An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells

Nature Immunology

Volumn 5, Issue 1, 2004, Pages 64-73

  Eberl, Gérard ^a,d   Marmon, Shana ^a   Sunshine, Mary Jean ^a   Rennert, Paul D ^b   Choi, Yongwon ^c   Littmann, Dan R ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BIOGEN   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d AARON DIAMOND AIDS RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CELL NUCLEUS RECEPTOR; EPIDERMAL GROWTH FACTOR; HORMONE RECEPTOR; LYMPHOTOXIN; LYMPHOTOXIN BETA; RETINOIC ACID RECEPTOR; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL ACTIVITY; CONTROLLED STUDY; FEMALE; FETUS DEVELOPMENT; LYMPH NODE; LYMPHOID TISSUE; MESENCHYME; MOUSE; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TISSUE REGENERATION;

ANIMALS; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FLOW CYTOMETRY; GREEN FLUORESCENT PROTEINS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR ADHESION MOLECULE-1; LUMINESCENT PROTEINS; LYMPHOID TISSUE; LYMPHOTOXIN-ALPHA; MALE; MICE; MICE, KNOCKOUT; ORGANOGENESIS; RECEPTORS, INTERLEUKIN-7; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; T-LYMPHOCYTES, HELPER-INDUCER; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0346496018     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni1022     Document Type: Article

References (43)

1. Wigle, J.T. & Oliver, G. Prox1 function is required for the development of the murine lymphatic system. Cell 98, 769-778 (1999).
2. - cells to colonize lymph nodes. Proc. Natl. Acad. Sci. USA 93, 11019-11024 (1996).
3. + cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells. Immunity 7, 493-504 (1997).
4. Adachi, S., Yoshida, H., Kataoka, H. & Nishikawa, S. Three distinctive steps in Peyer's patch formation of murine embryo. Int. Immunol. 9, 507-514 (1997).
5. - cells in the embryonic intestine induces the organizing center of Peyer's patches. Int. Immunol. 11, 643-655 (1999).
6. - cells in lymphoid organ development. Immunol. Rev. 189, 41-50 (2002).
7. Adachi, S. et al. Essential role of IL-7 receptor α in the formation of Peyer's patch anlage. Int. Immunol. 10, 1-6 (1998).
8. 1, integrin activation by CXCR5. Immunity 17, 363-373 (2002).
9. + cells. Immunity 17, 31-40 (2002).
10. Yoshida, H. et al. Different cytokines induce surface lymphotoxin-αβ on IL-7 receptor a cells that differentially engender lymph nodes and Peyer's patches. Immunity 17, 823-833 (2002).
11. Honda, K. et al. Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis. J. Exp. Med. 193, 621-630 (2001).
12. Rennert, P.D., James, D., Mackay, F., Browning, J.L. & Hochman, P.S. Lymph node genesis is induced by signaling through the lymphotoxin β receptor. Immunity 9, 71-79 (1998).
13. De Togni, P. et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264, 703-707 (1994).
14. Futterer, A., Mink, K., Luz, A., Kosco-Vilbois, M.H. & Pfeffer, K. The lymphotoxin β receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 9, 59-70 (1998).
15. Miyawaki, S. et al. A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur. J. Immunol. 24, 429-434 (1994).
16. Senftleben, U. et al. Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway. Science 293, 1495-1499 (2001).
17. Alcamo, E. et al. Requirement for the NF-κB family member RelA in the development of secondary lymphoid organs. J. Exp. Med. 195, 233-244 (2002).
18. Yokota, Y. et al. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature 397, 702-706 (1999).
19. Sun, Z. et al. Requirement for RORγ in thymocyte survival and lymphoid organ development. Science 288, 2369-2373 (2000).
20. Kurebayashi, S. et al. Retinoid-related orphan receptor γ (RORγ) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. Proc. Natl. Acad. Sci. USA 97, 10132-10137 (2000).
21. Medvedev, A., Yan, Z.H., Hirose, T., Giguere, V. & Jetten, A.M. Cloning of a cDNA encoding the murine orphan receptor RZR/RORγ and characterization of its response element. Gene 181, 199-206 (1996).
22. He, Y.W., Deftos, M.L., Ojala, E.W. & Bevan, M.J. RORγt, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. Immunity 9, 797-806 (1998).
23. Villey, I., de Chasseval, R. & de Villartay, J.P. RORγT, a thymus-specific isoform of the orphan nuclear receptor RORγ/TOR, is up-regulated by signaling through the pre-T cell receptor and binds to the TEA promoter. Eur. J. Immunol. 29, 4072-4080 (1999).
24. Medvedev, A., Chistokhina, A., Hirose, T. & Jetten, A.M. Genomic structure and chromosomal mapping of the nuclear orphan receptor RORγ (RORC) gene. Genomics 46, 93-102 (1997).
25. Delassus, S., Darche, S., Kourilsky, P. & Cumano, A. Ontogeny of the heavy chain immunoglobulin repertoire in fetal liver and bone marrow. J. Immunol. 160, 3274-3280 (1998).
26. + thymocytes. Nat. Immunol. 3, 469-476 (2002).
27. Luther, S.A., Ansel, K.M. & Cyster, J.G. Overlapping roles of CXCL13, interleukin 7 receptor α and CCR7 ligands in lymph node development. J. Exp. Med. 197, 1191-1198 (2003).
28. Ross, G.D. Role of the lectin domain of Mac-1/CR3 (CD11b/CD18) in regulating intercellular adhesion. Immunol. Res. 25, 219-227 (2002).
29. Hacker, C. et al. Transcriptional profiling identifies Id2 function in dendritic cell development. Nat. Immunol. 4, 380-386 (2003).
30. Fu, Y.X. & Chaplin, D.D. Development and maturation of secondary lymphoid tissues. Annu. Rev. Immunol. 17, 399-433 (1999).
31. Ansel, K.M. et al. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 4O6, 309-314 (2000).
32. Forster, R. et al. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87, 1037-1047 (1996).
33. Kim, D. et al. Regulation of peripheral lymph node genesis by the tumor necrosis factor family member TRANCE. J. Exp. Med. 192, 1467-1478 (2000).
34. Korner, H. et al. Distinct roles for lymphotoxin-α and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur. J. Immunol. 27, 2600-2609 (1997).
35. Neumann, B., Luz, A., Pfeffer, K. & Holzmann, B. Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor. J. Exp. Med. 184, 259-264 (1996).
36. Benezra, R., Davis, R.L., Lockshon, D., Turner, D.L. & Weintraub, H. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 61, 49-59 (1990).
37. Eberl, G. & Littman, D.R. The role of the nuclear hormone receptor RORγt in the development of lymph nodes and Payer's patches. Immunol. Rev. 195, 81-90 (2003).
38. Ohl, L. et al. Cooperating mechanisms of CXCR5 and CCR7 in development and organization of secondary lymphoid organs. J. Exp. Med. 197, 1199-1204 (2003).
39. Mebius, R.E. Organogenesis of lymphoid tissues. Nat. Rev. Immunol. 3, 292-303 (2003).
40. Ngo, V.N. et al. Lymphotoxin α/β and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J. Exp. Med. 189, 403-412 (1999).
41. Dejardin, E. et al. The lymphotoxin-β receptor induces different patterns of gene expression via two NF-κB pathways. Immunity 17, 525-535 (2002).
42. Rennert, P.D., Browning, J.L., Mebius, R., Mackay, F. & Hochman, P.S. Surface lymphotoxin α/β complex is required for the development of peripheral lymphoid organs. J. Exp. Med. 184, 1999-2006 (1996).
43. Bachmann, M.F. et al. TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation. J. Exp. Med. 189, 1025-1031 (1999).