Associations between connexin37 gene polymorphism and markers of subclinical atherosclerosis: The Cardiovascular Risk in Young Finns study

Atherosclerosis

Volumn 195, Issue 2, 2007, Pages 379-384

  Collings, Auni ^a   Islam, Md Shaheenul ^a   Juonala, Markus ^c   Rontu, Riikka ^a   Kähönen, Mika ^a   Hutri Kähönen, Nina ^a   Laitinen, Tomi ^d   Marniemi, Jukka ^e   Viikari, Jorma S A ^b   Raitakari, Olli T ^b   Lehtimäki, Terho J ^a  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d KUOPIO UNIVERSITY HOSPITAL   (Finland)

^e NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Carotid artery compliance; Connexin37; Flow mediated dilatation; Intima media thickness; Polymorphism

Indexed keywords

CONNEXIN 37;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ARTERY BLOOD FLOW; ARTICLE; ATHEROSCLEROSIS; BODY MASS; BRACHIAL ARTERY; CARDIOVASCULAR RISK; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; FEMALE; GENETIC ANALYSIS; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADULT; AGE FACTORS; BRACHIAL ARTERY; CAROTID ARTERY DISEASES; COHORT STUDIES; CONNEXINS; FEMALE; FINLAND; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; TUNICA INTIMA; TUNICA MEDIA; VASODILATION;

EID: 36048939780     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2006.10.016     Document Type: Article

References (40)

1. Fox C.S., Polak J.F., Chazaro I., et al. Genetic and environmental contributions to atherosclerosis phenotypes in men and women: heritability of carotid intima-media thickness in the Framingham Heart Study. Stroke 34 (2003) 397-401
2. Espeland M.A., Tang R., Terry J.G., Davis D.H., Mercuri M., and Crouse III J.R. Associations of risk factors with segment-specific intimal-medial thickness of the extracranial carotid artery. Stroke 30 (1999) 1047-1055
3. Folsom A.R., Eckfeldt J.H., Weitzman S., et al. Relation of carotid artery wall thickness to diabetes mellitus, fasting glucose and insulin, body size, and physical activity. Atherosclerosis Risk in Communities (ARIC) Study Investigators. Stroke 25 (1994) 66-73
4. Järvisalo M.J., Jartti L., Näntö-Salonen K., et al. Increased aortic intima-media thickness: a marker of preclinical atherosclerosis in high-risk children. Circulation 104 (2001) 2943-2947
5. Pauciullo P., Iannuzzi A., Sartorio R., et al. Increased intima-media thickness of the common carotid artery in hypercholesterolemic children. Arterioscler Thromb 14 (1994) 1075-1079
6. Davis P.H., Dawson J.D., Riley W.A., and Lauer R.M. Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age: the Muscatine Study. Circulation 104 (2001) 2815-2819
7. Raitakari O.T., Juonala M., Kähönen M., et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA 290 (2003) 2277-2283
8. Li S., Chen W., Srinivasan S.R., et al. Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa Heart Study. JAMA 290 (2003) 2271-2276
9. Cuomo S., Guarini P., Gaeta G., et al. Increased carotid intima-media thickness in children-adolescents, and young adults with a parental history of premature myocardial infarction. Eur Heart J 23 (2002) 1345-1350
10. Jousilahti P., Puska P., Vartiainen E., Pekkanen J., and Tuomilehto J. Parental history of premature coronary heart disease: an independent risk factor of myocardial infarction. J Clin Epidemiol 49 (1996) 497-503
11. Blacher J., Pannier B., Guerin A.P., Marchais S.J., Safar M.E., and London G.M. Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease. Hypertension 32 (1998) 570-574
12. Juonala M., Järvisalo M.J., Mäki-Torkko N., Kähönen M., Viikari J.S., and Raitakari O.T. Risk factors identified in childhood and decreased carotid artery elasticity in adulthood: the Cardiovascular Risk in Young Finns Study. Circulation 112 (2005) 1486-1493
13. Ferreira I., Henry R.M., Twisk J.W., van Mechelen W., Kemper H.C., and Stehouwer C.D. The metabolic syndrome, cardiopulmonary fitness, and subcutaneous trunk fat as independent determinants of arterial stiffness: the Amsterdam Growth and Health Longitudinal Study. Arch Intern Med 165 (2005) 875-882
14. Celermajer D.S., Sorensen K.E., Gooch V.M., et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340 (1992) 1111-1115
15. Neunteufl T., Katzenschlager R., Hassan A., et al. Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease. Atherosclerosis 129 (1997) 111-118
16. Sosa-Melgarejo J.A., and Berry C.L. Myoendothelial contacts in arteriolosclerosis. J Pathol 167 (1992) 235-239
17. Griendling K.K., and Alexander R.W. Endothelial control of the cardiovascular system: recent advances. FASEB J 10 (1996) 283-292
18. Goodenough D.A., Goliger J.A., and Paul D.L. Connexins, connexons, and intercellular communication. Annu Rev Biochem 65 (1996) 475-502
19. Bruzzone R., Haefliger J.A., Gimlich R.L., and Paul D.L. Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins. Mol Biol Cell 4 (1993) 7-20
20. Gabriels J.E., and Paul D.L. Connexin43 is highly localized to sites of disturbed flow in rat aortic endothelium but connexin37 and connexin40 are more uniformly distributed. Circ Res 83 (1998) 636-643
21. Yeh H.I., Dupont E., Coppen S., Rothery S., and Severs N.J. Gap junction localization and connexin expression in cytochemically identified endothelial cells of arterial tissue. J Histochem Cytochem 45 (1997) 539-550
22. Cai W.J., Koltai S., Kocsis E., Scholz D., Schaper W., and Schaper J. Connexin37, not Cx40 and Cx43, is induced in vascular smooth muscle cells during coronary arteriogenesis. J Mol Cell Cardiol 33 (2001) 957-967
23. Yeh H.I., Lai Y.J., Chang H.M., Ko Y.S., Severs N.J., and Tsai C.H. Multiple connexin expression in regenerating arterial endothelial gap junctions. Arterioscler Thromb Vasc Biol 20 (2000) 1753-1762
24. Yeh H.I., Chang H.M., Lu W.W., et al. Age-related alteration of gap junction distribution and connexin expression in rat aortic endothelium. J Histochem Cytochem 48 (2000) 1377-1389
25. Yeh H.I., Lu C.S., Wu Y.J., et al. Reduced expression of endothelial connexin37 and connexin40 in hyperlipidemic mice: recovery of connexin37 after 7-day simvastatin treatment. Arterioscler Thromb Vasc Biol 23 (2003) 1391-1397
26. Li H., Brodsky S., Kumari S., et al. Paradoxical overexpression and translocation of connexin43 in homocysteine-treated endothelial cells. Am J Physiol Heart Circ Physiol 282 (2002) H2124-H2133
27. van Rijen H.V., van Kempen M.J., Postma S., and Jongsma H.J. Tumour necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cells. Cytokine 10 (1998) 258-264
28. Hu J., and Cotgreave I.A. Differential regulation of gap junctions by proinflammatory mediators in vitro. J Clin Invest 99 (1997) 2312-2316
29. Kwak B.R., Mulhaupt F., Veillard N., Gros D.B., and Mach F. Altered pattern of vascular connexin expression in atherosclerotic plaques. Arterioscler Thromb Vasc Biol 22 (2002) 225-230
30. Looft-Wilson R.C., Payne G.W., and Segal S.S. Connexin expression and conducted vasodilation along arteriolar endothelium in mouse skeletal muscle. J Appl Physiol 97 (2004) 1152-1158
31. Boerma M., Forsberg L., Van Zeijl L., et al. A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development. J Intern Med 246 (1999) 211-218
32. Yeh H.I., Chou Y., Liu H.F., Chang S.C., and Tsai C.H. Connexin37 gene polymorphism and coronary artery disease in Taiwan. Int J Cardiol 81 (2001) 251-255
33. Hirashiki A., Yamada Y., Murase Y., et al. Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors. J Am Coll Cardiol 42 (2003) 1429-1437
34. Yamada Y., Izawa H., Ichihara S., et al. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N Engl J Med 347 (2002) 1916-1923
35. Listi F., Candore G., Lio D., et al. Association between C1019T polymorphism of connexin37 and acute myocardial infarction: a study in patients from sicily. Int J Cardiol 102 (2005) 269-271
36. Åkerblom H.K., Viikari J., Uhari M., et al. Atherosclerosis precursors in Finnish children and adolescents. I. General description of the cross-sectional study of 1980, and an account of the children's and families' state of health. Acta Paediatr Scand Suppl 318 (1985) 49-63
37. Juonala M., Viikari J.S., Hutri-Kähönen N., et al. The 21-year follow-up of the Cardiovascular Risk in Young Finns Study: risk factor levels, secular trends and east-west difference. J Intern Med 255 (2004) 457-468
38. Juonala M., Viikari J.S., Laitinen T., et al. Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: the cardiovascular risk in young Finns study. Circulation 110 (2004) 2918-2923
39. Livak K.J. Allelic discrimination using fluorogenic probes and the 5' nuclease assay. Genet Anal 14 (1999) 143-149
40. Wong C.W., Christen T., Pfenniger A., James R.W., and Kwak B.R. Do allelic variants of the connexin37 1019 gene polymorphism differentially predict for coronary artery disease and myocardial infarction?. Atherosclerosis 191 (2007) 355-361