A role for T cell-derived interleukin 22 in psoriatic skin inflammation

Clinical and Experimental Immunology

Volumn 150, Issue 3, 2007, Pages 407-415

  Boniface, K ^a   Guignouard, E ^a   Pedretti, N ^b   Garcia, M ^a   Delwail, A ^a   Bernard, F X ^b   Nau, F ^a   Guillet, G ^c   Dagregorio, G ^c   Yssel, H ^d   Lecron, J C ^a   Morel, F ^a  

^a UNIVERSITÉ DE POITIERS   (France)

^b BIOalternatives   (France)

^c POITIERS UNIVERSITY HOSPITAL   (France)

^d UNIV MONTPELLIER   (France)

Author keywords

Cytokines; Inflammation; Psoriasis; Skin disease; T cells

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 22; INTERLEUKIN RECEPTOR; MESSENGER RNA;

ADULT; AGED; ARTICLE; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPIDERMIS; FEMALE; HUMAN; KERATINOCYTE; LYMPHOCYTIC INFILTRATION; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; SKIN BIOPSY; SKIN DEFECT; SKIN INFLAMMATION; SUPERNATANT; T LYMPHOCYTE ACTIVATION;

ADULT; AGED; AGED, 80 AND OVER; CELLS, CULTURED; FEMALE; GENE EXPRESSION PROFILING; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKINS; KERATINOCYTES; MALE; MIDDLE AGED; PSORIASIS; RECEPTORS, INTERLEUKIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKIN; T-LYMPHOCYTES; UP-REGULATION;

EID: 36048953799     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2007.03511.x     Document Type: Article

References (39)

1. Lew W, Bowcock AM, Krueger JG. Psoriasis vulgaris: cutaneous lymphoid tissue supports T-cell activation and 'Type 1' inflammatory gene expression. Trends Immunol 2004 25 : 295 305.
2. Gearing AJ, Fincham NJ, Bird CR et al. Cytokines in skin lesions of psoriasis. Cytokine 1990 2 : 68 75.
3. Boyman O, Conrad C, Tonel G, Gilliet M, Nestle FO. The pathogenic role of tissue-resident immune cells in psoriasis. Trends Immunol 2007 28 : 51 7.
4. Boniface K, Diveu C, Morel F et al. Oncostatin M secreted by skin infiltrating T lymphocytes is a potent keratinocyte activator involved in skin inflammation. J Immunol 2007 178 : 4615 22.
5. Schlaak JF, Buslau M, Jochum W et al. T cells involved in psoriasis vulgaris belong to the Th1 subset. J Invest Dermatol 1994 102 : 145 9.
6. Uyemura K, Yamamura M, Fivenson DF, Modlin RL, Nickoloff BJ. The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 cell-mediated response. J Invest Dermatol 1993 101 : 701 5.
7. Dumoutier L, Van Roost E, Colau D, Renauld JC. Human interleukin-10- related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. Proc Natl Acad Sci USA 2000 97 : 10144 9.
8. Aggarwal S, Xie MH, Maruoka M, Foster J, Gurney AL. Acinar cells of the pancreas are a target of interleukin-22. J Interferon Cytokine Res 2001 21 : 1047 53.
9. Nagalakshmi ML, Rascle A, Zurawski S, Menon S, de Waal Malefyt R. Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells. Int Immunopharmacol 2004 4 : 679 91.
10. Boniface K, Bernard FX, Garcia M, Gurney AL, Lecron JC, Morel F. IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. J Immunol 2005 174 : 3695 702.
11. Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R. IL-22 increases the innate immunity of tissues. Immunity 2004 21 : 241 54.
12. Dumoutier L, Louahed J, Renauld JC. Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9. J Immunol 2000 164 : 1814 19.
13. Wolk K, Kunz S, Asadullah K, Sabat R. Cutting edge: immune cells as sources and targets of the IL-10 family members? J Immunol 2002 168 : 5397 402.
14. Xie MH, Aggarwal S, Ho WH et al. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J Biol Chem 2000 275 : 31335 9.
15. Kotenko SV, Izotova LS, Mirochnitchenko OV et al. Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. J Biol Chem 2001 276 : 2725 32.
16. Lejeune D, Dumoutier L, Constantinescu S, Kruijer W, Schuringa JJ, Renauld JC. Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10. J Biol Chem 2002 277 : 33676 82.
17. Dumoutier L, Lejeune D, Colau D, Renauld JC. Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J Immunol 2001 166 : 7090 5.
18. Kotenko SV, Izotova LS, Mirochnitchenko OV et al. Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. J Immunol 2001 166 : 7096 103.
19. Xu W, Presnell SR, Parrish-Novak J et al. A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. Proc Natl Acad Sci USA 2001 98 : 9511 16.
20. Broome AM, Ryan D, Eckert RL. S100 protein subcellular localization during epidermal differentiation and psoriasis. J Histochem Cytochem 2003 51 : 675 85.
21. Schaerli P, Britschgi M, Keller M et al. Characterization of human T cells that regulate neutrophilic skin inflammation. J Immunol 2004 173 : 2151 8.
22. Bowcock AM, Krueger JG. Getting under the skin: the immunogenetics of psoriasis. Nat Rev Immunol 2005 5 : 699 711.
23. Liang SC, Tan XY, Luxenberg DP et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 2006 203 : 2271 9.
24. Zheng Y, Danilenko DM, Valdez P et al. Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 2007 445 : 648 51.
25. Yssel H, Spits H. In vitro culture of subpopulations of human T lymphocytes. In : Strober W, ed. Current protocols in immunology. New York : Green and Wiley 2001 : 7 19.
26. Trickett A, Kwan YL. T cell stimulation and expansion using anti-CD3/CD28 beads. J Immunol Methods 2003 275 : 251 5.
27. Boniface K, Lecron JC, Bernard FX et al. Keratinocytes as targets for interleukin-10-related cytokines: a putative role in the pathogenesis of psoriasis. Eur Cytokine Netw 2005 16 : 309 19.
28. Vandesompele J, De Preter K, Pattyn F et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002 3 : 1 12.
29. Asadullah K, Sterry W, Stephanek K et al. IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: a new therapeutic approach. J Clin Invest 1998 101 : 783 94.
30. Asadullah K, Docke WD, Ebeling M et al. Interleukin 10 treatment of psoriasis: clinical results of a phase 2 trial. Arch Dermatol 1999 135 : 187 92.
31. Reich K, Garbe C, Blaschke V et al. Response of psoriasis to interleukin-10 is associated with suppression of cutaneous type 1 inflammation, downregulation of the epidermal interleukin-8/CXCR2 pathway and normalization of keratinocyte maturation. J Invest Dermatol 2001 116 : 319 29.
32. Bowcock AM, Shannon W, Du F et al. Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies. Hum Mol Genet 2001 10 : 1793 805.
33. Harder J, Schroder JM. Psoriatic scales: a promising source for the isolation of human skin-derived antimicrobial proteins. J Leukoc Biol 2005 77 : 476 86.
34. Nickoloff BJ. Cracking the cytokine code in psoriasis. Nat Med 2007 13 : 242 4.
35. Wolk K, Witte E, Wallace E et al. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol 2006 36 : 1309 23.
36. Otkjaer K, Kragballe K, Funding AT et al. The dynamics of gene expression of interleukin-19 and interleukin-20 and their receptors in psoriasis. Br J Dermatol 2005 153 : 911 18.
37. Piskin G, Sylva-Steenland RM, Bos JD, Teunissen MB. T cells in psoriatic lesional skin that survive conventional therapy with NB-UVB radiation display reduced IFN-gamma expression. Arch Dermatol Res 2004 295 : 509 16.
38. Wilson NJ, Boniface K, Chan JR et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 2007 8 : 950 7.
39. Harrington LE, Mangan PR, Weaver CT. Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr Opin Immunol 2006 18 : 349 56.