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Volumn 2, Issue 1, 2009, Pages 8-23

Celiac disease: From oral tolerance to intestinal inflammation, autoimmunity and lymphomagenesis

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CYTOKINE; HLA DQ2 ANTIGEN; HLA DQ8 ANTIGEN; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 21; NATURAL KILLER CELL RECEPTOR;

EID: 58149119708     PISSN: 19330219     EISSN: None     Source Type: Journal    
DOI: 10.1038/mi.2008.75     Document Type: Review
Times cited : (128)

References (160)
  • 1
    • 0001298540 scopus 로고
    • Coeliac disease V. Some experiments on the cause of the harmful effect of wheat gliadin
    • Van de Kamer, J., Weijers, H. & Dicke, W. Coeliac disease V. Some experiments on the cause of the harmful effect of wheat gliadin. Acta Paediatr. Scand. 42, 223-231 (1953).
    • (1953) Acta Paediatr. Scand , vol.42 , pp. 223-231
    • Van de Kamer, J.1    Weijers, H.2    Dicke, W.3
  • 2
    • 0001763275 scopus 로고
    • Coeliac disease with atrophy of the small-intestine mucosa
    • Sakula, J. & Shiner, M. Coeliac disease with atrophy of the small-intestine mucosa. Lancet 273, 876-877 (1957).
    • (1957) Lancet , vol.273 , pp. 876-877
    • Sakula, J.1    Shiner, M.2
  • 3
    • 0015183229 scopus 로고
    • Quantitation of intraepithelial lymphocytes in human jejunum
    • Ferguson, A. & Murray, D. Quantitation of intraepithelial lymphocytes in human jejunum. Gut 12, 988-994 (1971).
    • (1971) Gut , vol.12 , pp. 988-994
    • Ferguson, A.1    Murray, D.2
  • 4
    • 84981828966 scopus 로고
    • The inheritance of coeliac disease
    • Carter, C., Sheldon, W. & Walker, C. The inheritance of coeliac disease. Ann. Hum. Genet. 23, 266-278 (1959).
    • (1959) Ann. Hum. Genet , vol.23 , pp. 266-278
    • Carter, C.1    Sheldon, W.2    Walker, C.3
  • 5
    • 0036109726 scopus 로고    scopus 로고
    • The first large population based twin study of coeliac disease
    • Greco, L. et al. The first large population based twin study of coeliac disease. Gut 50, 624-628 (2002).
    • (2002) Gut , vol.50 , pp. 624-628
    • Greco, L.1
  • 6
    • 0030838044 scopus 로고    scopus 로고
    • Identification of tissue transglutaminase as the autoantigen of celiac disease
    • Dieterich, W. et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat. Med. 3, 797-801 (1997).
    • (1997) Nat. Med , vol.3 , pp. 797-801
    • Dieterich, W.1
  • 7
    • 0022471694 scopus 로고
    • An HLA-D region restriction fragment length polymorphism associated with celiac disease
    • Howell, M.D., Austin, R.K., Kelleher, D., Nepom, G.T. & Kagnoff, M.F. An HLA-D region restriction fragment length polymorphism associated with celiac disease. J. Exp. Med. 164, 333-338 (1986).
    • (1986) J. Exp. Med , vol.164 , pp. 333-338
    • Howell, M.D.1    Austin, R.K.2    Kelleher, D.3    Nepom, G.T.4    Kagnoff, M.F.5
  • 8
    • 0024492512 scopus 로고
    • Evidence for a primary association of celiac disease to a particular HLA-DQ a/b heterodimer
    • Sollid, L.M., Markussen, G., Ek, J., Gjerde, H., Vardtal, F. & Thorsby, E. Evidence for a primary association of celiac disease to a particular HLA-DQ a/b heterodimer. J. Exp. Med. 169, 345-350 (1989).
    • (1989) J. Exp. Med , vol.169 , pp. 345-350
    • Sollid, L.M.1    Markussen, G.2    Ek, J.3    Gjerde, H.4    Vardtal, F.5    Thorsby, E.6
  • 9
    • 0034121187 scopus 로고    scopus 로고
    • Molecular basis of celiac disease
    • Sollid, L.M. Molecular basis of celiac disease. Annu. Rev. Immunol. 18, 53-81 (2000).
    • (2000) Annu. Rev. Immunol , vol.18 , pp. 53-81
    • Sollid, L.M.1
  • 10
    • 45849139002 scopus 로고    scopus 로고
    • Incidence of autoimmune diseases in celiac disease: Protective effect of the gluten-free diet
    • Cosnes, J. et al. Incidence of autoimmune diseases in celiac disease: Protective effect of the gluten-free diet. Clin. Gastroenterol. Hepatol. 6, 753-758 (2008).
    • (2008) Clin. Gastroenterol. Hepatol , vol.6 , pp. 753-758
    • Cosnes, J.1
  • 11
    • 0034661814 scopus 로고    scopus 로고
    • Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group [see comments]
    • Cellier, C. et al. Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group [see comments]. Lancet 356, 203-208 (2000).
    • (2000) Lancet , vol.356 , pp. 203-208
    • Cellier, C.1
  • 12
    • 0031890005 scopus 로고    scopus 로고
    • Abnormal intestinal intraepithelial lymphocytes in refractory sprue
    • Cellier, C. et al. Abnormal intestinal intraepithelial lymphocytes in refractory sprue. Gastroenterology 114, 471-481 (1998).
    • (1998) Gastroenterology , vol.114 , pp. 471-481
    • Cellier, C.1
  • 13
    • 0023727525 scopus 로고
    • Enteropathy-associated T cell lymphoma (malignant histiocytosis of the intestine) is recognized by a monoclonal antibody (HML-1) that defines a membrane molecule on human mucosal lymphocytes
    • Spencer, J. et al. Enteropathy-associated T cell lymphoma (malignant histiocytosis of the intestine) is recognized by a monoclonal antibody (HML-1) that defines a membrane molecule on human mucosal lymphocytes. Am. J. Pathol. 132, 1-5 (1988).
    • (1988) Am. J. Pathol , vol.132 , pp. 1-5
    • Spencer, J.1
  • 14
    • 0036715684 scopus 로고    scopus 로고
    • Coeliac disease: Dissecting a complex inflammatory disorder
    • Sollid, L. Coeliac disease: Dissecting a complex inflammatory disorder. Nat. Rev. Immunol. 9, 647-655 (2002).
    • (2002) Nat. Rev. Immunol , vol.9 , pp. 647-655
    • Sollid, L.1
  • 15
    • 33846005805 scopus 로고    scopus 로고
    • Celiac disease: Pathogenesis of a model immunogenetic disease
    • Kagnoff, M.F. Celiac disease: Pathogenesis of a model immunogenetic disease. J. Clin. Invest. 117, 41-49 (2007).
    • (2007) J. Clin. Invest , vol.117 , pp. 41-49
    • Kagnoff, M.F.1
  • 16
    • 0027319208 scopus 로고
    • Gliadin-specific, HLA-DQ(a1*0501,b1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients
    • Lundin, K.E.A. et al. Gliadin-specific, HLA-DQ(a1*0501,b1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J. Exp. Med. 178, 187-196 (1993).
    • (1993) J. Exp. Med , vol.178 , pp. 187-196
    • Lundin, K.E.A.1
  • 17
    • 13144283626 scopus 로고    scopus 로고
    • Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin
    • Van de Wal, Y. et al. Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin. Proc. Natl. Acad. Sci. USA 95, 10050-10054 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10050-10054
    • Van de Wal, Y.1
  • 18
    • 40349098215 scopus 로고    scopus 로고
    • Parallels between pathogens and gluten peptides in celiac sprue
    • Bethune, M.T. & Khosla, C. Parallels between pathogens and gluten peptides in celiac sprue. PLoS Pathog. 4, e34 (2008).
    • (2008) PLoS Pathog , vol.4
    • Bethune, M.T.1    Khosla, C.2
  • 19
    • 33748885488 scopus 로고    scopus 로고
    • Chemistry of gluten proteins
    • Wieser, H. Chemistry of gluten proteins. Food Microbiol. 24, 115-119 (2007).
    • (2007) Food Microbiol , vol.24 , pp. 115-119
    • Wieser, H.1
  • 20
    • 49749217711 scopus 로고
    • Gluten-induced enteropathy: The effect of partially digested gluten
    • Frazer, A. et al. Gluten-induced enteropathy: The effect of partially digested gluten. Lancet 2, 252-255 (1959).
    • (1959) Lancet , vol.2 , pp. 252-255
    • Frazer, A.1
  • 21
    • 0037183929 scopus 로고    scopus 로고
    • Structural basis for gluten intolerance in celiac sprue
    • Shan, L. et al. Structural basis for gluten intolerance in celiac sprue. Science 297, 2218-2220 (2002).
    • (2002) Science , vol.297 , pp. 2218-2220
    • Shan, L.1
  • 22
    • 3242801934 scopus 로고    scopus 로고
    • Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion
    • Qiao, S.W. et al. Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion. J. Immunol. 173, 1757-1762 (2004).
    • (2004) J. Immunol , vol.173 , pp. 1757-1762
    • Qiao, S.W.1
  • 23
    • 46749147598 scopus 로고    scopus 로고
    • Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury
    • Siegel, M. et al. Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury. PLoS ONE 3, e1861 (2008).
    • (2008) PLoS ONE , vol.3
    • Siegel, M.1
  • 24
    • 0036804796 scopus 로고    scopus 로고
    • Transglutaminase 2: An enigmatic enzyme with diverse functions
    • Fesus, L. & Piacentini, M. Transglutaminase 2: An enigmatic enzyme with diverse functions. Trends Biochem. Sci. 27, 534-539 (2002).
    • (2002) Trends Biochem. Sci , vol.27 , pp. 534-539
    • Fesus, L.1    Piacentini, M.2
  • 25
    • 0031438699 scopus 로고    scopus 로고
    • Autoantibodies in coeliac disease: Tissue transglutaminase - guilt by association?
    • Sollid, L.M., Molberg, O., McAdam, S. & Lundin, K.E. Autoantibodies in coeliac disease: Tissue transglutaminase - guilt by association? Gut 41, 851-852 (1997).
    • (1997) Gut , vol.41 , pp. 851-852
    • Sollid, L.M.1    Molberg, O.2    McAdam, S.3    Lundin, K.E.4
  • 26
    • 0037018095 scopus 로고    scopus 로고
    • Specificity of tissue transglutaminase explains cereal toxicity in celiac disease
    • Vader, L. et al. Specificity of tissue transglutaminase explains cereal toxicity in celiac disease. J. Exp. Med. 195, 643-649 (2002).
    • (2002) J. Exp. Med , vol.195 , pp. 643-649
    • Vader, L.1
  • 27
    • 0031779478 scopus 로고    scopus 로고
    • Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease
    • Molberg, O. et al. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat. Med. 4, 713-717 (1998).
    • (1998) Nat. Med , vol.4 , pp. 713-717
    • Molberg, O.1
  • 28
    • 0032528813 scopus 로고    scopus 로고
    • Selective deamidation by tissue transglutaminase strongly enhances gliadin-specfic T cell reactivity
    • Van de Wal, Y. et al. Selective deamidation by tissue transglutaminase strongly enhances gliadin-specfic T cell reactivity. J. Immunol. 161, 1585-1588 (1998).
    • (1998) J. Immunol , vol.161 , pp. 1585-1588
    • Van de Wal, Y.1
  • 29
    • 1642447710 scopus 로고    scopus 로고
    • Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease
    • Kim, C.Y., Quarsten, H., Bergseng, E., Khosla, C. & Sollid, L.M. Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease. Proc. Natl. Acad. Sci. USA 101, 4175-4179 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4175-4179
    • Kim, C.Y.1    Quarsten, H.2    Bergseng, E.3    Khosla, C.4    Sollid, L.M.5
  • 30
    • 21244462254 scopus 로고    scopus 로고
    • Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: Importance of proline spacing and glutamine deamidation
    • Qiao, S.W. et al. Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation. J. Immunol. 175, 254-261 (2005).
    • (2005) J. Immunol , vol.175 , pp. 254-261
    • Qiao, S.W.1
  • 31
    • 48149094447 scopus 로고    scopus 로고
    • Large-scale characterization of natural ligands explains the unique gluten-binding properties of HLA-DQ2
    • Stepniak, D. et al. Large-scale characterization of natural ligands explains the unique gluten-binding properties of HLA-DQ2. J. Immunol. 180, 3268-3278 (2008).
    • (2008) J. Immunol , vol.180 , pp. 3268-3278
    • Stepniak, D.1
  • 32
    • 0141817727 scopus 로고    scopus 로고
    • Characterization of cereal toxicity for celiac disease patients based on protein homology in grains
    • Vader, L.W. et al. Characterization of cereal toxicity for celiac disease patients based on protein homology in grains. Gastroenterology 125, 1105-1113 (2003).
    • (2003) Gastroenterology , vol.125 , pp. 1105-1113
    • Vader, L.W.1
  • 33
    • 33744540439 scopus 로고    scopus 로고
    • A unique dendritic cell subset accumulates in the celiac lesion and effi ciently activates gluten-reactive T cells
    • Raki, M. et al. A unique dendritic cell subset accumulates in the celiac lesion and effi ciently activates gluten-reactive T cells. Gastroenterology 131, 428-438 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 428-438
    • Raki, M.1
  • 34
    • 0028828948 scopus 로고
    • Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with TH1 or TH0 profile dominated by interferon g
    • Nilsen, E., Lundin, K., Krajci, P., Sollid, L. & Brantzaeg, P. Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with TH1 or TH0 profile dominated by interferon g. Gut 37, 766-776 (1995).
    • (1995) Gut , vol.37 , pp. 766-776
    • Nilsen, E.1    Lundin, K.2    Krajci, P.3    Sollid, L.4    Brantzaeg, P.5
  • 35
    • 0031937067 scopus 로고    scopus 로고
    • Small bowel enteropathy - role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-γ, TNF) in the induction of epithelial cell death and renewal
    • Guy-Grand, D., Disanto, J.P., Henchoz, P., Malassis-Seris, M. & Vassalli, P. Small bowel enteropathy - role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-γ, TNF) in the induction of epithelial cell death and renewal. Eur. J. Immunol. 28, 730-744 (1998).
    • (1998) Eur. J. Immunol , vol.28 , pp. 730-744
    • Guy-Grand, D.1    Disanto, J.P.2    Henchoz, P.3    Malassis-Seris, M.4    Vassalli, P.5
  • 36
    • 0142091358 scopus 로고    scopus 로고
    • The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses
    • Vader, W. et al. The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses. Proc. Natl. Acad. Sci. USA 100, 12390-12395 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12390-12395
    • Vader, W.1
  • 37
    • 33644778510 scopus 로고    scopus 로고
    • Human leukocyte antigen-DQ2 homozygosity and the development of refractory celiac disease and enteropathy-associated T-cell lymphoma
    • Al-Toma, A. et al. Human leukocyte antigen-DQ2 homozygosity and the development of refractory celiac disease and enteropathy-associated T-cell lymphoma. Clin. Gastroenterol. Hepatol. 3, 315-319 (2006).
    • (2006) Clin. Gastroenterol. Hepatol , vol.3 , pp. 315-319
    • Al-Toma, A.1
  • 38
    • 85185095077 scopus 로고    scopus 로고
    • Presentation and long-term follow-up of refractory celiac disease: Comparison of type I and type II
    • in press
    • Malamut, G. et al. Presentation and long-term follow-up of refractory celiac disease: Comparison of type I and type II. Gastroenterology (in press).
    • Gastroenterology
    • Malamut, G.1
  • 39
    • 34948825770 scopus 로고    scopus 로고
    • Long-term follow-up of 61 coeliac patients diagnosed in childhood: Evolution toward latency is possible on a normal diet
    • Matysiak-Budnik, T. et al. Long-term follow-up of 61 coeliac patients diagnosed in childhood: Evolution toward latency is possible on a normal diet. Gut 56, 1379-1386 (2007).
    • (2007) Gut , vol.56 , pp. 1379-1386
    • Matysiak-Budnik, T.1
  • 40
    • 0025950576 scopus 로고
    • Increase in γ/δ T cell receptor bearing lymphocytes in normal small bowel mucosa in latent celiac disease
    • Mäki, M., Holm, K., Collin, P. & Savilahti, E. Increase in γ/δ T cell receptor bearing lymphocytes in normal small bowel mucosa in latent celiac disease. Gut 32, 1412-1414 (1991).
    • (1991) Gut , vol.32 , pp. 1412-1414
    • Mäki, M.1    Holm, K.2    Collin, P.3    Savilahti, E.4
  • 41
    • 0035186416 scopus 로고    scopus 로고
    • Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells
    • Weiner, H. Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol. Rev. 182 207-214 (2001).
    • (2001) Immunol. Rev , vol.182 , pp. 207-214
    • Weiner, H.1
  • 42
    • 0037111368 scopus 로고    scopus 로고
    • HLA-DQ determines the response to exogenous wheat proteins: A model of gluten sensitivity in transgenic knockout mice
    • Black, K., Murray, J. & David, C.S. HLA-DQ determines the response to exogenous wheat proteins: A model of gluten sensitivity in transgenic knockout mice. J. Immunol. 169, 5595-5600 (2002).
    • (2002) J. Immunol , vol.169 , pp. 5595-5600
    • Black, K.1    Murray, J.2    David, C.S.3
  • 43
    • 9644294268 scopus 로고    scopus 로고
    • A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice
    • Marietta, E. et al. A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice. J. Clin. Invest. 114, 1090-1097 (2004).
    • (2004) J. Clin. Invest , vol.114 , pp. 1090-1097
    • Marietta, E.1
  • 44
    • 0037128650 scopus 로고    scopus 로고
    • Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis
    • Sardy, M., Karpati, S., Merkl, B., Paulsson, M. & Smyth, N. Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis. J. Exp. Med. 195, 747-757 (2002).
    • (2002) J. Exp. Med , vol.195 , pp. 747-757
    • Sardy, M.1    Karpati, S.2    Merkl, B.3    Paulsson, M.4    Smyth, N.5
  • 45
    • 0025310166 scopus 로고
    • + (TCRαβ or TCRγδ) and CD3-lymphocytes isolated from normal human gut epithelium differ from their PBL counterparts
    • + (TCRαβ or TCRγδ) and CD3-lymphocytes isolated from normal human gut epithelium differ from their PBL counterparts. Eur. J. Immunol. 20, 1097-1103 (1990).
    • (1990) Eur. J. Immunol , vol.20 , pp. 1097-1103
    • Jarry, A.1    Cerf-Bensussan, N.2    Brousse, N.3    Selz, F.4    Guy-Grand, D.5
  • 46
    • 0027414723 scopus 로고
    • + intraepithelial lymphocytes correlate with the grade of villous atrophy in coeliac patients on a long term normal diet
    • + intraepithelial lymphocytes correlate with the grade of villous atrophy in coeliac patients on a long term normal diet. Gut 34, 208-214 (1993).
    • (1993) Gut , vol.34 , pp. 208-214
    • Kutlu, T.1
  • 47
    • 0035057254 scopus 로고    scopus 로고
    • Increased enterocyte apoptosis and Fas-Fas ligand system in celiac disease
    • Ciccocioppo, R. et al. Increased enterocyte apoptosis and Fas-Fas ligand system in celiac disease. Am. J. Clin. Pathol. 115, 494-503 (2001).
    • (2001) Am. J. Clin. Pathol , vol.115 , pp. 494-503
    • Ciccocioppo, R.1
  • 48
    • 0034869813 scopus 로고    scopus 로고
    • Intraepithelial and lamina propria lymphocytes show distinct patterns of apoptosis whereas both populations are active in Fas based cytotoxicity in coeliac disease
    • Di Sabatino, A. et al. Intraepithelial and lamina propria lymphocytes show distinct patterns of apoptosis whereas both populations are active in Fas based cytotoxicity in coeliac disease. Gut 49 380-386 (2001).
    • (2001) Gut , vol.49 , pp. 380-386
    • Di Sabatino, A.1
  • 49
    • 0029864897 scopus 로고    scopus 로고
    • Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in Giardiasis
    • Oberhuber, G. et al. Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in Giardiasis. Am. J. Pathol. 148, 1351-1357 (1996).
    • (1996) Am. J. Pathol , vol.148 , pp. 1351-1357
    • Oberhuber, G.1
  • 50
    • 0036456903 scopus 로고    scopus 로고
    • Interferon-gamma-secreting T cells localize to the epithelium in coeliac disease
    • Olaussen, R.W. et al. Interferon-gamma-secreting T cells localize to the epithelium in coeliac disease. Scand. J. Immunol. 56, 652-664 (2002).
    • (2002) Scand. J. Immunol , vol.56 , pp. 652-664
    • Olaussen, R.W.1
  • 51
    • 38149047616 scopus 로고    scopus 로고
    • Small intestinal CD8TCRgammadeltaNKG2A intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease
    • Bhagat, G. et al. Small intestinal CD8TCRgammadeltaNKG2A intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease. J. Clin. Invest. 118, 281-293 (2008).
    • (2008) J. Clin. Invest , vol.118 , pp. 281-293
    • Bhagat, G.1
  • 52
    • 0038786874 scopus 로고    scopus 로고
    • Recurrent partial trisomy 1q22-q42 in clonal intraepithelial lymphocytes in refractory celiac sprue
    • Verkarre, V. et al. Recurrent partial trisomy 1q22-q42 in clonal intraepithelial lymphocytes in refractory celiac sprue. Gastroenterology 125, 40-46 (2003).
    • (2003) Gastroenterology , vol.125 , pp. 40-46
    • Verkarre, V.1
  • 53
    • 0033168262 scopus 로고    scopus 로고
    • Mucosal intraepithelial lymphocytes in enteropathy-associated T-cell lymphoma, unlcerative jejunitis, and refractory celiac sprue constitute a neoplastic population
    • Badgi, E., Diss, T., Munson, P. & Isaacson, P. Mucosal intraepithelial lymphocytes in enteropathy-associated T-cell lymphoma, unlcerative jejunitis, and refractory celiac sprue constitute a neoplastic population. Blood 94, 260-264 (1999).
    • (1999) Blood , vol.94 , pp. 260-264
    • Badgi, E.1    Diss, T.2    Munson, P.3    Isaacson, P.4
  • 55
    • 34948909526 scopus 로고    scopus 로고
    • Survival in refractory coeliac disease and enteropathy-associated T-cell lymphoma: Retrospective evaluation of single-centre experience
    • Al-Toma, A., Verbeek, W.H., Hadithi, M., von Blomberg, B.M. & Mulder, C.J. Survival in refractory coeliac disease and enteropathy-associated T-cell lymphoma: Retrospective evaluation of single-centre experience. Gut 56, 1373-1378 (2007).
    • (2007) Gut , vol.56 , pp. 1373-1378
    • Al-Toma, A.1    Verbeek, W.H.2    Hadithi, M.3    von Blomberg, B.M.4    Mulder, C.J.5
  • 56
    • 0037373255 scopus 로고    scopus 로고
    • Celiac disease association with CD8(+) T cell responses: Identification of a novel gliadin-derived HLA-A2-restricted epitope
    • Gianfrani, C. et al. Celiac disease association with CD8(+) T cell responses: Identification of a novel gliadin-derived HLA-A2-restricted epitope. J. Immunol. 170, 2719-2726 (2003).
    • (2003) J. Immunol , vol.170 , pp. 2719-2726
    • Gianfrani, C.1
  • 57
    • 41349088139 scopus 로고    scopus 로고
    • + T cells in celiac disease intestinal mucosa and induces the enterocyte apoptosis
    • + T cells in celiac disease intestinal mucosa and induces the enterocyte apoptosis. Gastroenterology 134, 1017-1027 (2008).
    • (2008) Gastroenterology , vol.134 , pp. 1017-1027
    • Mazzarella, G.1
  • 58
    • 4444251461 scopus 로고    scopus 로고
    • A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease
    • Hue, S. et al. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity 21, 367-377 (2004).
    • (2004) Immunity , vol.21 , pp. 367-377
    • Hue, S.1
  • 59
    • 0034058876 scopus 로고    scopus 로고
    • Selective expansion of intraepithelial lymphocytes expressing the HLA-E-specific natural killer receptor CD94 in celiac disease
    • Jabri, B. et al. Selective expansion of intraepithelial lymphocytes expressing the HLA-E-specific natural killer receptor CD94 in celiac disease. Gastroenterology 118, 867-879 (2000).
    • (2000) Gastroenterology , vol.118 , pp. 867-879
    • Jabri, B.1
  • 60
    • 4444240035 scopus 로고    scopus 로고
    • Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease
    • Meresse, B. et al. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity 21, 357-366 (2004).
    • (2004) Immunity , vol.21 , pp. 357-366
    • Meresse, B.1
  • 61
    • 33645118120 scopus 로고    scopus 로고
    • Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease
    • Di Sabatino, A. et al. Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease. Gut 55, 469-477 (2006).
    • (2006) Gut , vol.55 , pp. 469-477
    • Di Sabatino, A.1
  • 62
    • 0042324649 scopus 로고    scopus 로고
    • Interleukin 15: A key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease
    • Mention, J.J. et al. Interleukin 15: A key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease. Gastroenterology 125, 730-745 (2003).
    • (2003) Gastroenterology , vol.125 , pp. 730-745
    • Mention, J.J.1
  • 63
    • 85185122944 scopus 로고    scopus 로고
    • Budagian, V., Bulanova, E., Paus, R. & Bulfone-Paus, S. IL-15/IL-15 receptor biology: A guided tour through an expanding universe. Cytokine Growth Factor Rev. 17, 259-280 (2006).
    • Budagian, V., Bulanova, E., Paus, R. & Bulfone-Paus, S. IL-15/IL-15 receptor biology: A guided tour through an expanding universe. Cytokine Growth Factor Rev. 17, 259-280 (2006).
  • 64
    • 0035169507 scopus 로고    scopus 로고
    • Interleukin 15: Biology and relevance to human disease
    • Fehniger, T.A. & Caligiuri, M.A. Interleukin 15: Biology and relevance to human disease. Blood 97, 14-32 (2001).
    • (2001) Blood , vol.97 , pp. 14-32
    • Fehniger, T.A.1    Caligiuri, M.A.2
  • 65
    • 42949147181 scopus 로고    scopus 로고
    • Intracellular interaction of IL-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity
    • Bergamaschi, C. et al. Intracellular interaction of IL-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity. J. Biol. Chem. 283, 4189-4199 (2008).
    • (2008) J. Biol. Chem , vol.283 , pp. 4189-4199
    • Bergamaschi, C.1
  • 66
    • 0035862325 scopus 로고    scopus 로고
    • + T cells
    • + T cells. J. Exp. Med. 193, 219-231 (2001).
    • (2001) J. Exp. Med , vol.193 , pp. 219-231
    • Fehniger, T.1
  • 67
    • 33947322862 scopus 로고    scopus 로고
    • Inhibition of TGF-beta signaling by interleukin-15 via phospho-c-jun upregulation: A new role for interleukin-15 in the loss of immune homeostasis in celiac disease
    • Ben Ahmed, M. et al. Inhibition of TGF-beta signaling by interleukin-15 via phospho-c-jun upregulation: A new role for interleukin-15 in the loss of immune homeostasis in celiac disease. Gastroenterology 132, 994-1008 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 994-1008
    • Ben Ahmed, M.1
  • 68
    • 85185097758 scopus 로고    scopus 로고
    • Fina, D. et al. Interleukin-21 contributes to the mucosal T helper cell type 1 response in celiac disease. Gut (2007).
    • Fina, D. et al. Interleukin-21 contributes to the mucosal T helper cell type 1 response in celiac disease. Gut (2007).
  • 69
    • 0033778725 scopus 로고    scopus 로고
    • Interleukin 15 mediates epithelial changes in celiac disease
    • Maiuri, L. et al. Interleukin 15 mediates epithelial changes in celiac disease. Gastroenterology 119, 996-1006 (2000).
    • (2000) Gastroenterology , vol.119 , pp. 996-1006
    • Maiuri, L.1
  • 70
    • 85185107426 scopus 로고    scopus 로고
    • + T cells. Proc. Natl. Acad. Sci. USA 101, 15154-15159 (2004).
    • + T cells. Proc. Natl. Acad. Sci. USA 101, 15154-15159 (2004).
  • 71
    • 0035889934 scopus 로고    scopus 로고
    • NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment
    • Roberts, A.I. et al. NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment. J. Immunol. 167, 5527-5530 (2001).
    • (2001) J. Immunol , vol.167 , pp. 5527-5530
    • Roberts, A.I.1
  • 72
    • 0142197631 scopus 로고    scopus 로고
    • Roles of NKG2D immunoreceptor and its ligands
    • Raulet, D. Roles of NKG2D immunoreceptor and its ligands. Nat. Rev. Immunol. 3, 781-790 (2003).
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 781-790
    • Raulet, D.1
  • 73
    • 0032513388 scopus 로고    scopus 로고
    • Recognition of stress-induced MHC molecules by intestinal gammadelta T cells
    • Groh, V., Steinle, A., Bauer, S. & Spies, T. Recognition of stress-induced MHC molecules by intestinal gammadelta T cells. Science 279, 1737-1740 (1998).
    • (1998) Science , vol.279 , pp. 1737-1740
    • Groh, V.1    Steinle, A.2    Bauer, S.3    Spies, T.4
  • 74
    • 27144559440 scopus 로고    scopus 로고
    • NKG2 receptor-mediated regulation of effector CTL functions in the human tissue microenvironment
    • Jabri, B. & Meresse, B. NKG2 receptor-mediated regulation of effector CTL functions in the human tissue microenvironment. Curr. Top Microbiol. Immunol. 298, 139-156 (2006).
    • (2006) Curr. Top Microbiol. Immunol , vol.298 , pp. 139-156
    • Jabri, B.1    Meresse, B.2
  • 75
    • 0036799629 scopus 로고    scopus 로고
    • TCR specificity dictates CD94/NKG2A expression by human CTL
    • Jabri, B. et al. TCR specificity dictates CD94/NKG2A expression by human CTL. Immunity 17, 487-499 (2002).
    • (2002) Immunity , vol.17 , pp. 487-499
    • Jabri, B.1
  • 76
    • 0029862501 scopus 로고    scopus 로고
    • + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium
    • + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium. Proc. Natl. Acad. Sci. USA 93, 11774-11779 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 11774-11779
    • Roberts, S.C.1
  • 77
    • 33646675580 scopus 로고    scopus 로고
    • Reprogramming of CTLs into natural killer-like cells in celiac disease
    • Meresse, B. et al. Reprogramming of CTLs into natural killer-like cells in celiac disease. J. Exp. Med. 203, 1343-1355 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 1343-1355
    • Meresse, B.1
  • 78
    • 34250807802 scopus 로고    scopus 로고
    • Gliadin regulates the NK-dendritic cell cross-talk by HLA-E surface stabilization
    • Terrazzano, G. et al. Gliadin regulates the NK-dendritic cell cross-talk by HLA-E surface stabilization. J. Immunol. 179, 372-381 (2007).
    • (2007) J. Immunol , vol.179 , pp. 372-381
    • Terrazzano, G.1
  • 79
    • 0242662878 scopus 로고    scopus 로고
    • Human CD94 gene expression: Dual promoters differing in responsiveness to IL-2 or IL-15
    • Lieto, L.D., Borrego, F., You, C.H. & Coligan, J.E. Human CD94 gene expression: Dual promoters differing in responsiveness to IL-2 or IL-15. J. Immunol. 171, 5277-5286 (2003).
    • (2003) J. Immunol , vol.171 , pp. 5277-5286
    • Lieto, L.D.1    Borrego, F.2    You, C.H.3    Coligan, J.E.4
  • 80
    • 33846202575 scopus 로고    scopus 로고
    • Cutting edge: Distinct NK receptor profiles are imprinted on CD8 T cells in the mucosa and periphery during the same antigen challenge: Role of tissue-specific factors
    • Laouar, A. et al. Cutting edge: Distinct NK receptor profiles are imprinted on CD8 T cells in the mucosa and periphery during the same antigen challenge: Role of tissue-specific factors. J. Immunol. 178, 652-656 (2007).
    • (2007) J. Immunol , vol.178 , pp. 652-656
    • Laouar, A.1
  • 81
    • 50249179101 scopus 로고    scopus 로고
    • Vitamin effects on the immune system: Vitamins A and D take centre stage
    • 2008, Epub ahead of print
    • Mora, J., Iwata, M. & von Andrian, U. Vitamin effects on the immune system: Vitamins A and D take centre stage. Nat. Rev. Immunol. (2008)) [Epub ahead of print].
    • Nat. Rev. Immunol
    • Mora, J.1    Iwata, M.2    von Andrian, U.3
  • 82
    • 15844396467 scopus 로고    scopus 로고
    • The role of TCR stimulation and TGF-beta in controlling the expression of CD94/NKG2A receptors on CD8 T cells
    • Gunturi, A., Berg, R. E., Crossley, E., Murray, S. & Forman, J. The role of TCR stimulation and TGF-beta in controlling the expression of CD94/NKG2A receptors on CD8 T cells. Eur. J. Immunol. 35, 766-775 (2005).
    • (2005) Eur. J. Immunol , vol.35 , pp. 766-775
    • Gunturi, A.1    Berg, R.E.2    Crossley, E.3    Murray, S.4    Forman, J.5
  • 83
    • 34249678653 scopus 로고    scopus 로고
    • TGFbeta signalling in control of T-cell-mediated self-reactivity
    • Rubtsov, Y.P. & Rudensky, A.Y. TGFbeta signalling in control of T-cell-mediated self-reactivity. Nat. Rev. Immunol. 7, 443-453 (2007).
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 443-453
    • Rubtsov, Y.P.1    Rudensky, A.Y.2
  • 84
    • 0033104503 scopus 로고    scopus 로고
    • Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
    • Yang, X. et al. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J. 18, 1280-1291 (1999).
    • (1999) EMBO J , vol.18 , pp. 1280-1291
    • Yang, X.1
  • 85
    • 0037388134 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells
    • Castriconi, R. et al. Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells. Proc. Natl. Acad. Sci. USA 100, 4120-4125 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4120-4125
    • Castriconi, R.1
  • 86
    • 33748465396 scopus 로고    scopus 로고
    • Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor
    • Marie, J.C., Liggitt, D. & Rudensky, A.Y. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25, 441-454 (2006).
    • (2006) Immunity , vol.25 , pp. 441-454
    • Marie, J.C.1    Liggitt, D.2    Rudensky, A.Y.3
  • 87
    • 34250666265 scopus 로고    scopus 로고
    • NKG2D recognition mediates Toll-like receptor 3 signaling-induced breakdown of epithelial homeostasis in the small intestines of mice
    • Zhou, R., Wei, H., Sun, R., Zhang, J. & Tian, Z. NKG2D recognition mediates Toll-like receptor 3 signaling-induced breakdown of epithelial homeostasis in the small intestines of mice. Proc. Natl. Acad. Sci. USA 104, 7512-7515 (2007).
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 7512-7515
    • Zhou, R.1    Wei, H.2    Sun, R.3    Zhang, J.4    Tian, Z.5
  • 88
    • 0015993561 scopus 로고
    • in vitro model of gluten-sensitive enteropathy. Effect of gliadin on intestinal epithelial cells of patients with gluten-sensitive enteropathy in organ culture
    • Falchuk, Z.M., Gebhard, R.L., Sessoms, C. & Strober, W. An in vitro model of gluten-sensitive enteropathy. Effect of gliadin on intestinal epithelial cells of patients with gluten-sensitive enteropathy in organ culture. J. Clin. Invest. 53, 487-500 (1974).
    • (1974) J. Clin. Invest , vol.53 , pp. 487-500
    • Falchuk, Z.M.1    Gebhard, R.L.2    Sessoms, C.3    Strober, W.A.4
  • 89
    • 0018886442 scopus 로고
    • Gluten-sensitive enteropathy. Influence of histocompatibility type on gluten sensitivity in vitro
    • Falchuk, Z.M. et al. Gluten-sensitive enteropathy. Influence of histocompatibility type on gluten sensitivity in vitro. J. Clin. Invest. 66, 227-233 (1980).
    • (1980) J. Clin. Invest , vol.66 , pp. 227-233
    • Falchuk, Z.M.1
  • 90
    • 0035056814 scopus 로고    scopus 로고
    • FAS engagement drives apoptosis of enterocytes of coeliac patients
    • Maiuri, L. et al. FAS engagement drives apoptosis of enterocytes of coeliac patients. Gut 48, 418-424 (2001).
    • (2001) Gut , vol.48 , pp. 418-424
    • Maiuri, L.1
  • 91
    • 0023849698 scopus 로고
    • In vitro (organ culture) studies of the toxicity of specific A-gliadin peptides in celiac disease
    • de Ritis, G. et al. In vitro (organ culture) studies of the toxicity of specific A-gliadin peptides in celiac disease. Gastroenterology 94, 41-49 (1988).
    • (1988) Gastroenterology , vol.94 , pp. 41-49
    • de Ritis, G.1
  • 92
    • 0028300097 scopus 로고
    • Wheat peptide challenge in coeliac disease
    • Sturgess, R. et al. Wheat peptide challenge in coeliac disease. Lancet 343, 758-761 (1994).
    • (1994) Lancet , vol.343 , pp. 758-761
    • Sturgess, R.1
  • 93
    • 0030006037 scopus 로고    scopus 로고
    • In vitro activities of A-gliadin-related synthetic peptides: Damaging effect on the atrophic coeliac mucosa and activation of mucosal immune response in the treated coeliac mucosa
    • Maiuri, L. et al. In vitro activities of A-gliadin-related synthetic peptides: Damaging effect on the atrophic coeliac mucosa and activation of mucosal immune response in the treated coeliac mucosa. Scand. J. Gastroenterol. 31, 247-253 (1996).
    • (1996) Scand. J. Gastroenterol , vol.31 , pp. 247-253
    • Maiuri, L.1
  • 94
    • 0038501062 scopus 로고    scopus 로고
    • Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease
    • Maiuri, L. et al. Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet 362, 30-37 (2003).
    • (2003) Lancet , vol.362 , pp. 30-37
    • Maiuri, L.1
  • 95
    • 27744482891 scopus 로고    scopus 로고
    • Unexpected role of surface transglutaminase type II in celiac disease
    • Maiuri, L. et al. Unexpected role of surface transglutaminase type II in celiac disease. Gastroenterology 129, 1400-1413 (2005).
    • (2005) Gastroenterology , vol.129 , pp. 1400-1413
    • Maiuri, L.1
  • 96
    • 34147212320 scopus 로고    scopus 로고
    • Growth factor-like activity of gliadin, an alimentary protein: Implications for celiac disease
    • Barone, M.V. et al. Growth factor-like activity of gliadin, an alimentary protein: Implications for celiac disease. Gut 56, 480-488 (2007).
    • (2007) Gut , vol.56 , pp. 480-488
    • Barone, M.V.1
  • 97
    • 33847417938 scopus 로고    scopus 로고
    • Gliadin peptides activate blood monocytes from patients with celiac disease
    • Cinova, J. et al. Gliadin peptides activate blood monocytes from patients with celiac disease. J. Clin. Immunol. 27, 201-209 (2007).
    • (2007) J. Clin. Immunol , vol.27 , pp. 201-209
    • Cinova, J.1
  • 98
    • 30744435342 scopus 로고    scopus 로고
    • The role of NF-kappaB, IRF-1, and STAT-1alpha transcription factors in the iNOS gene induction by gliadin and IFN-gamma in RAW 264.7 macrophages
    • De Stefano, D. et al. The role of NF-kappaB, IRF-1, and STAT-1alpha transcription factors in the iNOS gene induction by gliadin and IFN-gamma in RAW 264.7 macrophages. J. Mol. Med. 84, 65-74 (2006).
    • (2006) J. Mol. Med , vol.84 , pp. 65-74
    • De Stefano, D.1
  • 99
    • 27744526778 scopus 로고    scopus 로고
    • Gliadin fragments induce phenotypic and functional maturation of human dendritic cells
    • Palova-Jelinkova, L. et al. Gliadin fragments induce phenotypic and functional maturation of human dendritic cells. J. Immunol. 175, 7038-7045 (2005).
    • (2005) J. Immunol , vol.175 , pp. 7038-7045
    • Palova-Jelinkova, L.1
  • 100
    • 32044441878 scopus 로고    scopus 로고
    • Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: Role of the innate immune response in Celiac disease
    • Thomas, K.E., Sapone, A., Fasano, A. & Vogel, S.N. Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: Role of the innate immune response in Celiac disease. J. Immunol. 176, 2512-2521 (2006).
    • (2006) J. Immunol , vol.176 , pp. 2512-2521
    • Thomas, K.E.1    Sapone, A.2    Fasano, A.3    Vogel, S.N.4
  • 101
    • 0036553914 scopus 로고    scopus 로고
    • Activation of macrophages by gliadin fragments: Isolation and characterization of active peptide
    • Tuckova, L. et al. Activation of macrophages by gliadin fragments: isolation and characterization of active peptide. J. Leukoc. Biol. 71, 625-631 (2002).
    • (2002) J. Leukoc. Biol , vol.71 , pp. 625-631
    • Tuckova, L.1
  • 102
    • 0033011434 scopus 로고    scopus 로고
    • Serum immunoglobulin A from patients with celiac disease inhibits human T84 intestinal crypt epithelial cell differentiation
    • Halttunen, T. & Maki, M. Serum immunoglobulin A from patients with celiac disease inhibits human T84 intestinal crypt epithelial cell differentiation. Gastroenterology 116, 566-572 (1999).
    • (1999) Gastroenterology , vol.116 , pp. 566-572
    • Halttunen, T.1    Maki, M.2
  • 103
    • 40449089491 scopus 로고    scopus 로고
    • Coeliac disease-specific autoantibodies targeted against transglutaminase 2 disturb angiogenesis
    • Myrsky, E. et al. Coeliac disease-specific autoantibodies targeted against transglutaminase 2 disturb angiogenesis. Clin. Exp. Immunol. 152, 111-119 (2008).
    • (2008) Clin. Exp. Immunol , vol.152 , pp. 111-119
    • Myrsky, E.1
  • 104
    • 33749002571 scopus 로고    scopus 로고
    • In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes
    • Zanoni, G. et al. In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes. PLoS Med. 3, e358 (2006).
    • (2006) PLoS Med , vol.3
    • Zanoni, G.1
  • 105
    • 21044456731 scopus 로고    scopus 로고
    • Small-bowel mucosal transglutaminase 2-specific IgA deposits in coeliac disease without villous atrophy: A prospective and randomized clinical study
    • Kaukinen, K. et al. Small-bowel mucosal transglutaminase 2-specific IgA deposits in coeliac disease without villous atrophy: A prospective and randomized clinical study. Scand. J. Gastroenterol. 40, 564-572 (2005).
    • (2005) Scand. J. Gastroenterol , vol.40 , pp. 564-572
    • Kaukinen, K.1
  • 106
    • 58149121362 scopus 로고    scopus 로고
    • Immunoglobulin A anti-tissue transglutaminase antibody deposits in the small intestinal mucosa of children with no villous atrophy
    • Tosco, A. et al. Immunoglobulin A anti-tissue transglutaminase antibody deposits in the small intestinal mucosa of children with no villous atrophy. J. Pediatr. Gastroenterol. Nutr. 47, 293-298 (2008).
    • (2008) J. Pediatr. Gastroenterol. Nutr , vol.47 , pp. 293-298
    • Tosco, A.1
  • 107
    • 0036073617 scopus 로고    scopus 로고
    • Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase activity both in vitro and in situ
    • Esposito, C. et al. Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase activity both in vitro and in situ. Gut 51, 177-181 (2002).
    • (2002) Gut , vol.51 , pp. 177-181
    • Esposito, C.1
  • 108
    • 13944250722 scopus 로고    scopus 로고
    • Immunoglobulin, complement and epidermal transglutaminase deposition in the cutaneous vessels in dermatitis herpetiformis
    • Preisz, K., Sardy, M., Horvath, A. & Karpati, S. Immunoglobulin, complement and epidermal transglutaminase deposition in the cutaneous vessels in dermatitis herpetiformis. J. Eur. Acad. Dermatol. Venereol. 19, 74-79 (2005).
    • (2005) J. Eur. Acad. Dermatol. Venereol , vol.19 , pp. 74-79
    • Preisz, K.1    Sardy, M.2    Horvath, A.3    Karpati, S.4
  • 109
    • 0034728821 scopus 로고    scopus 로고
    • Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease
    • Fasano, A. et al. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet 355, 1518-1519 (2000).
    • (2000) Lancet , vol.355 , pp. 1518-1519
    • Fasano, A.1
  • 110
    • 46049100586 scopus 로고    scopus 로고
    • Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3 e3
    • Lammers, K.M. et al. Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology 135, 194-204 e3 (2008).
    • (2008) Gastroenterology , vol.135 , pp. 194-204
    • Lammers, K.M.1
  • 111
    • 28444452580 scopus 로고    scopus 로고
    • Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect
    • Monsuur, A.J. et al. Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Nat. Genet. 37, 1341-1344 (2005).
    • (2005) Nat. Genet , vol.37 , pp. 1341-1344
    • Monsuur, A.J.1
  • 112
    • 0042324662 scopus 로고    scopus 로고
    • Alterations of the intestinal transport and processing of gliadin peptides in celiac disease
    • Matysiak-Budnik, T. et al. Alterations of the intestinal transport and processing of gliadin peptides in celiac disease. Gastroenterology 125, 696-707 (2003).
    • (2003) Gastroenterology , vol.125 , pp. 696-707
    • Matysiak-Budnik, T.1
  • 113
    • 38749093329 scopus 로고    scopus 로고
    • Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease
    • Matysiak-Budnik, T. et al. Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease. J. Exp. Med. 205, 143-154 (2008).
    • (2008) J. Exp. Med , vol.205 , pp. 143-154
    • Matysiak-Budnik, T.1
  • 114
    • 44149102725 scopus 로고    scopus 로고
    • Mechanisms of epithelial translocation of the alpha(2)-gliadin-33mer in coeliac sprue
    • Schumann, M. et al. Mechanisms of epithelial translocation of the alpha(2)-gliadin-33mer in coeliac sprue. Gut 57, 747-754 (2008).
    • (2008) Gut , vol.57 , pp. 747-754
    • Schumann, M.1
  • 115
    • 0033802220 scopus 로고    scopus 로고
    • Enhanced intestinal transepithelial antigen transport in allergic rats is mediated by IgE and CD23 (FcepsilonRII)
    • Yang, P., Berin, M.C., Yu, L., Conrad, D. & Perdue, M. Enhanced intestinal transepithelial antigen transport in allergic rats is mediated by IgE and CD23 (FcepsilonRII). J. Clin. Invest 106 879-886 (2000).
    • (2000) J. Clin. Invest , vol.106 , pp. 879-886
    • Yang, P.1    Berin, M.C.2    Yu, L.3    Conrad, D.4    Perdue, M.5
  • 116
    • 2942516894 scopus 로고    scopus 로고
    • Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells
    • Yoshida, M. et al. Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity 20, 769-783 (2004).
    • (2004) Immunity , vol.20 , pp. 769-783
    • Yoshida, M.1
  • 117
    • 0021734410 scopus 로고
    • Segregation of transferrin to a mildly acidic (pH 6.5) para-Golgi compartment in the recycling pathway
    • Yamashiro, D.J., Tycko, B., Fluss, S.R. & Maxfield, F.R. Segregation of transferrin to a mildly acidic (pH 6.5) para-Golgi compartment in the recycling pathway. Cell 37, 789-800 (1984).
    • (1984) Cell , vol.37 , pp. 789-800
    • Yamashiro, D.J.1    Tycko, B.2    Fluss, S.R.3    Maxfield, F.R.4
  • 118
    • 0035920589 scopus 로고    scopus 로고
    • Identification of the transferrin receptor as a novel immunoglobulin (Ig)A1 receptor and its enhanced expression on mesangial cells in IgA nephropathy
    • Moura, I. C. et al. Identification of the transferrin receptor as a novel immunoglobulin (Ig)A1 receptor and its enhanced expression on mesangial cells in IgA nephropathy. J. Exp. Med. 194, 417-425 (2001).
    • (2001) J. Exp. Med , vol.194 , pp. 417-425
    • Moura, I.C.1
  • 119
    • 3042850647 scopus 로고    scopus 로고
    • Adaptive changes of duodenal iron transport proteins in celiac disease
    • Barisani, D. et al. Adaptive changes of duodenal iron transport proteins in celiac disease. Physiol. Genomics 17, 316-325 (2004).
    • (2004) Physiol. Genomics , vol.17 , pp. 316-325
    • Barisani, D.1
  • 120
    • 48249148222 scopus 로고    scopus 로고
    • Dependence of antibody-mediated presentation of antigen on FcRn
    • Qiao, S. W. et al. Dependence of antibody-mediated presentation of antigen on FcRn. Proc. Natl. Acad. Sci. USA 105, 9337-9342 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 9337-9342
    • Qiao, S.W.1
  • 121
    • 0037568363 scopus 로고    scopus 로고
    • Constitutive activation of the signal transducer and activator of transcription pathway in celiac disease lesions
    • Mazzarella, G. et al. Constitutive activation of the signal transducer and activator of transcription pathway in celiac disease lesions. Am. J. Pathol. 162, 1845-1855 (2003).
    • (2003) Am. J. Pathol , vol.162 , pp. 1845-1855
    • Mazzarella, G.1
  • 122
    • 0034954034 scopus 로고    scopus 로고
    • Interferons α and β as immune regulators-a new look
    • Biron, C.A. Interferons α and β as immune regulators-a new look. Immunity 14, 661-664 (2001).
    • (2001) Immunity , vol.14 , pp. 661-664
    • Biron, C.A.1
  • 123
    • 0035063548 scopus 로고    scopus 로고
    • Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease
    • Monteleone, G. et al. Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease. Gut 48, 425-429 (2001).
    • (2001) Gut , vol.48 , pp. 425-429
    • Monteleone, G.1
  • 124
    • 33646798786 scopus 로고    scopus 로고
    • Celiac disease - sandwiched between innate and adaptive immunity
    • Stepniak, D. & Koning, F. Celiac disease - sandwiched between innate and adaptive immunity. Hum. Immunol. 67, 460-468 (2006).
    • (2006) Hum. Immunol , vol.67 , pp. 460-468
    • Stepniak, D.1    Koning, F.2
  • 125
    • 0034843855 scopus 로고    scopus 로고
    • Interferon-a drives T-cell mediated immunopathology in the intestine
    • Monteleone, G., Pender, S.L.F., Wathen, N.C. & MacDonald, T.T. Interferon-a drives T-cell mediated immunopathology in the intestine. Eur. J. Immunol. 31, 2247-2255 (2001).
    • (2001) Eur. J. Immunol , vol.31 , pp. 2247-2255
    • Monteleone, G.1    Pender, S.L.F.2    Wathen, N.C.3    MacDonald, T.T.4
  • 126
    • 34848853541 scopus 로고    scopus 로고
    • Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease
    • Di Sabatino, A. et al. Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease. Gastroenterology 133, 1175-1187 (2007).
    • (2007) Gastroenterology , vol.133 , pp. 1175-1187
    • Di Sabatino, A.1
  • 127
    • 0036155753 scopus 로고    scopus 로고
    • Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease
    • Salvati, V.M. et al. Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease. Gut 50, 186-190 (2002).
    • (2002) Gut , vol.50 , pp. 186-190
    • Salvati, V.M.1
  • 128
    • 0036376644 scopus 로고    scopus 로고
    • Type I interferon production by plasmacytoid dendritic cells and monocytes is triggered by viruses, but the level of production is controlled by distinct cytokines
    • Gary-Gouy, H., Lebon, P. & Dalloul, A.H. Type I interferon production by plasmacytoid dendritic cells and monocytes is triggered by viruses, but the level of production is controlled by distinct cytokines. J. Interferon Cytokine Res. 22, 653-659 (2002).
    • (2002) J. Interferon Cytokine Res , vol.22 , pp. 653-659
    • Gary-Gouy, H.1    Lebon, P.2    Dalloul, A.H.3
  • 129
    • 85185138079 scopus 로고    scopus 로고
    • Mattei, F., Schiavoni, G., Belardelli, F. & Tough, D. F. IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation. J. Immunol. 167, 1179-1187 (2001).
    • Mattei, F., Schiavoni, G., Belardelli, F. & Tough, D. F. IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation. J. Immunol. 167, 1179-1187 (2001).
  • 130
    • 33645775256 scopus 로고    scopus 로고
    • + T cell response during cross-priming
    • + T cell response during cross-priming. J. Immunol. 176, 4682-4689 (2006).
    • (2006) J. Immunol , vol.176 , pp. 4682-4689
    • Le Bon, A.1
  • 131
    • 25444434157 scopus 로고    scopus 로고
    • Interleukin-21: A modulator of lymphoid proliferation, apoptosis and differentiation
    • Leonard, W.J. & Spolski, R. Interleukin-21: A modulator of lymphoid proliferation, apoptosis and differentiation. Nat. Rev. Immunol. 5, 688-698 (2005).
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 688-698
    • Leonard, W.J.1    Spolski, R.2
  • 133
    • 85185148460 scopus 로고    scopus 로고
    • + T cells. J. Immunol. 176, 1490-1497 (2006).
    • + T cells. J. Immunol. 176, 1490-1497 (2006).
  • 134
    • 19944434230 scopus 로고    scopus 로고
    • + T cell expansion and function
    • + T cell expansion and function. J. Exp. Med. 201, 139-148 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 139-148
    • Zeng, R.1
  • 135
    • 34247862225 scopus 로고    scopus 로고
    • Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene
    • Torgerson, T.R. et al. Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene. Gastroenterology 132, 1705-1717 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 1705-1717
    • Torgerson, T.R.1
  • 136
    • 33749548860 scopus 로고    scopus 로고
    • FOXP3 polymorphisms in type 1 diabetes and coeliac disease
    • Bjornvold, M. et al. FOXP3 polymorphisms in type 1 diabetes and coeliac disease. J. Autoimmun. 27, 140-144 (2006).
    • (2006) J. Autoimmun , vol.27 , pp. 140-144
    • Bjornvold, M.1
  • 137
    • 43349106670 scopus 로고    scopus 로고
    • Infi Infiltration of forkhead box P3-expressing cells in small intestinal mucosa in coeliac disease but not in type 1 diabetes
    • Tiittanen, M., Westerholm-Ormio, M., Verkasalo, M., Savilahti, E. & Vaarala, O. Infi Infiltration of forkhead box P3-expressing cells in small intestinal mucosa in coeliac disease but not in type 1 diabetes. Clin. Exp. Immunol. 152, 498-507 (2008).
    • (2008) Clin. Exp. Immunol , vol.152 , pp. 498-507
    • Tiittanen, M.1    Westerholm-Ormio, M.2    Verkasalo, M.3    Savilahti, E.4    Vaarala, O.5
  • 138
    • 33846196712 scopus 로고    scopus 로고
    • + T lymphocytes
    • + T lymphocytes. J. Immunol. 178, 732-739 (2007).
    • (2007) J. Immunol , vol.178 , pp. 732-739
    • Peluso, I.1
  • 139
    • 33746949327 scopus 로고    scopus 로고
    • Adulthood-onset celiac disease is associated with intercellular adhesion molecule-1 (ICAM-1) gene polymorphism
    • Abel, M. et al. Adulthood-onset celiac disease is associated with intercellular adhesion molecule-1 (ICAM-1) gene polymorphism. Hum. Immunol. 67, 612-617 (2006).
    • (2006) Hum. Immunol , vol.67 , pp. 612-617
    • Abel, M.1
  • 140
    • 47249136580 scopus 로고    scopus 로고
    • Translational mini-review series on the immunogenetics of gut disease: Immunogenetics of coeliac disease
    • Dubois, P.C. & van Heel, D.A. Translational mini-review series on the immunogenetics of gut disease: Immunogenetics of coeliac disease. Clin. Exp. Immunol. 153, 162-173 (2008).
    • (2008) Clin. Exp. Immunol , vol.153 , pp. 162-173
    • Dubois, P.C.1    van Heel, D.A.2
  • 141
    • 0031825969 scopus 로고    scopus 로고
    • CTLA-4 gene polymorphism is associated with predisposition to coeliac disease
    • Djilali-Saiah, I. et al. CTLA-4 gene polymorphism is associated with predisposition to coeliac disease. Gut 43, 187-189 (1998).
    • (1998) Gut , vol.43 , pp. 187-189
    • Djilali-Saiah, I.1
  • 142
    • 41349103493 scopus 로고    scopus 로고
    • Newly identified genetic risk variants for celiac disease related to the immune response
    • Hunt, K.A. et al. Newly identified genetic risk variants for celiac disease related to the immune response. Nat. Genet. 40 395-402 (2008).
    • (2008) Nat. Genet , vol.40 , pp. 395-402
    • Hunt, K.A.1
  • 143
    • 34347324029 scopus 로고    scopus 로고
    • A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
    • van Heel, D.A. et al. A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat. Genet. 39, 827-829 (2007).
    • (2007) Nat. Genet , vol.39 , pp. 827-829
    • van Heel, D.A.1
  • 144
    • 44849084957 scopus 로고    scopus 로고
    • Association study of IL2/IL21 and FcgRIIa: Significant association with the IL2/IL21 region in Scandinavian coeliac disease families
    • Adamovic, S. et al. Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families. Genes Immun. 9, 364-367 (2008).
    • (2008) Genes Immun , vol.9 , pp. 364-367
    • Adamovic, S.1
  • 145
    • 33847246293 scopus 로고    scopus 로고
    • Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
    • Yamanouchi, J. et al. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat. Genet. 39, 329-337 (2007).
    • (2007) Nat. Genet , vol.39 , pp. 329-337
    • Yamanouchi, J.1
  • 146
    • 46349101155 scopus 로고    scopus 로고
    • The cytokine interleukin 21: A new player in coeliac disease?
    • Meresse, B., Verdier, J. & Cerf-Bensussan, N. The cytokine interleukin 21: A new player in coeliac disease? Gut 57, 879-881 (2008).
    • (2008) Gut , vol.57 , pp. 879-881
    • Meresse, B.1    Verdier, J.2    Cerf-Bensussan, N.3
  • 147
    • 0037301766 scopus 로고    scopus 로고
    • Refractory celiac sprue is a diffuse gastrointestinal disease
    • Verkarre, V. et al. Refractory celiac sprue is a diffuse gastrointestinal disease. Gut 52, 205-211 (2003).
    • (2003) Gut , vol.52 , pp. 205-211
    • Verkarre, V.1
  • 148
    • 0021678706 scopus 로고
    • Possible role for a human adenovirus in the pathogenesis of celiac disease
    • Kagnoff, M.F., Austin, R.K., Hubert, J.J., Bernardin, J.E. & Kasarda, D.D. Possible role for a human adenovirus in the pathogenesis of celiac disease. J. Exp. Med. 160, 1544-1557 (1984).
    • (1984) J. Exp. Med , vol.160 , pp. 1544-1557
    • Kagnoff, M.F.1    Austin, R.K.2    Hubert, J.J.3    Bernardin, J.E.4    Kasarda, D.D.5
  • 149
    • 85185143357 scopus 로고    scopus 로고
    • Nieuwenhuizen, W.F., Pieters, R.H., Knippels, L.M., Jansen, M.C. & Koppelman, S.J. Is Candida albicans a trigger in the onset of coeliac disease? Lancet 361, 2152-2154 (2003).
    • Nieuwenhuizen, W.F., Pieters, R.H., Knippels, L.M., Jansen, M.C. & Koppelman, S.J. Is Candida albicans a trigger in the onset of coeliac disease? Lancet 361, 2152-2154 (2003).
  • 150
    • 2942642613 scopus 로고    scopus 로고
    • Presence of bacteria and innate immunity of intestinal epithelium in childhood celiac disease
    • Forsberg, G. et al. Presence of bacteria and innate immunity of intestinal epithelium in childhood celiac disease. Am. J. Gastroenterol. 99, 894-904 (2004).
    • (2004) Am. J. Gastroenterol , vol.99 , pp. 894-904
    • Forsberg, G.1
  • 151
    • 33749175937 scopus 로고    scopus 로고
    • Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: A longitudinal study
    • Stene, L.C. et al. Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: A longitudinal study. Am. J. Gastroenterol. 101, 2333-2340 (2006).
    • (2006) Am. J. Gastroenterol , vol.101 , pp. 2333-2340
    • Stene, L.C.1
  • 152
    • 42949110060 scopus 로고    scopus 로고
    • Review article: Future research on coeliac disease - a position report from the European multistakeholder platform on coeliac disease (CDEUSSA)
    • Troncone, R., Ivarsson, A., Szajewska, H. & Mearin, M. L. Review article: Future research on coeliac disease - a position report from the European multistakeholder platform on coeliac disease (CDEUSSA). Aliment Pharmacol. Ther. 27, 1030-1043 (2008).
    • (2008) Aliment Pharmacol. Ther , vol.27 , pp. 1030-1043
    • Troncone, R.1    Ivarsson, A.2    Szajewska, H.3    Mearin, M.L.4
  • 153
    • 34447647295 scopus 로고    scopus 로고
    • Structure-based design of alpha-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2
    • Siegel, M., Xia, J. & Khosla, C. Structure-based design of alpha-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2. Bioorg. Med. Chem. 15, 6253-6261 (2007).
    • (2007) Bioorg. Med. Chem , vol.15 , pp. 6253-6261
    • Siegel, M.1    Xia, J.2    Khosla, C.3
  • 154
    • 34548120540 scopus 로고    scopus 로고
    • Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease
    • Xia, J. et al. Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease. Bioorg. Med. Chem. 15, 6565-6573 (2007).
    • (2007) Bioorg. Med. Chem , vol.15 , pp. 6565-6573
    • Xia, J.1
  • 155
    • 33846962165 scopus 로고    scopus 로고
    • Oral proteases: A new approach to managing coeliac disease
    • Cerf-Bensussan, N., Matysiak-Budnik, T., Cellier, C. & Heyman, M. Oral proteases: A new approach to managing coeliac disease. Gut 56 157-160 (2007).
    • (2007) Gut , vol.56 , pp. 157-160
    • Cerf-Bensussan, N.1    Matysiak-Budnik, T.2    Cellier, C.3    Heyman, M.4
  • 156
    • 34547494627 scopus 로고    scopus 로고
    • Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue
    • Gass, J., Bethune, M.T., Siegel, M., Spencer, A. & Khosla, C. Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue. Gastroenterology 133, 472-480 (2007).
    • (2007) Gastroenterology , vol.133 , pp. 472-480
    • Gass, J.1    Bethune, M.T.2    Siegel, M.3    Spencer, A.4    Khosla, C.5
  • 157
    • 33749440740 scopus 로고    scopus 로고
    • Highly efficient gluten degradation with a newly identified prolyl endoprotease: Implications for celiac disease
    • Stepniak, D. et al. Highly efficient gluten degradation with a newly identified prolyl endoprotease: Implications for celiac disease. Am. J. Physiol. Gastrointest. Liver Physiol. 291, G621-G629 (2006).
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol , vol.291
    • Stepniak, D.1
  • 158
    • 45449108449 scopus 로고    scopus 로고
    • A non-human primate model for gluten sensitivity
    • Bethune, M.T. et al. A non-human primate model for gluten sensitivity. PLoS ONE 3, e1614 (2008).
    • (2008) PLoS ONE , vol.3
    • Bethune, M.T.1
  • 159
    • 46649111178 scopus 로고    scopus 로고
    • Transepithelial transport and enzymatic detoxification of gluten in gluten-sensitive rhesus macaques
    • Bethune, M.T., Ribka, E., Khosla, C. & Sestak, K. Transepithelial transport and enzymatic detoxification of gluten in gluten-sensitive rhesus macaques. PLoS ONE 3, e1857 (2008).
    • (2008) PLoS ONE , vol.3
    • Bethune, M.T.1    Ribka, E.2    Khosla, C.3    Sestak, K.4
  • 160
    • 6044249060 scopus 로고    scopus 로고
    • Gluten-free diet, chromosomal abnormalities, and cancer risk in coeliac disease
    • Verkarre, V., Romana, S.P. & Cerf-Bensussan, N. Gluten-free diet, chromosomal abnormalities, and cancer risk in coeliac disease. J. Pediatr. Gastroenterol. Nutr. 38, 140-142 (2004).
    • (2004) J. Pediatr. Gastroenterol. Nutr , vol.38 , pp. 140-142
    • Verkarre, V.1    Romana, S.P.2    Cerf-Bensussan, N.3


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