Deoxyxylulose phosphate pathway to terpenoids

Trends in Plant Science

Volumn 6, Issue 2, 2001, Pages 78-84

  Eisenreich, Wolfgang ^a   Rohdich, Felix ^a   Bacher, Adelbert ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXY 2 PENTULOSE; 1-DEOXY-2-PENTULOSE; DRUG DERIVATIVE; ENZYME; HEMITERPENE; ISOPENTENYL DIPHOSPHATE; MEVALONIC ACID; ORGANOPHOSPHORUS COMPOUND; PYROPHOSPHATE; TERPENE; XYLULOSE;

BACTERIAL GENE; GENE; METABOLISM; REVIEW;

DIPHOSPHATES; ENZYMES; GENES, BACTERIAL; GENES, PLANT; HEMITERPENES; MEVALONIC ACID; ORGANOPHOSPHORUS COMPOUNDS; TERPENES; XYLULOSE;

BACTERIA (MICROORGANISMS);

EID: 0035208850     PISSN: 13601385     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1360-1385(00)01812-4     Document Type: Review

References (49)

1. Creating isoprenoid diversity
2. Biosynthesis of mevalonic acid from acetyl-CoA
3. Isoprenoid biosynthesis in bacteria: A novel pathway for the early steps leading to isopentenyl diphosphate
4. The deoxyxylulose phosphate pathway of terpenoid biosynthesis in plants and microorganisms
5. Ginkgolide biosynthesis
6. A mevalonate-independent route to isopentenyl diphosphate
7. Stable isotope studies on the biosynthesis of the thiazole moiety of thiamin in Escherichia coli
8. 1-Deoxy-D-threo-2-pentulose: The precursor of the five-carbon chain of the thiazole of thiamine
9. 6: Incorporation of D-1-deoxyxylulose
10. The role of lateral gene transfer in the evolution of isoprenoid biosynthesis pathways
11. Terpene biosynthesis from 1-deoxy-D-xylulose in higher plants by intramolecular skeletal rearrangement
12. Biosynthesis of the isoprene units of chamomile sesqiterpenes
13. Biosynthesis of heteroscyphic acid A in cell cultures of Heteroscyphus planus: Non-equivalent labelling of C-5 units in diterpene biosynthesis
14. Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol
15. Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyses the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursur for isoprenoid, thiamin, and pyridoxol biosynthesis
16. A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway
17. Dedicated roles of plastid transketolases during the early onset of isoprenoid biogenesis in pepper fruits
18. Temperature-sensitive Arabidopsis mutant defective in 1-deoxy-D-xylulose 5-phosphate synthase within the plastid non-mevalonate pathway of isoprenoid biosynthesis
19. The non-mevalonate isoprenoid biosynthesis of plants as a test system for new herbicides and drugs against pathogenic bacteria and the malaria parasite
20. Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis
21. A Synechococcus leopoliensis SAUG 1402-1 operon harboring the 1-deoxy-D-xylulose 5-phosphate gene and two additional open reading frames is functionally involved in the dimethylallyl diphosphate synthesis
22. Carotenoid biosynthesis during tomato fruit development: Regulatory role of 1-deoxy-D-xylulose 5 phosphate synthase
23. A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalysing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis
24. Characterization of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an enzyme involved in isopentenyl diphosphate biosynthesis, and identification of its catalytic amino acid residues
25. Stereochemistry of the reduction step mediated by recombinant 1-deoxy-D-xylulose 5-phosphate isomeroreductase
26. Cloning and heterologous expression of a cDNA encoding 1-deoxy-D-xylulose-5-phosphate reductoisomerase of Arabidopsis thaliana
27. Isoprenoid biosynthesis via a mevalonate-independent pathway in plants: Cloning and heterologous expression of 1-deoxy-D-xylulose-5-phosphate reductoisomerase from peppermint
28. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
29. Biosynthesis of terpenoids: 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Escherichia coli is a class B dehydrogenase
30. Fosmidomycin, a specific inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis
31. Cytidine 5′-triphosphate biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyses the formation of 4-diphosphocytidyl-2C-methylerythritol
32. acs1 of Haemophilus influenzae type a capsulation locus region II encodes a bifunctional ribulose 5-phosphate reductase-CDP-ribitol pyrophosphorylase
33. Formation of 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol from 2-C-methyl-D-erythritol 4-phosphate by 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase, a new enzyme in the nonmevalonate pathway
34. Biosynthesis of terpenoids: 4-diphoshocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thaliana
35. Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
36. Chromoplast development in ripening tomato fruit: Identification of cDNAs for chromoplast-targeted proteins and characterization of a cDNA encoding a plastid-localized low-molecular-weight heat shock protein
37. Biosynthesis of terpenoids: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from tomato
38. Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: Isopentenyl monophosphate kinase catalyses the terminal enzymatic step
39. Studies on the nonmevalonate pathway: Conversion of 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol to its 2-phospho derivative by 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol kinase
40. Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate
41. Studies on the nonmevalonate pathway: Formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate from 2-phospho-4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol
42. Structure determination of a novel cyclic phosphocompound isolated from Desulfovibrio desulfuricans
43. The ability of bacteria to synthesize a new cyclodiphosphate correlates with their tolerance to redox-cycling drugs: On a crossroad of chemotherapy, environmental toxicology and immunobiochemical problems
44. Effect of oxidative stress on the biosynthesis of 2-C-methyl-D-erythritol-2,4-cyclopyrophosphate and isoprenoids by several bacterial strains
45. Biosynthesis of isoprenoids in Escherichia coli: The fate of the 3-H and 4-H atoms of 1-deoxy-D-xylulose
46. Genetic evidence of branching in the isoprenoid pathway for the production of isopentenyl diphosphate and dimethylallyl diphosphate in Escherichia coli
47. Evidence of a role for LytB in the nonmevalonate pathway of isoprenoid biosynthesis
48. Cell-free conversion of 1-deoxy-D-xylulose 5-phosphate and 2-C-methyl-D-erythritol 4-phosphate into β-carotene in higher plants and its inhibition by fosmidomycin
49. Metabolic engineering of carotenoid accumulation in E. coli by modulation of the isoprenoid precursor pool with expression of deoxyxylulose phosphate synthase