Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase

Chemistry and Biology

Volumn 7, Issue 12, 2000, Pages 969-977

  Williams, David C ^a   Carroll, Brian J ^b   Jin, Qingwu ^c   Rithner, Christopher D ^d   Lenger, Steven R ^d   Floss, Heinz G ^b   Coates, Robert M ^c   Williams, Robert M ^d   Croteau, Rodney ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Biosynthesis; Electrophilic cyclization; Geranylgeranyl diphosphate; Intramolecular proton transfer; Proton transfer; Recombinant enzyme; Taxa 4(5), 11(12) diene; Taxadiene synthase; Taxol

Indexed keywords

TAXUS;

EID: 0034523479     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00046-6     Document Type: Article

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