Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans

American Journal of Hypertension

Volumn 17, Issue 7, 2004, Pages 560-567

  Li, Rongling ^a,b   Lyn, Deborah ^a   Lapu Bula, Rigobert ^a   Oduwole, Adefisayo ^a   Igho Pemu, Priscilla ^a   Lankford, Brenda ^a   Morgan, Jan ^a   Nkemdechi, Sunday ^a   Liu, Gang ^a   Pack, Cheryl ^a   Silvestrov, Natalia ^a   Von Deutsch, Daniel A ^a   Song, Qing ^a   Abukhalaf, Imad K ^a   Ofili, Elizabeth ^a  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

African Americans; Blood pressure; Endothelial function; Endothelial nitric oxide synthase gene; Nitric oxide

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; NITRIC OXIDE;

ADULT; AFRICAN AMERICAN; AGED; ARTERY BLOOD FLOW; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; BLOOD LEVEL; BODY MASS; BRACHIAL ARTERY; DIASTOLIC BLOOD PRESSURE; DNA FLANKING REGION; DNA POLYMORPHISM; EXON; FEMALE; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GLUCOSE BLOOD LEVEL; HUMAN; INTRON; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROMOTER REGION; SYSTOLIC BLOOD PRESSURE; ULTRASOUND;

ADOLESCENT; ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; BIOLOGICAL MARKERS; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; DIASTOLE; ENDOTHELIUM, VASCULAR; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GEORGIA; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, GENETIC; RISK FACTORS; STATISTICS; SYSTOLE; VASODILATION;

EID: 3042545771     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjhyper.2004.02.013     Document Type: Article

References (34)

1. Furchgott R.F., Zawadzki J.V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 288:1980;373-376
2. Palmer R.M., Ashton D.S., Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 333:1988;664-666
3. Janssens S.P., Shimouchi A., Quertermous T., Bloch D.B., Bloch K.D. Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. J Biol Chem. 267:1992;14519-14522
4. Marsden P.A., Schappert K.T., Chen H.S., Flowers M., Sundell C.L., Wilcox J.N., Lamas S., Michel T. Molecular cloning and characterization of human endothelial nitric oxide synthase. FEBS Lett. 307:1992;287-293
5. Marsden P.A., Heng H.H., Scherer S.W., Stewart R.J., Hall A.V., Shi X.M., Tsui L.C., Schappert K.T. Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem. 268:1993;17478-17488
6. Vallance P., Collier J., Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. 2:1989;997-1000
7. Ignarro L.J., Byrns R.E., Buga G.M., Wood K.S., Chaudhuri G. Pharmacological evidence that endothelium-derived relaxing factor is nitric oxide Use of pyrogallol and superoxide dismutase to study endothelium-dependent and nitric oxide-elicited vascular smooth muscle relaxation. J Pharmacol Exp Ther. 244:1988;181-189
8. Radomski M.W., Palmer R.M., Moncada S. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet. 2:1987;1057-1058
9. Baylis C., Vallance P. Measurement of nitrite and nitrate levels in plasma and urine - what does this measure tell us about the activity of the endogenous nitric oxide system? Curr Opin Nephrol Hypertens. 7:1998;59-62
10. Tsukada T., Yokoyama K., Arai T., Takemoto F., Hara S., Yamada A., Kawaguchi Y., Hosoya T., Igari J. Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans. Biochem Biophys Res Commun. 245:1998;190-193
11. Wang X.L., Mahaney M.C., Sim A.S., Wang J., Blangero J., Almasy L., Badenhop R.B., Wilcken D.E. Genetic contribution of the endothelial constitutive nitric oxide synthase gene to plasma nitric oxide levels. Arterioscler Thromb Vasc Biol. 17:1997;3147-3153
12. Bonnardeaux A., Nadaud S., Charru A., Jeunemaitre X., Corvol P., Soubrier F. Lack of evidence for linkage of the endothelial cell nitric oxide synthase gene to essential hypertension. Circulation. 91:1995;96-102
13. Miyamoto Y., Saito Y., Kajiyama N., Yoshimura M., Shimasaki Y., Nakayama M., Kamitani S., Harada M., Ishikawa M., Kuwahara K., Ogawa E., Hamanaka I., Takahashi N., Kaneshige T., Teraoka H., Akamizu T., Azuma N., Yoshimasa Y., Yoshimasa T., Itoh H., Masuda I., Yasue H., Nakao K. Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension. 32:1998;3-8
14. Hooper W.C., Lally C., Austin H., Benson J., Dilley A., Wenger N.K., Whitsett C., Rawlins P., Evatt B.L. The relationship between polymorphisms in the endothelial cell nitric oxide synthase gene and the platelet GPIIIa gene with myocardial infarction and venous thromboembolism in African Americans. Chest. 116:1999;880-886
15. Poirier O., Mao C., Mallet C., Nicaud V., Herrmann S.M., Evans A., Ruidavets J.B., Arveiler D., Luc G., Tiret L., Soubrier F., Cambien F. Polymorphisms of the endothelial nitric oxide synthase gene - no consistent association with myocardial infarction in the ECTIM study. Eur J Clin Invest. 29:1999;284-290
16. Tanus-Santos J.E., Desai M., Flockhart D.A. Effects of ethnicity on the distribution of clinically relevant endothelial nitric oxide variants. Pharmacogenetics. 11:2001;719-725
17. Celermajer D.S., Sorensen K.E., Gooch V.M., Spiegelhalter D.J., Miller O.I., Sullivan I.D., Lloyd J.K., Deanfield J.E. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 340:1992;1111-1115
18. Wang X.L., Sim A.S., Wang M.X., Murrell G.A., Trudinger B., Wang J. Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity. FEBS Lett. 471:2000;45-50
19. Sarkar R., Gelabert H.A., Mohiuddin K.R., Thakor D.K., Santibanez-Gallerani A.S. Effect of cigarette smoke on endothelial regeneration in vivo and nitric oxide levels. J Surg Res. 82:1999;43-47
20. Zaykin D.V., Westfall P.H., Young S.S., Karnoub M.A., Wagner M.J., Ehm M.G. Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals. Hum Hered. 53:2002;79-91
21. Node K., Kitakaze M., Yoshikawa H., Kosaka H., Hori M. Reduced plasma concentrations of nitrogen oxide in individuals with essential hypertension. Hypertension. 30:1997;405-408
22. Freedman B.I., Yu H., Anderson P.J., Roh B.H., Rich S.S., Bowden D.W. Genetic analysis of nitric oxide and endothelin in end-stage renal disease. Nephrol Dial Transplant. 15:2000;1794-1800
23. Huang P.L., Huang Z., Mashimo H., Bloch K.D., Moskowitz M.A., Bevan J.A., Fishman M.C. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 377:1995;239-242
24. Hirooka Y., Kishi T., Sakai K., Shimokawa H., Takeshita A. Effect of overproduction of nitric oxide in the brain stem on the cardiovascular response in conscious rats. J Cardiovasc Pharmacol. 41:(Suppl 1):2003;S119-S126
25. Sakai K., Hirooka Y., Matsuo I., Eshima K., Shigematsu H., Shimokawa H., Takeshita A. Overexpression of eNOS in NTS causes hypotension and bradycardia in vivo. Hypertension. 36:2000;1023-1028
26. Ohashi Y., Kawashima S., Hirata K., Yamashita T., Ishida T., Inoue N., Sakoda T., Kurihara H., Yazaki Y., Yokoyama M. Hypotension and reduced nitric oxide-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase. J Clin Invest. 102:1998;2061-2071
27. Kelm M., Preik-Steinhoff H., Preik M., Strauer B.E. Serum nitrite sensitively reflects endothelial NO formation in human forearm vasculature Evidence for biochemical assessment of the endothelial l-arginine-no pathway. Cardiovasc Res. 41:1999;765-772
28. Yamashita T., Kawashima S., Ohashi Y., Ozaki M., Rikitake Y., Inoue N., Hirata K., Akita H., Yokoyama M. Mechanisms of reduced nitric oxide/cGMP-mediated vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase. Hypertension. 36:2000;97-102
29. Yamashita T., Kawashima S., Ohashi Y., Ozaki M., Ueyama T., Ishida T., Inoue N., Hirata K., Akita H., Yokoyama M. Resistance to endotoxin shock in transgenic mice overexpressing endothelial nitric oxide synthase. Circulation. 101:2000;931-937
30. Chiueh C.C. Neuroprotective properties of nitric oxide. Ann N Y Acad Sci. 890:1999;301-311
31. Keaney J.F. Jr, Vita J.A. Atherosclerosis, oxidative stress, and antioxidant protection in endothelium-derived relaxing factor action. Prog Cardiovasc Dis. 38:1995;129-154
32. Antoniades C., Tousoulis D., Tentolouris C., Toutouzas P., Stefanadis C. Oxidative stress, antioxidant vitamins, and atherosclerosis. From basic research to clinical practice. Herz. 28:2003;628-638
33. Orth S.R. Effects of smoking on systemic and intrarenal hemodynamics Influence on renal function. J Am Soc Nephrol. 15:(Suppl 1):2004;S58-S63
34. Yoon S., Moon J., Shin C., Kim E., Jo S.A., Jo I. Smoking status-dependent association of the 27-bp repeat polymorphism in intron 4 of endothelial nitric oxide synthase gene with plasma nitric oxide concentrations. Clin Chim Acta. 324:2002;113-120