Lifestyle choices and endothelial function: Risk and relevance

Current Vascular Pharmacology

Volumn 7, Issue 2, 2009, Pages 209-224

  Wang, Jingli ^a   Widlansky, Michael E ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Diet; Endothelium; Environment; Exercise; Nitric oxide

Indexed keywords

ADDUCIN; ADVANCED GLYCATION END PRODUCT; ALPHA 2B ADRENERGIC RECEPTOR; ALPHA TOCOPHEROL; ARYLDIALKYLPHOSPHATASE 1; BRADYKININ B2 RECEPTOR; C REACTIVE PROTEIN; CHOLESTEROL; CONNEXIN 37; DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; GLUTAMATE CYSTEINE LIGASE; HIGH DENSITY LIPOPROTEIN; INSULIN RECEPTOR SUBSTRATE 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN; NEUROPEPTIDE Y; OMEGA 3 FATTY ACID; PROSTACYCLIN; REACTIVE OXYGEN METABOLITE; THROMBOCYTE ACTIVATING FACTOR; TRANSMEMBRANE CONDUCTANCE REGULATOR; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR; VASCULAR CELL ADHESION MOLECULE 1; XANTHINE OXIDASE;

ATHEROSCLEROTIC CARDIOVASCULAR DISEASE; BIOAVAILABILITY; BRACHIAL ARTERY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CELL MEMBRANE PERMEABILITY; CHOLESTEROL BLOOD LEVEL; CORONARY BLOOD VESSEL; DIETARY INTAKE; EMOTIONAL STRESS; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENVIRONMENTAL FACTOR; EXERCISE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HEART INFARCTION; HOMEOSTASIS; HUMAN; IMMOBILIZATION; LIFESTYLE MODIFICATION; LIPID DIET; LIPOPROTEIN BLOOD LEVEL; MORBIDITY; OBESITY; OCCUPATIONAL EXPOSURE; OXIDATIVE STRESS; PHENOTYPE; PHYSIOLOGICAL STRESS; POLLUTION; REVIEW; SMOKING; SMOKING CESSATION; THROMBOCYTE ADHESION; TRIACYLGLYCEROL BLOOD LEVEL; TYPE A BEHAVIOR; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; WEIGHT REDUCTION;

CARDIOVASCULAR DISEASES; DIET; ENDOTHELIUM, VASCULAR; ENVIRONMENTAL POLLUTION; EXERCISE; HUMANS; LIFE STYLE; OBESITY; POLYMORPHISM, GENETIC; RISK FACTORS; SMOKING;

EID: 66049089254     PISSN: 15701611     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016109787455581     Document Type: Review

References (230)

1. American Heart Association. Heart Disease and Stroke Statistics-2007 Update: A Report for the American Heart Association Statistics Committee and Stroke Subcommittee 2008.
2. Khot UN, Khot MB, Bajzer CT, Sapp SK, Ohman EM, Brener SJ, et al. Prevalence of conventional risk factors in patients with coronary heart disease. JAMA 2003; 290: 898-904.
3. Greenland P, Knoll MD, Stamler J, Neaton JD, Dyer AR, Garside DB, et al. Major risk factors as antecedents of fatal and nonfatal coronary heart disease events. JAMA 2003; 290: 891-7.
4. Stampfer MJ, Hu FB, Manson JE, Rimm EB, Willett WC. Primary prevention of coronary heart disease in women through diet and lifestyle. N Engl J Med 2000; 343: 16-22.
5. Hu FB, Manson JE, Stampfer MJ, Colditz G, Liu S, Solomon CG, et al. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 2001; 345: 790-7.
6. Topol EJ. The genetics of heart attack. Heart 2006; 92: 855-61.
7. Widlansky ME, Gokce N, Keaney JF Jr., Vita JA. The clinical implications of endothelial dysfunction. J Am Coll Cardiol 2003; 42: 1149-60.
8. Celermajer DS, Adams MR, Clarkson P, Robinson J, McCredie R, Donald A, et al. Passive smoking and impaired endothelium-dependent arterial dilitation in healthy young adults. N Engl J Med 1996; 334: 150-4.
9. Higashi Y, Sasaki S, Nakagawa K, Matsuura H, Kajiyama G, Oshima T. Effect of obesity on endothelium-dependent, nitric oxide-mediated vasodilation in normotensive individuals and patients with essential hypertension. Am J Hypertens 2001; 14: 1038-45.
10. Vogel RA, Corretti MC, Plotnick GD. Effect of a single high-fat meal on endothelial function in healthy subjects. Am J Cardiol 1997; 79: 350-4.
11. Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E, et al. Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler Thromb Vasc Biol 2007; 27: 2650-6.
12. Gokce N, Vita JA, Donnell M, Forse AR, Istfan N, Stoeckl M, et al. Weight reduction improves endothelial vasomotor function in overweight and obese patients. Am J Cardiol 2005; 95: 266-8.
13. Glantz SA, Parmley WW. Passive smoking and heart disease. Mechanisms and risk. JAMA 1995; 273: 1047-53.
14. Barnoya J, Glantz SA. Cardiovascular effects of secondhand smoke: nearly as large as smoking. Circulation 2005; 111: 2684-98.
15. Tornqvist H, Mills NL, Gonzalez M, Miller MR, Robinson SD, Megson IL, et al. Persistent endothelial dysfunction in humans after diesel exhaust inhalation. Am J Respir Crit Care Med 2007; 176: 395-400.
16. Ghiadoni L, Donald AE, Cropley M, Mullen MJ, Oakley G, Taylor M, et al. Mental stress induces transient endothelial dysfunction in humans. Circulation 2000; 102: 2473-8.
17. Guang-da X, Qiong-shu W, Wen J. A T-786C polymorphism in 5'-flanking region of the endothelial nitric oxide synthase gene and endothelium-dependent arterial dilation in Type 2 diabetes. Diabet Med 2005; 22: 1663-9.
18. Leeson CP, Hingorani AD, Mullen MJ, Jeerooburkhan N, Kattenhorn M, Cole TJ, et al. Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function. Circ Res 2002; 90: 1153-8.
19. Wang J, Dudley D, Wang XL. Haplotype-specific effects on endothelial NO synthase promoter efficiency: modifiable by cigarette smoking. Arterioscler Thromb Vasc Biol 2002; 22: e1-e4.
20. Gimbrone MA. Vascular Endothelium and Atherosclerosis. New York Marcel Dekker Inc., 1981; pp. 25-52.
21. Gokce N, Keaney JF Jr., Vita JA. In: Loscalzo J, Shafer AI Eds, Thrombosis and Hemorrhage. Williams and Wilkins 1998; pp. 901-924.
22. Levick JR. An Introduction to Cardiovascular Physiology. London Arnold 2003; pp. 131-148.
23. Cines DB, Pollak ES, Buck CA, Loscalzo J, Zimmerman GA, McEver RP, et al. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 1998; 91: 3527-61.
24. Harker LA, Ross R, Glomset JA. The role of endothelial cell injury and platelet response in atherogenesis. Thromb Haemost 1978; 39: 312-21.
25. Ross R, Glomset JA. Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. Science 1973; 180: pp. 1332-1339.
26. Ross R, Glomset JA. The pathogenesis of atherosclerosis (first of two parts). N Engl J Med 1976; 295: 369-77.
27. Ross R, Glomset JA. The pathogenesis of atherosclerosis (second of two parts). N Engl J Med 1976; 295: 420-5.
28. Ross R, Harker L. Hyperlipidemia and atherosclerosis. Science 1976; 193: 1094-1100.
29. Ardlie NG. In: Miller NE Ed, Lipoproteins, platelet function, and blood coagulation. 1981; pp. 107-126.
30. Casino PR, Kilcoyne CM, Cannon RO III, Quyyumi AA, Panza JA. Impaired endothelium-dependent vascular relaxation in patients with hypercholesterolemia extends beyond the muscarinic receptor. Am J Cardiol 1995; 75: 40-4.
31. Haidar, Soeatmadji DW. Effects of high-carbohydrate and high fat diet on formation of foam cells and expression of TNF-alpha in Rattus novergicus. Acta Med Indones 2007; 39: 119-23.
32. Harvey KA, Arnold T, Rasool T, Antalis C, Miller SJ, Siddiqui RA. Trans-fatty acids induce pro-inflammatory responses and endothelial cell dysfunction. Br J Nutr 2008; 99: 723-31.
33. Barua RS. In: Aird WC Ed, Endothelial Biomedicine 2007; pp. 1320-31.
34. Chen CC, Li TC, Chang PC, Liu CS, Lin WY, Wu MT, et al. Association among cigarette smoking, metabolic syndrome, and its individual components: the metabolic syndrome study in Taiwan. Metabolism 2008; 57: 544-48.
35. Cavusoglu Y, Timuralp B, Us T, Akgun Y, Kudaiberdieva G, Gorenek B, et al. Cigarette smoking increases plasma concentrations of vascular cell adhesion molecule-1 in patients with coronary artery disease. Angiology 2004; 55: 397-402.
36. Orosz Z, Csiszar A, Labinskyy N, Smith K, Kaminski PM, Ferdinandy P, et al. Cigarette smoke-induced proinflammatory alterations in the endothelial phenotype: role of NAD(P)H oxidase activation. Am J Physiol Heart Circ Physiol 2007; 292: H130-H139.
37. Aird WC. Endothelial biomedicine. New York, Cambridge University Press, 2007.
38. Zhou B, Wu Y, Yang J, Li Y, Zhang H, Zhao L. Overweight is an independent risk factor for cardiovascular disease in Chinese populations. Obes Rev 2002; 3: 147-56.
39. Coban E, Yilmaz A, Sari R. The effect of weight loss on the mean platelet volume in obese patients. Platelets 2007; 18: 212-6.
40. von KR, Mills PJ, Fainman C, Dimsdale JE. Effects of psychological stress and psychiatric disorders on blood coagulation and fibrinolysis: a biobehavioral pathway to coronary artery disease? Psychosom Med 2001; 63: 531-44.
41. Beall HD, Coffin JD. In: Aird WC Ed, Endothelial Biomedicine 2007; pp. 527-535.
42. Kunzli N, Jerrett M, Mack WJ, Beckerman B, LaBree L, Gilliland F, et al. Ambient air pollution and atherosclerosis in Los Angeles. Environ Health Perspect 2005; 113: 201-6.
43. Nurkiewicz TR, Porter DW, Barger M, Castranova V, Boegehold MA. Particulate matter exposure impairs systemic microvascular endothelium-dependent dilation. Environ Health Perspect 2004; 112: 1299-1306.
44. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. Am J Physiol 1996; 271: C1424-C1437.
45. O'Donnell VB, Freeman BA. Interactions between nitric oxide and lipid oxidation pathways: implications for vascular disease. Circ Res 2001; 88: 12-21.
46. Yoshizumi M, Perrella MA, Burnett JC Jr., Lee ME. Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ Res 1993; 73: 205-9.
47. Liao JK, Shin WS, Lee WY, Clark SL. Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase. J Biol Chem 1995; 270: 319-24.
48. Tai SC, Robb GB, Marsden PA. Endothelial nitric oxide synthase: A new paradigm for gene regulation in the injured blood vessel. Arterioscler Thromb Vasc Biol 2004; 24: 1-8.
49. Griendling KK, FitzGerald GA. Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS. Circulation 2003; 108: 1912-6.
50. Vasquez-Vivar J, Kalyanaraman B, Martasek P, Hogg N, Masters BS, Karoui H et al. Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc Natl Acad Sci USA 1998; 95: 9220-5.
51. Huang A, Vita JA, Venema RC, Keaney JF, Jr. Ascorbic acid enhances endothelial nitric oxide synthase activity by increasing intracellular tetrahydrobiopterin. J Biol Chem 2000; 275: 17399-06.
52. Stocker R, Huang A, Jeranian E, Hou JY, Wu T, Thomas SR, et al. Hypochlorous acid impairs endothelium-derived nitric oxide bioactivity through a superoxide-dependent mechanism. Arterioscler Thromb Vasc Biol 2004; 24: 2028-33.
53. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002; 105: 1135-43.
54. Li H, Cybulsky MI, Gimbrone MA, Libby P. An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler Thromb 1993; 13: 197-204.
55. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 1999; 19: 972-8.
56. Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Elevated C-reactive protein levels in overweight and obese adults. JAMA 1999; 282: 2131-5.
57. Vita JA. Nitric oxide-dependent vasodilation in human subjects. Methods Enzymol 2002; 359: 186-200.
58. Perticone F, Ceravolo R, Pujia A, Ventura G, Iacopino S, Scozzafava A, et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation 2001; 104: 191-6.
59. Modena MG, Bonetti L, Coppi F, Bursi F, Rossi R. Prognostic role of reversible endothelial dysfunction in hypertensive postmenopausal women. J Am Coll Cardiol 2002; 40: 505-10.
60. Schindler TH, Hornig B, Buser PT, Olschewski M, Magosaki N, Pfisterer M, et al. Prognostic value of abnormal vasoreactivity of epicardial coronary arteries to sympathetic stimulation in patients with normal coronary angiograms. Arterioscler Thromb Vasc Biol 2003; 23: 495-501.
61. Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long- term outcome of coronary heart disease. Circulation 2000; 101: 1899-906.
62. Suwaidi JA, Hamasaki S, Higano ST, Nishimura RA, Holmes DR, Lerman A. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 2000; 101: 948-54.
63. Neunteufl T, Heher S, Katzenschlager R, Wolfl G, Kostner K, Maurer G, et al. Late prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain. Am J Cardiol 2000; 86: 207-10.
64. Halcox JP, Schenke WH, Zalos G, Mincemoyer R, Prasad A, Waclawiw MA, et al. Prognostic value of coronary vascular endothelial dysfunction. Circulation 2002; 106: 653-8.
65. Vita JA, Keaney JF Jr. Endothelial function: a barometer for cardiovascular risk? Circulation 2002; 106: 640-2.
66. Modena MG, Bonetti L, Coppi F, Bursi F, Rossi R. Prognostic role of reversible endothelial dysfunction in hypertensive postmenopausal women. J Am Coll Cardiol 2002; 40: 505-10.
67. McMackin CJ, Vita JA. Update on nitric oxide-dependent vasodilation in human subjects. Methods Enzymol 2005; 396: 541-53.
68. Oliver JJ, Webb DJ. Noninvasive assessment of arterial stiffness and risk of atherosclerotic events. Arterioscler Thromb Vasc Biol 2003; 23: 554-66.
69. Ludmer PL, Selwyn AP, Shook TL, Wayne RR, Mudge GH, Alexander RW, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986; 315: 1046-51.
70. Cox DA, Vita JA, Treasure CB, Fish RD, Alexander RW, Ganz P, et al. Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans. Circulation 1989; 80: 458-65.
71. Creager MA, Cooke JP, Mendelsohn ME, Gallagher SJ, Coleman SM, Loscalzo J, et al. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest 1990; 86: 228-34.
72. Anderson TJ, Uehata A, Gerhard MD, Meredith IT, Knab S, Delagrange D, et al. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol 1995; 26: 1235-41.
73. Perticone F, Ceravolo R, Pujia A, Ventura G, Iacopino S, Scozzafava A, et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation 2001; 104: 191-6.
74. Chan SY, Mancini GB, Kuramoto L, Schulzer M, Frohlich J, Ignaszewski A. The prognostic importance of endothelial dysfunction and carotid atheroma burden in patients with coronary artery disease. J Am Coll Cardiol 2003; 42: 1037-43.
75. Gokce N, Keaney JF Jr., Hunter LM, Watkins MT, Nedeljkovic ZS, Menzoian JO et al. Predictive value of non-invasively-determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease. J Am Coll Cardiol 2003; 41: 1769-75.
76. Brevetti G, Silvestro A, Schiano V, Chiariello M. Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease: Additive value of flow-mediated dilation to ankle-brachial pressure index. Circulation 2003; 108: 2093-8.
77. Fathi R, Haluska B, Isbel N, Short L, Marwick TH. The relative importance of vascular structure and function in predicting cardiovascular events. J Am Coll Cardiol 2004; 43: 616-23.
78. Shimbo D, Grahame-Clarke C, Miyake Y, Rodriguez C, Sciacca R, Di TM, et al. The association between endothelial dysfunction and cardiovascular outcomes in a population-based multi-ethnic cohort. Atherosclerosis 2007; 192: 197-203.
79. Yeboah J, Crouse JR, Hsu FC, Burke GL, Herrington DM. Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation 2007; 115: 2390-7.
80. Mora S, Cook N, Buring JE, Ridker PM, Lee IM. Physical activity and reduced risk of cardiovascular events: potential mediating mechanisms. Circulation 2007; 116: 2110-8.
81. Roberts CK, Vaziri ND, Barnard RJ. Effect of diet and exercise intervention on blood pressure, insulin, oxidative stress, and nitric oxide availability. Circulation 2002; 106: 2530-2.
82. Nohria A, Gerhard-Herman M, Creager MA, Hurley S, Mitra D, Ganz P. Role of nitric oxide in the regulation of digital pulse volume amplitude in humans. J Appl Physiol 2006; 101: 545-8.
83. Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001; 37: 1236-41.
84. Meaume S, Benetos A, Henry OF, Rudnichi A, Safar ME. Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of age. Arterioscler Thromb Vasc Biol 2001; 21: 2046-50.
85. Boutouyrie P, Tropeano AI, Asmar R, Gautier I, Benetos A, Lacolley P, et al. Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study. Hypertension 2002; 39: 10-15.
86. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002; 106: 3143-21.
87. Clarkson P, Montgomery HE, Mullen MJ, Donald AE, Powe AJ, Bull T, et al. Exercise training enhances endothelial function in young men. J Am Coll Cardiol 1999; 33: 1379-85.
88. DeSouza CA, Shapiro LF, Clevenger CM, Dinenno FA, Monahan KD, Tanaka H et al. Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation 2000; 102: 1351-7.
89. Hambrecht R, Fiehn E, Weigl C, Gielen S, Hamann C. Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation 1998; 98: 2709-15.
90. Hambrecht R, Wolf A, Gielen S, Linke A, Hofer J, Erbs S, et al. Effect of physical exercise on coronary endothelial function in coronary artery disease. N Engl J Med 2000; 342: 454-60.
91. Higashi Y, Sasaki S, Kurisu S, Yoshimizu A, Sasaki N, Matsuura H, et al. Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide. Circulation 1999; 100: 1194-202.
92. Benjamin EJ, Larson MG, Keyes MJ, Mitchell GF, Vasan RS, Keaney JF, Jr., et al. Clinical correlates and heritability of flow-mediated dilation in the community: the Framingham Heart Study. Circulation 2004; 109: 613-9.
93. Boyd NL, Park H, Yi H, Boo YC, Sorescu GP, Sykes M, et al. Chronic shear induces caveolae formation and alters ERK and Akt responses in endothelial cells. Am J Physiol Heart Circ Physiol 2003; 285: H1113-H1122.
94. Gokce N, Vita JA, Bader DS, Sherman DL, Hunter LM, Holbrook M, et al. Effect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease. Am J Cardiol 2002; 90: 124-7.
95. Roberts CK, Won D, Pruthi S, Kurtovic S, Sindhu RK, Vaziri ND, et al. Effect of a short-term diet and exercise intervention on oxidative stress, inflammation, MMP-9, and monocyte chemotactic activity in men with metabolic syndrome factors. J Appl Physiol 2006; 100: 1657-65.
96. Frisbee JC, Samora JB, Peterson J, Bryner R. Exercise training blunts microvascular rarefaction in the metabolic syndrome. Am J Physiol Heart Circ Physiol 2006; 291: H2483-H2492.
97. Marcus BH, Williams DM, Dubbert PM, Sallis JF, King AC, Yancey AK, et al. Physical activity intervention studies: what we know and what we need to know: a scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity); Council on Cardiovascular Disease in the Young; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research. Circulation 2006; 114: 2739-52.
98. Kannel WB, Belanger A, D'Agostino R, Israel I. Physical activity and physical demand on the job and risk of cardiovascular disease and death: the Framingham Study. Am Heart J 1986; 112: 820-5.
99. Sherman SE, D'Agostino RB, Cobb JL, Kannel WB. Physical activity and mortality in women in the Framingham Heart Study. Am Heart J 1994; 128: 879-84.
100. Pitsavos C, Panagiotakos DB, Chrysohoou C, Kokkinos P, Menotti A, Singh S, et al. Physical activity decreases the risk of stroke in middle-age men with left ventricular hypertrophy: 40-year follow-up (1961-2001) of the Seven Countries Study (the Corfu cohort). J Hum Hypertens 2004; 18: 495-501.
101. Tully MA, Cupples ME, Chan WS, McGlade K, Young IS. Brisk walking, fitness, and cardiovascular risk: a randomized controlled trial in primary care. Prev Med 2005; 41: 622-8.
102. Goto C, Higashi Y, Kimura M, Noma K, Hara K, Nakagawa K, et al. Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress. Circulation 2003; 108: 530-5.
103. Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH. The disease burden associated with overweight and obesity. JAMA 1999; 282: 1523-9.
104. Allison DB, Fontaine KR, Manson JE, Stevens J, VanItallie TB. Annual deaths attributable to obesity in the United States. JAMA 1999; 282: 1530-8.
105. Prentice AM. The emerging epidemic of obesity in developing countries. Int J Epidemiol 2006; 35: 93-9.
106. Rashid MN, Fuentes F, Touchon RC, Wehner PS. Obesity and the risk for cardiovascular disease. Prev Cardiol 2003; 6: 42-47.
107. Finkelstein EFIWG. Medical spending attributable to overweight and obesity: How much, and who's paying? Health Aff 2003; W3: 219-26.
108. Ziccardi P, Nappo F, Giugliano G, Esposito K, Marfella R, Cioffi M, et al. Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation 2002; 105: 804-9.
109. Shimabukuro M, Chinen I, Higa N, Takasu N, Yamakawa K, Ueda S. Effects of dietary composition on postprandial endothelial function and adiponectin concentrations in healthy humans: a crossover controlled study. Am J Clin Nutr 2007; 86: 923-8.
110. Hamburg NM, Larson MG, Vita JA, Vasan RS, Keyes MJ, Widlansky ME, et al. Metabolic syndrome, insulin resistance, and brachial artery vasodilator function in Framingham Offspring participants without clinical evidence of cardiovascular disease. Am J Cardiol 2008; 101: 82-8.
111. Pulerwitz T, Grahame-Clarke C, Rodriguez CJ, Miyake Y, Sciacca RR, Hirata K, et al. Association of increased body mass index and impaired endothelial function among Hispanic women. Am J Cardiol 2006; 97: 68-70.
112. Arcaro G, Zamboni M, Rossi L, Turcato E, Covi G, Armellini F, et al. Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity. Int J Obes Relat Metab Disord 1999; 23: 936-42.
113. Hashimoto M, Akishita M, Eto M, Kozaki K, Ako J, Sugimoto N, et al. The impairment of flow-mediated vasodilatation in obese men with visceral fat accumulation. Int J Obes Relat Metab Disord 1998; 22: 477-84.
114. Brook RD, Bard RL, Rubenfire M, Ridker PM, Rajagopalan S. Usefulness of visceral obesity (waist/hip ratio) in predicting vascular endothelial function in healthy overweight adults. Am J Cardiol 2001; 88: 1264-9.
115. Perticone F, Ceravolo R, Candigliota M, Ventura G, Iacopino S, Sinopoli F, et al. Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C. Diabetes 2001; 50: 159-65.
116. Sciacqua A, Candigliota M, Ceravolo R, Scozzafava A, Sinopoli F, Corsonello A, et al. Weight loss in combination with physical activity improves endothelial dysfunction in human obesity. Diabetes Care 2003; 26: 1673-8.
117. Arkin JM, Alsdorf R, Bigornia S, Palmisano J, Beal R, Istfan N, et al. Relation of cumulative weight burden to vascular endothelial dysfunction in obesity. Am J Cardiol 2008; 101: 98-101.
118. Phillips SA, Jurva JW, Syed AQ, Syed AQ, Kulinski JP, Pleuss J, et al. Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity. Hypertension 2008; 51: 376-82.
119. Lichtenstein AH, Appel LJ, Brands M, Carnethon M, Daniels S, Franch HA, et al. Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation 2006; 114: 82-96.
120. Staprans I, Rapp JH, Pan XM, Feingold KR. Oxidized lipids in the diet are incorporated by the liver into very low density lipoprotein in rats. J Lipid Res 1996; 37: 420-30.
121. Rodriguez-Lee M, Bondjers G, Camejo G. Fatty acid-induced atherogenic changes in extracellular matrix proteoglycans. Curr Opin Lipidol 2007; 18: 546-53.
122. Khan F, Elherik K, Bolton-Smith C, Barr R, Hill A, Murrie I, et al. The effects of dietary fatty acid supplementation on endothelial function and vascular tone in healthy subjects. Cardiovasc Res 2003; 59: 955-62.
123. Goodfellow J, Bellamy MF, Ramsey MW, Jones CJ, Lewis MJ. Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia. J Am Coll Cardiol 2000; 35: 265-70.
124. Shah AP, Ichiuji AM, Han JK, Traina M, El-Bialy A, Meymandi SK, et al. Cardiovascular and endothelial effects of fish oil supplementation in healthy volunteers. J Cardiovasc Pharmacol Ther 2007; 12: 213-9.
125. Ros E, Nunez I, Perez-Heras A, Serra M, Gilabert R, Casals E, et al. A walnut diet improves endothelial function in hypercholesterolemic subjects. a randomized crossover trial. Circulation 2004; 109: 1609-14.
126. Cortes B, Nunez I, Cofan M, Gilabert R, Perez-Heras A, Casals E, et al. Acute effects of high-fat meals enriched with walnuts or olive oil on postprandial endothelial function. J Am Coll Cardiol 2006; 48: 1666-71.
127. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet 1999; 354: 447-55.
128. Brown AA, Hu FB. Dietary modulation of endothelial function: implications for cardiovascular disease. Am J Clin Nutr 2001; 73: 673-86.
129. Perez-Jimenez F, Castro P, Lopez-Miranda J, Paz-Rojas E, Blanco A, Lopez-Segura F, et al. Circulating levels of endothelial function are modulated by dietary monounsaturated fat. Atherosclerosis 1999; 145: 351-8.
130. Ryan M, McInerney D, Owens D, Collins P, Johnson A, Tomkin GH. Diabetes and the Mediterranean diet: a beneficial effect of oleic acid on insulin sensitivity, adipocyte glucose transport and endothelium-dependent vasoreactivity. QJM 2000; 93: 85-91.
131. Fuentes F, Lopez-Miranda J, Sanchez E, Sanchez F, Paez J, Paz-Rojas E, et al. Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men. Ann Intern Med 2001; 134: 1115-9.
132. de Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, Mamelle N. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study see comments. Circulation 1999; 99: 779-85.
133. Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med 2003; 348: 2599-608.
134. Trichopoulou A, Bamia C, Norat T, Overvad K, Schmidt EB, Tjonneland A, et al. Modified Mediterranean diet and survival after myocardial infarction: the EPIC-Elderly study. Eur J Epidemiol 2007; 22: 871-81.
135. Dauchet L, Amouyel P, Hercberg S, Dallongeville J. Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies. J Nutr 2006; 136: 2588-93.
136. Vita JA. Tea consumption and cardiovascular disease: effects on endothelial function. J Nutr 2003; 133: 3293S-3297S.
137. Widlansky ME, Hamburg NM, Anter E, Holbrook M, Kahn DF, Elliott JG, et al. Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease. J Am Coll Nutr 2007; 26: 95-102.
138. Lotito SB, Frei B. Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Free Radic Biol Med 2006; 41: 1727-46.
139. Anter E, Thomas SR, Schulz E, Shapira OM, Vita JA, Keaney JF Jr. Activation of eNOS by the p38 MAP kinase in response to black tea polyphenols. J Biol Chem 2004; 45: 46637-43.
140. Wallerath T, Li H, Godtel-Ambrust U, Schwarz PM, Forstermann U. A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase. Nitric Oxide 2005; 12: 97-104.
141. Anter E, Chen K, Shapira OM, Karas RH, Keaney JF Jr. p38 mitogen-activated protein kinase activates eNOS in endothelial cells by an estrogen receptor alpha-dependent pathway in response to black tea polyphenols. Circ Res 2005; 96: 1072-8.
142. Kim JA, Formoso G, Li Y, Potenza MA, Marasciulo FL, Montagnani M, et al. Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn. J Biol Chem 2007; 282: 13736-45.
143. Edirisinghe I, Burton-Freeman B, Tissa KC. Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract. Clin Sci (Lond) 2008; 114: 331-7.
144. Leikert JF, Rathel TR, Wohlfart P, Cheynier V, Vollmar AM, Dirsch VM. Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells. Circulation 2002; 106: 1614-7.
145. Mahn K, Borras C, Knock GA, Taylor P, Khan IY, Sugden D, et al. Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo. FASEB J 2005; 19: 1755-7.
146. de NF, Williams-Ignarro S, Lerman LO, Crimi E, Botti C, Mansueto G, et al. Beneficial effects of pomegranate juice on oxidation-sensitive genes and endothelial nitric oxide synthase activity at sites of perturbed shear stress. Proc Natl Acad Sci USA 2005; 102: 4896-901.
147. Di Castelnuovo A, Rotondo S, Iacoviello L, Donati MB, de Gaetano G. Meta-analysis of wine and beer consumption in relation to vascular risk. Circulation 2002; 105: 2836-44.
148. Klatsky AL, Friedman GD, Armstrong MA, Kipp H. Wine, liquor, beer, and mortality. Am J Epidemiol 2003; 158: 585-95.
149. Stein JH, Keevil JG, Wiebe DA, Aeschlimann S, Folts JD. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 1999; 100: 1050-5.
150. Hodgson JM, Puddey IB, Burke V, Watts GF, Beilin LJ. Regular ingestion of black tea improves brachial artery vasodilator function. Clin Sci (Lond) 2002; 102: 195-201.
151. Widlansky ME, Duffy SJ, Hamburg NM, Gokce N, Warden BA, Wiseman S, et al. Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease. Free Radic Biol Med 2005; 38: 499-506.
152. Engler MB, Engler MM, Chen CY, Malloy MJ, Browne A, Chiu EY, et al. Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults. J Am Coll Nutr 2004; 23: 197-204.
153. Heiss C, Finis D, Kleinbongard P, Hoffmann A, Rassaf T, Kelm M, et al. Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week. J Cardiovasc Pharmacol 2007; 49: 74-80.
154. Flammer AJ, Hermann F, Sudano I, Spieker L, Hermann M, Cooper KA, et al. Dark chocolate improves coronary vasomotion and reduces platelet reactivity. Circulation 2007; 116: 2376-82.
155. Office on Smoking and Health. The Health Benefits of Smoking Cessation: A Report of the Surgeon General. 1990. Rockville, MD, US Office of the Surgeon General.
156. Gordon T, Kannel WB, McGee D, Dawber TR. Death and coronary attacks in men after giving up cigarette smoking. A report from the Framingham study. Lancet 1974; 2: 1345-8.
157. Lightwood JM, Glantz SA. Short-term economic and health benefits of smoking cessation: myocardial infarction and stroke. Circulation 1997; 96: 1089-96.
158. Rohani M, Agewall S. Oral snuff impairs endothelial function in healthy snuff users. J Intern Med 2004; 255: 379-83.
159. Ambrose JA, Barua RS. The pathophysiology of cigarette smoking and cardiovascular disease: an update. J Am Coll Cardiol 2004; 43: 1731-7.
160. Bermudez EA, Rifai N, Buring JE, Manson JE, Ridker PM. Relation between markers of systemic vascular inflammation and smoking in women. Am J Cardiol 2002; 89: 1117-9.
161. Mendall MA, Patel P, Asante M, Ballam L, Morris J, Strachan DP, et al. Relation of serum cytokine concentrations to cardiovascular risk factors and coronary heart disease. Heart 1997; 78: 273-7.
162. Tappia PS, Troughton KL, Langley-Evans SC, Grimble RF. Cigarette smoking influences cytokine production and antioxidant defences. Clin Sci (Lond) 1995; 88: 485-9.
163. Tracy RP, Psaty BM, Macy E, Bovill EG, Cushman M, Cornell ES, et al. Lifetime smoking exposure affects the association of C-reactive protein with cardiovascular disease risk factors and subclinical disease in healthy elderly subjects. Arterioscler Thromb Vasc Biol 1997; 17: 2167-76.
164. Davis JW, Shelton L, Eigenberg DA, Hignite CE, Watanabe IS. Effects of tobacco and non-tobacco cigarette smoking on endothelium and platelets. Clin Pharmacol Ther 1985; 37: 529-33.
165. Michael PR. Cigarette smoking, endothelial injury and cardiovascular disease. Int J Exp Pathol 2000; 81: 219-30.
166. Heitzer T, Yla-Herttuala S, Luoma J, Kurz S, Münzel T, Just H, et al. Cigarette smoking potentiates endothelial dysfunction of forearm resistance vessels in patients with hypercholesterolemia. Role of
167. Heitzer T, Yla HS, Wild E, Luoma J, Drexler H. Effect of vitamin E on endothelial vasodilator function in patients with hypercholesterolemia, chronic smoking or both. J Am Coll Cardiol 1999; 33: 499-505.
168. Celermajer DS, Sorensen KE, Georgakopoulos D, Bull C, Thomas O, Robinson J, et al. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation 1993; 88: 2149-55.
169. Strike PC, Steptoe A. Psychosocial factors in the development of coronary artery disease. Prog Cardiovasc Dis 2004; 46: 337-47.
170. Vlachopoulos C, Kosmopoulou F, Alexopoulos N, Ioakeimidis N, Siasos G, Stefanadis C. Acute mental stress has a prolonged unfavorable effect on arterial stiffness and wave reflections. Psychosom Med 2006; 68: 231-7.
171. Lucini D, Milani RV, Costantino G, Lavie CJ, Porta A, Pagani M. Effects of cardiac rehabilitation and exercise training on autonomic regulation in patients with coronary artery disease. Am Heart J 2002; 143: 977-83.
172. Pagani M, Mazzuero G, Ferrari A, Liberati D, Cerutti S, Vaitl D, et al. Sympathovagal interaction during mental stress. A study using spectral analysis of heart rate variability in healthy control subjects and patients with a prior myocardial infarction. Circulation 1991; 83(4 Suppl): II43-II51.
173. Traub W, Berk BC. Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler Thromb Vasc Biol 1998; 18: 677-85.
174. Gottdiener JS, Kop WJ, Hausner E, McCeney MK, Herrington D, Krantz DS. Effects of mental stress on flow-mediated brachial arterial dilation and influence of behavioral factors and hypercholesterolemia in subjects without cardiovascular disease. Am J Cardiol 2003; 92: 687-91.
175. Harris KF, Matthews KA, Sutton-Tyrrell K, Kuller LH. Associations between psychological traits and endothelial function in postmenopausal women. Psychosom Med 2003; 65(3): 402-9.
176. Caso JR, Moro MA, Lorenzo P, Lizasoain I, Leza JC. Involvement of IL-1beta in acute stress-induced worsening of cerebral ischaemia in rats. Eur Neuropsychopharmacol 2007; 17: 600-7.
177. Shah R, Burg MM, Vashist A, Collins D, Liu J, Jadbabaie F, et al. C-reactive protein and vulnerability to mental stress-induced myocardial ischemia. Mol Med 2006; 12: 269-74.
178. Strike PC, Magid K, Whitehead DL, Brydon L, Bhattacharyya MR, Steptoe A. Pathophysiological processes underlying emotional triggering of acute cardiac events. Proc Natl Acad Sci USA 2006; 103: 4322-7.
179. Miller M, Mangano C, Park Y, Goel R, Plotnick GD, Vogel RA. Impact of cinematic viewing on endothelial function. Heart 2006; 92: 261-2.
180. Wang JS, Lan C, Chen SY, Wong MK. Tai Chi Chuan training is associated with enhanced endothelium-dependent dilation in skin vasculature of healthy older men. J Am Geriatr Soc 2002; 50: 1024-30.
181. Harris KF, Matthews KA, Sutton-Tyrrell K, Kuller LH. Associations between psychological traits and endothelial function in postmenopausal women. Psychosom Med 2003; 65: 402-9.
182. Sivasankaran S, Pollard-Quintner S, Sachdeva R, Pugeda J, Hoq SM, Zarich SW. The effect of a six-week program of yoga and meditation on brachial artery reactivity: do psychosocial interventions affect vascular tone? Clin Cardiol 2006; 29: 393-8.
183. Dockery DW, Pope CA III, Xu X, Spengler JD, Ware JH, Fay ME, et al. An association between air pollution and mortality in six U.S. cities. N Engl J Med 1993; 329: 1753-9.
184. Samet JM, Dominici F, Curriero FC, Coursac I, Zeger SL. Fine particulate air pollution and mortality in 20 U.S. cities, 1987-94. N Engl J Med 2000; 343: 1742-49.
185. Otsuka R, Watanabe H, Hirata K, Tokai K, Muro T, Yoshiyama M, et al. Acute effects of passive smoking on the coronary circulation in healthy young adults. JAMA 2001; 286: 436-41.
186. O'Neill MS, Veves A, Zanobetti A, Sarnat JA, Gold DR, Economides PA, et al. Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial function. Circulation 2005; 111: 2913-20.
187. Bai N, Khazaei M, van Eeden SF, Laher I. The pharmacology of particulate matter air pollution-induced cardiovascular dysfunction. Pharmacol Ther 2007; 113: 16-29.
188. Paradossi U, Ciofini E, Clerico A, Botto N, Biagini A, Colombo MG. Endothelial function and carotid intima-media thickness in young healthy subjects among endothelial nitric oxide synthase Glu298-->Asp and T-786-->C polymorphisms. Stroke 2004; 35: 1305-9.
189. Imamura A, Okumura K, Matsui H, Mizuno T, Ogawa Y, Imai H, et al. Endothelial nitric oxide synthase and methylenetetrahydrofolate reductase gene polymorphisms are associated with endothelial dysfunction in young, healthy men. Can J Cardiol 2004; 20: 1229-34.
190. Godfrey V, Chan SL, Cassidy A, Butler R, Choy A, Fardon T, et al. The functional consequence of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in young healthy volunteers. Cardiovasc Drug Rev 2007; 25: 280-8.
191. Guzik TJ, Black E, West NE, McDonald D, Ratnatunga C, Pillai R, et al. Relationship between the G894T polymorphism (Glu298Asp variant) in endothelial nitric oxide synthase and nitric oxide-mediated endothelial function in human atherosclerosis. Am J Med Genet 2001; 100: 130-7.
192. Erbs S, Baither Y, Linke A, Adams V, Shu Y, Lenk K, et al. Promoter but not exon 7 polymorphism of endothelial nitric oxide synthase affects training-induced correction of endothelial dysfunction. Arterioscler Thromb Vasc Biol 2003; 23: 1814-9.
193. Erbs S, Mobius-Winkler S, Linke A, Adams V, Doll N, Gielen S, et al. Both T-786C and G894T polymorphism of endothelial nitric oxide synthase affect in vitro endothelium-dependent relaxation of internal mammary artery rings from patients with coronary artery disease. Eur J Cardiovasc Prev Rehabil 2006; 13: 826-31.
194. Li R, Lyn D, Lapu-Bula R, Oduwole A, Igho-Pemu P, Lankford B, et al. Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans. Am J Hypertens 2004; 17: 560-7.
195. Dell'Omo G, Penno G, Pucci L, Fotino C, Lucchesi D, Del PS, et al. Lack of association between endothelial nitric oxide synthase gene polymorphisms, microalbuminuria and endothelial dysfunction in hypertensive men. J Hypertens 2007; 25: 1389-95.
196. Bilsborough W, Green DJ, Mamotte CD, van Bockxmeer FM, O'Driscoll GJ, Taylor RR. Endothelial nitric oxide synthase gene polymorphism, homocysteine, cholesterol and vascular endothelial function. Atherosclerosis 2003; 169: 131-8.
197. Perticone F, Sciacqua A, Barlassina C, Del VL, Signorello MC, Dal FC, et al. Gly460Trp alpha-adducin gene polymorphism and endothelial function in untreated hypertensive patients. J Hypertens 2007; 25: 2234-9.
198. Heinonen P, Jartti L, Jarvisalo MJ, Pesonen U, Kaprio JA, Ronnemaa T, et al. Deletion polymorphism in the alpha2B-adrenergic receptor gene is associated with flow-mediated dilatation of the brachial artery. Clin Sci (Lond) 2002; 103: 517-24.
199. Vasan RS, Larson MG, Aragam J, Wang TJ, Mitchell GF, Kathiresan S et al. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. BMC Med Genet 2007; 8 Suppl 1:S2.
200. Collings A, Islam MS, Juonala M, Rontu R, Kahonen M, Hutri-Kahonen N, et al. Associations between connexin37 gene polymorphism and markers of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns study. Atherosclerosis 2007; 195: 379-84.
201. Perticone F, Ceravolo R, Maio R, Ventura G, Zingone A, Perrotti N, et al. Angiotensin-converting enzyme gene polymorphism is associated with endothelium-dependent vasodilation in never treated hypertensive patients. Hypertension 1998; 31: 900-5.
202. Gainer JV, Stein CM, Neal T, Vaughan DE, Brown NJ. Interactive Effect of Ethnicity and ACE Insertion/Deletion Polymorphism on Vascular Reactivity. Hypertension 2001; 37: 46-51.
203. Butler R, Morris AD, Burchell B, Struthers AD. DD angiotensin-converting enzyme gene polymorphism is associated with endothelial dysfunction in normal humans. Hypertension 1999; 33: 1164-8.
204. Gainer JV, Stein CM, Neal T, Vaughan DE, Brown NJ. Interactive Effect of Ethnicity and ACE Insertion/Deletion Polymorphism on Vascular Reactivity. Hypertension 2001; 37: 46-51.
205. Methot J, Hamelin BA, Arsenault M, Bogaty P, Plante S, Poirier P. The ACE-DD genotype is associated with endothelial dysfunction in postmenopausal women. Menopause 2006; 13: 959-66.
206. Tanriverdi H, Evrengul H, Tanriverdi S, Turgut S, Akdag B, Kaftan HA, et al. Improved endothelium dependent vasodilation in endurance athletes and its relation with ACE I/D polymorphism. Circ J 2005; 69: 1105-10.
207. Fan M, Raitakari OT, Kahonen M, Juonala M, Hutri-Kahonen N, Marniemi J, et al. CYBA C242T gene polymorphism and flow-mediated vasodilation in a population of young adults: the Cardiovascular Risk in Young Finns Study. J Hypertens 2007; 25: 1381-7.
208. Schneider MP, Hilgers KF, Huang Y, Delles C, John S, Oehmer S, et al. The C242T p22phox polymorphism and endothelium-dependent vasodilation in subjects with hypercholesterolaemia. Clin Sci (Lond) 2003; 105: 97-103.
209. Li A, Prasad A, Mincemoyer R, Satorius C, Epstein N, Finkel T, et al. Relationship of the C242T p22phox gene polymorphism to angiographic coronary artery disease and endothelial function. Am J Med Genet 1999; 86: 57-61.
210. Schachinger V, Britten MB, Dimmeler S, Zeiher AM. NADH/NADPH oxidase p22 phox gene polymorphism is associated with improved coronary endothelial vasodilator function. Eur Heart J 2001; 22: 96-101.
211. Pretorius MM, Gainer JV, Van Guilder GP, Coelho EB, Luther JM, Fong P, et al. The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance. Clin Pharmacol Ther 2008; 83: 122-9.
212. Paolisso G, Manzella D, Tagliamonte MR, Barbieri M, Marfella R, Zito G, et al. The BB-paraoxonase genotype is associated with impaired brachial reactivity after acute hypertriglyceridemia in healthy subjects. J Clin Endocrinol Metab 2001; 86: 1078-82.
213. Yamane T, Matsumoto T, Nakae I, Takashima H, Tarutani Y, Tamaki S, et al. Impact of paraoxonase polymorphism (Q192R) on endothelial function in intact coronary circulation. Hypertens Res 2006; 29: 417-22.
214. Perticone F, Sciacqua A, Scozzafava A, Ventura G, Laratta E, Pujia A, et al. Impaired endothelial function in never-treated hypertensive subjects carrying the Arg972 polymorphism in the insulin receptor substrate-1 gene. J Clin Endocrinol Metab 2004; 89: 3606-9.
215. Jarvisalo MJ, Jartti L, Karvonen MK, Pesonen U, Koulu M, Marniemi J, et al. Enhanced endothelium-dependent vasodilation in subjects with Proline7 substitution in the signal peptide of neuropeptide Y. Atherosclerosis 2003; 167: 319-26.
216. Koide S, Kugiyama K, Sugiyama S, Nakamura S, Fukushima H, Honda O, et al. Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction. J Am Coll Cardiol 2003; 41: 539-45.
217. Nakamura S, Sugiyama S, Fujioka D, Kawabata K, Ogawa H, Kugiyama K. Polymorphism in glutamate-cysteine ligase modifier subunit gene is associated with impairment of nitric oxide-mediated coronary vasomotor function. Circulation 2003; 108: 1425-27.
218. Miller EA, Pankow JS, Millikan RC, Bray MS, Ballantyne CM, Bell DA, et al. Glutathione-S-transferase genotypes, smoking, and their association with markers of inflammation, hemostasis, and endothelial function: the atherosclerosis risk in communities (ARIC) study. Atherosclerosis 2003; 171: 265-2.
219. Sackett DL, Snow JC. In: Haynes R.B., Taylor D.W., Sackett D.L. Eds, Compliance in health care. Baltimore, Johns Hopkins University Press, 1979.
220. Pullar T, Kumar S, Feely M. Compliance in clinical trials. Ann Rheum Dis 1989; 48: 871-5.
221. Fletcher R.H., Fletcher S.W., Wagner E.H. In: Satterfield T.S. Ed, Clinical Epidemiology. Baltimore, Lippincott Williams & Wilkins 1996; pp. 136-164.
222. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111-5.
223. Vita JA, Keaney JF Jr. Hormone replacement therapy and endothelial function: the exception that proves the rule? Arterioscler Thromb Vasc Biol 2001; 21: 1867-9.
224. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA 2002; 288: 321-33.
225. Widlansky ME, Price DT, Gokce N, Eberhardt RT, Duffy SJ, Holbrook M, et al. Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension. Hypertension 2003; 42: 310-5.
226. Chenevard R, Hurlimann D, Bechir M, Enseleit F, Spieker L, Hermann M, et al. Selective COX-2 inhibition improves endothelial function in coronary artery disease. Circulation 2003; 107: 405-9.
227. Bombardier C, Laine L, Reicin A, Shapiro D, Burgos-Vargas R, Davis B, et al. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med 2000; 343: 1520-8.
228. Colombo PC, Ashton AW, Celaj S, Talreja A, Banchs JE, Dubois NB, et al. Biopsy coupled to quantitative immunofluorescence: a new method to study the human vascular endothelium. J Appl Physiol 2002; 92: 1331-8.
229. Silver AE, Beske SD, Christou DD, Donato AJ, Moreau KL, Eskurza I, et al. Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47(phox) expression and evidence of endothelial oxidative stress. Circulation 2007; 115: 627-37.
230. Phillips SA, Hatoum OA, Gutterman DD. The mechanism of flow-induced dilation in human adipose arterioles involves hydrogen peroxide during CAD. Am J Physiol Heart Circ Physiol 2007; 292: H93-100.