-
1
-
-
0024353079
-
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties
-
Mosmann T.R., and Coffman R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7 (1989) 145-173
-
(1989)
Annu Rev Immunol
, vol.7
, pp. 145-173
-
-
Mosmann, T.R.1
Coffman, R.L.2
-
2
-
-
13244283212
-
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
-
This was the first paper to suggest the existence of distinct IL-17-producing cells that are involved in organ-specific autoimmunity.
-
Langrish C.L., Chen Y., Blumenschein W.M., Mattson J., Basham B., Sedgwick J.D., McClanahan T., Kastelein R.A., and Cua D.J. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201 (2005) 233-240. This was the first paper to suggest the existence of distinct IL-17-producing cells that are involved in organ-specific autoimmunity.
-
(2005)
J Exp Med
, vol.201
, pp. 233-240
-
-
Langrish, C.L.1
Chen, Y.2
Blumenschein, W.M.3
Mattson, J.4
Basham, B.5
Sedgwick, J.D.6
McClanahan, T.7
Kastelein, R.A.8
Cua, D.J.9
-
3
-
-
27544490377
-
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
-
This study showed inhibitory effects of IFNγ and IL-4 on Th17 cell differentiation, and demonstrated that STAT1, T-bet, STAT4, and STAT6 were dispensable for development of IL-17-producing effectors in vitro, establishing an independent developmental lineage for Th17 cells.
-
Harrington L.E., Hatton R.D., Mangan P.R., Turner H., Murphy T.L., Murphy K.M., and Weaver C.T. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6 (2005) 1123-1132. This study showed inhibitory effects of IFNγ and IL-4 on Th17 cell differentiation, and demonstrated that STAT1, T-bet, STAT4, and STAT6 were dispensable for development of IL-17-producing effectors in vitro, establishing an independent developmental lineage for Th17 cells.
-
(2005)
Nat Immunol
, vol.6
, pp. 1123-1132
-
-
Harrington, L.E.1
Hatton, R.D.2
Mangan, P.R.3
Turner, H.4
Murphy, T.L.5
Murphy, K.M.6
Weaver, C.T.7
-
4
-
-
27544465354
-
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
-
This report provided independent evidence of a distinct developmental lineage for Th17 cells and observations for in vivo function of IL-17.
-
Park H., Li Z., Yang X.O., Chang S.H., Nurieva R., Wang Y.H., Wang Y., Hood L., Zhu Z., Tian Q., et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6 (2005) 1133-1141. This report provided independent evidence of a distinct developmental lineage for Th17 cells and observations for in vivo function of IL-17.
-
(2005)
Nat Immunol
, vol.6
, pp. 1133-1141
-
-
Park, H.1
Li, Z.2
Yang, X.O.3
Chang, S.H.4
Nurieva, R.5
Wang, Y.H.6
Wang, Y.7
Hood, L.8
Zhu, Z.9
Tian, Q.10
-
5
-
-
33646560950
-
Transforming growth factor-beta induces development of the T(H)17 lineage
-
This study showed that IL-23 is important for IL-6/TGF-β-induced Th17 cells to protect the host from infection with a mucosal pathogen.
-
Mangan P.R., Harrington L.E., O'Quinn D.B., Helms W.S., Bullard D.C., Elson C.O., Hatton R.D., Wahl S.M., Schoeb T.R., and Weaver C.T. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441 (2006) 231-234. This study showed that IL-23 is important for IL-6/TGF-β-induced Th17 cells to protect the host from infection with a mucosal pathogen.
-
(2006)
Nature
, vol.441
, pp. 231-234
-
-
Mangan, P.R.1
Harrington, L.E.2
O'Quinn, D.B.3
Helms, W.S.4
Bullard, D.C.5
Elson, C.O.6
Hatton, R.D.7
Wahl, S.M.8
Schoeb, T.R.9
Weaver, C.T.10
-
6
-
-
40049083827
-
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
-
Zheng Y., Valdez P.A., Danilenko D.M., Hu Y., Sa S.M., Gong Q., Abbas A.R., Modrusan Z., Ghilardi N., de Sauvage F.J., et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med 14 (2008) 282-289
-
(2008)
Nat Med
, vol.14
, pp. 282-289
-
-
Zheng, Y.1
Valdez, P.A.2
Danilenko, D.M.3
Hu, Y.4
Sa, S.M.5
Gong, Q.6
Abbas, A.R.7
Modrusan, Z.8
Ghilardi, N.9
de Sauvage, F.J.10
-
7
-
-
40049098958
-
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
-
Aujla S.J., Chan Y.R., Zheng M., Fei M., Askew D.J., Pociask D.A., Reinhart T.A., McAllister F., Edeal J., Gaus K., et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med 14 (2008) 275-281
-
(2008)
Nat Med
, vol.14
, pp. 275-281
-
-
Aujla, S.J.1
Chan, Y.R.2
Zheng, M.3
Fei, M.4
Askew, D.J.5
Pociask, D.A.6
Reinhart, T.A.7
McAllister, F.8
Edeal, J.9
Gaus, K.10
-
8
-
-
33746534417
-
IL-23 promotes tumour incidence and growth
-
Langowski J.L., Zhang X., Wu L., Mattson J.D., Chen T., Smith K., Basham B., McClanahan T., Kastelein R.A., and Oft M. IL-23 promotes tumour incidence and growth. Nature 442 (2006) 461-465
-
(2006)
Nature
, vol.442
, pp. 461-465
-
-
Langowski, J.L.1
Zhang, X.2
Wu, L.3
Mattson, J.D.4
Chen, T.5
Smith, K.6
Basham, B.7
McClanahan, T.8
Kastelein, R.A.9
Oft, M.10
-
10
-
-
0348223787
-
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
-
Chen W., Jin W., Hardegen N., Lei K.J., Li L., Marinos N., McGrady G., and Wahl S.M. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198 (2003) 1875-1886
-
(2003)
J Exp Med
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
Jin, W.2
Hardegen, N.3
Lei, K.J.4
Li, L.5
Marinos, N.6
McGrady, G.7
Wahl, S.M.8
-
11
-
-
41549134361
-
Th17 cell differentiation: the long and winding road
-
McGeachy M.J., and Cua D.J. Th17 cell differentiation: the long and winding road. Immunity 28 (2008) 445-453
-
(2008)
Immunity
, vol.28
, pp. 445-453
-
-
McGeachy, M.J.1
Cua, D.J.2
-
12
-
-
32244442562
-
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
This was the first study to show that treatment of IL-6 plus TGF-β induces Th17 cell differentiation in vitro.
-
Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., and Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006) 179-189. This was the first study to show that treatment of IL-6 plus TGF-β induces Th17 cell differentiation in vitro.
-
(2006)
Immunity
, vol.24
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
Locksley, R.M.4
Stockinger, B.5
-
13
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
+ Treg cells and IL-17-producing T cells.
-
+ Treg cells and IL-17-producing T cells.
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
Korn, T.4
Strom, T.B.5
Oukka, M.6
Weiner, H.L.7
Kuchroo, V.K.8
-
14
-
-
44049104564
-
The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
-
Manel N., Unutmaz D., and Littman D.R. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol 9 (2008) 641-649
-
(2008)
Nat Immunol
, vol.9
, pp. 641-649
-
-
Manel, N.1
Unutmaz, D.2
Littman, D.R.3
-
15
-
-
44049102724
-
A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses
-
Volpe E., Servant N., Zollinger R., Bogiatzi S.I., Hupe P., Barillot E., and Soumelis V. A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol 9 (2008) 650-657
-
(2008)
Nat Immunol
, vol.9
, pp. 650-657
-
-
Volpe, E.1
Servant, N.2
Zollinger, R.3
Bogiatzi, S.I.4
Hupe, P.5
Barillot, E.6
Soumelis, V.7
-
16
-
-
47549112840
-
IL-21 and TGF-beta are required for differentiation of human T(H)17 cells
-
Yang L., Anderson D.E., Baecher-Allan C., Hastings W.D., Bettelli E., Oukka M., Kuchroo V.K., and Hafler D.A. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature 454 (2008) 350-352
-
(2008)
Nature
, vol.454
, pp. 350-352
-
-
Yang, L.1
Anderson, D.E.2
Baecher-Allan, C.3
Hastings, W.D.4
Bettelli, E.5
Oukka, M.6
Kuchroo, V.K.7
Hafler, D.A.8
-
17
-
-
0036885067
-
The lineage decisions of helper T cells
-
Murphy K.M., and Reiner S.L. The lineage decisions of helper T cells. Nat Rev Immunol 2 (2002) 933-944
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 933-944
-
-
Murphy, K.M.1
Reiner, S.L.2
-
18
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori S., Nomura T., and Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299 (2003) 1057-1061
-
(2003)
Science
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
19
-
-
0037385330
-
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
-
Fontenot J.D., Gavin M.A., and Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4 (2003) 330-336
-
(2003)
Nat Immunol
, vol.4
, pp. 330-336
-
-
Fontenot, J.D.1
Gavin, M.A.2
Rudensky, A.Y.3
-
20
-
-
33748588423
-
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
-
This paper described a Th17 specific transcription factor and validated that IL-17-producing cells are indeed a unique T cell subset.
-
Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., Cua D.J., and Littman D.R. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126 (2006) 1121-1133. This paper described a Th17 specific transcription factor and validated that IL-17-producing cells are indeed a unique T cell subset.
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
McKenzie, B.S.2
Zhou, L.3
Tadokoro, C.E.4
Lepelley, A.5
Lafaille, J.J.6
Cua, D.J.7
Littman, D.R.8
-
21
-
-
33847206969
-
IL-17 family cytokines and the expanding diversity of effector T cell lineages
-
Weaver C.T., Hatton R.D., Mangan P.R., and Harrington L.E. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 25 (2007) 821-852
-
(2007)
Annu Rev Immunol
, vol.25
, pp. 821-852
-
-
Weaver, C.T.1
Hatton, R.D.2
Mangan, P.R.3
Harrington, L.E.4
-
22
-
-
45749101727
-
Induction and effector functions of T(H)17 cells
-
Bettelli E., Korn T., Oukka M., and Kuchroo V.K. Induction and effector functions of T(H)17 cells. Nature 453 (2008) 1051-1057
-
(2008)
Nature
, vol.453
, pp. 1051-1057
-
-
Bettelli, E.1
Korn, T.2
Oukka, M.3
Kuchroo, V.K.4
-
23
-
-
53349173070
-
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
-
Ivanov I.I., Frutos Rde L., Manel N., Yoshinaga K., Rifkin D.B., Sartor R.B., Finlay B.B., and Littman D.R. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 4 (2008) 337-349
-
(2008)
Cell Host Microbe
, vol.4
, pp. 337-349
-
-
Ivanov, I.I.1
Frutos Rde, L.2
Manel, N.3
Yoshinaga, K.4
Rifkin, D.B.5
Sartor, R.B.6
Finlay, B.B.7
Littman, D.R.8
-
24
-
-
58149251898
-
Late developmental plasticity in the T helper 17 lineage
-
Lee Y.K., Turner H., Maynard C.L., Oliver J.R., Chen D., Elson C.O., and Weaver C.T. Late developmental plasticity in the T helper 17 lineage. Immunity 30 (2009) 92-107
-
(2009)
Immunity
, vol.30
, pp. 92-107
-
-
Lee, Y.K.1
Turner, H.2
Maynard, C.L.3
Oliver, J.R.4
Chen, D.5
Elson, C.O.6
Weaver, C.T.7
-
25
-
-
34547188748
-
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
-
•].
-
•].
-
(2007)
Nat Immunol
, vol.8
, pp. 967-974
-
-
Zhou, L.1
Ivanov, I.I.2
Spolski, R.3
Min, R.4
Shenderov, K.5
Egawa, T.6
Levy, D.E.7
Leonard, W.J.8
Littman, D.R.9
-
26
-
-
34547232503
-
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
-
•].
-
•].
-
(2007)
Nature
, vol.448
, pp. 484-487
-
-
Korn, T.1
Bettelli, E.2
Gao, W.3
Awasthi, A.4
Jager, A.5
Strom, T.B.6
Oukka, M.7
Kuchroo, V.K.8
-
27
-
-
34547204946
-
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
-
•] showed that IL-21, together with TGF-β, could program Th17 cell differentiation in an autocrine manner.
-
•] showed that IL-21, together with TGF-β, could program Th17 cell differentiation in an autocrine manner.
-
(2007)
Nature
, vol.448
, pp. 480-483
-
-
Nurieva, R.1
Yang, X.O.2
Martinez, G.3
Zhang, Y.4
Panopoulos, A.D.5
Ma, L.6
Schluns, K.7
Tian, Q.8
Watowich, S.S.9
Jetten, A.M.10
-
29
-
-
46749156754
-
Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis
-
•] provided evidence that IL-21 deficiency had little effects on in vivo differentiation of Th17 cells and autoimmunity, suggesting potential redundancy of proinflammatory cytokines.
-
•] provided evidence that IL-21 deficiency had little effects on in vivo differentiation of Th17 cells and autoimmunity, suggesting potential redundancy of proinflammatory cytokines.
-
(2008)
J Immunol
, vol.180
, pp. 7097-7101
-
-
Coquet, J.M.1
Chakravarti, S.2
Smyth, M.J.3
Godfrey, D.I.4
-
30
-
-
33846906224
-
Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
-
Zheng Y., Danilenko D.M., Valdez P., Kasman I., Eastham-Anderson J., Wu J., and Ouyang W. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445 (2007) 648-651
-
(2007)
Nature
, vol.445
, pp. 648-651
-
-
Zheng, Y.1
Danilenko, D.M.2
Valdez, P.3
Kasman, I.4
Eastham-Anderson, J.5
Wu, J.6
Ouyang, W.7
-
31
-
-
43449135305
-
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
-
This study was the first to show that RORγt activity is inhibited by Foxp3 and that TGF-β concentration may have a significant impact on Th17/Treg cell differentiation, suggesting that the cytokine microenvironment dictates whether progenitor cells adopt either fate.
-
Zhou L., Lopes J.E., Chong M.M., Ivanov I.I., Min R., Victora G.D., Shen Y., Du J., Rubtsov Y.P., Rudensky A.Y., et al. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453 (2008) 236-240. This study was the first to show that RORγt activity is inhibited by Foxp3 and that TGF-β concentration may have a significant impact on Th17/Treg cell differentiation, suggesting that the cytokine microenvironment dictates whether progenitor cells adopt either fate.
-
(2008)
Nature
, vol.453
, pp. 236-240
-
-
Zhou, L.1
Lopes, J.E.2
Chong, M.M.3
Ivanov, I.I.4
Min, R.5
Victora, G.D.6
Shen, Y.7
Du, J.8
Rubtsov, Y.P.9
Rudensky, A.Y.10
-
32
-
-
57449112782
-
IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells
-
Korn T., Mitsdoerffer M., Croxford A.L., Awasthi A., Dardalhon V.A., Galileos G., Vollmar P., Stritesky G.L., Kaplan M.H., Waisman A., et al. IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A 105 (2008) 18460-18465
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 18460-18465
-
-
Korn, T.1
Mitsdoerffer, M.2
Croxford, A.L.3
Awasthi, A.4
Dardalhon, V.A.5
Galileos, G.6
Vollmar, P.7
Stritesky, G.L.8
Kaplan, M.H.9
Waisman, A.10
-
33
-
-
48449086316
-
TGF-beta: a master of all T cell trades
-
Li M.O., and Flavell R.A. TGF-beta: a master of all T cell trades. Cell 134 (2008) 392-404
-
(2008)
Cell
, vol.134
, pp. 392-404
-
-
Li, M.O.1
Flavell, R.A.2
-
34
-
-
46749138596
-
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
-
Yang X.O., Nurieva R., Martinez G.J., Kang H.S., Chung Y., Pappu B.P., Shah B., Chang S.H., Schluns K.S., Watowich S.S., et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29 (2008) 44-56
-
(2008)
Immunity
, vol.29
, pp. 44-56
-
-
Yang, X.O.1
Nurieva, R.2
Martinez, G.J.3
Kang, H.S.4
Chung, Y.5
Pappu, B.P.6
Shah, B.7
Chang, S.H.8
Schluns, K.S.9
Watowich, S.S.10
-
35
-
-
0034733039
-
Requirement for RORgamma in thymocyte survival and lymphoid organ development
-
Sun Z., Unutmaz D., Zou Y.R., Sunshine M.J., Pierani A., Brenner-Morton S., Mebius R.E., and Littman D.R. Requirement for RORgamma in thymocyte survival and lymphoid organ development. Science 288 (2000) 2369-2373
-
(2000)
Science
, vol.288
, pp. 2369-2373
-
-
Sun, Z.1
Unutmaz, D.2
Zou, Y.R.3
Sunshine, M.J.4
Pierani, A.5
Brenner-Morton, S.6
Mebius, R.E.7
Littman, D.R.8
-
36
-
-
20444493969
-
Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors
-
Egawa T., Eberl G., Taniuchi I., Benlagha K., Geissmann F., Hennighausen L., Bendelac A., and Littman D.R. Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity 22 (2005) 705-716
-
(2005)
Immunity
, vol.22
, pp. 705-716
-
-
Egawa, T.1
Eberl, G.2
Taniuchi, I.3
Benlagha, K.4
Geissmann, F.5
Hennighausen, L.6
Bendelac, A.7
Littman, D.R.8
-
37
-
-
0346496018
-
An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
-
Eberl G., Marmon S., Sunshine M.J., Rennert P.D., Choi Y., and Littman D.R. An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol 5 (2004) 64-73
-
(2004)
Nat Immunol
, vol.5
, pp. 64-73
-
-
Eberl, G.1
Marmon, S.2
Sunshine, M.J.3
Rennert, P.D.4
Choi, Y.5
Littman, D.R.6
-
38
-
-
59849114998
-
RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F
-
Leppkes M., Becker C., Ivanov I.I., Hirth S., Wirtz S., Neufert C., Pouly S., Murphy A.J., Valenzuela D.M., Yancopoulos G.D., et al. RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology 136 (2009) 257-267
-
(2009)
Gastroenterology
, vol.136
, pp. 257-267
-
-
Leppkes, M.1
Becker, C.2
Ivanov, I.I.3
Hirth, S.4
Wirtz, S.5
Neufert, C.6
Pouly, S.7
Murphy, A.J.8
Valenzuela, D.M.9
Yancopoulos, G.D.10
-
39
-
-
37849048599
-
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
-
The paper reported that Th17 cells express the RORγt-related nuclear receptor, RORα. Double deficiencies in RORγt and RORα impaired Th17 generation and protected mice against autoimmunity.
-
Yang X.O., Pappu B.P., Nurieva R., Akimzhanov A., Kang H.S., Chung Y., Ma L., Shah B., Panopoulos A.D., Schluns K.S., et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28 (2008) 29-39. The paper reported that Th17 cells express the RORγt-related nuclear receptor, RORα. Double deficiencies in RORγt and RORα impaired Th17 generation and protected mice against autoimmunity.
-
(2008)
Immunity
, vol.28
, pp. 29-39
-
-
Yang, X.O.1
Pappu, B.P.2
Nurieva, R.3
Akimzhanov, A.4
Kang, H.S.5
Chung, Y.6
Ma, L.7
Shah, B.8
Panopoulos, A.D.9
Schluns, K.S.10
-
40
-
-
54549100120
-
Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells
-
This paper provided independent confirmation of Foxp3 inhibition of RORγt activity, and showed that Runx1 influences Th17 cell differentiation by inducing RORγt expression and by binding to and acting together with RORγt during il17 transcription.
-
Zhang F., Meng G., and Strober W. Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat Immunol 9 (2008) 1297-1306. This paper provided independent confirmation of Foxp3 inhibition of RORγt activity, and showed that Runx1 influences Th17 cell differentiation by inducing RORγt expression and by binding to and acting together with RORγt during il17 transcription.
-
(2008)
Nat Immunol
, vol.9
, pp. 1297-1306
-
-
Zhang, F.1
Meng, G.2
Strober, W.3
-
41
-
-
41549107522
-
Cytokine signaling modules in inflammatory responses
-
O'Shea J.J., and Murray P.J. Cytokine signaling modules in inflammatory responses. Immunity 28 (2008) 477-487
-
(2008)
Immunity
, vol.28
, pp. 477-487
-
-
O'Shea, J.J.1
Murray, P.J.2
-
42
-
-
36849036211
-
IL-21 is produced by TH17 cells and drives IL-17 production in a STAT3-dependent manner
-
Wei L., Laurence A., Elias K.M., and O'Shea J.J. IL-21 is produced by TH17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem 282 (2007) 34605-34610
-
(2007)
J Biol Chem
, vol.282
, pp. 34605-34610
-
-
Wei, L.1
Laurence, A.2
Elias, K.M.3
O'Shea, J.J.4
-
43
-
-
33744479688
-
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
-
Chen Z., Laurence A., Kanno Y., Pacher-Zavisin M., Zhu B.M., Tato C., Yoshimura A., Hennighausen L., and O'Shea J.J. Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci U S A 103 (2006) 8137-8142
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 8137-8142
-
-
Chen, Z.1
Laurence, A.2
Kanno, Y.3
Pacher-Zavisin, M.4
Zhu, B.M.5
Tato, C.6
Yoshimura, A.7
Hennighausen, L.8
O'Shea, J.J.9
-
44
-
-
44449131480
-
Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3
-
Du J., Huang C., Zhou B., and Ziegler S.F. Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3. J Immunol 180 (2008) 4785-4792
-
(2008)
J Immunol
, vol.180
, pp. 4785-4792
-
-
Du, J.1
Huang, C.2
Zhou, B.3
Ziegler, S.F.4
-
45
-
-
45149109643
-
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells
-
Lochner M., Peduto L., Cherrier M., Sawa S., Langa F., Varona R., Riethmacher D., Si-Tahar M., Di Santo J.P., and Eberl G. In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med 205 (2008) 1381-1393
-
(2008)
J Exp Med
, vol.205
, pp. 1381-1393
-
-
Lochner, M.1
Peduto, L.2
Cherrier, M.3
Sawa, S.4
Langa, F.5
Varona, R.6
Riethmacher, D.7
Si-Tahar, M.8
Di Santo, J.P.9
Eberl, G.10
-
46
-
-
47749124186
-
Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat
-
Ichiyama K., Yoshida H., Wakabayashi Y., Chinen T., Saeki K., Nakaya M., Takaesu G., Hori S., Yoshimura A., and Kobayashi T. Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat. J Biol Chem 283 (2008) 17003-17008
-
(2008)
J Biol Chem
, vol.283
, pp. 17003-17008
-
-
Ichiyama, K.1
Yoshida, H.2
Wakabayashi, Y.3
Chinen, T.4
Saeki, K.5
Nakaya, M.6
Takaesu, G.7
Hori, S.8
Yoshimura, A.9
Kobayashi, T.10
-
47
-
-
34247215187
-
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
-
Ono M., Yaguchi H., Ohkura N., Kitabayashi I., Nagamura Y., Nomura T., Miyachi Y., Tsukada T., and Sakaguchi S. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature 446 (2007) 685-689
-
(2007)
Nature
, vol.446
, pp. 685-689
-
-
Ono, M.1
Yaguchi, H.2
Ohkura, N.3
Kitabayashi, I.4
Nagamura, Y.5
Nomura, T.6
Miyachi, Y.7
Tsukada, T.8
Sakaguchi, S.9
-
48
-
-
34548128307
-
The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4
-
+ T cells from such mice failed to differentiate into Th17 cells and had less expression of RORγt and more expression of Foxp3.
-
+ T cells from such mice failed to differentiate into Th17 cells and had less expression of RORγt and more expression of Foxp3.
-
(2007)
Nat Immunol
, vol.8
, pp. 958-966
-
-
Brustle, A.1
Heink, S.2
Huber, M.3
Rosenplanter, C.4
Stadelmann, C.5
Yu, P.6
Arpaia, E.7
Mak, T.W.8
Kamradt, T.9
Lohoff, M.10
-
49
-
-
58549094107
-
IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype
-
Huber M., Brustle A., Reinhard K., Guralnik A., Walter G., Mahiny A., von Low E., and Lohoff M. IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc Natl Acad Sci U S A 105 (2008) 20846-20851
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 20846-20851
-
-
Huber, M.1
Brustle, A.2
Reinhard, K.3
Guralnik, A.4
Walter, G.5
Mahiny, A.6
von Low, E.7
Lohoff, M.8
-
50
-
-
57449105853
-
IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor
-
This paper demonstrated that the specific interaction of IRF-4 and IBP prevented IRF-4 from targeting the ill17 and il21 genes. Absence of IBP led to enhanced expression of IL-21 and IL-17 and to the development of autoimmunity.
-
Chen Q., Yang W., Gupta S., Biswas P., Smith P., Bhagat G., and Pernis A.B. IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor. Immunity 29 (2008) 899-911. This paper demonstrated that the specific interaction of IRF-4 and IBP prevented IRF-4 from targeting the ill17 and il21 genes. Absence of IBP led to enhanced expression of IL-21 and IL-17 and to the development of autoimmunity.
-
(2008)
Immunity
, vol.29
, pp. 899-911
-
-
Chen, Q.1
Yang, W.2
Gupta, S.3
Biswas, P.4
Smith, P.5
Bhagat, G.6
Pernis, A.B.7
-
51
-
-
58449124804
-
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
-
Bauquet A.T., Jin H., Paterson A.M., Mitsdoerffer M., Ho I.C., Sharpe A.H., and Kuchroo V.K. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol 10 (2009) 167-175
-
(2009)
Nat Immunol
, vol.10
, pp. 167-175
-
-
Bauquet, A.T.1
Jin, H.2
Paterson, A.M.3
Mitsdoerffer, M.4
Ho, I.C.5
Sharpe, A.H.6
Kuchroo, V.K.7
-
53
-
-
42649095378
-
Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor
-
••] identified AhR as an important transcription factor for Th17 cell differentiation. Reference [51] further suggested that different AhR ligands may have opposite functions in Treg/Th17 differentiation, but this notion is controversial as suggested by reference [55].
-
••] identified AhR as an important transcription factor for Th17 cell differentiation. Reference [51] further suggested that different AhR ligands may have opposite functions in Treg/Th17 differentiation, but this notion is controversial as suggested by reference [55].
-
(2008)
Nature
, vol.453
, pp. 65-71
-
-
Quintana, F.J.1
Basso, A.S.2
Iglesias, A.H.3
Korn, T.4
Farez, M.F.5
Bettelli, E.6
Caccamo, M.7
Oukka, M.8
Weiner, H.L.9
-
54
-
-
38949097735
-
The search for endogenous activators of the aryl hydrocarbon receptor
-
Nguyen L.P., and Bradfield C.A. The search for endogenous activators of the aryl hydrocarbon receptor. Chem Res Toxicol 21 (2008) 102-116
-
(2008)
Chem Res Toxicol
, vol.21
, pp. 102-116
-
-
Nguyen, L.P.1
Bradfield, C.A.2
-
55
-
-
47749107262
-
Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells
-
Kimura A., Naka T., Nohara K., Fujii-Kuriyama Y., and Kishimoto T. Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proc Natl Acad Sci U S A 105 (2008) 9721-9726
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 9721-9726
-
-
Kimura, A.1
Naka, T.2
Nohara, K.3
Fujii-Kuriyama, Y.4
Kishimoto, T.5
-
56
-
-
60549095448
-
Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells
-
Veldhoen M., Hirota K., Christensen J., O'Garra A., and Stockinger B. Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells. J Exp Med 206 (2009) 43-49
-
(2009)
J Exp Med
, vol.206
, pp. 43-49
-
-
Veldhoen, M.1
Hirota, K.2
Christensen, J.3
O'Garra, A.4
Stockinger, B.5
-
57
-
-
34547757390
-
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
-
Sun C.M., Hall J.A., Blank R.B., Bouladoux N., Oukka M., Mora J.R., and Belkaid Y. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 204 (2007) 1775-1785
-
(2007)
J Exp Med
, vol.204
, pp. 1775-1785
-
-
Sun, C.M.1
Hall, J.A.2
Blank, R.B.3
Bouladoux, N.4
Oukka, M.5
Mora, J.R.6
Belkaid, Y.7
-
58
-
-
34547788180
-
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
-
Coombes J.L., Siddiqui K.R., Arancibia-Carcamo C.V., Hall J., Sun C.M., Belkaid Y., and Powrie F. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 204 (2007) 1757-1764
-
(2007)
J Exp Med
, vol.204
, pp. 1757-1764
-
-
Coombes, J.L.1
Siddiqui, K.R.2
Arancibia-Carcamo, C.V.3
Hall, J.4
Sun, C.M.5
Belkaid, Y.6
Powrie, F.7
-
59
-
-
34447503805
-
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
-
Mucida D., Park Y., Kim G., Turovskaya O., Scott I., Kronenberg M., and Cheroutre H. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317 (2007) 256-260
-
(2007)
Science
, vol.317
, pp. 256-260
-
-
Mucida, D.1
Park, Y.2
Kim, G.3
Turovskaya, O.4
Scott, I.5
Kronenberg, M.6
Cheroutre, H.7
-
60
-
-
34547769253
-
All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
-
Benson M.J., Pino-Lagos K., Rosemblatt M., and Noelle R.J. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med 204 (2007) 1765-1774
-
(2007)
J Exp Med
, vol.204
, pp. 1765-1774
-
-
Benson, M.J.1
Pino-Lagos, K.2
Rosemblatt, M.3
Noelle, R.J.4
-
61
-
-
34548762585
-
Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation
-
Schambach F., Schupp M., Lazar M.A., and Reiner S.L. Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation. Eur J Immunol 37 (2007) 2396-2399
-
(2007)
Eur J Immunol
, vol.37
, pp. 2396-2399
-
-
Schambach, F.1
Schupp, M.2
Lazar, M.A.3
Reiner, S.L.4
-
62
-
-
38949164425
-
Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway
-
Elias K.M., Laurence A., Davidson T.S., Stephens G., Kanno Y., Shevach E.M., and O'Shea J.J. Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. Blood 111 (2008) 1013-1020
-
(2008)
Blood
, vol.111
, pp. 1013-1020
-
-
Elias, K.M.1
Laurence, A.2
Davidson, T.S.3
Stephens, G.4
Kanno, Y.5
Shevach, E.M.6
O'Shea, J.J.7
-
63
-
-
55549084247
-
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4(+)CD44(hi) cells
-
Hill J.A., Hall J.A., Sun C.M., Cai Q., Ghyselinck N., Chambon P., Belkaid Y., Mathis D., and Benoist C. Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4(+)CD44(hi) cells. Immunity 29 (2008) 758-770
-
(2008)
Immunity
, vol.29
, pp. 758-770
-
-
Hill, J.A.1
Hall, J.A.2
Sun, C.M.3
Cai, Q.4
Ghyselinck, N.5
Chambon, P.6
Belkaid, Y.7
Mathis, D.8
Benoist, C.9
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