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Volumn 8, Issue 8, 2009, Pages 1370-1385

Taxol: A complex diterpenoid natural product with an evolutionary obscure origin

Author keywords

Endophytic fungi; Isoprenoids; Paclitaxel; Taxol; Taxus

Indexed keywords

10 DEACETYLBACCATIN III; ACYLTRANSFERASE; BACCATIN III; CAMPTOTHECIN; DOCETAXEL; OXYGENASE; PACLITAXEL; SYNTHETASE; TAXA 4 (5),11 (12)DIENE SYNTHASE; TAXANE DERIVATIVE; TAXOID; TAXOID HYDROXYLASE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 66749184905     PISSN: None     EISSN: 16845315     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (38)

References (124)
  • 1
    • 0004273081 scopus 로고    scopus 로고
    • Bacon CW, White JF 2000, eds, Marcel Dekker Inc, New York
    • Bacon CW, White JF (2000) (eds). Microbial Endophytes. Marcel Dekker Inc, New York.
    • Microbial Endophytes
  • 2
    • 0032718086 scopus 로고    scopus 로고
    • The taxane diterpenoids
    • Baloglu E, Kingston DG (1999). The taxane diterpenoids. J. Nat. Prod. 62(10): 1448-1472.
    • (1999) J. Nat. Prod , vol.62 , Issue.10 , pp. 1448-1472
    • Baloglu, E.1    Kingston, D.G.2
  • 4
    • 33751120932 scopus 로고    scopus 로고
    • Production of isoprenoid pharmaceuticals by entineered microbes
    • Chang MCY, Keasling JD (2006). Production of isoprenoid pharmaceuticals by entineered microbes. Nat. Chem. Biol. 2: 647-681.
    • (2006) Nat. Chem. Biol , vol.2 , pp. 647-681
    • Chang, M.C.Y.1    Keasling, J.D.2
  • 5
    • 2642547256 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a cytochrome P450 taxoid 2α-hydroxylase involved in Taxol biosynthesis
    • Chau M, Croteau RB (2004). Molecular cloning and characterization of a cytochrome P450 taxoid 2α-hydroxylase involved in Taxol biosynthesis. Arch. Biochem. Biophys. 427(1): 48-57.
    • (2004) Arch. Biochem. Biophys , vol.427 , Issue.1 , pp. 48-57
    • Chau, M.1    Croteau, R.B.2
  • 6
    • 2642550828 scopus 로고    scopus 로고
    • Taxol biosynthesis: Molecular cloning and characterization of a cytochrome P450 taxoid 7β-hydroxylase
    • Chau M, Jennewein S, Walker KD, Croteau RB (2004a). Taxol biosynthesis: Molecular cloning and characterization of a cytochrome P450 taxoid 7β-hydroxylase. Chem. Biol. 11 (5): 663-672.
    • (2004) Chem. Biol , vol.11 , Issue.5 , pp. 663-672
    • Chau, M.1    Jennewein, S.2    Walker, K.D.3    Croteau, R.B.4
  • 7
    • 4444236702 scopus 로고    scopus 로고
    • Regioselectivity of taxoid-O-acetyltransferases: Heterologous expression and characterization of a new taxadien-5a-ol-O-acetyltransferase
    • Chau M, Walker KD, Long RM, Croteau RB (2004b). Regioselectivity of taxoid-O-acetyltransferases: heterologous expression and characterization of a new taxadien-5a-ol-O-acetyltransferase. Arch. Biochem. Biophys. 430(2): 237-246.
    • (2004) Arch. Biochem. Biophys , vol.430 , Issue.2 , pp. 237-246
    • Chau, M.1    Walker, K.D.2    Long, R.M.3    Croteau, R.B.4
  • 8
    • 0027430002 scopus 로고
    • The taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agents
    • Cragg GM, Schepartz SA, Suffness M, Grever MR (1993). The taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agents. J. Nat. Prod. 56: 1657-1668.
    • (1993) J. Nat. Prod , vol.56 , pp. 1657-1668
    • Cragg, G.M.1    Schepartz, S.A.2    Suffness, M.3    Grever, M.R.4
  • 9
    • 66749090191 scopus 로고    scopus 로고
    • Croom EM (1995). Taxus for taxol and taxoids. In: Suffness M (ed) Taxol: Sci. Appl., CRC Press, Boca Raton, pp 37-70. Croteau RB, Ketchum REB, Long RM, Kaspera R, Wildung MR (2006). Taxol biosynthesis and molecular genetics. Phytochem. Rev. 5(1): 75-97.
    • Croom EM (1995). Taxus for taxol and taxoids. In: Suffness M (ed) Taxol: Sci. Appl., CRC Press, Boca Raton, pp 37-70. Croteau RB, Ketchum REB, Long RM, Kaspera R, Wildung MR (2006). Taxol biosynthesis and molecular genetics. Phytochem. Rev. 5(1): 75-97.
  • 13
    • 0000748967 scopus 로고
    • Instability of indole alkaloid production in Catharanthus roseus cell suspension cultures
    • Deus-Neumann B, Zenk MH (1984). Instability of indole alkaloid production in Catharanthus roseus cell suspension cultures. Plan Med. 50(5): 427-431.
    • (1984) Plan Med , vol.50 , Issue.5 , pp. 427-431
    • Deus-Neumann, B.1    Zenk, M.H.2
  • 14
    • 0028724354 scopus 로고
    • Potential of fungi in the discovery of novel, low-molecular-weight pharmaceuticals
    • Dreyfuss MM, Chapela IH (1994). Potential of fungi in the discovery of novel, low-molecular-weight pharmaceuticals. Biotechnol. Ser. 26: 49-80.
    • (1994) Biotechnol. Ser , vol.26 , pp. 49-80
    • Dreyfuss, M.M.1    Chapela, I.H.2
  • 15
    • 0030003383 scopus 로고    scopus 로고
    • Studies on the biosynthesis of taxol: The taxane carbon skeleton is not of mevalonoid origin
    • Eisenreich W, Menhard B, Hylands PJ, Zenk MH, Bacher A (1996). Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin. Proc. Natl. Acad. Sci. U. S. A. 93(13): 6431-6436.
    • (1996) Proc. Natl. Acad. Sci. U. S. A , vol.93 , Issue.13 , pp. 6431-6436
    • Eisenreich, W.1    Menhard, B.2    Hylands, P.J.3    Zenk, M.H.4    Bacher, A.5
  • 16
    • 0035208850 scopus 로고    scopus 로고
    • Deoxyxylulose phosphate pathway to terpenoids
    • Eisenreich W, Rohdich F, Bacher A (2001). Deoxyxylulose phosphate pathway to terpenoids. Trends Plant Sci. 6(2): 78-84.
    • (2001) Trends Plant Sci , vol.6 , Issue.2 , pp. 78-84
    • Eisenreich, W.1    Rohdich, F.2    Bacher, A.3
  • 17
    • 0032170425 scopus 로고    scopus 로고
    • The deoxyxylulose phosphate pathway of terpenoid biosynthesis in plants and microorganisms
    • Eisenreich W, Schwarz M, Cartayrade A, Arigoni D, Zenk MH and Bacher A (1998). The deoxyxylulose phosphate pathway of terpenoid biosynthesis in plants and microorganisms. Chem. Biol. 5(9): 221-233.
    • (1998) Chem. Biol , vol.5 , Issue.9 , pp. 221-233
    • Eisenreich, W.1    Schwarz, M.2    Cartayrade, A.3    Arigoni, D.4    Zenk, M.H.5    Bacher, A.6
  • 18
    • 0028190717 scopus 로고
    • Sensitivity of plant pathogenic fungi to taxane extracts from ornamental yews
    • Elmer WH, Mattina MJI, MacEachern GJ (1994). Sensitivity of plant pathogenic fungi to taxane extracts from ornamental yews. Phytopathology 84(10): 1179-1185.
    • (1994) Phytopathology , vol.84 , Issue.10 , pp. 1179-1185
    • Elmer, W.H.1    Mattina, M.J.I.2    MacEachern, G.J.3
  • 19
    • 44749083814 scopus 로고    scopus 로고
    • Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production
    • Engels B, Dahm P, Jennewein S (2008). Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production. Metab. Eng. 10(3-4): 201-206.
    • (2008) Metab. Eng , vol.10 , Issue.3-4 , pp. 201-206
    • Engels, B.1    Dahm, P.2    Jennewein, S.3
  • 22
    • 66749153548 scopus 로고    scopus 로고
    • Floss HG, Mocek U (1995). Biosynthesis of taxol. In: Suffness M (ed) Taxol: Sci. Appl., CRC Press, Boca Raton, pp 191-208.
    • Floss HG, Mocek U (1995). Biosynthesis of taxol. In: Suffness M (ed) Taxol: Sci. Appl., CRC Press, Boca Raton, pp 191-208.
  • 23
    • 0001472945 scopus 로고
    • Initiation and growth of cell lines of Taxus brevifolia (Pacific yew)
    • Gibson DM, Ketchum REB, Vance NV, Christen AA (1993). Initiation and growth of cell lines of Taxus brevifolia (Pacific yew). Plant Cell Rep. 12(9): 479-482.
    • (1993) Plant Cell Rep , vol.12 , Issue.9 , pp. 479-482
    • Gibson, D.M.1    Ketchum, R.E.B.2    Vance, N.V.3    Christen, A.A.4
  • 24
    • 0347019541 scopus 로고    scopus 로고
    • Facile orthoester formation in a model compound of the taxol oxetane: Are biologically active epoxy esters, orthoesters, and oxetanyl esters latent electrophiles?
    • Giner J-L, Faraldos JA (2003). Facile orthoester formation in a model compound of the taxol oxetane: Are biologically active epoxy esters, orthoesters, and oxetanyl esters latent electrophiles? Helv. Chim. Acta 86(11): 3613-3622.
    • (2003) Helv. Chim. Acta , vol.86 , Issue.11 , pp. 3613-3622
    • Giner, J.-L.1    Faraldos, J.A.2
  • 25
    • 0030879715 scopus 로고    scopus 로고
    • Clinical overview of the taxanes
    • Goldspiel BR (1997). Clinical overview of the taxanes. Pharmacotherapy 17: 1105-1255.
    • (1997) Pharmacotherapy , vol.17 , pp. 1105-1255
    • Goldspiel, B.R.1
  • 26
    • 45549107234 scopus 로고    scopus 로고
    • Novel cytotoxic agents: Epothilones
    • Goodin S (2008). Novel cytotoxic agents: epothilones. Am. J. Health Syst. Pharm. 65(10): 10-15.
    • (2008) Am. J. Health Syst. Pharm , vol.65 , Issue.10 , pp. 10-15
    • Goodin, S.1
  • 27
  • 28
    • 33646900283 scopus 로고    scopus 로고
    • An endophytic taxol-producing fungus BT2 isolated from Taxus chinensis var. mairei
    • Guo BH, Wang YC, Zhou XW, Hu K, Tan F, Miao ZQ, Tang KX (2006). An endophytic taxol-producing fungus BT2 isolated from Taxus chinensis var. mairei. Afr. J. Biotechnol. 5(10): 875-877.
    • (2006) Afr. J. Biotechnol , vol.5 , Issue.10 , pp. 875-877
    • Guo, B.H.1    Wang, Y.C.2    Zhou, X.W.3    Hu, K.4    Tan, F.5    Miao, Z.Q.6    Tang, K.X.7
  • 29
    • 0000837640 scopus 로고
    • Intercellular and intercultural heterogeneity in secondary metabolite accumulation in cultures of Catharanthus roseus following cell line selection
    • Hall RD, Yeoman MM (1987). Intercellular and intercultural heterogeneity in secondary metabolite accumulation in cultures of Catharanthus roseus following cell line selection. J. Exp. Bot. 38(193): 1391-1398.
    • (1987) J. Exp. Bot , vol.38 , Issue.193 , pp. 1391-1398
    • Hall, R.D.1    Yeoman, M.M.2
  • 31
    • 66749135015 scopus 로고
    • The yew tree, a thousand whispers
    • Eugene, Oregon
    • Hartzell H (1991). The yew tree, a thousand whispers. Hulogosi, Eugene, Oregon.
    • (1991) Hulogosi
    • Hartzell, H.1
  • 32
    • 0032422236 scopus 로고    scopus 로고
    • Cloning and functional expression of a cDNA encoding geranylgeranyl diphosphate synthase from Taxus canadensis and assessment of the role of this prenyltransferase in cells induced for taxol production
    • Hefner J, Ketchum REB, Croteau RB (1998). Cloning and functional expression of a cDNA encoding geranylgeranyl diphosphate synthase from Taxus canadensis and assessment of the role of this prenyltransferase in cells induced for taxol production. Arch. Biochem. Biophys. 360(1): 62-74.
    • (1998) Arch. Biochem. Biophys , vol.360 , Issue.1 , pp. 62-74
    • Hefner, J.1    Ketchum, R.E.B.2    Croteau, R.B.3
  • 33
    • 0030154837 scopus 로고    scopus 로고
    • Hefner J, Rubenstein SM, Ketchum REB, Gibson DM, Williams RM, Croteau RB (1996). Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis. Chem. Biol. 3(6): 479-489.
    • Hefner J, Rubenstein SM, Ketchum REB, Gibson DM, Williams RM, Croteau RB (1996). Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5alpha-ol: the first oxygenation step in taxol biosynthesis. Chem. Biol. 3(6): 479-489.
  • 34
    • 0031568221 scopus 로고    scopus 로고
    • Taxol production and taxadiene synthase activity in Taxus canadensis cell suspension cultures
    • Hezari M, Ketchum REB, Gibson DM, Croteau RB (1997). Taxol production and taxadiene synthase activity in Taxus canadensis cell suspension cultures. Arch. Biochem. Biophys. 337(2): 185-190.
    • (1997) Arch. Biochem. Biophys , vol.337 , Issue.2 , pp. 185-190
    • Hezari, M.1    Ketchum, R.E.B.2    Gibson, D.M.3    Croteau, R.B.4
  • 35
    • 0029087870 scopus 로고    scopus 로고
    • Hezari M, Lewis NG, Croteau RB (1995). Purification and characterization of taxa-4(5),11(12)-diene synthase from Pacific yew (Taxus brevifolia) that catalyzes the first committed step of taxol biosynthesis. Arch. Biochem. Biophys. 322(2): 437-444.
    • Hezari M, Lewis NG, Croteau RB (1995). Purification and characterization of taxa-4(5),11(12)-diene synthase from Pacific yew (Taxus brevifolia) that catalyzes the first committed step of taxol biosynthesis. Arch. Biochem. Biophys. 322(2): 437-444.
  • 36
    • 66749148131 scopus 로고    scopus 로고
    • Holton RA, Biediger RJ, Boatman PD (1995). Semisynthesis of taxol and taxotere. In: Suffness M (ed) Taxol: Sci. Appl., CRC Press, Boca Raton, pp 97-121.
    • Holton RA, Biediger RJ, Boatman PD (1995). Semisynthesis of taxol and taxotere. In: Suffness M (ed) Taxol: Sci. Appl., CRC Press, Boca Raton, pp 97-121.
  • 39
    • 33947508713 scopus 로고    scopus 로고
    • Drug-eluting stent: A review and update. Vasc. Health Risk Manag
    • T, Liu MW 2005
    • T, Liu MW (2005). Drug-eluting stent: a review and update. Vasc. Health Risk Manag. 1 (4): 263-276.
    • , vol.1 , Issue.4 , pp. 263-276
  • 40
    • 27544462926 scopus 로고    scopus 로고
    • Taxoids occurring in the genus Taxus
    • Itokawa H, Lee KH eds, Taylor &Francis, London, pp
    • Itokawa H (2003). Taxoids occurring in the genus Taxus. In: Itokawa H, Lee KH (eds), Taxus - The Genus Taxus, Taylor &Francis, London, pp 35-78.
    • (2003) Taxus - The Genus Taxus , pp. 35-78
    • Itokawa, H.1
  • 41
    • 2642518854 scopus 로고    scopus 로고
    • Cytochrome P450 taxadiene 5a-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis
    • Jennewein S, Long RM, Williams RM, Croteau RB (2004a). Cytochrome P450 taxadiene 5a-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis. Chem. Biol. 11(3): 379-387.
    • (2004) Chem. Biol , vol.11 , Issue.3 , pp. 379-387
    • Jennewein, S.1    Long, R.M.2    Williams, R.M.3    Croteau, R.B.4
  • 42
    • 15944383707 scopus 로고    scopus 로고
    • Coexpression in yeast of Taxus cytochrome P450 reductase with cytochrome P450 oxygenases involved in Taxol biosynthesis
    • Jennewein S, Park H, DeJong JM, Long RM, Bollon AP and Croteau RB (2005). Coexpression in yeast of Taxus cytochrome P450 reductase with cytochrome P450 oxygenases involved in Taxol biosynthesis. Biotechnol. Bioeng. 89(5): 588-598.
    • (2005) Biotechnol. Bioeng , vol.89 , Issue.5 , pp. 588-598
    • Jennewein, S.1    Park, H.2    DeJong, J.M.3    Long, R.M.4    Bollon, A.P.5    Croteau, R.B.6
  • 43
    • 0242669969 scopus 로고    scopus 로고
    • Jennewein S, Rithner CD, Williams RM, Croteau RB (2003). Taxoid metabolism: Taxoid 14(3-hydroxylase is a cytochrome P450- dependent monooxygenase. Arch. Biochem. Biophys. 413(2): 262-270.
    • Jennewein S, Rithner CD, Williams RM, Croteau RB (2003). Taxoid metabolism: Taxoid 14(3-hydroxylase is a cytochrome P450- dependent monooxygenase. Arch. Biochem. Biophys. 413(2): 262-270.
  • 44
    • 0035923612 scopus 로고    scopus 로고
    • Taxol biosynthesis: Taxane 13a-hydroxylase is a cytochrome P450- dependent monooxygenase
    • Jennewein S, Rithner CD, Williams RM, Croteau RB (2001). Taxol biosynthesis: taxane 13a-hydroxylase is a cytochrome P450- dependent monooxygenase. Proc. Natl. Acad. Sci. U. S. A. 98(24):13595-13600.
    • (2001) Proc. Natl. Acad. Sci. U. S. A , vol.98 , Issue.24 , pp. 13595-13600
    • Jennewein, S.1    Rithner, C.D.2    Williams, R.M.3    Croteau, R.B.4
  • 45
    • 2942656782 scopus 로고    scopus 로고
    • Random sequencing of an induced Taxus cell cDNA library for identification of clones involved in Taxol biosynthesis
    • Jennewein S, Wildung MR, Chau M, Walker K, Croteau RB (2004b). Random sequencing of an induced Taxus cell cDNA library for identification of clones involved in Taxol biosynthesis. Proc. Natl. Acad. Sci. U. S. A. 101(24): 9149-9154.
    • (2004) Proc. Natl. Acad. Sci. U. S. A , vol.101 , Issue.24 , pp. 9149-9154
    • Jennewein, S.1    Wildung, M.R.2    Chau, M.3    Walker, K.4    Croteau, R.B.5
  • 46
    • 20344394434 scopus 로고    scopus 로고
    • Stereochemistry of the macrocyclization and elimination steps in taxadiene biosynthesis through deuterium labeling
    • Jin Q, Williams DC, Hezari M, Croteau RB, Coates RM (2005a). Stereochemistry of the macrocyclization and elimination steps in taxadiene biosynthesis through deuterium labeling. J. Org. Chem. 70(12): 4667-4675.
    • (2005) J. Org. Chem , vol.70 , Issue.12 , pp. 4667-4675
    • Jin, Q.1    Williams, D.C.2    Hezari, M.3    Croteau, R.B.4    Coates, R.M.5
  • 47
    • 19744366357 scopus 로고    scopus 로고
    • Taxadiene synthase-catalyzed cyclization of 6-fluorogeranylgeranyl diphosphate to 7-fluoroverticillenes
    • Jin Y, Williams DC, Croteau RB, Coates RM (2005b). Taxadiene synthase-catalyzed cyclization of 6-fluorogeranylgeranyl diphosphate to 7-fluoroverticillenes. J. Am. Chem. Soc. 127(21): 7834-7842.
    • (2005) J. Am. Chem. Soc , vol.127 , Issue.21 , pp. 7834-7842
    • Jin, Y.1    Williams, D.C.2    Croteau, R.B.3    Coates, R.M.4
  • 48
    • 77957192530 scopus 로고    scopus 로고
    • Function and evolution of plant cytochrome P450
    • Kahn RA, Durst F (2000). Function and evolution of plant cytochrome P450. Recent Adv. Phytochem. 34: 151-189.
    • (2000) Recent Adv. Phytochem , vol.34 , pp. 151-189
    • Kahn, R.A.1    Durst, F.2
  • 49
    • 33845402189 scopus 로고    scopus 로고
    • Cytochrome P450 oxygenases of Taxol biosynthesis
    • Kaspera R, Croteau RB (2006). Cytochrome P450 oxygenases of Taxol biosynthesis. Phytochem. Rev. 5(2-3): 433-444.
    • (2006) Phytochem. Rev , vol.5 , Issue.2-3 , pp. 433-444
    • Kaspera, R.1    Croteau, R.B.2
  • 50
    • 33845457895 scopus 로고    scopus 로고
    • The Taxus metabolome and the elucidation of the Taxol biosynthetic pathway in cell suspension cultures
    • Ketchum REB, Croteau RB (2006). The Taxus metabolome and the elucidation of the Taxol biosynthetic pathway in cell suspension cultures. Biotechnol. Agric. For. 57: 291-309.
    • (2006) Biotechnol. Agric. For , vol.57 , pp. 291-309
    • Ketchum, R.E.B.1    Croteau, R.B.2
  • 51
    • 0033524365 scopus 로고    scopus 로고
    • The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonate
    • Ketchum REB, Gibson DM, Croteau RB, Shuler ML (1999). The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonate. Biotechnol. Bioeng. 62(1): 97-105.
    • (1999) Biotechnol. Bioeng , vol.62 , Issue.1 , pp. 97-105
    • Ketchum, R.E.B.1    Gibson, D.M.2    Croteau, R.B.3    Shuler, M.L.4
  • 52
    • 33846188515 scopus 로고    scopus 로고
    • Administering cultured Taxus cells with early precursors reveals bifurcations in the taxoid biosynthetic pathway
    • Ketchum REB, Horiguchi T, Qiu D, Williams RM, Croteau RB (2007). Administering cultured Taxus cells with early precursors reveals bifurcations in the taxoid biosynthetic pathway. Phytochemistry 68(3): 335-341.
    • (2007) Phytochemistry , vol.68 , Issue.3 , pp. 335-341
    • Ketchum, R.E.B.1    Horiguchi, T.2    Qiu, D.3    Williams, R.M.4    Croteau, R.B.5
  • 53
    • 0345701916 scopus 로고    scopus 로고
    • Taxus metabolomics: Methyl jasmonate preferentially induces production of taxoids oxygenated at C-13 in Taxus x media cell cultures
    • Ketchum REB, Rithner CD, Qiu D, Kim YS, Williams RM, Croteau RB (2003). Taxus metabolomics: methyl jasmonate preferentially induces production of taxoids oxygenated at C-13 in Taxus x media cell cultures. Phytochemistry 62(6): 901-909.
    • (2003) Phytochemistry , vol.62 , Issue.6 , pp. 901-909
    • Ketchum, R.E.B.1    Rithner, C.D.2    Qiu, D.3    Kim, Y.S.4    Williams, R.M.5    Croteau, R.B.6
  • 54
    • 23044532439 scopus 로고    scopus 로고
    • Regulation of the biosynthesis of plant hormones by cytochrome P450s
    • Kim G-T, Tsukaya H (2002). Regulation of the biosynthesis of plant hormones by cytochrome P450s. J. Plant Res. 115(1119): 169-177.
    • (2002) J. Plant Res , vol.115 , Issue.1119 , pp. 169-177
    • Kim, G.-T.1    Tsukaya, H.2
  • 56
    • 85177020741 scopus 로고    scopus 로고
    • Koepp AE, Hezari M, Zajicek J, Vogel BS, LaFever RE, Lewis NG, Croteau RB (1995). Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yew. J. Biol. Chem. 270(15): 8686-8690.
    • Koepp AE, Hezari M, Zajicek J, Vogel BS, LaFever RE, Lewis NG, Croteau RB (1995). Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yew. J. Biol. Chem. 270(15): 8686-8690.
  • 57
    • 0028083884 scopus 로고
    • Heterologous expression of the plant proteins strictosidine synthase and berberine bridge enzyme in insect cell culture
    • Kutchan TM, Bock A, Dittrich H (1994). Heterologous expression of the plant proteins strictosidine synthase and berberine bridge enzyme in insect cell culture. Phytochemistry 35(2): 353-360.
    • (1994) Phytochemistry , vol.35 , Issue.2 , pp. 353-360
    • Kutchan, T.M.1    Bock, A.2    Dittrich, H.3
  • 58
    • 0037394552 scopus 로고    scopus 로고
    • Diversity of the biosynthesis of the isoprene units
    • Kuzuyama T, Seto H (2003). Diversity of the biosynthesis of the isoprene units. Nat. Prod. Rep. 20(2): 171-183.
    • (2003) Nat. Prod. Rep , vol.20 , Issue.2 , pp. 171-183
    • Kuzuyama, T.1    Seto, H.2
  • 60
    • 0034712864 scopus 로고    scopus 로고
    • Purification and partial characterization of geranylgeranyl diphosphate synthase, from Taxus baccata cell cultures. An enzyme that regulates taxane biosynthesis
    • Laskaris G, van der Heijden R, Verpoorte R (2000). Purification and partial characterization of geranylgeranyl diphosphate synthase, from Taxus baccata cell cultures. An enzyme that regulates taxane biosynthesis. Plant Sci. 153(2): 97-105.
    • (2000) Plant Sci , vol.153 , Issue.2 , pp. 97-105
    • Laskaris, G.1    van der Heijden, R.2    Verpoorte, R.3
  • 61
    • 0001646456 scopus 로고
    • The biosynthesis of 3-dimethylamino-3- phenylpropanoic acid in yew
    • Leete E, Bodem GB (1966). The biosynthesis of 3-dimethylamino-3- phenylpropanoic acid in yew. Tetrahedron Lett.(33): 3925-3927.
    • (1966) Tetrahedron Lett , vol.33 , pp. 3925-3927
    • Leete, E.1    Bodem, G.B.2
  • 62
    • 0029979356 scopus 로고    scopus 로고
    • Mechanism of taxadiene synthase, a diterpene cyclase that catalyzes the first step of taxol biosynthesis in Pacific yew
    • Lin X, Hezari M, Koepp AE, Floss HG, Croteau RB (1996). Mechanism of taxadiene synthase, a diterpene cyclase that catalyzes the first step of taxol biosynthesis in Pacific yew. Biochemistry 35(9): 2968-2977.
    • (1996) Biochemistry , vol.35 , Issue.9 , pp. 2968-2977
    • Lin, X.1    Hezari, M.2    Koepp, A.E.3    Floss, H.G.4    Croteau, R.B.5
  • 63
    • 27544457332 scopus 로고    scopus 로고
    • Preliminary assessment of the C13-side chain 2'-hydroxylase involved in Taxol biosynthesis
    • Long RM, Croteau RB (2005). Preliminary assessment of the C13-side chain 2'-hydroxylase involved in Taxol biosynthesis. Biochem. Biophys. Res. Commun. 338(1): 410-417.
    • (2005) Biochem. Biophys. Res. Commun , vol.338 , Issue.1 , pp. 410-417
    • Long, R.M.1    Croteau, R.B.2
  • 64
    • 50149089756 scopus 로고    scopus 로고
    • Specificity of the W-benzoyl transferase responsible for the last step of Taxol biosynthesis
    • Long RM, Lagisetti C, Coates RM, Croteau RB (2008). Specificity of the W-benzoyl transferase responsible for the last step of Taxol biosynthesis. Arch. Biochem. Biophys. 477(2): 384-389.
    • (2008) Arch. Biochem. Biophys , vol.477 , Issue.2 , pp. 384-389
    • Long, R.M.1    Lagisetti, C.2    Coates, R.M.3    Croteau, R.B.4
  • 66
    • 0003090417 scopus 로고
    • Regulation of product synthesis in cell cultures of Catharanthus roseus. V. Long- term maintenance of cells on a production medium
    • Morris P, Rudge K, Cresswell R, Fowler MW (1989). Regulation of product synthesis in cell cultures of Catharanthus roseus. V. Long- term maintenance of cells on a production medium. Plant Cell, Tissue Organ Cult. 17(2): 79-90.
    • (1989) Plant Cell, Tissue Organ Cult , vol.17 , Issue.2 , pp. 79-90
    • Morris, P.1    Rudge, K.2    Cresswell, R.3    Fowler, M.W.4
  • 67
    • 0035983834 scopus 로고    scopus 로고
    • Taxol content in the bark of Himalayan Yew in relation to tree age and sex
    • Nadeem M, Rikhari HC, Kumar A, Palni LM, Nandi SK (2002). Taxol content in the bark of Himalayan Yew in relation to tree age and sex. Phytochemistry 60(6): 627-631.
    • (2002) Phytochemistry , vol.60 , Issue.6 , pp. 627-631
    • Nadeem, M.1    Rikhari, H.C.2    Kumar, A.3    Palni, L.M.4    Nandi, S.K.5
  • 69
    • 1442334562 scopus 로고    scopus 로고
    • Camptothecin and taxol: Historic achievements in natural products research
    • Oberlies NH, Kroll DJ (2004). Camptothecin and taxol: historic achievements in natural products research. J. Nat. Prod. 67(2): 129-135.
    • (2004) J. Nat. Prod , vol.67 , Issue.2 , pp. 129-135
    • Oberlies, N.H.1    Kroll, D.J.2
  • 70
    • 0023812476 scopus 로고    scopus 로고
    • Ogden L (1988). Taxus (yews)-a highly toxic plant. United States, Oklahoma Animal Disease Diagnostic Laboratory, Oklahoma State University, Stillwater 74078: 563-564.
    • Ogden L (1988). Taxus (yews)-a highly toxic plant. United States, Oklahoma Animal Disease Diagnostic Laboratory, Oklahoma State University, Stillwater 74078: 563-564.
  • 71
    • 0036269778 scopus 로고    scopus 로고
    • Gibberellin signaling: Biosynthesis, catabolism, and response pathways
    • Olszewski N, Sun T-P, Gubler F (2002). Gibberellin signaling: Biosynthesis, catabolism, and response pathways. Plant Cell 14: 61-80.
    • (2002) Plant Cell , vol.14 , pp. 61-80
    • Olszewski, N.1    Sun, T.-P.2    Gubler, F.3
  • 72
    • 0001120062 scopus 로고
    • Variation in tropane alkaloid accumulation within the Solanaceae and strategies for its exploitation
    • Parr AJ, Payne J, Eagles J, Chapman BT, Robins RJ, Rhodes MJC (1990). Variation in tropane alkaloid accumulation within the Solanaceae and strategies for its exploitation. Phytochemistry 29(8): 2545-2550.
    • (1990) Phytochemistry , vol.29 , Issue.8 , pp. 2545-2550
    • Parr, A.J.1    Payne, J.2    Eagles, J.3    Chapman, B.T.4    Robins, R.J.5    Rhodes, M.J.C.6
  • 73
    • 0033779923 scopus 로고    scopus 로고
    • Genetics and biochemistry of secondary metabolites in plants: An evolutionary perspective
    • Pichersky E, Gang DR (2000). Genetics and biochemistry of secondary metabolites in plants: an evolutionary perspective. Trends Plant Sci. 5(10): 439-445.
    • (2000) Trends Plant Sci , vol.5 , Issue.10 , pp. 439-445
    • Pichersky, E.1    Gang, D.R.2
  • 74
    • 0000373865 scopus 로고
    • Plant proanthocyanidins. Part 8. Biosynthesis of flavan-3-ols and other secondary plant products from (2S)-phenylalanine
    • Platt RV, Opie CT, Haslam E (1984). Plant proanthocyanidins. Part 8. Biosynthesis of flavan-3-ols and other secondary plant products from (2S)-phenylalanine. Phytochemistry 23(10): 2211-2217.
    • (1984) Phytochemistry , vol.23 , Issue.10 , pp. 2211-2217
    • Platt, R.V.1    Opie, C.T.2    Haslam, E.3
  • 75
    • 32844471142 scopus 로고    scopus 로고
    • Drug-eluting stents and the future of coronary artery bypass surgery: Facts and fiction
    • Raja SG (2006). Drug-eluting stents and the future of coronary artery bypass surgery: facts and fiction. Ann. Thorac. Surg. 81(3): 1162-1171.
    • (2006) Ann. Thorac. Surg , vol.81 , Issue.3 , pp. 1162-1171
    • Raja, S.G.1
  • 76
    • 3242878404 scopus 로고    scopus 로고
    • Green innovations
    • Ritter SK (2004). Green innovations. Chem. Eng. News 82: 25-30.
    • (2004) Chem. Eng. News , vol.82 , pp. 25-30
    • Ritter, S.K.1
  • 77
    • 20344404474 scopus 로고    scopus 로고
    • Loblolly pine abietadienol/abietadienal oxidase PtAO (CYP720B1) is a multifunctional, multisubstrate cytochrome P450 monooxygenase
    • Ro D-K, Arimura G-I, Lau SYW, Piers E, Bohlmann J (2005). Loblolly pine abietadienol/abietadienal oxidase PtAO (CYP720B1) is a multifunctional, multisubstrate cytochrome P450 monooxygenase. Proc. Natl. Acad. Sci. U. S. A. 102(22): 8060-8065.
    • (2005) Proc. Natl. Acad. Sci. U. S. A , vol.102 , Issue.22 , pp. 8060-8065
    • Ro, D.-K.1    Arimura, G.-I.2    Lau, S.Y.W.3    Piers, E.4    Bohlmann, J.5
  • 78
    • 0033213706 scopus 로고    scopus 로고
    • The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants
    • Rohmer M (1999). The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants. Nat. Prod. Rep. 16(5): 565-574.
    • (1999) Nat. Prod. Rep , vol.16 , Issue.5 , pp. 565-574
    • Rohmer, M.1
  • 79
    • 0018387446 scopus 로고
    • Promotion of microtubule assembly in vitro by taxol
    • Schiff PB, Fant J, Horwitz SB (1979). Promotion of microtubule assembly in vitro by taxol. Nature 277(5698): 665-667.
    • (1979) Nature , vol.277 , Issue.5698 , pp. 665-667
    • Schiff, P.B.1    Fant, J.2    Horwitz, S.B.3
  • 80
    • 0035852639 scopus 로고    scopus 로고
    • Schoendorf A, Rithner CD, Williams RM, Croteau RB (2001). Molecular cloning of a cytochrome P450 taxane 10(3-hydroxylase cDNA from Taxus and functional expression in yeast. Proc. Natl. Acad. Sci. U. S. A. 98(4): 1501-1506.
    • Schoendorf A, Rithner CD, Williams RM, Croteau RB (2001). Molecular cloning of a cytochrome P450 taxane 10(3-hydroxylase cDNA from Taxus and functional expression in yeast. Proc. Natl. Acad. Sci. U. S. A. 98(4): 1501-1506.
  • 81
    • 0031841398 scopus 로고    scopus 로고
    • Identification of elicitor-induced cytochrome P450 of soybean (Glycine max L.) using differential display of mRNA
    • Schopfer CR, Ebel J (1998). Identification of elicitor-induced cytochrome P450 of soybean (Glycine max L.) using differential display of mRNA. Mol. Gen. Genet. 258(4): 315-322.
    • (1998) Mol. Gen. Genet , vol.258 , Issue.4 , pp. 315-322
    • Schopfer, C.R.1    Ebel, J.2
  • 82
    • 0026755830 scopus 로고
    • Search for factors related to the indole alkaloid production in cell suspension cultures of Tabernaemontana divaricata
    • Schripsema J, Verpoorte R (1992). Search for factors related to the indole alkaloid production in cell suspension cultures of Tabernaemontana divaricata. Planta Med. 58(3): 245-249.
    • (1992) Planta Med , vol.58 , Issue.3 , pp. 245-249
    • Schripsema, J.1    Verpoorte, R.2
  • 83
    • 0001733185 scopus 로고    scopus 로고
    • Plant cytochrome P450 monooxygenases
    • Schuler MA (1996). Plant cytochrome P450 monooxygenases. Crit. Rev. Plant Sci. 15(3): 235-284.
    • (1996) Crit. Rev. Plant Sci , vol.15 , Issue.3 , pp. 235-284
    • Schuler, M.A.1
  • 84
    • 0034957018 scopus 로고    scopus 로고
    • Evidence for paclitaxel from 3 new endophytic fungi of Himalayan yew of Nepal
    • Shrestha K, Strobel GA, Shrivastava SP, Gewali MB (2001). Evidence for paclitaxel from 3 new endophytic fungi of Himalayan yew of Nepal. Planta Med. 67(4): 374-376.
    • (2001) Planta Med , vol.67 , Issue.4 , pp. 374-376
    • Shrestha, K.1    Strobel, G.A.2    Shrivastava, S.P.3    Gewali, M.B.4
  • 86
    • 0029361226 scopus 로고
    • Taxol production in bioreactors: Kinetics of biomass accumulation, nutrient uptake, and taxol production by cell suspension of Taxus baccata
    • Srinivasan V, Pestchanker L, Moser S, Hirasuma TJ, Taticek RA, Shuler ML (1995). Taxol production in bioreactors: kinetics of biomass accumulation, nutrient uptake, and taxol production by cell suspension of Taxus baccata. Biotechnol. Bioeng. 47(6): 666-676.
    • (1995) Biotechnol. Bioeng , vol.47 , Issue.6 , pp. 666-676
    • Srinivasan, V.1    Pestchanker, L.2    Moser, S.3    Hirasuma, T.J.4    Taticek, R.A.5    Shuler, M.L.6
  • 87
    • 66749132275 scopus 로고    scopus 로고
    • Taxus phenylalanine aminomutase and methods to improve taxol production
    • Bristol-Myers Squibb Company, USA, 38 pp
    • Steele CL, Chen Y, Dougherty BA, Hofstead S, Lam KS, Li W, Xing Z (2003). Taxus phenylalanine aminomutase and methods to improve taxol production. Application: WO (Bristol-Myers Squibb Company, USA). 38 pp.
    • (2003) Application: WO
    • Steele, C.L.1    Chen, Y.2    Dougherty, B.A.3    Hofstead, S.4    Lam, K.S.5    Li, W.6    Xing, Z.7
  • 88
    • 0027270462 scopus 로고
    • Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew
    • Stierle A, Strobel GA, Stierle D (1993). Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. Science 260(5105): 214-216.
    • (1993) Science , vol.260 , Issue.5105 , pp. 214-216
    • Stierle, A.1    Strobel, G.A.2    Stierle, D.3
  • 89
    • 0036450211 scopus 로고    scopus 로고
    • Rainforest endophytes and bioactive products
    • Strobel GA (2002). Rainforest endophytes and bioactive products. Crit. Rev. Biotechnol. 22(4): 315-333.
    • (2002) Crit. Rev. Biotechnol , vol.22 , Issue.4 , pp. 315-333
    • Strobel, G.A.1
  • 90
    • 0348109344 scopus 로고    scopus 로고
    • Bioprospecting for microbial endophytes and their natural products
    • Strobel GA, Daisy B (2003). Bioprospecting for microbial endophytes and their natural products. Microbiol. Mol. Biol. Rev. 67(4): 491-502.
    • (2003) Microbiol. Mol. Biol. Rev , vol.67 , Issue.4 , pp. 491-502
    • Strobel, G.A.1    Daisy, B.2
  • 91
    • 1442310075 scopus 로고    scopus 로고
    • Natural products from endophytic microorganisms
    • Strobel GA, Daisy B, Castillo U, Harper J (2004). Natural products from endophytic microorganisms. J. Nat. Prod. 67(2): 257-268.
    • (2004) J. Nat. Prod , vol.67 , Issue.2 , pp. 257-268
    • Strobel, G.A.1    Daisy, B.2    Castillo, U.3    Harper, J.4
  • 92
    • 0032873186 scopus 로고    scopus 로고
    • Seimatoantlerium tepuiense gen. nov., a unique epiphytic fungus producing taxol from the Venezuelan Guyana
    • Strobel GA, Ford E, Li JY, Sears J, Sidhu RS, Hess WM (1999). Seimatoantlerium tepuiense gen. nov., a unique epiphytic fungus producing taxol from the Venezuelan Guyana. Syst. Appl. Microbiol. 22(3): 426-433.
    • (1999) Syst. Appl. Microbiol , vol.22 , Issue.3 , pp. 426-433
    • Strobel, G.A.1    Ford, E.2    Li, J.Y.3    Sears, J.4    Sidhu, R.S.5    Hess, W.M.6
  • 93
    • 0031414635 scopus 로고    scopus 로고
    • Pestalotiopsis guepinii, a taxol-producing endophyte of the wollemi pine, Wollemia nobilis
    • Strobel GA, Hess WM, Li J-Y, Ford E, Sears J, Sidhu RS, Summerell B (1997). Pestalotiopsis guepinii, a taxol-producing endophyte of the wollemi pine, Wollemia nobilis. Aust. J. Bot. 45(6): 1073-1082.
    • (1997) Aust. J. Bot , vol.45 , Issue.6 , pp. 1073-1082
    • Strobel, G.A.1    Hess, W.M.2    Li, J.-Y.3    Ford, E.4    Sears, J.5    Sidhu, R.S.6    Summerell, B.7
  • 94
    • 0030059628 scopus 로고    scopus 로고
    • Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana
    • Strobel GA, Yang X, Sears J, Kramer R, Sidhu RS, Hess WM (1996). Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana. Microbiology 142(2): 435-440.
    • (1996) Microbiology , vol.142 , Issue.2 , pp. 435-440
    • Strobel, G.A.1    Yang, X.2    Sears, J.3    Kramer, R.4    Sidhu, R.S.5    Hess, W.M.6
  • 95
    • 66749101042 scopus 로고    scopus 로고
    • Suffness M, Wall ME (1995). Discovery and developement of taxol. In: Suffness M (ed) Taxol: Sci. Appl., CRC Press, Boca Raton, pp 1-25.
    • Suffness M, Wall ME (1995). Discovery and developement of taxol. In: Suffness M (ed) Taxol: Sci. Appl., CRC Press, Boca Raton, pp 1-25.
  • 96
    • 35148872240 scopus 로고    scopus 로고
    • Update on stents: Recent studies on the TAXUS stent system in small vessels
    • Tanimoto S, Daemen J, Serruys PW (2007). Update on stents: recent studies on the TAXUS stent system in small vessels. Vasc. Health Risk Manag. 3(4): 481-490.
    • (2007) Vasc. Health Risk Manag , vol.3 , Issue.4 , pp. 481-490
    • Tanimoto, S.1    Daemen, J.2    Serruys, P.W.3
  • 100
    • 0034980234 scopus 로고    scopus 로고
    • Genomic organization of plant terpene synthases and molecular evolutionary implications
    • Trapp SC, Croteau RB (2001). Genomic organization of plant terpene synthases and molecular evolutionary implications. Genetics 158(2): 811-832.
    • (2001) Genetics , vol.158 , Issue.2 , pp. 811-832
    • Trapp, S.C.1    Croteau, R.B.2
  • 101
    • 0345369681 scopus 로고    scopus 로고
    • Gibberellin biosynthetic pathway in Gibberella fujikuroi: Evidence for a gene cluster
    • Tudzynski B, Holter K (1998). Gibberellin biosynthetic pathway in Gibberella fujikuroi: evidence for a gene cluster. Fungal Genet. Biol. 25(3): 157-170.
    • (1998) Fungal Genet. Biol , vol.25 , Issue.3 , pp. 157-170
    • Tudzynski, B.1    Holter, K.2
  • 102
    • 0002489590 scopus 로고    scopus 로고
    • Taxol biosynthesis: A review of some determinant steps
    • Walker KD, Croteau RB (1999). Taxol biosynthesis: A review of some determinant steps. Recent Adv. Phytochem. 33: 31-50.
    • (1999) Recent Adv. Phytochem , vol.33 , pp. 31-50
    • Walker, K.D.1    Croteau, R.B.2
  • 103
    • 0034681193 scopus 로고    scopus 로고
    • Walker KD, Croteau RB (2000a). Molecular cloning of a 10- deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. Proc. Natl. Acad. Sci. U. A. 97(2): 583-587.
    • Walker KD, Croteau RB (2000a). Molecular cloning of a 10- deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. Proc. Natl. Acad. Sci. U. A. 97(2): 583-587.
  • 104
    • 0034610386 scopus 로고    scopus 로고
    • Taxol biosynthesis: Molecular cloning of a benzoyl-CoA:taxane 2a-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli
    • Walker KD, Croteau RB (2000b). Taxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane 2a-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 97(25): 13591-13596.
    • (2000) Proc. Natl. Acad. Sci. U. S. A , vol.97 , Issue.25 , pp. 13591-13596
    • Walker, K.D.1    Croteau, R.B.2
  • 105
  • 106
    • 0036789932 scopus 로고    scopus 로고
    • Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain-CoA acyltransferase that functions in Taxol biosynthesis
    • Walker KD, Fujisaki S, Long RM, Croteau RB (2002a). Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain-CoA acyltransferase that functions in Taxol biosynthesis. Proc. Natl. Acad. Sci. U. S. A. 99(20): 12715-12720.
    • (2002) Proc. Natl. Acad. Sci. U. S. A , vol.99 , Issue.20 , pp. 12715-12720
    • Walker, K.D.1    Fujisaki, S.2    Long, R.M.3    Croteau, R.B.4
  • 107
    • 0033560575 scopus 로고    scopus 로고
    • Walker KD, Ketchum REB, Hezari M, Gatfield D, Goleniowski M, Barthol A, Croteau RB (1999). Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5a-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesis. Arch. Biochem. Biophys. 364(2): 273-279.
    • Walker KD, Ketchum REB, Hezari M, Gatfield D, Goleniowski M, Barthol A, Croteau RB (1999). Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5a-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesis. Arch. Biochem. Biophys. 364(2): 273-279.
  • 108
    • 0037047151 scopus 로고    scopus 로고
    • The final acylation step in taxol biosynthesis: Cloning of the taxoid C13-side-chain N- benzoyltransferase from Taxus
    • Walker KD, Long RM, Croteau RB (2002b). The final acylation step in taxol biosynthesis: cloning of the taxoid C13-side-chain N- benzoyltransferase from Taxus. Proc. Natl. Acad. Sci. U. S. A. 99(14): 9166-9171.
    • (2002) Proc. Natl. Acad. Sci. U. S. A , vol.99 , Issue.14 , pp. 9166-9171
    • Walker, K.D.1    Long, R.M.2    Croteau, R.B.3
  • 109
    • 0034652139 scopus 로고    scopus 로고
    • Walker KD, Schoendorf A, Croteau RB (2000). Molecular cloning of a taxa-4(20),11(12)-dien-5a-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. Arch. Biochem. Biophys. 374(2): 371-380.
    • Walker KD, Schoendorf A, Croteau RB (2000). Molecular cloning of a taxa-4(20),11(12)-dien-5a-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. Arch. Biochem. Biophys. 374(2): 371-380.
  • 110
    • 0032479018 scopus 로고    scopus 로고
    • Detection of a phenylalanine aminomutase in cell-free extracts of Taxus brevifolia and preliminary characterization of its reaction
    • Walker KD, Floss HG (1998). Detection of a phenylalanine aminomutase in cell-free extracts of Taxus brevifolia and preliminary characterization of its reaction. J. Am. Chem. Soc. 120(21): 5333-5334.
    • (1998) J. Am. Chem. Soc , vol.120 , Issue.21 , pp. 5333-5334
    • Walker, K.D.1    Floss, H.G.2
  • 111
    • 11144225850 scopus 로고    scopus 로고
    • Cloning, heterologous expression, and characterization of a phenylalanine aminomutase involved in taxol biosynthesis
    • Walker KD, Klettke K, Akiyama T, Croteau RB (2004). Cloning, heterologous expression, and characterization of a phenylalanine aminomutase involved in taxol biosynthesis. J. Biol. Chem. 279(52): 53947-53954.
    • (2004) J. Biol. Chem , vol.279 , Issue.52 , pp. 53947-53954
    • Walker, K.D.1    Klettke, K.2    Akiyama, T.3    Croteau, R.B.4
  • 112
    • 0033762670 scopus 로고    scopus 로고
    • Horizontal gene transfer and the evolution of secondary metabolite gene clusters in fungi: A hypothesis
    • Walton JD (2000). Horizontal gene transfer and the evolution of secondary metabolite gene clusters in fungi: a hypothesis. Fungal genetics and biology 30(3): 167-171.
    • (2000) Fungal genetics and biology , vol.30 , Issue.3 , pp. 167-171
    • Walton, J.D.1
  • 113
    • 0034672382 scopus 로고    scopus 로고
    • Taxol from Tubercularia sp. strain TF5, an endophytic fungus of Taxus mairei
    • Wang J, Li G, Lu H, Zheng Z, Huang Y and Su W (2000). Taxol from Tubercularia sp. strain TF5, an endophytic fungus of Taxus mairei. FEMS Microbiol. Lett. 193(2): 249-253.
    • (2000) FEMS Microbiol. Lett , vol.193 , Issue.2 , pp. 249-253
    • Wang, J.1    Li, G.2    Lu, H.3    Zheng, Z.4    Huang, Y.5    Su, W.6
  • 114
    • 0015211527 scopus 로고
    • Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia
    • Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT (1971). Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J. Am. Chem. Soc. 93(9): 2325-2327.
    • (1971) J. Am. Chem. Soc , vol.93 , Issue.9 , pp. 2325-2327
    • Wani, M.C.1    Taylor, H.L.2    Wall, M.E.3    Coggon, P.4    McPhail, A.T.5
  • 115
    • 27244462261 scopus 로고    scopus 로고
    • Taxol Biosynthesis: Differential transformations of taxadien-5a-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells
    • Wheeler AL, Long RM, Ketchum REB, Rithner CD, Williams RM, Croteau RB (2001). Taxol Biosynthesis: Differential transformations of taxadien-5a-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells. Arch. Biochem. Biophys. 390(2): 265-278.
    • (2001) Arch. Biochem. Biophys , vol.390 , Issue.2 , pp. 265-278
    • Wheeler, A.L.1    Long, R.M.2    Ketchum, R.E.B.3    Rithner, C.D.4    Williams, R.M.5    Croteau, R.B.6
  • 116
    • 0029873176 scopus 로고    scopus 로고
    • A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis
    • Wildung MR, Croteau RB (1996). A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis. J. Biol. Chem. 271(16): 9201-9204.
    • (1996) J. Biol. Chem , vol.271 , Issue.16 , pp. 9201-9204
    • Wildung, M.R.1    Croteau, R.B.2
  • 117
    • 0034523479 scopus 로고    scopus 로고
    • Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase
    • Williams DC, Carroll BJ, Jin Q, Rithner CD, Lenger SR, Floss HG, Coates RM, Williams RM, Croteau RB (2000a). Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase. Chem. Biol. 7(12): 969-977.
    • (2000) Chem. Biol , vol.7 , Issue.12 , pp. 969-977
    • Williams, D.C.1    Carroll, B.J.2    Jin, Q.3    Rithner, C.D.4    Lenger, S.R.5    Floss, H.G.6    Coates, R.M.7    Williams, R.M.8    Croteau, R.B.9
  • 118
    • 0034234699 scopus 로고    scopus 로고
    • Heterologous expression and characterization of a "pseudomature" form of taxadiene synthase involved in paclitaxel (Taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction
    • Williams DC, Wildung MR, Jin AQ, Dalal D, Oliver JS, Coates RM, Croteau RB (2000b). Heterologous expression and characterization of a "pseudomature" form of taxadiene synthase involved in paclitaxel (Taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction. Arch. Biochem. Biophys. 379(1): 137-146.
    • (2000) Arch. Biochem. Biophys , vol.379 , Issue.1 , pp. 137-146
    • Williams, D.C.1    Wildung, M.R.2    Jin, A.Q.3    Dalal, D.4    Oliver, J.S.5    Coates, R.M.6    Croteau, R.B.7
  • 119
    • 15944428289 scopus 로고    scopus 로고
    • Total synthesis of taxoids
    • Itokawa H, Lee KH eds, Taylor &Francis, London, pp
    • Xiao Z, Itokawa H, Lee K-H (2003). Total synthesis of taxoids. In: Itokawa H, Lee KH (eds), Taxus - The Genus Taxus, Taylor &Francis, London, pp. 245-297.
    • (2003) Taxus - The Genus Taxus , pp. 245-297
    • Xiao, Z.1    Itokawa, H.2    Lee, K.-H.3
  • 121
    • 0029737648 scopus 로고    scopus 로고
    • Methyl jasmonate- induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures
    • Yukimune Y, Tabata H, Higashi Y, Hara Y (1996). Methyl jasmonate- induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures. Nature Biotech. 14 (9): 1129-1132.
    • (1996) Nature Biotech , vol.14 , Issue.9 , pp. 1129-1132
    • Yukimune, Y.1    Tabata, H.2    Higashi, Y.3    Hara, Y.4
  • 122
    • 54849403288 scopus 로고    scopus 로고
    • Screening of taxol- producing fungi based on PCR amplification from Taxus
    • Zhang P, Zhou P-p, Jiang C, Yu H, Yu L-J (2008). Screening of taxol- producing fungi based on PCR amplification from Taxus. Biotechnol. Lett. 30(12): 2119-2123.
    • (2008) Biotechnol. Lett , vol.30 , Issue.12 , pp. 2119-2123
    • Zhang, P.1    Zhou, P.-P.2    Jiang, C.3    Yu, H.4    Yu, L.-J.5
  • 124
    • 34547168999 scopus 로고    scopus 로고
    • Screening of taxol-producing endophytic fungi from Taxus chinensis var. mairei
    • Zhou X, Wang Z, Jiang K, Wei Y, Lin J, Sun X, Tang K (2007). Screening of taxol-producing endophytic fungi from Taxus chinensis var. mairei. Appl. Biochem. Microbiol. 43(4): 439-443.
    • (2007) Appl. Biochem. Microbiol , vol.43 , Issue.4 , pp. 439-443
    • Zhou, X.1    Wang, Z.2    Jiang, K.3    Wei, Y.4    Lin, J.5    Sun, X.6    Tang, K.7


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