Stereochemistry of the macrocyclization and elimination steps in taxadiene biosynthesis through deuterium labeling

Journal of Organic Chemistry

Volumn 70, Issue 12, 2005, Pages 4667-4675

  Jin, Qingwu ^a   Williams, David C ^b   Hezari, Mehri ^b   Croteau, Rodney ^b   Coates, Robert M ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITION REACTIONS; BIOSYNTHESIS; CATALYSIS; DEUTERIUM; ENZYMES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION KINETICS;

CYCLIZATION REACTIONS; ELECTROPHILIC ADDITION; PROTON ABSTRACTION;

STEREOCHEMISTRY;

3,7,11,15 TETRAMETHYL 2,6,10,14 HEXADECATETRAEN 1 YL DIPHOSPHATE; DEUTERIUM; PACLITAXEL; RECOMBINANT ENZYME; TAXADIENE; TAXADIENE SYNTHASE; TAXANE DERIVATIVE; TAXUS BREVIFOLIA EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; CHEMICAL REACTION; CYCLIZATION; DRUG SYNTHESIS; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STEREOCHEMISTRY; TAXUS BREVIFOLIA;

CATALYSIS; CYCLIZATION; DEUTERIUM; ISOMERASES; ISOTOPE LABELING; MOLECULAR STRUCTURE; PACLITAXEL; PLANTS, MEDICINAL; STEREOISOMERISM; TAXUS;

EID: 20344394434     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0502091     Document Type: Article

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