.B.2
Langley, R.G.3
Menter, A.4
Chartash, E.K.5
Valdes, J.6
-
66
-
-
33846458998
-
IL-25 regulates Th17 function in autoimmune inflammation
-
Kleinschek MA, Owyang AM, Joyce-Shaikh B, Langrish CL, Chen Y, Gorman DM et al. (2007) IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med 204:161-70
-
(2007)
J Exp Med
, vol.204
, pp. 161-170
-
-
Kleinschek, M.A.1
Owyang, A.M.2
Joyce-Shaikh, B.3
Langrish, C.L.4
Chen, Y.5
Gorman, D.M.6
-
67
-
-
53949103784
-
Possible pathogenic role of Th17 cells for atopic dermatitis
-
Koga C, Kabashima K, Shiraishi N, Kobayashi M, Tokura Y (2008) Possible pathogenic role of Th17 cells for atopic dermatitis. J Invest Dermatol 128:2625-30
-
(2008)
J Invest Dermatol
, vol.128
, pp. 2625-2630
-
-
Koga, C.1
Kabashima, K.2
Shiraishi, N.3
Kobayashi, M.4
Tokura, Y.5
-
68
-
-
39149121448
-
Interleukin-17 gene expression in patients with rheumatoid arthritis
-
Kohno M, Tsutsumi A, Matsui H, Sugihara M, Suzuki T, Mamura M et al. (2007) Interleukin-17 gene expression in patients with rheumatoid arthritis. Mod Rheumatol 18:15-22
-
(2007)
Mod Rheumatol
, vol.18
, pp. 15-22
-
-
Kohno, M.1
Tsutsumi, A.2
Matsui, H.3
Sugihara, M.4
Suzuki, T.5
Mamura, M.6
-
69
-
-
33745321276
-
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
-
Komiyama Y, Nakae S, Matsuki T, Nambu A, Ishigame H, Kakuta S et al. (2006) IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol 177:566-73
-
(2006)
J Immunol
, vol.177
, pp. 566-573
-
-
Komiyama, Y.1
Nakae, S.2
Matsuki, T.3
Nambu, A.4
Ishigame, H.5
Kakuta, S.6
-
70
-
-
0038189842
-
IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: Evidence for enhanced cutaneous immunity
-
Kopp T, Lenz P, Bello-Fernandez C, Kastelein RA, Kupper TS, Stingl G (2003) IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: evidence for enhanced cutaneous immunity. J Immunol 170:5438-44
-
(2003)
J Immunol
, vol.170
, pp. 5438-5444
-
-
Kopp, T.1
Lenz, P.2
Bello-Fernandez, C.3
Kastelein, R.A.4
Kupper, T.S.5
Stingl, G.6
-
71
-
-
34547232503
-
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
-
Korn T, Bettelli E, Gao W, Awasthi A, Jager A, Strom TB et al. (2007) IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448:484-7
-
(2007)
Nature
, vol.448
, pp. 484-487
-
-
Korn, T.1
Bettelli, E.2
Gao, W.3
Awasthi, A.4
Jager, A.5
Strom, T.B.6
-
72
-
-
0033134608
-
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
-
Kotake S, Udagawa N, Takahashi N, Matsuzaki K, Itoh K, Ishiyama S et al. (1999) IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 103:1345-52
-
(1999)
J Clin Invest
, vol.103
, pp. 1345-1352
-
-
Kotake, S.1
Udagawa, N.2
Takahashi, N.3
Matsuzaki, K.4
Itoh, K.5
Ishiyama, S.6
-
73
-
-
33846889522
-
A human interleukin-12/23 monoclonal antibody for the treatment of plaque psoriasis
-
CNTO 1275 Psoriasis Study Group
-
Krueger GG, Langley RG, Leonardi C, Yeilding N, Guzzo C, Wang Y, et al., CNTO 1275 Psoriasis Study Group (2007) A human interleukin-12/23 monoclonal antibody for the treatment of plaque psoriasis. N Eng J Med 356:580-92
-
(2007)
N Eng J Med
, vol.356
, pp. 580-592
-
-
Krueger, G.G.1
Langley, R.G.2
Leonardi, C.3
Yeilding, N.4
Guzzo, C.5
Wang, Y.6
-
74
-
-
0033758344
-
Increased interleukin-17 production in patients with systemic sclerosis
-
Kurasawa K, Hirose K, Sano H, Endo H, Shinkai H, Nawata Y et al. (2000) Increased interleukin-17 production in patients with systemic sclerosis. Arthritis Rheum 43:2455-63
-
(2000)
Arthritis Rheum
, vol.43
, pp. 2455-2463
-
-
Kurasawa, K.1
Hirose, K.2
Sano, H.3
Endo, H.4
Shinkai, H.5
Nawata, Y.6
-
75
-
-
13244283212
-
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
-
Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD et al. (2005) IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201:233-40
-
(2005)
J Exp Med
, vol.201
, pp. 233-240
-
-
Langrish, C.L.1
Chen, Y.2
Blumenschein, W.M.3
Mattson, J.4
Basham, B.5
Sedgwick, J.D.6
-
76
-
-
0347285359
-
Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris
-
Lee E, Trepicchio WL, Oestreicher JL, Pittman D, Wang F, Chamian F et al. (2004) Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med 199:125-30
-
(2004)
J Exp Med
, vol.199
, pp. 125-130
-
-
Lee, E.1
Trepicchio, W.L.2
Oestreicher, J.L.3
Pittman, D.4
Wang, F.5
Chamian, F.6
-
77
-
-
34249026701
-
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
-
LeibundGut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, Tsoni SV et al. (2007) Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol 8:630-8
-
(2007)
Nat Immunol
, vol.8
, pp. 630-638
-
-
LeibundGut-Landmann, S.1
Gross, O.2
Robinson, M.J.3
Osorio, F.4
Slack, E.C.5
Tsoni, S.V.6
-
78
-
-
0030692778
-
Regulation of the inflammatory response in animal models of multiple sclerosis by interleukin-12
-
Leonard JP, Waldburger KE, Schaub RG, Smith T, Hewson AK, Cuzner ML et al. (1997) Regulation of the inflammatory response in animal models of multiple sclerosis by interleukin-12. Crit Rev Immunol 17:545-53
-
(1997)
Crit Rev Immunol
, vol.17
, pp. 545-553
-
-
Leonard, J.P.1
Waldburger, K.E.2
Schaub, R.G.3
Smith, T.4
Hewson, A.K.5
Cuzner, M.L.6
-
79
-
-
43449111187
-
Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
-
Leonardi CL, Kimball AB, Papp KA, Yeilding N, Guzzo C, Wang Y et al. (2008) Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet 371:1665-74
-
(2008)
Lancet
, vol.371
, pp. 1665-1674
-
-
Leonardi, C.L.1
Kimball, A.B.2
Papp, K.A.3
Yeilding, N.4
Guzzo, C.5
Wang, Y.6
-
80
-
-
2342485676
-
Psoriasis vulgaris: Cutaneous lymphoid tissue supports T-cell activation and "Type 1" inflammatory gene expression
-
Lew W, Bowcock AM, Krueger JG (2004) Psoriasis vulgaris: cutaneous lymphoid tissue supports T-cell activation and "Type 1" inflammatory gene expression. Trends Immunol 25:295-305
-
(2004)
Trends Immunol
, vol.25
, pp. 295-305
-
-
Lew, W.1
Bowcock, A.M.2
Krueger, J.G.3
-
81
-
-
33846593869
-
Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia
-
Li Y, Chu N, Hu A, Gran B, Rostami A, Zhang GX (2007) Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia. Brain 130:490-501
-
(2007)
Brain
, vol.130
, pp. 490-501
-
-
Li, Y.1
Chu, N.2
Hu, A.3
Gran, B.4
Rostami, A.5
Zhang, G.X.6
-
82
-
-
38549149944
-
Inducible IL-23p19 expression in human microglia via p38 MAPK and NF-kappaB signal pathways
-
Li Y, Chu N, Hu A, Gran B, Rostami A, Zhang GX (2008) Inducible IL-23p19 expression in human microglia via p38 MAPK and NF-kappaB signal pathways. Exp Mol Pathol 84:1-8
-
(2008)
Exp Mol Pathol
, vol.84
, pp. 1-8
-
-
Li, Y.1
Chu, N.2
Hu, A.3
Gran, B.4
Rostami, A.5
Zhang, G.X.6
-
83
-
-
38849097777
-
An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment
-
Liang SC, Long AJ, Bennett F, Whitters MJ, Karim R, Collins M et al. (2007) An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment. J Immunol 179: 7791-9
-
(2007)
J Immunol
, vol.179
, pp. 7791-7799
-
-
Liang, S.C.1
Long, A.J.2
Bennett, F.3
Whitters, M.J.4
Karim, R.5
Collins, M.6
-
84
-
-
33749318470
-
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
-
Liang SC, Tan XY, Luxenberg DP, Karim R, Dunussi-Joannopoulos K, Collins M et al. (2006) Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 203:2271-9
-
(2006)
J Exp Med
, vol.203
, pp. 2271-2279
-
-
Liang, S.C.1
Tan, X.Y.2
Luxenberg, D.P.3
Karim, R.4
Dunussi-Joannopoulos, K.5
Collins, M.6
-
85
-
-
0036105484
-
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
-
Lock C, Hermans G, Pedotti R, Brendolan A, Schadt E, Garren H et al. (2002) Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med 8:500-8
-
(2002)
Nat Med
, vol.8
, pp. 500-508
-
-
Lock, C.1
Hermans, G.2
Pedotti, R.3
Brendolan, A.4
Schadt, E.5
Garren, H.6
-
86
-
-
42149087160
-
Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells
-
Lowes MA, Kikuchi T, Fuentes-Duculan J, Cardinale I, Zaba LC, Haider AS et al. (2008) Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J Invest Dermatol 128:1207-11
-
(2008)
J Invest Dermatol
, vol.128
, pp. 1207-1211
-
-
Lowes, M.A.1
Kikuchi, T.2
Fuentes-Duculan, J.3
Cardinale, I.4
Zaba, L.C.5
Haider, A.S.6
-
87
-
-
38849187386
-
IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation
-
Ma HL, Liang S, Li J, Napierata L, Brown T, Benoit S et al. (2008) IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J Clin Invest 118:597-607
-
(2008)
J Clin Invest
, vol.118
, pp. 597-607
-
-
Ma, H.L.1
Liang, S.2
Li, J.3
Napierata, L.4
Brown, T.5
Benoit, S.6
-
88
-
-
44049104564
-
The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
-
Manel N, Unutmaz D, Littman DR (2008) The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol 9:641-9
-
(2008)
Nat Immunol
, vol.9
, pp. 641-649
-
-
Manel, N.1
Unutmaz, D.2
Littman, D.R.3
-
89
-
-
33646560950
-
Transforming growth factor-beta induces development of the T(H)17 lineage
-
Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO et al. (2006) Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441:231-4
-
(2006)
Nature
, vol.441
, pp. 231-234
-
-
Mangan, P.R.1
Harrington, L.E.2
O'Quinn, D.B.3
Helms, W.S.4
Bullard, D.C.5
Elson, C.O.6
-
90
-
-
8344284998
-
Anti-interleukin-12 antibody for active Crohn's disease
-
Mannon PJ, Fuss IJ, Mayer L, Elson CO, Sandborn WJ, Present D et al. (2004) Anti-interleukin-12 antibody for active Crohn's disease. N Engl J Med 351:2069-79
-
(2004)
N Engl J Med
, vol.351
, pp. 2069-2079
-
-
Mannon, P.J.1
Fuss, I.J.2
Mayer, L.3
Elson, C.O.4
Sandborn, W.J.5
Present, D.6
-
91
-
-
34247122412
-
Stat3 and Stat4 direct development of IL-17-secreting Th cells
-
Mathur AN, Chang HC, Zisoulis DG, Stritesky GL, Yu Q, O'Malley JT et al. (2007) Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol 178:4901-7
-
(2007)
J Immunol
, vol.178
, pp. 4901-4907
-
-
Mathur, A.N.1
Chang, H.C.2
Zisoulis, D.G.3
Stritesky, G.L.4
Yu, Q.5
O'Malley, J.T.6
-
92
-
-
0344389016
-
Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis
-
Matusevicius D, Kivisakk P, He B, Kostulas N, Ozenci V, Fredrikson S et al. (1999) Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult Scler 5:101-4
-
(1999)
Mult Scler
, vol.5
, pp. 101-104
-
-
Matusevicius, D.1
Kivisakk, P.2
He, B.3
Kostulas, N.4
Ozenci, V.5
Fredrikson, S.6
-
93
-
-
0022640843
-
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
-
Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136:2348-57
-
(1986)
J Immunol
, vol.136
, pp. 2348-2357
-
-
Mosmann, T.R.1
Cherwinski, H.2
Bond, M.W.3
Giedlin, M.A.4
Coffman, R.L.5
-
95
-
-
0346962972
-
Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
-
Murphy CA, Langrish CL, Chen Y, Blumenschein W, McClanahan T, Kastelein RA et al. (2003) Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 198:1951-7
-
(2003)
J Exp Med
, vol.198
, pp. 1951-1957
-
-
Murphy, C.A.1
Langrish, C.L.2
Chen, Y.3
Blumenschein, W.4
McClanahan, T.5
Kastelein, R.A.6
-
96
-
-
42149140747
-
Polymorphisms of the IL12B and IL23R genes are associated with psoriasis
-
Nair RP, Ruether A, Stuart PE, Jenisch S, Tejasvi T, Hiremagalore R et al. (2008) Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. J Invest Dermatol 128:1653-61
-
(2008)
J Invest Dermatol
, vol.128
, pp. 1653-1661
-
-
Nair, R.P.1
Ruether, A.2
Stuart, P.E.3
Jenisch, S.4
Tejasvi, T.5
Hiremagalore, R.6
-
97
-
-
0344585384
-
Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
-
Nakae S, Nambu A, Sudo K, Iwakura Y (2003) Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 171:6173-7
-
(2003)
J Immunol
, vol.171
, pp. 6173-6177
-
-
Nakae, S.1
Nambu, A.2
Sudo, K.3
Iwakura, Y.4
-
98
-
-
9744229972
-
The IL-12 family member p40 chain as a master switch and novel therapeutic target in psoriasis
-
Nestle FO, Conrad C (2004) The IL-12 family member p40 chain as a master switch and novel therapeutic target in psoriasis. J Invest Dermatol 123:xiv-xv
-
(2004)
J Invest Dermatol
, vol.123
-
-
Nestle, F.O.1
Conrad, C.2
-
99
-
-
0028245467
-
Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines
-
Nestle FO, Turka LA, Nickoloff BJ (1994) Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines. J Clin Invest 94:202-9
-
(1994)
J Clin Invest
, vol.94
, pp. 202-209
-
-
Nestle, F.O.1
Turka, L.A.2
Nickoloff, B.J.3
-
100
-
-
0028861975
-
Antibodies to interleukin 12 abrogate established experimental colitis in mice
-
Neurath MF, Fuss I, Kelsall BL, Stuber E, Strober W (1995) Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 182:1281-90
-
(1995)
J Exp Med
, vol.182
, pp. 1281-1290
-
-
Neurath, M.F.1
Fuss, I.2
Kelsall, B.L.3
Stuber, E.4
Strober, W.5
-
101
-
-
0032986504
-
Injection of pre-psoriatic skin with CD4+ T cells induces psoriasis
-
Nickoloff BJ, Wrone-Smith T (1999) Injection of pre-psoriatic skin with CD4+ T cells induces psoriasis. Am J Pathol 155:145-58
-
(1999)
Am J Pathol
, vol.155
, pp. 145-158
-
-
Nickoloff, B.J.1
Wrone-Smith, T.2
-
102
-
-
44849127017
-
IL23R: A susceptibility locus for celiac disease and multiple sclerosis?
-
Nunez C, Dema B, Cenit MC, Polanco I, Maluenda C, Arroyo R et al. (2008) IL23R: a susceptibility locus for celiac disease and multiple sclerosis? Genes Immun 9:289-93
-
(2008)
Genes Immun
, vol.9
, pp. 289-293
-
-
Nunez, C.1
Dema, B.2
Cenit, M.C.3
Polanco, I.4
Maluenda, C.5
Arroyo, R.6
-
103
-
-
44049108877
-
Differentiation of human T(H)-17 cells does require TGF-beta!
-
O'Garra A, Stockinger B, Veldhoen M (2008) Differentiation of human T(H)-17 cells does require TGF-beta!. Nat Immunol 9:588-90
-
(2008)
Nat Immunol
, vol.9
, pp. 588-590
-
-
O'Garra, A.1
Stockinger, B.2
Veldhoen, M.3
-
104
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B et al. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13:715-25
-
(2000)
Immunity
, vol.13
, pp. 715-725
-
-
Oppmann, B.1
Lesley, R.2
Blom, B.3
Timans, J.C.4
Xu, Y.5
Hunte, B.6
-
105
-
-
0033556145
-
IL-12 is not required for induction of type 1 cytokine responses in viral infections
-
Oxenius A, Karrer U, Zinkernagel RM, Hengartner H (1999) IL-12 is not required for induction of type 1 cytokine responses in viral infections. J Immunol 162:965-73
-
(1999)
J Immunol
, vol.162
, pp. 965-973
-
-
Oxenius, A.1
Karrer, U.2
Zinkernagel, R.M.3
Hengartner, H.4
-
106
-
-
43449139402
-
Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
-
Papp KA, Langley RG, Lebwohl M, Krueger GG, Szapary P, Yeilding N et al. (2008) Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet 371:1675-84
-
(2008)
Lancet
, vol.371
, pp. 1675-1684
-
-
Papp, K.A.1
Langley, R.G.2
Lebwohl, M.3
Krueger, G.G.4
Szapary, P.5
Yeilding, N.6
-
107
-
-
0036604306
-
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
-
Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J et al. (2002) A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol 168:5699-708
-
(2002)
J Immunol
, vol.168
, pp. 5699-5708
-
-
Parham, C.1
Chirica, M.2
Timans, J.3
Vaisberg, E.4
Travis, M.5
Cheung, J.6
-
108
-
-
27544465354
-
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
-
Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH et al. (2005) A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6:1133-41
-
(2005)
Nat Immunol
, vol.6
, pp. 1133-1141
-
-
Park, H.1
Li, Z.2
Yang, X.O.3
Chang, S.H.4
Nurieva, R.5
Wang, Y.H.6
-
109
-
-
18444385868
-
IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells
-
Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J et al. (2002) IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 16:779-90
-
(2002)
Immunity
, vol.16
, pp. 779-790
-
-
Pflanz, S.1
Timans, J.C.2
Cheung, J.3
Rosales, R.4
Kanzler, H.5
Gilbert, J.6
-
110
-
-
0037111202
-
Regulation of virus-induced IL-12 and IL-23 expression in human macrophages
-
Pirhonen J, Matikainen S, Julkunen I (2002) Regulation of virus-induced IL-12 and IL-23 expression in human macrophages. J Immunol 169:5673-8
-
(2002)
J Immunol
, vol.169
, pp. 5673-5678
-
-
Pirhonen, J.1
Matikainen, S.2
Julkunen, I.3
-
111
-
-
31144441631
-
In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: Enhanced expression in psoriatic skin
-
Piskin G, Sylva-Steenland RMR, Bos JD, Teunissen MBM (2006) In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin. J Immunol 176:1908-15
-
(2006)
J Immunol
, vol.176
, pp. 1908-1915
-
-
Piskin, G.1
Sylva-Steenland, R.M.R.2
Bos, J.D.3
Teunissen, M.B.M.4
-
112
-
-
10344243973
-
Clinical improvement in chronic plaque-type psoriasis lesions after narrow-band UVB therapy is accompanied by a decrease in the expression of IFN-gamma inducers - IL-12, IL-18 and IL-23
-
Piskin G, Tursen U, Sylva-Steenland RM, Bos JD, Teunissen MB (2004) Clinical improvement in chronic plaque-type psoriasis lesions after narrow-band UVB therapy is accompanied by a decrease in the expression of IFN-gamma inducers - IL-12, IL-18 and IL-23. Exp Dermatol 13:764-72
-
(2004)
Exp Dermatol
, vol.13
, pp. 764-772
-
-
Piskin, G.1
Tursen, U.2
Sylva-Steenland, R.M.3
Bos, J.D.4
Teunissen, M.B.5
-
113
-
-
42649095378
-
Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor
-
Quintana FJ, Basso AS, Iglesias AH, Korn T, Farez MF, Bettelli E et al. (2008) Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 453:65-71
-
(2008)
Nature
, vol.453
, pp. 65-71
-
-
Quintana, F.J.1
Basso, A.S.2
Iglesias, A.H.3
Korn, T.4
Farez, M.F.5
Bettelli, E.6
-
114
-
-
42649110747
-
Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion
-
Rachitskaya AV, Hansen AM, Horai R, Li Z, Villasmil R, Luger D et al. (2008) Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion. J Immunol 180:5167-71
-
(2008)
J Immunol
, vol.180
, pp. 5167-5171
-
-
Rachitskaya, A.V.1
Hansen, A.M.2
Horai, R.3
Li, Z.4
Villasmil, R.5
Luger, D.6
-
115
-
-
34648836878
-
Modulation of CLA, IL-12R, CD40L, and IL-2Ra expression and inhibition of IL-12- and IL-23-induced cytokine secretion by CNTO 1275
-
Reddy M, Davis C, Wong J, Marsters P, Pendley C, Prabhakar U (2007) Modulation of CLA, IL-12R, CD40L, and IL-2Ra expression and inhibition of IL-12- and IL-23-induced cytokine secretion by CNTO 1275. Cell Immunol 247:1-11
-
(2007)
Cell Immunol
, vol.247
, pp. 1-11
-
-
Reddy, M.1
Davis, C.2
Wong, J.3
Marsters, P.4
Pendley, C.5
Prabhakar, U.6
-
116
-
-
45449084802
-
gammadelta T cells: An important source of IL-17
-
Roark CL, Simonian PL, Fontenot AP, Born WK, O'Brien RL (2008) gammadelta T cells: an important source of IL-17. Curr Opin Immunol 20:353-7
-
(2008)
Curr Opin Immunol
, vol.20
, pp. 353-357
-
-
Roark, C.L.1
Simonian, P.L.2
Fontenot, A.P.3
Born, W.K.4
O'Brien, R.L.5
-
117
-
-
53049097091
-
The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis
-
Rueda B, Orozco G, Raya E, Fernandez-Sueiro JL, Mulero J, Blanco FJ et al. (2008) The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis. Ann Rheum Dis 67:1451-4
-
(2008)
Ann Rheum Dis
, vol.67
, pp. 1451-1454
-
-
Rueda, B.1
Orozco, G.2
Raya, E.3
Fernandez-Sueiro, J.L.4
Mulero, J.5
Blanco, F.J.6
-
118
-
-
33846940253
-
The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis
-
Sa SM, Valdez PA, Wu J, Jung K, Zhong F, Hall L et al. (2007) The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J Immunol 178:2229-40
-
(2007)
J Immunol
, vol.178
, pp. 2229-2240
-
-
Sa, S.M.1
Valdez, P.A.2
Wu, J.3
Jung, K.4
Zhong, F.5
Hall, L.6
-
119
-
-
33751521013
-
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
-
Sato K, Suematsu A, Okamoto K, Yamaguchi A, Morishita Y, Kadono Y et al. (2006) Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med 203:2673-82
-
(2006)
J Exp Med
, vol.203
, pp. 2673-2682
-
-
Sato, K.1
Suematsu, A.2
Okamoto, K.3
Yamaguchi, A.4
Morishita, Y.5
Kadono, Y.6
-
120
-
-
0028105784
-
T cells involved in psoriasis vulgaris belong to the Th1 subset
-
Schlaak JF, Buslau M, Jochum W, Hermann E, Girndt M, Gallati H et al. (1994) T cells involved in psoriasis vulgaris belong to the Th1 subset. J Invest Dermatol 102:145-9
-
(1994)
J Invest Dermatol
, vol.102
, pp. 145-149
-
-
Schlaak, J.F.1
Buslau, M.2
Jochum, W.3
Hermann, E.4
Girndt, M.5
Gallati, H.6
-
121
-
-
13944281011
-
Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: Elevated interleukin-23p19 and interleu-kin-27p28 in Crohn's disease but not in ulcerative colitis
-
Schmidt C, Giese T, Ludwig B, Mueller-Molaian I, Marth T, Zeuzem S et al. (2005) Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleu-kin-27p28 in Crohn's disease but not in ulcerative colitis. Inflamm Bowel Dis 11:16-23
-
(2005)
Inflamm Bowel Dis
, vol.11
, pp. 16-23
-
-
Schmidt, C.1
Giese, T.2
Ludwig, B.3
Mueller-Molaian, I.4
Marth, T.5
Zeuzem, S.6
-
122
-
-
0033119051
-
Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway
-
Shin HC, Benbernou N, Esnault S, Guenounou M (1999) Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway. Cytokine 11:257-66
-
(1999)
Cytokine
, vol.11
, pp. 257-266
-
-
Shin, H.C.1
Benbernou, N.2
Esnault, S.3
Guenounou, M.4
-
123
-
-
33747593830
-
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
-
Stumhofer JS, Laurence A, Wilson EH, Huang E, Tato CM, Johnson LM et al. (2006) Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol 7:937-45
-
(2006)
Nat Immunol
, vol.7
, pp. 937-945
-
-
Stumhofer, J.S.1
Laurence, A.2
Wilson, E.H.3
Huang, E.4
Tato, C.M.5
Johnson, L.M.6
-
124
-
-
25444476685
-
Suppression of ongoing disease in a nonhuman primate model of multiple sclerosis by a human-anti-human IL-12p40 antibody
-
t
-
t Hart BA, Brok HP, Remarque E, Benson J, Treacy G, Amor S et al. (2005) Suppression of ongoing disease in a nonhuman primate model of multiple sclerosis by a human-anti-human IL-12p40 antibody. J Immunol 175:4761-8
-
(2005)
J Immunol
, vol.175
, pp. 4761-4768
-
-
Hart, B.A.1
Brok, H.P.2
Remarque, E.3
Benson, J.4
Treacy, G.5
Amor, S.6
-
125
-
-
0031691282
-
Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes
-
Teunissen MB, Koomen CW, de Waal Malefyt R, Wierenga EA, Bos JD (1998) Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J Invest Dermatol 111:645-9
-
(1998)
J Invest Dermatol
, vol.111
, pp. 645-649
-
-
Teunissen, M.B.1
Koomen, C.W.2
de Waal Malefyt, R.3
Wierenga, E.A.4
Bos, J.D.5
-
126
-
-
33749151636
-
An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL-12/IL-23 in psoriasis
-
Toichi E, Torres G, McCormick TS, Chang T, Mascelli MA, Kauffman CL et al. (2006) An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL-12/IL-23 in psoriasis. J Immunol 177:4917-26
-
(2006)
J Immunol
, vol.177
, pp. 4917-4926
-
-
Toichi, E.1
Torres, G.2
McCormick, T.S.3
Chang, T.4
Mascelli, M.A.5
Kauffman, C.L.6
-
127
-
-
0031937388
-
Proinflammatory and immunoregulatory functions of interleukin-12
-
Trinchieri G (1998) Proinflammatory and immunoregulatory functions of interleukin-12. Int Rev Immunol 16:365-96
-
(1998)
Int Rev Immunol
, vol.16
, pp. 365-396
-
-
Trinchieri, G.1
-
128
-
-
33744936550
-
IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production
-
Vaknin-Dembinsky A, Balashov K, Weiner HL (2006) IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J Immunol 176:7768-74
-
(2006)
J Immunol
, vol.176
, pp. 7768-7774
-
-
Vaknin-Dembinsky, A.1
Balashov, K.2
Weiner, H.L.3
-
129
-
-
42649106556
-
The aryl hydrocarbon receptor links TH17-cell-mediated auto-immunity to environmental toxins
-
Veldhoen M, Hirota K, Westendorf AM, Buer J, Dumoutier L, Renauld JC et al. (2008) The aryl hydrocarbon receptor links TH17-cell-mediated auto-immunity to environmental toxins. Nature 453:106-9
-
(2008)
Nature
, vol.453
, pp. 106-109
-
-
Veldhoen, M.1
Hirota, K.2
Westendorf, A.M.3
Buer, J.4
Dumoutier, L.5
Renauld, J.C.6
-
130
-
-
32244442562
-
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B (2006) TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24:179-89
-
(2006)
Immunity
, vol.24
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
Locksley, R.M.4
Stockinger, B.5
-
131
-
-
0035726290
-
Dominant lesional T cell receptor rearrangements persist in relapsing psoriasis but are absent from nonlesional skin: Evidence for a stable antigen-specific pathogenic T cell response in psoriasis vulgaris
-
Vollmer S, Menssen A, Prinz JC (2001) Dominant lesional T cell receptor rearrangements persist in relapsing psoriasis but are absent from nonlesional skin: evidence for a stable antigen-specific pathogenic T cell response in psoriasis vulgaris. J Invest Dermatol 117:1296-301
-
(2001)
J Invest Dermatol
, vol.117
, pp. 1296-1301
-
-
Vollmer, S.1
Menssen, A.2
Prinz, J.C.3
-
132
-
-
44049102724
-
A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses
-
Volpe E, Servant N, Zollinger R, Bogiatzi SI, Hupe P, Barillot E et al. (2008) A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol 9:650-7
-
(2008)
Nat Immunol
, vol.9
, pp. 650-657
-
-
Volpe, E.1
Servant, N.2
Zollinger, R.3
Bogiatzi, S.I.4
Hupe, P.5
Barillot, E.6
-
133
-
-
33846864685
-
Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor
-
Wada Y, Lu R, Zhou D, Chu J, Przewloka T, Zhang S et al. (2007) Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor. Blood 109:1156-64
-
(2007)
Blood
, vol.109
, pp. 1156-1164
-
-
Wada, Y.1
Lu, R.2
Zhou, D.3
Chu, J.4
Przewloka, T.5
Zhang, S.6
-
135
-
-
0035877257
-
Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death
-
Wiekowski MT, Leach MW, Evans EW, Sullivan L, Chen SC, Vassileva G et al. (2001) Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. J Immunol 166:7563-70
-
(2001)
J Immunol
, vol.166
, pp. 7563-7570
-
-
Wiekowski, M.T.1
Leach, M.W.2
Evans, E.W.3
Sullivan, L.4
Chen, S.C.5
Vassileva, G.6
-
136
-
-
34548133583
-
Development, cytokine profile and function of human interleukin 17-producing helper T cells
-
Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD et al. (2007) Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 8: 950-7
-
(2007)
Nat Immunol
, vol.8
, pp. 950-957
-
-
Wilson, N.J.1
Boniface, K.2
Chan, J.R.3
McKenzie, B.S.4
Blumenschein, W.M.5
Mattson, J.D.6
-
137
-
-
0036604122
-
Cutting edge: Immune cells as sources and targets of the IL-10 family members?
-
Wolk K, Kunz S, Asadullah K, Sabat R (2002) Cutting edge: immune cells as sources and targets of the IL-10 family members? J Immunol 168:5397-402
-
(2002)
J Immunol
, vol.168
, pp. 5397-5402
-
-
Wolk, K.1
Kunz, S.2
Asadullah, K.3
Sabat, R.4
-
138
-
-
33749983749
-
Interleukin-22: A novel T- and NK-cell derived cytokine that regulates the biology of tissue cells
-
Wolk K, Sabat R (2006) Interleukin-22: a novel T- and NK-cell derived cytokine that regulates the biology of tissue cells. Cytokine Growth Factor Rev 17:367-80
-
(2006)
Cytokine Growth Factor Rev
, vol.17
, pp. 367-380
-
-
Wolk, K.1
Sabat, R.2
-
139
-
-
33646552450
-
IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: A potential role in psoriasis
-
Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K et al. (2006) IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol 36:1309-23
-
(2006)
Eur J Immunol
, vol.36
, pp. 1309-1323
-
-
Wolk, K.1
Witte, E.2
Wallace, E.3
Docke, W.D.4
Kunz, S.5
Asadullah, K.6
-
140
-
-
0033772374
-
Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus
-
Wong CK, Ho CY, Li EK, Lam CW (2000) Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus. Lupus 9:589-93
-
(2000)
Lupus
, vol.9
, pp. 589-593
-
-
Wong, C.K.1
Ho, C.Y.2
Li, E.K.3
Lam, C.W.4
-
141
-
-
0029861579
-
Dermal injection of immunocytes induces psoriasis
-
Wrone-Smith T, Nickoloff BJ (1996) Dermal injection of immunocytes induces psoriasis. J Clin Invest 98:1878-87
-
(1996)
J Clin Invest
, vol.98
, pp. 1878-1887
-
-
Wrone-Smith, T.1
Nickoloff, B.J.2
-
142
-
-
47549112840
-
IL-21 and TGF-beta are required for differentiation of human T(H)17 cells
-
Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M et al. (2008a) IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature 454:350-2
-
(2008)
Nature
, vol.454
, pp. 350-352
-
-
Yang, L.1
Anderson, D.E.2
Baecher-Allan, C.3
Hastings, W.D.4
Bettelli, E.5
Oukka, M.6
-
143
-
-
34247593586
-
STAT3 regulates cytokine-mediated generation of inflammatory helper T cells
-
Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, Watowich SS et al. (2007) STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem 282:9358-63
-
(2007)
J Biol Chem
, vol.282
, pp. 9358-9363
-
-
Yang, X.O.1
Panopoulos, A.D.2
Nurieva, R.3
Chang, S.H.4
Wang, D.5
Watowich, S.S.6
-
144
-
-
37849048599
-
T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORalpha and RORgamma
-
Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y et al. (2008b) T helper 17 lineage differentiation is programmed by orphan nuclear receptors RORalpha and RORgamma. Immunity 28:29-39
-
(2008)
Immunity
, vol.28
, pp. 29-39
-
-
Yang, X.O.1
Pappu, B.P.2
Nurieva, R.3
Akimzhanov, A.4
Kang, H.S.5
Chung, Y.6
-
145
-
-
0034807936
-
Interleukin-17 and lung host defense against Klebsiella pneumoniae infection
-
Ye P, Garvey PB, Zhang P, Nelson S, Bagby G, Summer WR et al. (2001) Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am J Respir Cell Mol Biol 25:335-40
-
(2001)
Am J Respir Cell Mol Biol
, vol.25
, pp. 335-340
-
-
Ye, P.1
Garvey, P.B.2
Zhang, P.3
Nelson, S.4
Bagby, G.5
Summer, W.R.6
-
146
-
-
33646397611
-
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
-
Yen D, Cheung J, Scheerens H, Poulet F, McClanahan T, McKenzie B et al. (2006) IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 116:1310-6
-
(2006)
J Clin Invest
, vol.116
, pp. 1310-1316
-
-
Yen, D.1
Cheung, J.2
Scheerens, H.3
Poulet, F.4
McClanahan, T.5
McKenzie, B.6
-
147
-
-
37549011317
-
Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
-
Zaba LC, Cardinale I, Gilleaudeau P, Sullivan-Whalen M, Suarez Farinas M, Fuentes-Duculan J et al. (2007) Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J Exp Med 204:3183-94
-
(2007)
J Exp Med
, vol.204
, pp. 3183-3194
-
-
Zaba, L.C.1
Cardinale, I.2
Gilleaudeau, P.3
Sullivan-Whalen, M.4
Suarez Farinas, M.5
Fuentes-Duculan, J.6
-
148
-
-
58149331211
-
Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells
-
Zaba LC, Fuentes-Duculan J, Eungdamrong NJ, Abello MV, Novitskaya I, Pierson KC et al. (2009) Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells. J Invest Dermatol 129:79-88
-
(2009)
J Invest Dermatol
, vol.129
, pp. 79-88
-
-
Zaba, L.C.1
Fuentes-Duculan, J.2
Eungdamrong, N.J.3
Abello, M.V.4
Novitskaya, I.5
Pierson, K.C.6
-
149
-
-
33846906224
-
Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
-
Zheng Y, Danilenko DM, Valdez P, Kasman I, Eastham-Anderson J, Wu J et al. (2007) Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445:648-51
-
(2007)
Nature
, vol.445
, pp. 648-651
-
-
Zheng, Y.1
Danilenko, D.M.2
Valdez, P.3
Kasman, I.4
Eastham-Anderson, J.5
Wu, J.6
-
150
-
-
34547188748
-
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
-
Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T et al. (2007) IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 8:967-74
-
(2007)
Nat Immunol
, vol.8
, pp. 967-974
-
-
Zhou, L.1
Ivanov, I.I.2
Spolski, R.3
Min, R.4
Shenderov, K.5
Egawa, T.6
-
151
-
-
43449135305
-
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
-
Zhou L, Lopes JE, Chong MM, Ivanov II, Min R, Victora GD et al. (2008) TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453:236-40
-
(2008)
Nature
, vol.453
, pp. 236-240
-
-
Zhou, L.1
Lopes, J.E.2
Chong, M.M.3
Ivanov, I.I.4
Min, R.5
Victora, G.D.6
-
152
-
-
0031041596
-
Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases
-
Zou J, Presky DH, Wu CY, Gubler U (1997) Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases. J Biol Chem 272:6073-7
-
(1997)
J Biol Chem
, vol.272
, pp. 6073-6077
-
-
Zou, J.1
Presky, D.H.2
Wu, C.Y.3
Gubler, U.4
|