Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: Role of endothelium-dependent nitric oxide and oxidative stress

Circulation

Volumn 108, Issue 5, 2003, Pages 530-535

  Goto, Chikara ^a   Higashi, Yukihito ^b,c   Kimura, Masashi ^a,b   Noma, Kensuke ^b   Hara, Keiko ^b   Nakagawa, Keigo ^b   Kawamura, Mitsutoshi ^a,b   Chayama, Kazuaki ^b   Yoshizumi, Masao ^b   Nara, Isao ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Blood flow; Endothelium; Exercise; Free radicals; Nitric oxide

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ACETRYPTINE; FREE RADICAL; ISOSORBIDE DINITRATE; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; MERCURY; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SILASTIC;

ADULT; ARTICLE; CONTROLLED STUDY; EXERCISE; FOREARM BLOOD FLOW; HUMAN; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PLETHYSMOGRAPHY; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VASODILATATION;

ACETYLCHOLINE; ADULT; BLOOD FLOW VELOCITY; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; EXERCISE; EXERCISE TEST; FOREARM; HUMANS; ISOSORBIDE DINITRATE; MALE; NITRIC OXIDE; OMEGA-N-METHYLARGININE; OXIDATIVE STRESS; OXYGEN CONSUMPTION; TIME; VASODILATION; VASODILATOR AGENTS;

EID: 0041572924     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000080893.55729.28     Document Type: Article

References (32)

1. Hornig BH, Maier V, Drexler H. Physical training improves endothelial function in patients with chronic heart failure. Circulation. 1996;32: 210-214.
2. Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. The sixth report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure(JNC-VI). Arch Intern Med. 1997;157:2413-2446.
3. Wang J, Wolin MS, Hintze TH. Chronic exercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs. Circ Res. 1993;73:829-838.
4. Delep MD, McAllister RM, Langhline MH. Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta. J Appl Physiol. 1993;75:1354-1363.
5. Green DJ, Cabel T, Fox C, et al. Modification of forearm resistance vessels by exercise training in young men. J Appl Physiol. 1994;77: 1829-1833.
6. Paffenbarger RS, Hyde RT, Wing AL, et al. The association of changes in physical-activity level and other lifestyle characteristics with mortality among men. N Engl J Med. 1993;328:538-545.
7. Panza JA, Quyyumi AA, Buhler FR Jr, et al. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med. 1990;323:22-27.
8. Higashi Y, Sasaki S, Yoshimizu A, et al. Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide. Circulation. 1999;100:1194-1202.
9. Friedewald WT, Levy RI, Fredrickson DS. Estimation of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499-502.
10. Guidelines Sub-Committee. 1993 Guidelines for the management of mild hypertension: memorandum from World Health Organization/International Society of Hypertension meeting. J Hypertens. 1993;11:905-911.
11. World Hypertension League. Physical exercise in the management of hypertension: a consensus statement by the World Hypertension League. J Hypertens. 1991;9:283-287.
12. Benefits and recommendations for physical activity programs for all Americans: a statement for health professionals by the Committee on Exercise and Cardiac Rehabilitation of the Council on Clinical Cardiology, American Heart Association. Circulation. 1993;86:340-344.
13. Vane JR, Anggard EE, Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med. 1990;323:27-36.
14. Arakawa K. Antihypertensive mechanism of exercise. J Hypertens. 1993; 11:223-229.
15. Matsumoto A, Hirata Y, Momomura S, et al. Increased nitric oxide production during exercise. Lancet. 1994;343:849-850.
16. Miller VM, Vanhoutte PM. Enhanced release of endothelium-derived factors by chronic increases in blood flow. Am J Physiol. 1988;255: H446-H451.
17. Uematsu M, Ohara Y, Navas JP, et al. Regulation of endothelial cell nitric oxide synthase m RNA expression by shear stress. Am J Physiol. 1995; 269:C1371-C1378.
18. Sessa WC, Pritchard K, Seyedi N, et al. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res. 1994;74:349-353.
19. Niebauer J, Cooke JP. Cardiovascular effects of exercise: role of endothelial shear stress. J Am Coll Cardiol. 1996;28:1652-1660.
20. Kugiyama K, Kerns SA, Morrisett JD, et al. Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low density lipoproteins. Nature. 1990;334:160-162.
21. Chin JH, Azhar S, Hoffman BB. Inactivation of endothelial-derived relaxing factor by oxidized lipoproteins. J Clin Invest. 1994;93:10-18.
22. Tamai O, Matsuoka H, Itabe H, et al. Single LDL apheresis improves endothelium-dependent vasodilation in hypercholesterolemic humans. Circulation. 1997;95:76-82.
23. Leaf DA, Kleinman MT, Hamilton M, et al. The exercise-induced oxidative stress paradox: the effects of physical exercise training. Am J Med Sci. 1999;317:295-300.
24. Ress DD, Palmer RMJ, Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci U S A. 1989;86:3375-3378.
25. Lüscher TF. Imbalance of endothelium-derived relaxing and contracting factors. Am J Hypertens. 1990;3:317-330.
26. Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. 1989;2:997-1000.
27. Davies KJA, Quintanilha AT, Brooks GA, et al. Free radicals and tissue damage produced by exercise. Biochem Biophys Res Commun. 1982;107: 1198-1205.
28. Abraham P, Saumet JL, Chevalier JM. External iliac artery endofibrosis in athletes. Sports Med. 1997;24:221-226.
29. Bergholm R, Makimattila S, Valkonen M, et al. Intense physical training decreases circulating antioxidants and endothelium-dependent vasodilation in vivo. Atherosclerosis. 1999;145:341-349.
30. Matsumoto A, Hirata Y, Momomura S, et al. Increased nitric oxide production during exercise. Lancet. 1994;343:849-850.
31. Willson JR, Kapoor SC. Contribution of prostaglandins to exercise-induced vasodilation in humans. Am J Physiol. 1933;265:H171-H175.
32. Park KS, Kim JH, Kim MS, et al. Effects of insulin and antioxidant on plasma 8-hydroxyguanine and tissue 8-hydroxydeoxyguanosine in streptozotocin-induced diabetic rats. Diabetes. 2001;50:2837-2841.