Alterations in the p16INK4a and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts

Oncogene

Volumn 23, Issue 17, 2004, Pages 3116-3121

  Noble, Jane R ^a   Zhong, Ze Huai ^a   Neumann, Axel A ^a   Melki, John R ^b   Clark, Susan J ^b   Reddel, Roger R ^a  

^a CHILDREN'S MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

CDKN2A; hTERT; Immortalization; p16INK4a; Telomerase; TP53

Indexed keywords

PROTEIN P16; PROTEIN P53; TELOMERASE;

ALLELE; ARTICLE; CELL CULTURE; CELL GROWTH; CELL IMMORTALIZATION; CELL LINE; CONTROLLED STUDY; DOWN REGULATION; FIBROBLAST; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; TELOMERE; TUMOR SUPPRESSOR GENE; WILD TYPE;

CELL LINE, TRANSFORMED; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DACTINOMYCIN; DNA-BINDING PROTEINS; FIBROBLASTS; GENES, P53; HUMANS; INFANT, NEWBORN; KARYOTYPING; MALE; MUTATION; TELOMERASE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 2442612651     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207440     Document Type: Article

References (44)

1. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu C-P, Morin GB, Harley CB, Shay JW, Lichtsteiner S and Wright WE. (1998). Science, 279, 349-352.
2. Bryan TM, Englezou A, Gupta J, Bacchetti S and Reddel RR. (1995). EMBO J., 14, 4240-4248.
3. Bryan TM and Reddel RR. (1994). Crit. Rev. Oncogenesis, 5, 331-357.
4. Campisi J. (2001). Trends Cell Biol., 11, S27-S31.
5. Clark SJ, Harrison J, Paul CL and Frommer M. (1994). Nucleic Acids Res., 22, 2990-2997.
6. Colgin LM and Reddel RR. (1999). Curr. Opin. Genet. Dev., 9, 97-103.
7. Colgin LM, Wilkinson C, Englezou A, Kilian A, Robinson MO and Reddel RR. (2000). Neoplasia, 2, 426-432.
8. Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB and Bacchetti S. (1992). EMBO J., 11, 1921-1929.
9. Farwell DG, Shera KA, Koop JI, Bonnet GA, Matthews CP, Reuther GW, Coltrera MD, McDougall JK and Klingelhutz AJ. (2000). Am. J. Pathol., 156, 1537-1547.
10. Franco S, MacKenzie KL, Dias S, Alvarez S, Rafii S and Moore MAS. (2001). Exp. Cell Res., 268, 14-25.
11. Girardi AJ, Jensen FC and Koprowski H. (1965). J. Cell Comp. Physiol., 65, 69-84.
12. Harland M, Holland EA, Ghiorzo P, Mantelli M, Bianchi-Scarra G, Goldstein AM, Tucker MA, Ponder BA, Mann GJ, Bishop DT and Newton BJ. (2000). Genes Chromosomes Cancer, 28, 45-57.
13. Harley CB. (1991). Mutat. Res., 256, 271-282.
14. Hayflick L and Moorhead PS. (1961). Exp. Cell Res., 25, 585-621.
15. Holland EA, Beaton SC, Becker TM, Grulet OMC, Peters BA, Rizos H, Kefford RF and Mann GJ. (1995). Oncogene, 11, 2289-2294.
16. Huschtscha LI and Holliday R. (1983). J. Cell Sci., 63, 77-99.
17. Huschtscha LI, Noble JR, Neumann AA, Moy EL, Barry P, Melki JR, Clark SJ and Reddel RR. (1998). Cancer Res., 58, 3508-3512.
18. Jiang XR, Jimenez G, Chang E, Frolkis M, Kusler B, Sage M, Beeche M, Bodnar AG, Wahl GM, Tlsty TD and Chiu CP. (1999). Nat. Genet., 21, 111-114.
19. Kaul SC, Yaguchi T, Taira K, Reddel RR and Wadhwa R. (2003). Exp. Cell Res., 286, 96-101.
20. Kim H, Farris J, Christman SA, Kong BW, Foster LK, O'Grady SM and Foster DM. (2002). Biochem. J., 365, 765-772.
21. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PLC, Coviello GM, Wright WE, Weinrich SL and Shay JW. (1994). Science, 266, 2011-2015.
22. Kiyono T, Foster SA, Koop JI, McDougall JK, Galloway DA and Klingelhutz AJ. (1998). Nature, 396, 84-88.
23. Lane DP and Benchimol S. (1990). Genes Dev., 4, 1-8.
24. MacKenzie KL, Franco S, May C, Sadelain M and Moore MAS. (2000). Exp. Cell Res., 259, 336-350.
25. McGregor F, Muntoni A, Fleming J, Brown J, Felix DH, MacDonald DG, Parkinson EK and Harrison PR. (2002). Cancer Res., 62, 4757-4766.
26. Morales CP, Holt SE, Ouellette M, Kaur KJ, Yan Y, Wilson KS, White MA, Wright WE and Shay JW. (1999). Nat. Genet., 21, 115-118.
27. Noble JR, Rogan EM, Neumann AA, Maclean K, Bryan TM and Reddel RR. (1996). Oncogene, 13, 1259-1268.
28. O'Hare MJ, Bond J, Clarke C, Takeuchi Y, Atherton AJ, Berry C, Moody J, Silver ARJ, Davies DC, Alsop AE, Neville AM and Jat PS. (2001). Proc. Natl. Acad. Sci. USA, 98, 646-651.
29. Olivier M, Eeles R, Hollstein M, Khan MA, Harris CC and Hainaut P. (2002). Hum. Mutat., 19, 607-614.
30. Olovnikov AM. (1973). J. Theor. Biol., 41, 181-190.
31. Paul CL and Clark SJ. (1996). Bio - Techniques, 21, 126-133.
32. Perrem K, Bryan TM, Englezou A, Hackl T, Moy EL and Reddel RR. (1999). Oncogene, 18, 3383-3390.
33. Reddel RR. (2000). Carcinogenesis, 21, 477-484.
34. Rogan EM, Bryan TM, Hukku B, Maclean K, Chang ACM, Moy EL, Englezou A, Warneford SG, Dalla-Pozza L and Reddel RR. (1995). Mol. Cell. Biol., 15, 4745-4753.
35. Rooney DE and Czepulkowski, BH. (1992). Human Cytogenetics: A Practical Approach. Vol I. Constitutional Analysis. Oxford University Press: Oxford.
36. Shay JW and Wright WE. (1989). Exp. Cell Res., 184, 109-118.
37. Toouli CD, Huschtscha LI, Neumann AA, Noble JR, Colgin LM, Hukku B and Reddel RR. (2002). Oncogene, 21, 128-139.
38. Tsutsui T, Kumakura SI, Yamamoto A, Kanai H, Tamura Y, Kato T, Anpo M, Tahara H and Barrett JC. (2002). Carcinogenesis, 23, 2111-2117.
39. Vaziri H and Benchimol S. (1998). Curr. Biol., 8, 279-282.
40. Vaziri H, Squire JA, Pandita TK, Bradley G, Kuba RM, Zhang H, Gulyas S, Hill RP, Nolan GP and Benchimol S. (1999). Mol. Cell. Biol., 19, 2373-2379.
41. Von Zglinicki T. (2002). Trends Biochem. Sci., 27, 339-344.
42. Weinrich SL, Pruzan R, Ma L, Ouellette M, Tesmer VM, Holt SE, Bodnar AG, Lichtsteiner S, Kim NW, Trager JB, Taylor RD, Carlos R, Andrews WH, Wright WE, Shay JW, Harley CB and Morin GB. (1997). Nat. Genet., 17, 498-502.
43. Wright WE, Pereira-Smith OM and Shay JW. (1989). Mol. Cell. Biol., 9, 3088-3092.
44. Wright WE and Shay JW. (2002). Nat. Biotechnol., 20, 682-688.