CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism

Journal of Immunology

Volumn 170, Issue 4, 2003, Pages 1958-1963

  Chung, Doo Ryeon ^a   Kasper, Dennis L ^a,c   Panzo, Ronald J ^a   Chtinis, Tanuja ^b   Grusby, Michael J ^c   Sayegh, Mohamed H ^a   Tzianabos, Arthur O ^a,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d CHANNING LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOLYTE; CD28 ANTIGEN; CD4 ANTIGEN; INTERLEUKIN 17; NEUTRALIZING ANTIBODY; POLYSACCHARIDE; STAT4 PROTEIN; STAT6 PROTEIN;

ABDOMINAL ABSCESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTEROIDES FRAGILIS; CELLULAR IMMUNITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DISEASE ASSOCIATION; IMMUNE RESPONSE; IN VITRO STUDY; MORBIDITY; MOUSE; NONHUMAN; PATHOGENESIS; PERITONEAL CAVITY; PRIORITY JOURNAL; SEPSIS; STAPHYLOCOCCUS AUREUS; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH2 CELL; WILD TYPE;

EID: 0037442115     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.4.1958     Document Type: Article

References (24)

1. Gorbach, S. L., H. Thadepalli, and J. Norsen. 1974. Anaerobic Microorganisms in Intraabdominal Infections. Charles C. Thomas, Springfield.
2. Gorbach, S. L., and J. G. Bartlett. 1974. Anaerobic infections. N. Engl. J. Med. 290:1237.
3. Polk, B. J., and D. L. Kasper. 1977. Bacteriodes fragilis subspecies in clinical isolates. Ann. Intern. Med. 86:567.
4. Tzianabos, A. O., A. B. Onderdonk, B. Rosner, R. L. Cisneros, and D. L. Kasper. 1993. Structural features of polysaccharides that induce intra-abdominal abscesses. Science 262:416.
5. Tzianabos, A. O., J. Y. Wang, and J. C. Lee. 2001. Structural rationale for the modulation of abscess formation by Staphylococcus aureus capsular polysaccharides. Proc. Natl. Acad. Sci. USA 98:9365.
6. Tzianabos, A. O., R. W. Finberg, Y. Wang, M. Chan, A. B. Onderdonk, H. J. Jennings, and D. L. Kasper. 2000. T cells activated by zwitterionic molecules prevent abscesses induced by pathogenic bacteria. J. Biol. Chem. 275:6733.
7. + T-cell activation via the CD28-B7-2 costimulatory pathway. Infect. Immun. 68:6650.
8. Kaplan, M. H., U. Schindler, S. T. Smiley, and M. J. Grusby. 1996. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4:313.
9. Kaplan, M. H., Y. L. Sun, T. Hoey, and M. J. Grusby. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174.
10. + T cells regulate surgical and postinfectious adhesion formation. J. Exp. Med. 195:1471.
11. Tzianabos, A. O., D. L. Kasper, R. L. Cisneros, R. S. Smith, and A. B. Onderdonk. 1995. Polysaccharide-mediated protection against abscess formation in experimental intra-abdominal sepsis. J. Clin. Invest. 96:2727.
12. Witowski, J., K. Pawlaczyk, A. Breborowicz, A. Scheuren, M. Kuzlan-Pawlaczyk, J. Wisniewska, A. Polubinska, H. Friess, G. M. Gahl, U. Frei, and A. Jorres. 2000. IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GROα chemokine from mesothelial cells. J. Immunol. 165:5814.
13. Aarvak, T., M. Chabaud, P. Miossec, and J. B. Natvig. 1999. IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. J. Immunol. 162:1246.
14. Yao, Z., S. L. Painter, W. C. Fanslow, D. Ulrich, B. M. Macduff, M. K. Spriggs, and R. J. Armitage. 1995. Human IL-17: a novel cytokine derived from T cells. J. Immunol. 155:5483.
15. Laan, M., Z. H. Cui, H. Hoshino, J. Lotvall, M. Sjostrand, D. C. Gruenert, B. E. Skoogh, and A. Linden. 1999. Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J. Immunol. 162:2347.
16. Kennedy, K. J., and W. J. Karpus. 1999. Role of chemokines in the regulation of Th1/Th2 and autoimmune encephalomyelitis. J. Clin. Immunol. 19:273.
17. Gerard, C., and B. J. Rollins. 2001. Chemokines and disease. Nat. Immun. 2:108.
18. Lukacs, N. W., and K. K. Tekkanat. 2000. Role of chemokines in asthmatic airway inflammation. Immunol. Rev. 177:21.
19. Atamas, S. P., and B. White. 1999. Interleukin 4 in systemic sclerosis: not just an increase. Clin. Diagn. Lab. Immunol. 6:658.
20. Chiaramonte, M. G., D. D. Donaldson, A. W. Cheever, and T. A. Wynn. 1999. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J. Clin. Invest. 104:777.
21. Aarvak, T., M. Chabaud, P. Miossec, and J. B. Natvig. 1999. IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. J. Immunol. 162:1246.
22. Albanesi, C., C. Scarponi, A. Cavani, M. Federici, F. Nasoni, and G. Girolomoni. 2000. Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-γ- and interleukin-4-induced activation of human keratinocytes. J. Invest. Dermatol. 115:81.
23. Infante-Duarte, C., H. F. Horton, M. C. Byrne, and T. Kamradt. 2000. Microbial lipopeptides induce the production of IL-17 in Th cells. J. Immunol. 165:6107.
24. Chabaud, M., T. Aarvak, P. Garnero, J. B. Natvig, and P. Miossec. 2001. Potential contribution of IL-17-producing Th(1) cells to defective repair activity in joint inflammation: partial correction with Th(2)-promoting conditions. Cytokine 13:113.