Regulation of the inflammatory response in animal models of multiple sclerosis by interleukin-12

Critical Reviews in Immunology

Volumn 17, Issue 5-6, 1997, Pages 545-553

  Leonard, John P ^a   Waldburger, Kristine E ^a   Schaub, Robert G ^a   Smith, Terence ^b   Hewson, Adrian K ^b   Cuzner, M Louise ^b   Goldman, Samuel J ^a  

^a PFIZER INC   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Autoimmunity; EAE; iNOS; Interleukin 12; Macrophages

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; NEUTRALIZING ANTIBODY;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; HELPER CELL; IMMUNOREGULATION; INFLAMMATION; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; T LYMPHOCYTE ACTIVATION;

EID: 0030692778     PISSN: 10408401     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (54)

1. Kobayashi, M., Fitz, L., Ryan, M., Hewick, R. R., Clark, S. C., Chan, S., London, R., Sherman, F., Perussia, B., and Trinchieri. G., Identification and purification of natural killer cell stimulatory factor (NKSF) a cytokine with multiple biological effects on human lymphocytes, J. Exp. Med., 170, 827, 1989.
2. Merberg, D. M., Wolf, S. W., and Clark, S. C., Sequence similarity between NKSF and the IL-6/G-CSF family, Immunol. Today, 13, 77, 1992.
3. Gearing, D. P. and Cosman, D., Homology of the p40 subunit of NKSF with the extracellular domain of the interleukin 6 receptor, Cell, 66, 9, 1991.
4. D'Andrea, A., Rengarujuu, M., Valiante, N. M., Chehimi, J., Kubin, M., Aste-Amezaga, M., Chan, S. H., Kobayashi, M., Young, D., Nickbarg, E., Chizzoniti, R., Wolf, S. F., and Trinchieri, G., Production of natural killer cell stimulatory factor (NKSF/ IL-12) by peripheral blood mononuclear cells, J. Exp. Med., 176, 1387, 1992.
5. Smith, T. J., Ducharme, L. A., and Weis, J. H., Preferential expression of IL-12 or IL-4 by murine bone marrow mast cells derived in mast cell growth factor or IL-3, Eur. J. Immunol., 24, 822, 1994.
6. Yoshinori, A., Riemann, H., Bharwaj, R. S., Schwarz, A., Sawada, Y., Yamada, H., Luger, T. A., Kubin, M., Trinchieri, G., and Schwarz, T., IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines, J. Immunol., 153, 5366, 1994.
7. Cassatella, M. A., Meda, L., Gasperinin, S., D'Andrea, A., Ma, X., and Trinchieri, G., Interleukin 12 production by human polymorphonuclear leukocytes, Eur. J. Immunol., 25, 1, 1995.
8. Trinchieri, G., Interleukin 12: a cytokine produced by antigen presenting cells with immunoregulatory functions in the generation of T helper cells type 1 and cytotoxic lymphocytes, Blood, 84, 4008, 1994.
9. Brunda, M. J., Interleukin 12, J. Leukocyte Biol., 55, 280, 1994.
10. Wolf, S. F., Sieburth, D., and Sypek, J., Interleukin 12: a key modulator of immune function, Stem Cells, 12, 154, 1994.
11. Chan, S. H., Perussia, B., Gupta, J. W., Kobayashi, M., Pospisil, M., Young, H. A., Wolf, S. F., Young, D., Clark, S. C., and Trinchieri, G., Induction of interferon-γ production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers, J. Exp. Med., 173, 869, 1991.
12. Manetti, R., Parronchi, P., Giudizi, M.G., Piccinni, M. P., Maggi, E., Trinchieri, G., and Romagnani, S., Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4 producing Th cells, J. Exp. Med., 177, 1199, 1993.
13. + T cells to enhance priming for IFN-γ production and diminishes IL-4 inhibition of such priming, Proc. Natl. Acad. Sci. U.S.A., 90, 10188, 1993.
14. Manetti, R., Gerosa, F., Giudizi, M. G., Biagiotti, R., Parronchi, P., Piccinni, M., Sampognaro, S., Maggi, E., Romagnani, S., and Trinchieri, G., Interleukin 12 induces stable priming for IFN-γ production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones, J. Exp. Med., 179, 1273, 1994.
15. Sypek, J. P., Chung, C. L., Mayor, S. E., Subramanyam, J. M., Goldman, S. J., Sieburth, D. S., Wolf, S. F., and Schaub, R. G., Resolution of cutaneous Leishmaniasis: interleukin-12 initiates a protective T helper type 1 immune response, J. Exp. Med., 177, 1797, 1993.
16. Heinzel, F. P., Schoenhaut, D. S., Rerko, R. M., Rosser, L. E., and Gately, M. K., Interleukin-12 when administered multiple times systemically to Balb/ c mice during infection enhances their resistance to L. major, J. Exp. Med., 177, 1505, 1993.
17. Pettinelli, C. B., Fritz, R. B., Chou, C-H., and MacFarlin, D. E., Encephalitogenic activity of guinea pig myelin basic protein in the SJL mouse, J. Immunol., 129, 1209, 1982.
18. Tuohy, V. K., Sobel, R. A., and Lees, M. B., Myelin proteolipid protein induced experimental allergic encephalomyelitis: variations of disease expression in different strains of mice, J. Immunol., 140, 1868, 1988.
19. - T lymphocytes, J. Immunol., 127, 1420, 1981.
20. Kuchroo, V. K., Martin, C. A., Greer, J. M., Ju, S-T., Sobel, R. A., and Dorf, M. E., Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein specific T cell clones to mediate experimental allergic encephalomyelitis, J. Immunol., 151, 4371, 1993.
21. Baron, J. L., Madri, J. A, Ruddle, N. H., Hashim, G., and Janeway, C. A., Jr., Surface expression of α4 integrin by CD4 T cells is required for their entry into brain parenchyma, J. Exp. Med., 177, 57, 1993.
22. Kuchroo, V. K., Das, M., Brown, J. A., Ranger, A. M., Zamvil, S. S., Sobel, R. A., Weiner, H. L., Nabavi, N., and Glimcher, L. H., B7-1 and B7-2 costimulatory molecules activate differentially the Th1/ Th2 development pathways: application to autoimmune disease therapy, Cell, 80, 707, 1995.
23. Merrill, J. E., Kono, D. H., Clayton, J., Ando, D. G., Hinton, D. R., and Hofman, F., Inflammatory leukocytes and cytokines in the peptide induced disease of experimental allergic encephalomyelitis in SJL/ J and B10.PL mice, Proc. Natl. Acad. Sci. U.S.A., 89, 574, 1992.
24. Kennedy, M. K., Torrance, D. S., Picha, K. S., and Mohler, K. M., Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery, J. Immunol., 149, 2496, 1992.
25. Racke, M. K., Bonomo, A., Scott, D. E., Canella, B., Levine, A., Raine, C. S., Shevach, E. M., and Rocken, M., Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease, J. Exp. Med., 180, 1961, 1994.
26. Rott, O., Fleisher, B., and Cash, E., Interleukin 10 prevents experimental allergic encephalomyelitis in rats, Eur. J. Immunol., 24, 1434, 1994.
27. Cash, E., Minty, E., Ferrara, P., Caput, D., Fradelizi, D., and Rott, O., Macrophage-inactivating IL-13 suppresses experimental autoimmune encephalomyelitis in rats, J. Immunol., 153, 4258, 1994.
28. Leonard, J. P., Waldburger, K. E., and Goldman, S. J., Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12, J. Exp. Med., 181, 381, 1995.
29. Waldburger, K. E., Hastings, R. C., Schaub, R. G., Goldman, S. J., and Leonard, J. P., Adoptive transfer of EAE after in vitro treatment with rmIL-12: preferential expansion of IFN-γ-producing cells and increased expression of macrophages associated iNOS as immunomodulatory mechanisms, Am. J. Pathol., 148, 375, 1996.
30. Segal, B. M. and Shevach, E. M., IL-12 unmasks latent autoimmune disease in resistant mice, J. Exp. Med., 184, 771, 1996.
31. Merrill, J. E., Ignarro, L. J., Sherman, M. P., Melinek, J., and Lane, T. E., Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide, J. Immunol., 151, 2132, 1993.
32. Ovadia, H., Lehmann, D., Kol-Mizrachi, R., and Abramsky, O., Inhibition of experimental allergic encephalomyelitis by nitric oxide synthase inhibitor, Neurology, 44, 466P, 1994.
33. Issazadeh, S., Ljungdahl, A., Hojeberg, B., Mustafa, M., and Olsson, T., Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin 10, interleukin 12, cytolysin, tumor necrosis factor A, and tumor necrosis factor β, J. Neuroimmunol., 61, 205, 1995.
34. Smith T., Hewson, A. K., Kingsley, C. I., Leonard, J. P., and Cuzner, M. L., Interleukin 12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat, Am. J. Pathol., 150, 1909, 1997.
35. Brunda, M. J., Lusitro, L., Warrior, R. R., Wright, B. B., Hubbard, B. R., Murphy, M., Wolf, S. F., and Gately, M. K., Antitumor and antimetastatic activity of interleukin 12 against murine tumors, J. Exp. Med., 178, 1223, 1993.
36. Nastala, C. L., Edington, H. D., McKinney, T. G., Thara, H., Nalesnik, M. A., Brunda, M. J., Gately, M. K., Wolf, S. F., Schreiber, R. D., Storkus, W. J., and Lotze, M. T., Recombinant IL-12 administration induces tumor regression in association with IFN-γ production, J. Immunol., 153, 1697, 1994.
37. Zou, J-P., Yamamoto, N., Fujii, T., Takenaka, H., Kobayashi, M., Herrmann, S. H., Wolf, S. F., Fujiwara, H., and Hamaoka, T., Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells, Int. Immunol., 7, 1135, 1995.
38. Leonard, J. P., Waldburger, K. W., and Goldman, S. J., Regulation of experimental autoimmune encephalomyelitis by interleukin 12, Ann. NY Acad. Sci., 795, 216, 1996.
39. Ferber, I. A., Brocke, S., Taylor-Edwards, C., Ridgway, W., Dinisco, C., Steinman, L., Dalton, D., and Fathman, C. G., Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis, J. Immunol., 156, 5, 1996.
40. Duong, T. T., St. Louis, J., Gilbert, J. J., Finkelman, F. D., and Strejan, G. H., Effect of anti-interferon-γ and anti-interleukin-2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse, J. Neuroimmunol., 36, 105, 1992.
41. Willenborg, D. O., Fordham, S., Bernard, C. A., Cowden, W. B., and Ramshaw, I. A., IFN-γ plays a critical down regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein induced autoimmune encephalomyelitis, J. Immunol., 157, 3223, 1996.
42. Taylor, A. P. and Murray, H. W., Intracellular antimicrobial activity in the absence of IFN-γ: effect of interleukin-12 in experimental visceral leishmaniasis in IFN-γ gene-disrupted mice, J. Exp. Med., 185, 1231, 1997.
43. Germann, T., Szeliga, J., Hess, H., Storkel, S., Podlaski, F. J., Gately, M. K., Schmitt, E., and Rude, E., Administration of interleukin-12 in combination with type II collagen induces severe arthritis in DBA/1 mice, Proc. Natl. Acad. Sci. U.S.A., 92, 4823, 1995.
44. Adorini, L., Gregori, S., Magram, J., and Trembleau, S., The role of IL-12 in the pathogenesis of Th1 cell mediated autoimmune diseases, Ann. NY Acad. Sci., 795, 208, 1996.
45. Neurath, M. F., Fuss, I., Kelsall, B. L., Stuber, E., and Strober, W., Antibodies to interleukin 12 abrogate established experimental colitis in mice, J. Exp. Med., 182, 1281, 1995.
46. Widhagen, A., Newcombe, J., Dangond, F., Strand, C., Woodroofe, M. N., Cuzner, M. L., and Hafler, D. A., Expression of costimulatory molecules B7.1 (CD80) and B7.2 (CD86) and interleukin-12 cytokine multiple sclerosis lesions, J. Exp. Med., 182, 1985, 1995.
47. + T cells via CD40 ligand, Proc. Natl. Acad. Sci. U.S.A., 94, 599, 1997.
48. Cell, M., Scheidegger, D., Palmer-Lehmann, K., Lanzavecchia, A., and Alber, G., Ligation of CD40 on dendritic cells triggers production of high levels of interleukin 12 and enhances T cell stimulatory capacity: T-T help via APC activation, J. Exp. Med., 184, 747, 1996.
49. Koch, F., Stanzl, U, Jennewein, P., Janke, K., Heufler, C., Kampgen, E., Romani, N., and Schuler, G., High-level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and down-regulation by IL-4 and IL-10, J. Exp. Med., 184, 741, 1996.
50. De Kruyff, R. H., Gieni, R. S., and Umetsu, D. T., Antigen-driven but not lipopolysaccharide drive IL-12 production in macrophages requires triggering of CD40, J. Immunol., 158, 359, 1997.
51. Shu, U., Kiniwa, M., Wu, C. Y., Maliszewski, C., Vezzio, N., Hakimi, J., Gately, M., and Delespesse, G., Activated T cells induce interleukin 12 production by monocytes via CD40-CD40 ligand interaction, Eur. J. Immunol., 25, 1125, 1995.
52. Soong, L., Xu, J-C., Grewal, I. S., Kima, P., Sun, J., Longley, B. J., Ruddle, N. H., McMahon-Pratt, D., and Flavell, R. A., Disruption of CD40-CD40 ligand interactions results in enhanced susceptibility to Leishmania amazonensis infection, Immunity, 4, 263, 1996.
53. Grewal, I. S., Foellmer, H. G., Grewal, K. D., Xu, J., Hardardottir, F., Baron, J. L., Janeway, C. A., Jr., and Flavell, R. A., Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis, Science, 1996; 273, 1864, 1996.
54. Stuber, E., Strober, W., and Neurath, M., Blocking the CD40-CD40 ligand interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion, J. Exp. Med., 183, 693, 1996.