-
1
-
-
27144486962
-
Bypass of senescence, immortalization, and transformation of human hematopoietic progenitor cells
-
Akimov SS, Ramezani A, Hawley TS, Hawley RG: Bypass of senescence, immortalization, and transformation of human hematopoietic progenitor cells. Stem Cells 23:1423-1433 (2005).
-
(2005)
Stem Cells
, vol.23
, pp. 1423-1433
-
-
Akimov, S.S.1
Ramezani, A.2
Hawley, T.S.3
Hawley, R.G.4
-
2
-
-
33645769466
-
Differential protein profiling of primary versus immortalized human RPE cells identifies expression patterns associated with cytoskeletal remodeling and cell survival
-
Alge CS, Hauck SM, Priglinger SG, Kampik A, Ueffing M: Differential protein profiling of primary versus immortalized human RPE cells identifies expression patterns associated with cytoskeletal remodeling and cell survival. J Proteome Res 5:862-878 (2006).
-
(2006)
J Proteome Res
, vol.5
, pp. 862-878
-
-
Alge, C.S.1
Hauck, S.M.2
Priglinger, S.G.3
Kampik, A.4
Ueffing, M.5
-
3
-
-
0037062454
-
Constitutive telomerase expression promotes mammary carcinomas in aging mice
-
Artandi SE, Alson S, Tietze MK, Sharpless NE, Ye S, et al: Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc Natl Acad Sci USA 99:8191-8196 (2002).
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 8191-8196
-
-
Artandi, S.E.1
Alson, S.2
Tietze, M.K.3
Sharpless, N.E.4
Ye, S.5
-
4
-
-
33746591648
-
Genes and pathways downstream of telomerase in melanoma metastasis
-
Bagheri S, Nosrati M, Li S, Fong S, Torabian S, et al: Genes and pathways downstream of telomerase in melanoma metastasis. Proc Natl Acad Sci USA 103:11306-11311 (2006).
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 11306-11311
-
-
Bagheri, S.1
Nosrati, M.2
Li, S.3
Fong, S.4
Torabian, S.5
-
5
-
-
33749534161
-
Telomeres and telomerase: The path from maize, Tetrahymena and yeast to human cancer and aging
-
Blackburn EH, Greider CW, Szostak JW: Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med 12:1133-1138 (2006).
-
(2006)
Nat Med
, vol.12
, pp. 1133-1138
-
-
Blackburn, E.H.1
Greider, C.W.2
Szostak, J.W.3
-
6
-
-
49549114293
-
Introducing a single-cell-derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer
-
Bocker W, Yin Z, Drosse I, Haasters F, Rossmann O, et al: Introducing a single-cell-derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer. J Cell Mol Med 12:1347-1359 (2008).
-
(2008)
J Cell Mol Med
, vol.12
, pp. 1347-1359
-
-
Bocker, W.1
Yin, Z.2
Drosse, I.3
Haasters, F.4
Rossmann, O.5
-
7
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, et al: Extension of life-span by introduction of telomerase into normal human cells. Science 279:349-352 (1998).
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.P.5
-
8
-
-
17144384449
-
Tumorigenic heterogeneity in cancer stem cells evolved from long-term cultures of telomerase-immortalized human mesenchymal stem cells
-
Burns JS, Abdallah BM, Guldberg P, Rygaard J, Schroder HD, Kassem M: Tumorigenic heterogeneity in cancer stem cells evolved from long-term cultures of telomerase-immortalized human mesenchymal stem cells. Cancer Res 65:3126-3135 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 3126-3135
-
-
Burns, J.S.1
Abdallah, B.M.2
Guldberg, P.3
Rygaard, J.4
Schroder, H.D.5
Kassem, M.6
-
9
-
-
34548186667
-
Cellular senescence: When bad things happen to good cells
-
Campisi J, d'Adda di Fagagna F: Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8:729-740 (2007).
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 729-740
-
-
Campisi, J.1
d'Adda di Fagagna, F.2
-
10
-
-
16844382627
-
The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression
-
Cayuela ML, Flores JM, Blasco MA: The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression. EMBO Rep 6:268-274 (2005).
-
(2005)
EMBO Rep
, vol.6
, pp. 268-274
-
-
Cayuela, M.L.1
Flores, J.M.2
Blasco, M.A.3
-
11
-
-
23944496667
-
Comparison of early passage, senescent and hTERT immortalized endothelial cells
-
Chang MW, Grillari J, Mayrhofer C, Fortschegger K, Allmaier G, et al: Comparison of early passage, senescent and hTERT immortalized endothelial cells. Exp Cell Res 309:121-136 (2005).
-
(2005)
Exp Cell Res
, vol.309
, pp. 121-136
-
-
Chang, M.W.1
Grillari, J.2
Mayrhofer, C.3
Fortschegger, K.4
Allmaier, G.5
-
12
-
-
33747358598
-
Expression of hTERT immortalises normal human urothelial cells without inactivation of the p16/Rb pathway
-
Chapman EJ, Hurst CD, Pitt E, Chambers P, Aveyard JS, Knowles MA: Expression of hTERT immortalises normal human urothelial cells without inactivation of the p16/Rb pathway. Oncogene 25:5037-5045 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 5037-5045
-
-
Chapman, E.J.1
Hurst, C.D.2
Pitt, E.3
Chambers, P.4
Aveyard, J.S.5
Knowles, M.A.6
-
13
-
-
34147095342
-
Protein composition of catalytically active human telomerase from immortal cells
-
Cohen SB, Graham ME, Lovrecz GO, Bache N, Robinson PJ, Reddel RR: Protein composition of catalytically active human telomerase from immortal cells. Science 315:1850-1853 (2007).
-
(2007)
Science
, vol.315
, pp. 1850-1853
-
-
Cohen, S.B.1
Graham, M.E.2
Lovrecz, G.O.3
Bache, N.4
Robinson, P.J.5
Reddel, R.R.6
-
14
-
-
33745862398
-
The biogenesis and regulation of telomerase holoenzymes
-
Collins K: The biogenesis and regulation of telomerase holoenzymes. Nat Rev Mol Cell Biol 7:484-494 (2006).
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 484-494
-
-
Collins, K.1
-
15
-
-
0026523228
-
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
-
Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, et al: Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 11:1921-1929 (1992).
-
(1992)
EMBO J
, vol.11
, pp. 1921-1929
-
-
Counter, C.M.1
Avilion, A.A.2
LeFeuvre, C.E.3
Stewart, N.G.4
Greider, C.W.5
-
16
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, et al: A DNA damage checkpoint response in telomere-initiated senescence. Nature 426:194-198 (2003).
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
d'Adda di Fagagna, F.1
Reaper, P.M.2
Clay-Farrace, L.3
Fiegler, H.4
Carr, P.5
-
17
-
-
33845220059
-
Methylation of the p16(INK4a) promoter region in telomerase immortalized human keratinocytes co-cultured with feeder cells
-
Darbro BW, Lee KM, Nguyen NK, Domann FE, Klingelhutz AJ: Methylation of the p16(INK4a) promoter region in telomerase immortalized human keratinocytes co-cultured with feeder cells. Oncogene 25:7421-7433 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 7421-7433
-
-
Darbro, B.W.1
Lee, K.M.2
Nguyen, N.K.3
Domann, F.E.4
Klingelhutz, A.J.5
-
18
-
-
24944460598
-
Shelterin: The protein complex that shapes and safeguards human telomeres
-
de Lange T: Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev 19:2100-2110 (2005).
-
(2005)
Genes Dev
, vol.19
, pp. 2100-2110
-
-
de Lange, T.1
-
19
-
-
0038164977
-
Telomerase can extend the proliferative capacity of human myoblasts, but does not lead to their immortalization
-
Di Donna S, Mamchaoui K, Cooper RN, Seigneurin-Venin S, Tremblay J, et al: Telomerase can extend the proliferative capacity of human myoblasts, but does not lead to their immortalization. Mol Cancer Res 1:643-653 (2003).
-
(2003)
Mol Cancer Res
, vol.1
, pp. 643-653
-
-
Di Donna, S.1
Mamchaoui, K.2
Cooper, R.N.3
Seigneurin-Venin, S.4
Tremblay, J.5
-
20
-
-
2542561169
-
Akt stimulates aerobic glycolysis in cancer cells
-
Elstrom RL, Bauer DE, Buzzai M, Karnauskas R, Harris MH, et al: Akt stimulates aerobic glycolysis in cancer cells. Cancer Res 64:3892-3899 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 3892-3899
-
-
Elstrom, R.L.1
Bauer, D.E.2
Buzzai, M.3
Karnauskas, R.4
Harris, M.H.5
-
21
-
-
0033842950
-
Genetic and epigenetic changes in human epithelial cells immortalized by telomerase
-
Farwell DG, Shera KA, Koop JI, Bonnet GA, Matthews CP, et al: Genetic and epigenetic changes in human epithelial cells immortalized by telomerase. Am J Pathol 156:1537-1547 (2000).
-
(2000)
Am J Pathol
, vol.156
, pp. 1537-1547
-
-
Farwell, D.G.1
Shera, K.A.2
Koop, J.I.3
Bonnet, G.A.4
Matthews, C.P.5
-
22
-
-
0038159280
-
Photochemical internalization of a peptide nucleic acid targeting the catalytic subunit of human telomerase
-
Folini M, Berg K, Millo E, Villa R, Prasmickaite L, et al: Photochemical internalization of a peptide nucleic acid targeting the catalytic subunit of human telomerase. Cancer Res 63:3490-3494 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 3490-3494
-
-
Folini, M.1
Berg, K.2
Millo, E.3
Villa, R.4
Prasmickaite, L.5
-
23
-
-
0035355340
-
Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
-
Gonzalez-Suarez E, Samper E, Ramirez A, Flores JM, Martin-Caballero J, et al: Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J 20:2619-2630 (2001).
-
(2001)
EMBO J
, vol.20
, pp. 2619-2630
-
-
Gonzalez-Suarez, E.1
Samper, E.2
Ramirez, A.3
Flores, J.M.4
Martin-Caballero, J.5
-
24
-
-
0033614998
-
Creation of human tumour cells with defined genetic elements
-
Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA: Creation of human tumour cells with defined genetic elements. Nature 400:464-468 (1999).
-
(1999)
Nature
, vol.400
, pp. 464-468
-
-
Hahn, W.C.1
Counter, C.M.2
Lundberg, A.S.3
Beijersbergen, R.L.4
Brooks, M.W.5
Weinberg, R.A.6
-
25
-
-
0036118368
-
Enumeration of the simian virus 40 early region elements necessary for human cell transformation
-
Hahn WC, Dessain SK, Brooks MW, King JE, Elenbaas B, et al: Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol 22:2111-2123 (2002).
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2111-2123
-
-
Hahn, W.C.1
Dessain, S.K.2
Brooks, M.W.3
King, J.E.4
Elenbaas, B.5
-
26
-
-
34548215056
-
Absence of oncogenic transformation despite acquisition of cytogenetic aberrations in long-term cultured telomerase-immortalized human fetal hepatocytes
-
Haker B, Fuchs S, Dierlamm J, Brummendorf TH, Wege H: Absence of oncogenic transformation despite acquisition of cytogenetic aberrations in long-term cultured telomerase-immortalized human fetal hepatocytes. Cancer Lett 256:120-127 (2007).
-
(2007)
Cancer Lett
, vol.256
, pp. 120-127
-
-
Haker, B.1
Fuchs, S.2
Dierlamm, J.3
Brummendorf, T.H.4
Wege, H.5
-
27
-
-
10744231069
-
Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation
-
Harada H, Nakagawa H, Oyama K, Takaoka M, Andl CD, et al: Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation. Mol Cancer Res 1:729-738 (2003).
-
(2003)
Mol Cancer Res
, vol.1
, pp. 729-738
-
-
Harada, H.1
Nakagawa, H.2
Oyama, K.3
Takaoka, M.4
Andl, C.D.5
-
28
-
-
0025787643
-
Telomere loss: Mitotic clock or genetic time bomb?
-
Harley CB: Telomere loss: mitotic clock or genetic time bomb? Mutat Res 256:271-282 (1991).
-
(1991)
Mutat Res
, vol.256
, pp. 271-282
-
-
Harley, C.B.1
-
29
-
-
0037148328
-
Telomerase is not an oncogene
-
Harley CB: Telomerase is not an oncogene. Oncogene 21:494-502 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 494-502
-
-
Harley, C.B.1
-
30
-
-
39749163359
-
Telomerase and cancer therapeutics
-
Harley CB: Telomerase and cancer therapeutics. Nat Rev Cancer 8:167-179 (2008).
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 167-179
-
-
Harley, C.B.1
-
31
-
-
0037038681
-
p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells
-
Herbert BS, Wright WE, Shay JW: p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells. Oncogene 21:7897-7900 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 7897-7900
-
-
Herbert, B.S.1
Wright, W.E.2
Shay, J.W.3
-
32
-
-
0034667771
-
Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase
-
Hooijberg E, Ruizendaal JJ, Snijders PJ, Kueter EW, Walboomers JM, Spits H: Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase. J Immunol 165:4239-4245 (2000).
-
(2000)
J Immunol
, vol.165
, pp. 4239-4245
-
-
Hooijberg, E.1
Ruizendaal, J.J.2
Snijders, P.J.3
Kueter, E.W.4
Walboomers, J.M.5
Spits, H.6
-
33
-
-
0033532056
-
Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit
-
Kang SS, Kwon T, Kwon DY, Do SI: Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J Biol Chem 274:13085-13090 (1999).
-
(1999)
J Biol Chem
, vol.274
, pp. 13085-13090
-
-
Kang, S.S.1
Kwon, T.2
Kwon, D.Y.3
Do, S.I.4
-
34
-
-
27544453375
-
A network of genetic events sufficient to convert normal human cells to a tumorigenic state
-
Kendall SD, Linardic CM, Adam SJ, Counter CM: A network of genetic events sufficient to convert normal human cells to a tumorigenic state. Cancer Res 65:9824-9828 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 9824-9828
-
-
Kendall, S.D.1
Linardic, C.M.2
Adam, S.J.3
Counter, C.M.4
-
35
-
-
0032487675
-
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
-
Kiyono T, Foster SA, Koop JI, McDougall JK, Galloway DA, Klingelhutz AJ: Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 396:84-88 (1998).
-
(1998)
Nature
, vol.396
, pp. 84-88
-
-
Kiyono, T.1
Foster, S.A.2
Koop, J.I.3
McDougall, J.K.4
Galloway, D.A.5
Klingelhutz, A.J.6
-
36
-
-
45949096290
-
TERT promotes cellular and organismal survival independently of telomerase activity
-
Lee J, Sung YH, Cheong C, Choi YS, Jeon HK, et al: TERT promotes cellular and organismal survival independently of telomerase activity. Oncogene 27:3754-3760 (2008).
-
(2008)
Oncogene
, vol.27
, pp. 3754-3760
-
-
Lee, J.1
Sung, Y.H.2
Cheong, C.3
Choi, Y.S.4
Jeon, H.K.5
-
37
-
-
36549019589
-
Telomerase-immortalized non-malignant human prostate epithelial cells retain the properties of multipotent stem cells
-
Li H, Zhou J, Miki J, Furusato B, Gu Y, et al: Telomerase-immortalized non-malignant human prostate epithelial cells retain the properties of multipotent stem cells. Exp Cell Res 314:92-102 (2008).
-
(2008)
Exp Cell Res
, vol.314
, pp. 92-102
-
-
Li, H.1
Zhou, J.2
Miki, J.3
Furusato, B.4
Gu, Y.5
-
38
-
-
33747502096
-
Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase
-
Li HM, Man C, Jin Y, Deng W, Yip YL, et al: Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase. Int J Cancer 119:1567-1576 (2006).
-
(2006)
Int J Cancer
, vol.119
, pp. 1567-1576
-
-
Li, H.M.1
Man, C.2
Jin, Y.3
Deng, W.4
Yip, Y.L.5
-
39
-
-
34548686306
-
Human ovarian surface epithelial cells immortalized with hTERT maintain functional pRb and p53 expression
-
Li NF, Broad S, Lu YJ, Yang JS, Watson R, et al: Human ovarian surface epithelial cells immortalized with hTERT maintain functional pRb and p53 expression. Cell Prolif 40:780-794 (2007).
-
(2007)
Cell Prolif
, vol.40
, pp. 780-794
-
-
Li, N.F.1
Broad, S.2
Lu, Y.J.3
Yang, J.S.4
Watson, R.5
-
40
-
-
3142661809
-
Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA
-
Li S, Rosenberg JE, Donjacour AA, Botchkina IL, Hom YK, et al: Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA. Cancer Res 64:4833-4840 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 4833-4840
-
-
Li, S.1
Rosenberg, J.E.2
Donjacour, A.A.3
Botchkina, I.L.4
Hom, Y.K.5
-
41
-
-
21244502260
-
Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA
-
Li S, Crothers J, Haqq CM, Blackburn EH: Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA. J Biol Chem 280:23709-23717 (2005).
-
(2005)
J Biol Chem
, vol.280
, pp. 23709-23717
-
-
Li, S.1
Crothers, J.2
Haqq, C.M.3
Blackburn, E.H.4
-
42
-
-
0344837729
-
Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: Activation of the epiregulin gene
-
Lindvall C, Hou M, Komurasaki T, Zheng C, Henriksson M, et al: Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene. Cancer Res 63:1743-1747 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 1743-1747
-
-
Lindvall, C.1
Hou, M.2
Komurasaki, T.3
Zheng, C.4
Henriksson, M.5
-
43
-
-
40449129966
-
Clonal selection in malignant transformation of human fibroblasts transduced with defined cellular oncogenes
-
Mahale AM, Khan ZA, Igarashi M, Nanjangud GJ, Qiao RF, et al: Clonal selection in malignant transformation of human fibroblasts transduced with defined cellular oncogenes. Cancer Res 68:1417-1426 (2008).
-
(2008)
Cancer Res
, vol.68
, pp. 1417-1426
-
-
Mahale, A.M.1
Khan, Z.A.2
Igarashi, M.3
Nanjangud, G.J.4
Qiao, R.F.5
-
44
-
-
0043199578
-
Telomerase maintains telomere structure in normal human cells
-
Masutomi K, Yu EY, Khurts S, Ben-Porath I, Currier JL, et al: Telomerase maintains telomere structure in normal human cells. Cell 114:241-253 (2003).
-
(2003)
Cell
, vol.114
, pp. 241-253
-
-
Masutomi, K.1
Yu, E.Y.2
Khurts, S.3
Ben-Porath, I.4
Currier, J.L.5
-
45
-
-
20444371017
-
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses
-
Masutomi K, Possemato R, Wong JM, Currier JL, Tothova Z, et al: The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc Natl Acad Sci USA 102:8222-8227 (2005).
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 8222-8227
-
-
Masutomi, K.1
Possemato, R.2
Wong, J.M.3
Currier, J.L.4
Tothova, Z.5
-
46
-
-
0034326634
-
Ectopic human telomerase catalytic subunit expression maintains telomere length but is not sufficient for CD8+ T lymphocyte immortalization
-
Migliaccio M, Amacker M, Just T, Reichenbach P, Valmori D, et al: Ectopic human telomerase catalytic subunit expression maintains telomere length but is not sufficient for CD8+ T lymphocyte immortalization. J Immunol 165:4978-4984 (2000).
-
(2000)
J Immunol
, vol.165
, pp. 4978-4984
-
-
Migliaccio, M.1
Amacker, M.2
Just, T.3
Reichenbach, P.4
Valmori, D.5
-
47
-
-
10744219897
-
Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype
-
Milyavsky M, Shats I, Erez N, Tang X, Senderovich S, et al: Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype. Cancer Res 63:7147-7157 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 7147-7157
-
-
Milyavsky, M.1
Shats, I.2
Erez, N.3
Tang, X.4
Senderovich, S.5
-
48
-
-
4644311957
-
Telomeres, telomerase, and apoptosis
-
Mondello C, Scovassi AI: Telomeres, telomerase, and apoptosis. Biochem Cell Biol 82:498-507 (2004).
-
(2004)
Biochem Cell Biol
, vol.82
, pp. 498-507
-
-
Mondello, C.1
Scovassi, A.I.2
-
49
-
-
0041659132
-
Karyotype instability and anchorage-independent growth in telomerase-immortalized fibroblasts from two centenarian individuals
-
Mondello C, Chiesa M, Rebuzzini P, Zongaro S, Verri A, et al: Karyotype instability and anchorage-independent growth in telomerase-immortalized fibroblasts from two centenarian individuals. Biochem Biophys Res Commun 308:914-921 (2003).
-
(2003)
Biochem Biophys Res Commun
, vol.308
, pp. 914-921
-
-
Mondello, C.1
Chiesa, M.2
Rebuzzini, P.3
Zongaro, S.4
Verri, A.5
-
50
-
-
27744527486
-
The first molecular details of ALT in human tumor cells
-
Muntoni A, Reddel RR: The first molecular details of ALT in human tumor cells. Hum Mol Genet 14 Spec No. 2:R191-196 (2005).
-
(2005)
Hum Mol Genet
, vol.14
, Issue.SPEC 2
-
-
Muntoni, A.1
Reddel, R.R.2
-
51
-
-
2442612651
-
Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts
-
Noble JR, Zhong ZH, Neumann AA, Melki JR, Clark SJ, Reddel RR: Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts. Oncogene 23:3116-3121 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 3116-3121
-
-
Noble, J.R.1
Zhong, Z.H.2
Neumann, A.A.3
Melki, J.R.4
Clark, S.J.5
Reddel, R.R.6
-
52
-
-
0033608159
-
Telomerase activity does not always imply telomere maintenance
-
Ouellette MM, Aisner DL, Savre-Train I, Wright WE, Shay JW: Telomerase activity does not always imply telomere maintenance. Biochem Biophys Res Commun 254:795-803 (1999).
-
(1999)
Biochem Biophys Res Commun
, vol.254
, pp. 795-803
-
-
Ouellette, M.M.1
Aisner, D.L.2
Savre-Train, I.3
Wright, W.E.4
Shay, J.W.5
-
53
-
-
0034998040
-
Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells
-
Perrem K, Colgin LM, Neumann AA, Yeager TR, Reddel RR: Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells. Mol Cell Biol 21:3862-3875 (2001).
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3862-3875
-
-
Perrem, K.1
Colgin, L.M.2
Neumann, A.A.3
Yeager, T.R.4
Reddel, R.R.5
-
54
-
-
34447268986
-
Cellular lifespan and regenerative medicine
-
Petersen T, Niklason L: Cellular lifespan and regenerative medicine. Biomaterials 28:3751-3756 (2007).
-
(2007)
Biomaterials
, vol.28
, pp. 3751-3756
-
-
Petersen, T.1
Niklason, L.2
-
55
-
-
17844377872
-
Immortalization of human small airway epithelial cells by ectopic expression of telomerase
-
Piao CQ, Liu L, Zhao YL, Balajee AS, Suzuki M, Hei TK: Immortalization of human small airway epithelial cells by ectopic expression of telomerase. Carcinogenesis 26:725-731 (2005).
-
(2005)
Carcinogenesis
, vol.26
, pp. 725-731
-
-
Piao, C.Q.1
Liu, L.2
Zhao, Y.L.3
Balajee, A.S.4
Suzuki, M.5
Hei, T.K.6
-
56
-
-
0035114576
-
Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
-
Ramirez RD, Morales CP, Herbert BS, Rohde JM, Passons C, et al: Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev 15:398-403 (2001).
-
(2001)
Genes Dev
, vol.15
, pp. 398-403
-
-
Ramirez, R.D.1
Morales, C.P.2
Herbert, B.S.3
Rohde, J.M.4
Passons, C.5
-
57
-
-
10844284696
-
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
-
Ramirez RD, Sheridan S, Girard L, Sato M, Kim Y, et al: Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res 64:9027-9034 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 9027-9034
-
-
Ramirez, R.D.1
Sheridan, S.2
Girard, L.3
Sato, M.4
Kim, Y.5
-
58
-
-
13944283269
-
Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line
-
Robertson DM, Li L, Fisher S, Pearce VP, Shay JW, et al: Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line. Invest Ophthalmol Vis Sci 46:470-478 (2005).
-
(2005)
Invest Ophthalmol Vis Sci
, vol.46
, pp. 470-478
-
-
Robertson, D.M.1
Li, L.2
Fisher, S.3
Pearce, V.P.4
Shay, J.W.5
-
59
-
-
10744233012
-
Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord
-
Roy NS, Nakano T, Keyoung HM, Windrem M, Rashbaum WK, et al: Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord. Nat Biotechnol 22:297-305 (2004).
-
(2004)
Nat Biotechnol
, vol.22
, pp. 297-305
-
-
Roy, N.S.1
Nakano, T.2
Keyoung, H.M.3
Windrem, M.4
Rashbaum, W.K.5
-
60
-
-
0035437179
-
Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential
-
Rufer N, Migliaccio M, Antonchuk J, Humphries RK, Roosnek E, Lansdorp PM: Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential. Blood 98:597-603 (2001).
-
(2001)
Blood
, vol.98
, pp. 597-603
-
-
Rufer, N.1
Migliaccio, M.2
Antonchuk, J.3
Humphries, R.K.4
Roosnek, E.5
Lansdorp, P.M.6
-
61
-
-
38449094794
-
Oncogenic transformation and experimental models of human cancer
-
Schinzel AC, Hahn WC: Oncogenic transformation and experimental models of human cancer. Front Biosci 13:71-84 (2008).
-
(2008)
Front Biosci
, vol.13
, pp. 71-84
-
-
Schinzel, A.C.1
Hahn, W.C.2
-
62
-
-
19044390359
-
Transformation of normal human cells in the absence of telomerase activation
-
Seger YR, Garcia-Cao M, Piccinin S, Cunsolo CL, Doglioni C, et al: Transformation of normal human cells in the absence of telomerase activation. Cancer Cell 2:401-413 (2002).
-
(2002)
Cancer Cell
, vol.2
, pp. 401-413
-
-
Seger, Y.R.1
Garcia-Cao, M.2
Piccinin, S.3
Cunsolo, C.L.4
Doglioni, C.5
-
63
-
-
3042699460
-
Adult human mesenchymal stem cell as a target for neoplastic transformation
-
Serakinci N, Guldberg P, Burns JS, Abdallah B, Schrodder H, et al: Adult human mesenchymal stem cell as a target for neoplastic transformation. Oncogene 23:5095-5098 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 5095-5098
-
-
Serakinci, N.1
Guldberg, P.2
Burns, J.S.3
Abdallah, B.4
Schrodder, H.5
-
64
-
-
0037427086
-
hTERT associates with human telomeres and enhances genomic stability and DNA repair
-
Sharma GG, Gupta A, Wang H, Scherthan H, Dhar S, et al: hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene 22:131-146 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 131-146
-
-
Sharma, G.G.1
Gupta, A.2
Wang, H.3
Scherthan, H.4
Dhar, S.5
-
65
-
-
0026054961
-
A role for both RB and p53 in the regulation of human cellular senescence
-
Shay JW, Pereira-Smith OM, Wright WE: A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res 196:33-39 (1991).
-
(1991)
Exp Cell Res
, vol.196
, pp. 33-39
-
-
Shay, J.W.1
Pereira-Smith, O.M.2
Wright, W.E.3
-
66
-
-
0034682721
-
Cellular senescence: Mitotic clock or culture shock?
-
Sherr CJ, DePinho RA: Cellular senescence: mitotic clock or culture shock? Cell 102:407-410 (2000).
-
(2000)
Cell
, vol.102
, pp. 407-410
-
-
Sherr, C.J.1
DePinho, R.A.2
-
67
-
-
0038056347
-
Telomerase modulates expression of growth-controlling genes and enhances cell proliferation
-
Smith LL, Coller HA, Roberts JM: Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat Cell Biol 5:474-479 (2003).
-
(2003)
Nat Cell Biol
, vol.5
, pp. 474-479
-
-
Smith, L.L.1
Coller, H.A.2
Roberts, J.M.3
-
68
-
-
0031040086
-
TRF1, a mammalian telomeric protein
-
Smith S, de Lange T: TRF1, a mammalian telomeric protein. Trends Genet 13:21-26 (1997).
-
(1997)
Trends Genet
, vol.13
, pp. 21-26
-
-
Smith, S.1
de Lange, T.2
-
69
-
-
0035836727
-
Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells
-
Stampfer MR, Garbe J, Levine G, Lichtsteiner S, Vasserot AP, Yaswen P: Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells. Proc Natl Acad Sci USA 98:4498-4503 (2001).
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4498-4503
-
-
Stampfer, M.R.1
Garbe, J.2
Levine, G.3
Lichtsteiner, S.4
Vasserot, A.P.5
Yaswen, P.6
-
70
-
-
18644373013
-
Telomerase contributes to tumorigenesis by a telomere length-independent mechanism
-
Stewart SA, Hahn WC, O'Connor BF, Banner EN, Lundberg AS, et al: Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci USA 99:12606-12611 (2002).
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12606-12611
-
-
Stewart, S.A.1
Hahn, W.C.2
O'Connor, B.F.3
Banner, E.N.4
Lundberg, A.S.5
-
71
-
-
27244460431
-
The pleiotropy of telomerase against cell death
-
Sung YH, Choi YS, Cheong C, Lee HW: The pleiotropy of telomerase against cell death. Mol Cells 19:303-309 (2005).
-
(2005)
Mol Cells
, vol.19
, pp. 303-309
-
-
Sung, Y.H.1
Choi, Y.S.2
Cheong, C.3
Lee, H.W.4
-
72
-
-
6344265743
-
Inactivation of p16INK4a, with retention of pRB and p53/p21cip1 function, in human MRC5 fibroblasts that overcome a telomere-independent crisis during immortalization
-
Taylor LM, James A, Schuller CE, Brce J, Lock RB, Mackenzie KL: Inactivation of p16INK4a, with retention of pRB and p53/p21cip1 function, in human MRC5 fibroblasts that overcome a telomere-independent crisis during immortalization. J Biol Chem 279:43634-43645 (2004).
-
(2004)
J Biol Chem
, vol.279
, pp. 43634-43645
-
-
Taylor, L.M.1
James, A.2
Schuller, C.E.3
Brce, J.4
Lock, R.B.5
Mackenzie, K.L.6
-
73
-
-
0034660513
-
Risky immortalization by telomerase
-
Wang J, Hannon GJ, Beach DH: Risky immortalization by telomerase. Nature 405:755-756 (2000).
-
(2000)
Nature
, vol.405
, pp. 755-756
-
-
Wang, J.1
Hannon, G.J.2
Beach, D.H.3
-
74
-
-
33747883862
-
Immortalization of normal human cytotrophoblast cells by reconstitution of telomeric reverse transcriptase activity
-
Wang YL, Qiu W, Feng HC, Li YX, Zhuang LZ, et al: Immortalization of normal human cytotrophoblast cells by reconstitution of telomeric reverse transcriptase activity. Mol Hum Reprod 12:451-460 (2006).
-
(2006)
Mol Hum Reprod
, vol.12
, pp. 451-460
-
-
Wang, Y.L.1
Qiu, W.2
Feng, H.C.3
Li, Y.X.4
Zhuang, L.Z.5
-
75
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O: On the origin of cancer cells. Science 123:309-314 (1956).
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
76
-
-
8644254420
-
Immortalized fibroblast-like cells derived from human embryonic stem cells support undifferentiated cell growth
-
Xu C, Jiang J, Sottile V, McWhir J, Lebkowski J, Carpenter MK: Immortalized fibroblast-like cells derived from human embryonic stem cells support undifferentiated cell growth. Stem Cells 22:972-980 (2004).
-
(2004)
Stem Cells
, vol.22
, pp. 972-980
-
-
Xu, C.1
Jiang, J.2
Sottile, V.3
McWhir, J.4
Lebkowski, J.5
Carpenter, M.K.6
-
77
-
-
33847360556
-
Disruption of the retinoblastoma pathway by small interfering RNA and ectopic expression of the catalytic subunit of telomerase lead to immortalization of human ovarian surface epithelial cells
-
Yang G, Rosen DG, Colacino JA, Mercado-Uribe I, Liu J: Disruption of the retinoblastoma pathway by small interfering RNA and ectopic expression of the catalytic subunit of telomerase lead to immortalization of human ovarian surface epithelial cells. Oncogene 26:1492-1498 (2007a).
-
(2007)
Oncogene
, vol.26
, pp. 1492-1498
-
-
Yang, G.1
Rosen, D.G.2
Colacino, J.A.3
Mercado-Uribe, I.4
Liu, J.5
-
78
-
-
33845621580
-
Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells
-
Yang G, Rosen DG, Mercado-Uribe I, Colacino JA, Mills GB, et al: Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells. Carcinogenesis 28:174-182 (2007b).
-
(2007)
Carcinogenesis
, vol.28
, pp. 174-182
-
-
Yang, G.1
Rosen, D.G.2
Mercado-Uribe, I.3
Colacino, J.A.4
Mills, G.B.5
-
79
-
-
0033543760
-
Human endothelial cell life extension by telomerase expression
-
Yang J, Chang E, Cherry AM, Bangs CD, Oei Y, et al: Human endothelial cell life extension by telomerase expression. J Biol Chem 274:26141-26148 (1999).
-
(1999)
J Biol Chem
, vol.274
, pp. 26141-26148
-
-
Yang, J.1
Chang, E.2
Cherry, A.M.3
Bangs, C.D.4
Oei, Y.5
-
80
-
-
0035108952
-
Telomerized human microvasculature is functional in vivo
-
Yang J, Nagavarapu U, Relloma K, Sjaastad MD, Moss WC, et al: Telomerized human microvasculature is functional in vivo. Nat Biotechnol 19:219-224 (2001).
-
(2001)
Nat Biotechnol
, vol.19
, pp. 219-224
-
-
Yang, J.1
Nagavarapu, U.2
Relloma, K.3
Sjaastad, M.D.4
Moss, W.C.5
-
81
-
-
29244449848
-
Stepwise neoplastic transformation of a telomerase immortalized fibroblast cell line
-
Zongaro S, de Stanchina E, Colombo T, D'Incalci M, Giulotto E, Mondello C: Stepwise neoplastic transformation of a telomerase immortalized fibroblast cell line. Cancer Res 65:11411-11418 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 11411-11418
-
-
Zongaro, S.1
de Stanchina, E.2
Colombo, T.3
D'Incalci, M.4
Giulotto, E.5
Mondello, C.6
-
82
-
-
48849095194
-
Telomere length and radiosensitivity in human fibroblast clones immortalized by ectopic telomerase expression
-
Zongaro S, Verri A, Giulotto E, Mondello C: Telomere length and radiosensitivity in human fibroblast clones immortalized by ectopic telomerase expression. Oncol Rep 19:1605-1609 (2008).
-
(2008)
Oncol Rep
, vol.19
, pp. 1605-1609
-
-
Zongaro, S.1
Verri, A.2
Giulotto, E.3
Mondello, C.4
|