Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5α-ol: The first oxygenation step in taxol biosynthesis

Chemistry and Biology

Volumn 3, Issue 6, 1996, Pages 479-489

  Hefner, Jerry ^a   Rubenstein, Steven M ^b   Ketchum, Raymond E B ^c   Gibson, Donna M ^c   Williams, Robert M ^b   Croteau, Rodney ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

^c AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

Cytochrome P450; Taxadiene hydroxylase; Taxadienol synthesis; Taxol biosynthesis; Taxus enzymes

Indexed keywords

TAXUS;

ALKENE; CYTOCHROME P450; DITERPENE; OXYGEN; PACLITAXEL; TAXA 4(5),11(12)DIENE; TAXA-4(5),11(12)DIENE;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CELL CULTURE; CHEMISTRY; HYDROXYLATION; METABOLISM;

ALKENES; CATALYSIS; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DITERPENES; HYDROXYLATION; OXYGEN; PACLITAXEL;

EID: 0030154837     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(96)90096-4     Document Type: Article

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