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Volumn 64, Issue 14, 2004, Pages 4833-4840

Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT TEMPLATE TELOMERASE RNA; PROTEIN P53; RIBONUCLEOPROTEIN; SMALL INTERFERING RNA; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG;

EID: 3142661809     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-0953     Document Type: Article
Times cited : (178)

References (43)
  • 1
    • 0034597794 scopus 로고    scopus 로고
    • Telomere states and cell fates
    • Blackburn EH. Telomere states and cell fates. Nature (Lond) 2000;408:53-6.
    • (2000) Nature (Lond) , vol.408 , pp. 53-56
    • Blackburn, E.H.1
  • 2
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • Greider CW, Blackburn EH. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 1985;43:405-13.
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 3
    • 0025279059 scopus 로고
    • In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
    • Yu GL, Bradley JD, Attardi LD, Blackburn EH. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs, Nature (Lond) 1990;344:126-32.
    • (1990) Nature (Lond) , vol.344 , pp. 126-132
    • Yu, G.L.1    Bradley, J.D.2    Attardi, L.D.3    Blackburn, E.H.4
  • 4
    • 0037341611 scopus 로고    scopus 로고
    • Short telomeres induce a DNA damage response in Saccharomyces cerevisiae
    • Ijpma AS, Greider CW. Short telomeres induce a DNA damage response in Saccharomyces cerevisiae. Mol Biol Cell 2003;14:987-1001.
    • (2003) Mol Biol Cell , vol.14 , pp. 987-1001
    • Ijpma, A.S.1    Greider, C.W.2
  • 5
    • 0036677405 scopus 로고    scopus 로고
    • MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae
    • Enomoto S, Glowczewski L, Berman J. MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae. Mol Biol Cell 2002;13:2626-38.
    • (2002) Mol Biol Cell , vol.13 , pp. 2626-2638
    • Enomoto, S.1    Glowczewski, L.2    Berman, J.3
  • 6
    • 0037047068 scopus 로고    scopus 로고
    • The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae
    • Nautiyal S, DeRisi JL, Blackburn EH. The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 2002;99: 9316-21.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9316-9321
    • Nautiyal, S.1    DeRisi, J.L.2    Blackburn, E.H.3
  • 7
    • 0030455861 scopus 로고    scopus 로고
    • Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
    • Lendvay TS, Morris DK, Sah J, Balasubramanian B, Lundblad V. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 1996;144:1399-412.
    • (1996) Genetics , vol.144 , pp. 1399-1412
    • Lendvay, T.S.1    Morris, D.K.2    Sah, J.3    Balasubramanian, B.4    Lundblad, V.5
  • 9
    • 0027944347 scopus 로고
    • TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
    • Singer MS, Gottschling DE. TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science (Wash DC) 1994;266:404-9.
    • (1994) Science (Wash DC) , vol.266 , pp. 404-409
    • Singer, M.S.1    Gottschling, D.E.2
  • 10
    • 0033525558 scopus 로고    scopus 로고
    • Longevity, stress response, and cancer in aging telomerase-deficient mice
    • Rudolph KL, Chang S, Lee HW, et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 1999;96:701-12.
    • (1999) Cell , vol.96 , pp. 701-712
    • Rudolph, K.L.1    Chang, S.2    Lee, H.W.3
  • 11
    • 0035960043 scopus 로고    scopus 로고
    • The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
    • Vulliamy T, Marrone A, Goldman F, et al. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature (Lond) 2001;413: 432-5.
    • (2001) Nature (Lond) , vol.413 , pp. 432-435
    • Vulliamy, T.1    Marrone, A.2    Goldman, F.3
  • 12
    • 0029096515 scopus 로고
    • The RNA component of human telomerase
    • Feng J, Funk WD, Wang SS, et al. The RNA component of human telomerase. Science (Wash DC) 1995;269:1236-41.
    • (1995) Science (Wash DC) , vol.269 , pp. 1236-1241
    • Feng, J.1    Funk, W.D.2    Wang, S.S.3
  • 13
    • 0030819894 scopus 로고    scopus 로고
    • Telomerase catalytic subunit homologs from fission yeast and human
    • Nakamura TM, Morin GB, Chapman KB, et al. Telomerase catalytic subunit homologs from fission yeast and human. Science (Wash DC) 1997;277:955-9.
    • (1997) Science (Wash DC) , vol.277 , pp. 955-959
    • Nakamura, T.M.1    Morin, G.B.2    Chapman, K.B.3
  • 14
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science (Wash DC) 1994;266:2011-5.
    • (1994) Science (Wash DC) , vol.266 , pp. 2011-2015
    • Kim, N.W.1    Piatyszek, M.A.2    Prowse, K.R.3
  • 15
    • 0029872174 scopus 로고    scopus 로고
    • Telomerase activity in human germline and embryonic tissues and cells
    • Wright WE, Piatyszek MA, Rainey WE, et al. Telomerase activity in human germline and embryonic tissues and cells. Dev Genet 1996;18:173-9.
    • (1996) Dev Genet , vol.18 , pp. 173-179
    • Wright, W.E.1    Piatyszek, M.A.2    Rainey, W.E.3
  • 16
    • 0043199578 scopus 로고    scopus 로고
    • Telomerase maintains telomere structure in normal human cells
    • Masutomi K, Yu EY, Khurts S, et al. Telomerase maintains telomere structure in normal human cells. Cell 2003;114:241-53.
    • (2003) Cell , vol.114 , pp. 241-253
    • Masutomi, K.1    Yu, E.Y.2    Khurts, S.3
  • 17
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997;33:787-91.
    • (1997) Eur J Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 18
    • 0038056347 scopus 로고    scopus 로고
    • Telomerase modulates expression of growth-controlling genes and enhances cell proliferation
    • Smith LL, Coller HA, Roberts JM. Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat Cell Biol 2003;5:474-9.
    • (2003) Nat Cell Biol , vol.5 , pp. 474-479
    • Smith, L.L.1    Coller, H.A.2    Roberts, J.M.3
  • 19
    • 0037224923 scopus 로고    scopus 로고
    • Telomere-based crisis: Functional differences between telomerase activation and ALT in tumor progression
    • Chang S, Khoo CM, Naylor ML, et al. Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes Dev 2003;17: 88-100.
    • (2003) Genes Dev , vol.17 , pp. 88-100
    • Chang, S.1    Khoo, C.M.2    Naylor, M.L.3
  • 20
    • 0035825601 scopus 로고    scopus 로고
    • Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability
    • Guiducci C, Cerone MA, Bacchetti S. Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability. Oncogene 2001;20:714-25.
    • (2001) Oncogene , vol.20 , pp. 714-725
    • Guiducci, C.1    Cerone, M.A.2    Bacchetti, S.3
  • 21
    • 0034933876 scopus 로고    scopus 로고
    • A low threshold level of expression of mutant-template telomerase RNA is sufficient to inhibit human tumor cell growth
    • Kim MM, Rivera MA, Botchkina IL, et al. A low threshold level of expression of mutant-template telomerase RNA is sufficient to inhibit human tumor cell growth. Proc Natl Acad Sci USA 2001;98:7982-7.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7982-7987
    • Kim, M.M.1    Rivera, M.A.2    Botchkina, I.L.3
  • 22
    • 1842339879 scopus 로고    scopus 로고
    • Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability
    • Marusic L, Anton M, Tidy A, et al. Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability. Mol Cell Biol 1997;17:6394-401.
    • (1997) Mol Cell Biol , vol.17 , pp. 6394-6401
    • Marusic, L.1    Anton, M.2    Tidy, A.3
  • 23
    • 0029144984 scopus 로고
    • Altering specific telomerase RNA template residues affects active site function
    • Gilley D, Lee MS, Blackburn EH. Altering specific telomerase RNA template residues affects active site function, Genes Dev 1995;9:2214-26.
    • (1995) Genes Dev , vol.9 , pp. 2214-2226
    • Gilley, D.1    Lee, M.S.2    Blackburn, E.H.3
  • 25
    • 0029102354 scopus 로고
    • Runaway telomere elongation caused by telomerase RNA gene mutations
    • McEachern MJ, Blackburn EH, Runaway telomere elongation caused by telomerase RNA gene mutations. Nature (Lond) 1995;376:403-9.
    • (1995) Nature (Lond) , vol.376 , pp. 403-409
    • McEachern, M.J.1    Blackburn, E.H.2
  • 26
    • 0345643517 scopus 로고    scopus 로고
    • Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast
    • Smith CD, Blackburn EH. Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast. J Cell Biol 1999;145:203-14.
    • (1999) J Cell Biol , vol.145 , pp. 203-214
    • Smith, C.D.1    Blackburn, E.H.2
  • 27
    • 0025222442 scopus 로고
    • RAP1 protein interacts with yeast telomeres in vivo: Overproduction alters telomere structure and decreases chromosome stability
    • Conrad MN, Wright JH, Wolf AJ, Zakian VA. RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability. Cell 1990;63:739-50.
    • (1990) Cell , vol.63 , pp. 739-750
    • Conrad, M.N.1    Wright, J.H.2    Wolf, A.J.3    Zakian, V.A.4
  • 28
    • 0024306914 scopus 로고
    • A yeast telomere binding activity binds to two related telomere sequence motifs and is indistinguishable from RAPI
    • Longtine MS, Wilson NM, Petracek ME, Berman J. A yeast telomere binding activity binds to two related telomere sequence motifs and is indistinguishable from RAPI. Curr Genet 1989;16:225-39.
    • (1989) Curr Genet , vol.16 , pp. 225-239
    • Longtine, M.S.1    Wilson, N.M.2    Petracek, M.E.3    Berman, J.4
  • 29
    • 0025252456 scopus 로고
    • Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length
    • Lustig AJ, Kurtz S, Shore D. Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length. Science (Wash DC) 1990;250:549-53.
    • (1990) Science (Wash DC) , vol.250 , pp. 549-553
    • Lustig, A.J.1    Kurtz, S.2    Shore, D.3
  • 30
    • 0029845892 scopus 로고    scopus 로고
    • Cdc13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance
    • Nugent CI, Hughes TR, Lue NF, Lundblad V. Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science (Wash DC) 1996;274:249-52.
    • (1996) Science (Wash DC) , vol.274 , pp. 249-252
    • Nugent, C.I.1    Hughes, T.R.2    Lue, N.F.3    Lundblad, V.4
  • 31
    • 0035844082 scopus 로고    scopus 로고
    • Potl, the putative telomere end-binding protein in fission yeast and humans
    • Baumann P, Cech TR. Potl, the putative telomere end-binding protein in fission yeast and humans. Science (Wash DC) 2001;292:1171-5.
    • (2001) Science (Wash DC) , vol.292 , pp. 1171-1175
    • Baumann, P.1    Cech, T.R.2
  • 32
    • 0034847376 scopus 로고    scopus 로고
    • Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2
    • Fairall L, Chapman L, Moss H, de Lange T, Rhodes D. Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2. Mol Cell 2001;8:351-61.
    • (2001) Mol Cell , vol.8 , pp. 351-361
    • Fairall, L.1    Chapman, L.2    Moss, H.3    De Lange, T.4    Rhodes, D.5
  • 34
    • 0037102234 scopus 로고    scopus 로고
    • Different telomere damage signaling pathways in human and mouse cells
    • Smogorzewska A, de Lange T. Different telomere damage signaling pathways in human and mouse cells. EMBO J 2002;21:4338-48.
    • (2002) EMBO J , vol.21 , pp. 4338-4348
    • Smogorzewska, A.1    De Lange, T.2
  • 35
    • 0033049185 scopus 로고    scopus 로고
    • Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels
    • Yi X, Tesmer VM, Savre-Train I, Shay JW, Wright WE. Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels. Mol Cell Biol 1999;19:3989-97.
    • (1999) Mol Cell Biol , vol.19 , pp. 3989-3997
    • Yi, X.1    Tesmer, V.M.2    Savre-Train, I.3    Shay, J.W.4    Wright, W.E.5
  • 36
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science (Wash DC) 2002;296:550-3.
    • (2002) Science (Wash DC) , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 37
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir SM, Harborth J, Lendeckel W, et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (Lond) 2001;411: 494-8.
    • (2001) Nature (Lond) , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3
  • 38
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
    • Naldini L, Blomer U, Gallay P, et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science (Wash DC) 1996;272:263-7.
    • (1996) Science (Wash DC) , vol.272 , pp. 263-267
    • Naldini, L.1    Blomer, U.2    Gallay, P.3
  • 39
    • 12644252947 scopus 로고    scopus 로고
    • The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization
    • Bertrand E, Castanotto D, Zhou C, et al. The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization. RNA 1997;3:75-88.
    • (1997) RNA , vol.3 , pp. 75-88
    • Bertrand, E.1    Castanotto, D.2    Zhou, C.3
  • 40
    • 0037783661 scopus 로고
    • Oxford, United Kingdom: Pergamon Press
    • Tissue culture in medical research. Oxford, United Kingdom: Pergamon Press; 1980. p. 213-20.
    • (1980) Tissue Culture in Medical Research , pp. 213-220
  • 42
    • 0030697342 scopus 로고    scopus 로고
    • Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
    • Bryan TM, Englezou A, Dalla-Pozza L, Dunham MA, Reddel RR. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat Med 1997;3:1271-4.
    • (1997) Nat Med , vol.3 , pp. 1271-1274
    • Bryan, T.M.1    Englezou, A.2    Dalla-Pozza, L.3    Dunham, M.A.4    Reddel, R.R.5
  • 43
    • 0035355340 scopus 로고    scopus 로고
    • Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
    • Gonzalez-Suarez E, Samper E, Ramirez A, et al. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J 2001;20:2619-30.
    • (2001) EMBO J , vol.20 , pp. 2619-2630
    • Gonzalez-Suarez, E.1    Samper, E.2    Ramirez, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.