Intracellular interaction of interleukin-15 with its receptor α during production leads to mutual stabilization and increased bioactivity

Journal of Biological Chemistry

Volumn 283, Issue 7, 2008, Pages 4189-4199

  Bergamaschi, Cristina ^a   Rosati, Margherita ^a   Jalah, Rashmi ^a   Valentin, Antonio ^a   Kulkarni, Viraj ^a   Alicea, Candido ^a   Zhang, Gen Mu ^a   Patel, Vainav ^a   Felber, Barbara K ^a   Pavlakis, George N ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; COBALT; ENZYME ACTIVITY; FLOW INTERACTIONS; STABILIZATION;

BIOLOGICAL ACTIVITIES; CELL TYPES; CYTOKINE; EXTRACELLULAR; IN-VIVO; INTERLEUKIN 15; MEMORY CELLS; NATURAL KILLER CELLS; T LYMPHOCYTES;

ELECTRIC LOAD MANAGEMENT;

CYCLOHEXIMIDE; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR ALPHA; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDRODYNAMICS; MEMORY CELL; MOUSE; NATURAL KILLER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN STABILITY; T LYMPHOCYTE; BLOOD; CELL LINE; ENZYME LINKED IMMUNOSORBENT ASSAY; LIVER; LUNG; METABOLISM; PROTEIN BINDING; SPLEEN;

MUS;

CELL LINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERLEUKIN-15; INTERLEUKIN-15 RECEPTOR ALPHA SUBUNIT; LIVER; LUNG; PROTEIN BINDING; SPLEEN;

EID: 42949147181     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M705725200     Document Type: Article

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